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Program Director, Chronic Disease, Ottawa Hospital Research Institute
Senior Scientist, Chronic Disease, Ottawa Hospital Research Institute
Active Attending Medical Staff, Division of Endocrinology and Metabolism, Ottawa Hospital
Professor, Departments of Medicine and of Biochemistry, Microbiology and Immunology, University of Ottawa
Research Interests
Obesity
Adipocyte Differentiation
Insulin Action
Apoptosis
Diabetes
Major Research Activities
Dr. Sorisky's research focus is the regulation of adipose tissue growth. The importance of maintaining body fat at a healthy level is highlighted by the elevated risk of diabetes mellitus type II, lipid disorders, hypertension, and accelerated cardiovascular disease associated with obesity. The central defect arising from the obese state to account for this cluster of diseases is insulin resistance. He believes that a critical contribution towards overall adipose tissue mass derives from the regulated differentiation of precursor pools of fibroblast-like preradipocytes into lipid-laden mature adipocytes. Two main themes of research are underway in his laboratory. One project makes use of established preadipose cell lines to uncover key intracellular signals generated by differentiation-inducing factors such as insulin/insulin-like growth factor-1 (IGF-1). The second research program compares 1) rates of differentiation and 2) insulin/insulin-like growth factor-1signal transduction pathways between human preadipocytes in primary culture obtained from intra-abdominal versus subcutaneous adipose tissue.
The results of Dr. Sorisky's research will enhance our understanding of adipocyte differentiation, and identify critical cellular factors that may serve as potential targets for future intervention in the prevention or treatment of obesity.
Future Research
Basic research investigating the fundamental
intracellular regulators of adipogenesis will proceed. As potential key
mediators of differentiation factors in the preadipose cell are identified
and characterized, Dr. Sorisky's long-term plans are to develop clinical
trials during which these processes could be analysed. Participants in
these studies would include individuals who are overweight, with or without
diabetes mellitus. Interventions would consist of specific diets, exercise
protocols, or relevant pharmacologic agents. Dr. Sorisky Anticipates that
the data generated by these studies will provide information on how preadipocyte
differentiation is regulated during weight loss, and in the subsequent,
more diificult to achieve phase of weight maintenance.
Grant Support
Canadian Institutes of Health Research - Apr 2005-Mar 2009
Regulation of adipogenesis
Heart and Stroke Foundation of Canada Grant - July 2004-June 2007
Regulation of the pro-atherogenic adipokine IL-6 by TSH
Most Recent Publications (provided by The Ottawa Hospital Library Database)
Tomlinson JJ;Boudreau A;Wu D;Abdou SH;Carrigan A;Gagnon A;Mears AJ;Sorisky A;Atlas E;Hache RJ;, (2010 Jan), Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors, Mol Endocrinol, Vol.24, Issue 1, 104-113 -> view abstract
Artemenko Y;Gagnon A;Sorisky A;, (2009 Jan), Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes, Journal of Cellular Physiology, Vol.218, Issue 1, 228-236 -> view abstract
Yarmo MN;Landry A;Molgat AS;Gagnon A;Sorisky A;, (2009 Feb 1), Macrophage-conditioned medium inhibits differentiation-induced Rb phosphorylation in 3T3-L1 preadipocytes, Experimental Cell Research, Vol.315, Issue 3, 411-418 -> view abstract
Gagnon A;Landry A;Sorisky A;, (2009 Apr), IKKbeta and the anti-adipogenic effect of platelet-derived growth factor in human abdominal subcutaneous preadipocytes, J Endocrinol, Vol.201, Issue 1, 75-80 -> view abstract
Molgat AS;Gagnon A;Sorisky A;, (2009 Apr), Preadipocyte apoptosis is prevented by macrophage-conditioned medium in a PDGF-dependent manner, American Journal of Physiology - Cell Physiology, Vol.296, Issue 4, C757 -> view abstract
Antunes TT;Gagnon A;Langille ML;Sorisky A;, (2008 Jun), Thyroid-stimulating hormone induces interleukin-6 release from human adipocytes through activation of the nuclear factor-kappaB pathway, Endocrinology, Vol.149, Issue 6, 3062-3066 -> view abstract
Sorisky A;, (2008 Jan 29), A new predictor for type 2 diabetes?, CMAJ, Vol.178, Issue 3, 313-315
Sorisky A;Antunes TT;Gagnon A;, (2008 Jan), The Adipocyte as a novel TSH target, Mini Rev Med Chem, Vol.8, Issue 1, 91-96 -> view abstract
Constant VA;Gagnon A;Yarmo M;Sorisky A;, (2008 Apr), The antiadipogenic effect of macrophage-conditioned medium depends on ERK1/2 activation, Metabolism, Vol.57, Issue 4, 465-472 -> view abstract
Sorisky A;Gagnon A;, (2008), Measurement of phosphoinositide 3-kinase and its products to study adipogenic signal transduction, Methods in Molecular Biology, Vol.456, 317-325 -> view abstract
Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).
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