David A. Grimes, MD, FRCPC Civic Campus (see Contact page for maps)

Associate Scientist, Neuroscience, Ottawa Hospital Research Institute

Associate Professor, Division of Neurology, Department of Medicine, University of Ottawa

Director, Parkinson's Disease and Movement Disorders Clinic at The Ottawa Hospital

Co-Director of the Parkinson Research Consortium, Ottawa Health Research Institute

Biographical sketch

Dr. Grimes received his Doctorate in Medicine and completed his residency in Neurology at the University of Ottawa. He spent two years at the Toronto Hospital and the Centre for Research in Neurodegenerative Diseases as a research fellow in movement disorders and molecular genetics. He joined the Department of Medicine in Ottawa in 1999. His major clinical interests are in the diagnosis and treatment of a wide variety of movement disorders with an emphasis on Parkinson's disease and dystonia. As a basic scientist, he is interested in identifying mutated genes that cause Parkinson's disease and other movement disorders. He has received grants from the Parkinson's Society Canada, the Parkinson's Society of Ottawa-Carleton, the Dystonia Medical Research Foundation and the Myoclonus Research Foundation. Other professional activities include membership in the American Academy of Neurology, the Canadian Neurological Society, the Canadian Movement Disorder Group, the Parkinson Study Group and the Movement Disorder Society. He is a reviewer for the Movement Disorders Journal, Canadian Journal of Neurological Sciences, Brain, and Canadian Medical Association Journal. He is also the medical advisor for the Parkinson Society Ottawa. He received the Queen's Golden Jubilee Medal in 2002 for his work in Parkinson's disease.

CLINICAL INTERESTS

He is interested in the diagnosis and treatment of movement disorders including Parkinson's disease, dystonia, chorea, tics and myoclonus. He conducts clinical trials in Parkinson's disease and dystonia exploring novel treatment options. He has extensive experience with botulinum toxin injections for the treatment of focal dystonia and hemifacial spasm.

RESEARCH INTERESTS

Exploring the role of genes that cause or contribute to the development of abnormal movements. Currently involved in trying to identify a novel gene mutation for Parkinson's disease and for inherited myoclonus dystonia.

EDUCATIONAL INTERESTS

Involved in local teaching of movement disorders to undergraduate and post-graduate students. Also involved in teaching at the national level, giving lectures at the movement disorders review course to senior neurology residents and at review courses at the annual Canadian Congress of Neurologic Science meetings.

BOOKS, BOOK CHAPTERS

Grimes, David A. Parkinson’s Disease. Therapeutic Choices 5th Edition, Editor Jean Gray (2007)

Grimes, David A. Parkinson's - Stepping Forward. Toronto: Key Porter, 2004 pages 209

I. Litvan, D.A. Grimes, A.E. Lang. In: Litvan I, Goetz C and Lang AE editors. Phenotypes and Prognosis: Clinicopathologic Studies of Corticobasal Degeneration Corticobasal Degeneration. Philadelphia: Lippincott-Raven. Adv Neurol 2000;82:183-96

Grimes JD, Grimes D.A. One Step at a Time - Problems and Answers for Patients and Health Professionals - Third Edition, 1999, 234 pages.

Most Recent Publications (provided by The Ottawa Hospital Library Database)

Biglan K;Parkinson Study Group CALM Cohort Investigators;Grimes DA;, (2009 May), Long-term effect of initiating pramipexole vs levodopa in early Parkinson disease, Arch Neurol, Vol.66, Issue 5, 563-570 -> view abstract

Pankratz N;Nichols WC;Elsaesser VE;Pauciulo MW;Marek DK;Halter CA;Wojcieszek J;Rudolph A;Pfeiffer RF;Foroud T;Grimes DA;, (2009 Jun 15), Alpha-synuclein and familial Parkinson's disease, Mov Disord , Vol.24, Issue 8, 1125-1131 -> view abstract

Pankratz N;Kissell DK;Pauciulo MW;Halter CA;Rudolph A;Pfeiffer RF;Marder KS;Foroud T;Nichols WC;Grimes DA;, (2009 Jul 28), Parkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations, Neurology, Vol.73, Issue 4, 279-286 -> view abstract

Schwarzschild MA;Schwid SR;Marek K;Watts A;Lang AE;Oakes D;Shoulson I;Ascherio A;Hyson C;Gorbold E;Rudolph A;Kieburtz K;Fahn S;Gauger L;Goetz C;Seibyl J;Forrest M;Ondrasik J;Grimes DA;, (2008 Jun), Serum urate as a predictor of clinical and radiographic progression in Parkinson disease, Arch Neurol, Vol.65, Issue 6, 716-723 -> view abstract

Brin MF;Comella CL;Jankovic J;Lai F;Naumann M;Grimes DA;, (2008 Jul 30), Long-term treatment with botulinum toxin type A in cervical dystonia has low immunogenicity by mouse protection assay, Mov Disord , Vol.23, Issue 10, 1353-1360 -> view abstract

Jacobsen KX;MacDonald H;Lemonde S;Daigle M;Grimes DA;Bulman DE;Albert PR;, (2008 Jan), A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription, Neurobiol Dis, Vol.29, Issue 1, 117-122 -> view abstract

Han F;Racacho L;Yang H;Read T;Suchowersky O;Lang AE;Grimes DA;Bulman DE;, (2008 Feb 15), Large deletions account for an increasing number of mutations in SGCE, Mov Disord , Vol.23, Issue 3, 456-460 -> view abstract

Schifitto G;Friedman JH;Oakes D;Shulman L;Comella CL;Marek K;Fahn S;Grimes DA;, (2008 Aug 12), Fatigue in levodopa-naive subjects with Parkinson disease, Neurology, Vol.71, Issue 7, 481-485 -> view abstract

Grimes DA;, (2008), Non-Parkinsonian diseases caused by LRRK2 mutations., Journal Watch Neurology, Vol.10, Issue 6, 46

Postuma RB;Wolfson C;Rajput A;Stoessl AJ;Martin WR;Suchowersky O;Chouinard S;Panisset M;Jog MS;Grimes DA;Marras C;Lang AE;, (2007 Jun 15), Is there seasonal variation in risk of Parkinson's disease?, Movement Disorders, Vol.22, Issue 8, 1097-1101 -> view abstract

Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).