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Douglas A. Gray, PhD
dgray@ohri.ca
Telephone: 613-737-7700 ext 70331
Fax: 613-247-3524
 General Campus
(see Contact page for maps)
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Senior Scientist, Cancer Therapeutics, Ottawa Hospital Research Institute
Professor, Depts. of Medicine and
Biochemistry, Microbiology and Immunology,
University of Ottawa
University of Ottawa Joan Sealy Chair in Lung Cancer Research
Current Research Projects
We are interested in the molecular changes that occur during mammalian aging, and how these changes may predispose the individual to diseases of aging. The diseases of interest are lung cancer and neurodegeneration, both of which show dramatically increased frequencies during the later decades of life. We are particularly interested in age-related changes in the ubiquitin/proteasome pathway (the major pathway for the regulated destruction of cellular proteins). We are studying age-related changes in gene expression in the lungs and brains of mice and humans, and are modelling age-related perturbations in proteolytic pathways using transgenic mice. The involvement of ubiquitin chains in DNA repair is also under investigation using transgenic mice. We continue in our studies of USP4, a deubiquitinating enzyme first identified in the Gray laboratory, hoping to identify its substrates and elucidate its postulated role in lung cancer.
Research Group Members
Senior Research Associate:
Dr. Josée Coulombe
Research Associate:
Dr. Nina Fowler
Senior Research Technician:
Mei Zhang, M.Sc.
Graduate Students:
Sophie Bastarache, M.Sc. candidate in the Dept. of Biochemistry,
Microbiology and Immunology
Dr. James Villeneuve, Ph.D. candidate in the Dept. of Biochemistry,
Microbiology and Immunology
Matthew Tang, Ph.D. candidate in the Dept. of Biochemistry,
Microbiology and Immunology
Summer Students:
Laura Ho
Madison Gray
Yi Jin
Recent Publications:
Proctor, C.J., and Gray, D.A. (2008) Explaining oscillations and variability in the p53-Mdm2 system. BMC Systems Biology 2008, 2:75.
Brun, J., Chiu, R.K., Lockhart, K., Xiao, W., Wouters, B.G., and Gray, D.A. (2008) hMMS2 serves a redundant role in human PCNA polyubiquitination BMC Molecular Biology, 2008 9:24
Tsirigotis, M., Baldwin, R.M., Tang, M.Y., Lorimer, I.A.J., and Gray, D.A. (2008) Activation of p38MAPK contributes to polyglutamine-induced cytotoxicity. PLoS One 3(5): e2130 doi:10.1371/journal.pone.0002130.
Proctor, C.J., Tsirigotis, M., and Gray, D.A. (2007) An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline. BMC Systems Biology 1:17
Langie S.A.S., Knaapen, A.D., Ramaekers, C.H.M.A., Theys, J., Brun, J., Godschalk, R.W.L., van Schooten, F.-J., Lambin, P., Gray, D.A., Wouters, B.G., and Chiu, R.K. (2007) Formation of Lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity. DNA Repair 6, 852-862.
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