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Associate Scientist, Clinical Epidemiology Program, Ottawa Hospital Research Institute
Assistant Professor, Division of Thoracic Surgery & Critical Care Medicine, The Ottawa Hospital / University of Ottawa
Research
Dr. Seely's major research interests include theoretical research applying complex systems science to the care and understanding of critically ill and peri-operative patients, and experimental research applying dynamical analysis to the bedside of surgical and intensive care unit patients. Other clinical and research interests include outcomes following minimally invasive foregut surgery and the role of melatonin in preventing lung cancer recurrence, as well as past research regarding the role of neutrophil membrane receptor expression in regulating the processes of neutrophil migration and cell death (doctoral thesis).
Dr. Seely currently runs a hospital-based Dynamical Analysis Laboratory, and is currently supervising a post-doctoral fellow, a research associate, and two clinical research coordinators as well as surgical residents and students. Active collaboration with colleagues in both Thoracic Surgery and Critical Care Medicine is a big component of this research program. Rooted in a paradigm of complex systems science, the underlying hypothesis of ongoing research is that continuous multiorgan variability analysis offers a novel means to establish early diagnosis and real-time prognosis of critical illness. Current experiments address changes in multi-organ variability during exercise, as well as in the presence of infection and critical illness. Dr. Seely was recently awarded a New Investigator Award by the Canadian Institutes of Health Research (CIHR), and has received funding from local and regional funding organizations.
Dr. Seely's training includes a Bachelors of Science in Honours Physics at Carleton University (B.Sc. '89), medical school (MDCM '94), General Surgery (FRCSC '01), and a doctoral degree in basic science (Ph.D. '02) at McGill University, followed by Critical Care Medicine (2003) and Thoracic Surgery (FRCSC '04) at the University of Ottawa.
Selected Publications
Klein DJ, Derzko A, Foster D, Seely AJ, Brunet F, Romaschin AD, Marshall JC. Daily Variation in Endotoxin Levels is Associated with Increased Organ Failure in Critically Ill Patients. Shock 2007 Jun 21 [Epub ahead of print].
Seely AJE. Editorial: Heart Rate Variability And Infection: Diagnosis, Prognosis and Prediction. Journal of Critical Care 2006, 21:286-289.
Seely AJE, Sundaresan S, Finley RL, Principles of Laparoscopic Surgery of the Gastroesophageal Junction, JACS, 2005 200(1):77-87.
Seely AJE, Macklem PT. Complex Systems and the Technology of Variability Analysis, Critical Care 2004 8(6):R367-84.
Ferri LE, Pascual J, Seely AJE, Giannias B, Christou NV. Intra-abdominal sepsis attenuates local inflammation-mediated increases in microvascular permeability at remote sites in mice in vivo. Surgery 135: 187-95, 2004
Seely AJE, Pascual JL, Christou NV. Neutrophil membrane receptor expression (connectivity) regulates neutrophil delivery, function and clearance, Critical Care 2003. 7:291.
Pascual JL, Ferri, LE, Seely, AJE Campisi, G, Chaudhury, P, Giannias, B, Evans DC, Razek T, Michel, RP, Christou, NV. Hypertonic saline resuscitation of hemorrhagic shock diminishes neutrophil rolling and adherence to endothelium and reduces in vivo vascular leakage, Annals of Surgery 2002; 236:634.
Ferri LE, Pascual J, Seely AJE, Chaudhury P, Christou NV, Soluble L-selectin attenuates tumor necrosis factor - mediated leukocyte adherence and vascular permeability: a protective role for elevated soluble L-selectin in sepsis, Critical Care Medicine 2002; 30:1842.
Seely AJE, Naud J-F, Campisi G, Giannias B, Liu S, DiCarlo A, Ferri LE, Pascual JL, Tchervenkov J, Christou NV. Alteration of chemoattractant receptor expression regulates human neutrophil chemotaxis in vivo. Annals of Surgery 2002; 235:550-559.
Seely AJE, Snell L, Salasidis R. The impact of current experience, level of training, and post-call status on examination results in students and residents during a surgical ICU rotation. Medical Teacher 2001, 23(4):396.
Seely AJE, Christou NV. Multiple Organ Dysfunction Syndrome: Exploring the paradigm of complex non-linear systems. Critical Care Medicine 2000; 28:2193.
Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).
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