Duncan Stewart, MD, FRCPC djstewart@ohri.ca Telephone: 613-737-8899 x 79017 Fax: 613-739-6294

CEO & Scientific Director and Senior Scientist in the Regenerative Medicine Program and Evelyne and Rowell Laishley Chair, Ottawa Hospital Research Institute

Vice President, Research, The Ottawa Hospital

Professor, Department of Medicine, Faculty of Medicine, University of Ottawa

Biographical Sketch

Dr. Stewart received an MD from McGill University in 1977, where he also performed residency training in Internal Medicine and Cardiology. He completed three years of research fellowship training in Physiology and Pharmacology in Freiburg, Germany under the supervision of Drs. Busse and Bassenge. He returned to Canada in 1987 as an Assistant Professor of Medicine at McGill University and staff cardiologist at the Royal Victoria Hospital and established a Vascular Biology Laboratory with a major interest in endothelial factors, in particular the role of nitric oxide and endothelin in the pathogenesis of vascular disease. In 1994, he moved to Toronto and assumed the position of Head of Cardiology at St. Michael's Hospital which he held until 2003. In 1997, he became the Director of Cardiology of the University of Toronto and was awarded the Dexter Man Chair of Cardiology in 1999. He was promoted to Full Professor of Medicine at the University of Toronto in 1999, and in 2003 he became the Associate Director of Research at St. Michael's Hospital. In 2003 he was appointed as the leader of the Regenerative Medicine Program of the newly established McLaughlin Centre for Molecular Medicine, and in 2005 he assumed the Directorship of this Centre. In 2007 he became the CEO and Scientific Director of the Ottawa Hospital Research Institute, as well as the Vice President of Research at The Ottawa Hospital and Professor of Medicine at the University of Ottawa.

Research

Dr. Stewart's research interests have continued to focus on the endothelium in health and disease. He has established an important research focus in translational research: "From molecules to medicine". In particular, his research is seeking to use molecular approaches in the prevention and treatment of vascular diseases. He has published 165 peer-reviewed manuscripts and is on the Editorial Board of prestigious scientific journals including Circulation Research. He has developed several novel gene-based approaches to the therapy of cardiovascular diseases, specifically, a new cell-based gene transfer technology for the treatment of pulmonary hypertension. As well, his group has initiated Canada's first clinical trials using gene and cell therapy for cardiovascular disease, including therapeutic angiogenesis for end stage coronary artery disease and progenitor cell therapy for pulmonary hypertension.

Selected Publications

Mei S, McCarter S, Deng Y, Parker C, Liles C, Stewart DJ: Prevention of LPS-Induces Acute Lung Injury in Mice by Mesenchymal Stem Cells Overexpressing Angiopoietin 1. PLoS Medicine Vol. 4, No. 9, e269

Leong-Poi H, Kuliszewski M, Lekas M, Kuliszewska K, Klibanov AL, Stewart DJ, Lindner JR: Therapeutic Arteriogenesis by Ultrasound-Mediated VEGF165 Plasmid Gene Delivery to Chronically Ischemic Skeletal Muscle. Circ Res, E Pub, June 2007.

McCarter SD, Mei S, Lai PFH, Zhang Q, Parker CH, Suen RS, Hood RD, Zhao YD, Deng YP, Han RNN, Stewart DJ: Cell-based angiopoietin-1 gene therapy for acute lung injury. Am J Respir Crit Care Med, 175(10):1014-26, May 2007.

Handa S, Sadi AM, Cybulsky MI, Stewart DJ, Husain M: Region-specific Patterns of Vascular Remodelling Occur Early in Atherosclerosis and Without Smooth Muscle Cell De-Differentiation. In press, January 2007, Circulation Research.

Hansmann G, Wgner RA, Schellong S, de Jesus Perez V, Urashima T, Wang L, Suen RS, Stewart DJ, Rabinovitch M: Pulmonary Arterial Hypertension Is Linked to Insulin Resistance and Reversed by PPAR? Activation. Circulation, 115(10):1275-84, March 2007.

Szmitko P, Teoh H, Stewart DJ, Verma S: Adiponectin and Cardiovascular Disease. State of the Art? Am J Physiol Heart Circ Physiol 202: H1655-H1663, 2007.

McCarter SD, Lai PFH, Suen RS, Stewart DJ: Regulation of Endothelin-1 by Angiopoietin-1: Implications for Inflammation. Exp Biol Med (Maywood) 231(6):985-991, 2006.

Stewart DJ, Hilton JD, Arnold MO, Gregoire J, Rivard A, Archer SL, Charbonneau F, Cohen E, Curtis M, Buller C, Mendelsohn FO, Dib N, Nasmith J, Page P, Ducas J, Plante S, Sullivan J, Macko J, Rasmussen C, Kessler PD, Rasmussen HS: Angiogenic Gene Therapy in Patients with Nonrevascularizable Ischemic Heart Disease: A Phase 2 Randomized Controlled Trial of AdVEGF121 (AdVEGF121) Versus Maximum Medical Treatment. Gene Therapy. Jun 22, 2006.

Lekas M, Latter DA, Kutryk MB, Stewart DJ: Growth Factor-Induced Therapeutic Neovascularization for Ischemic Cardiovascular Disease: Lessons from the Latest Protein/Gene-Based Clinical Trials and Future Directions. Current Opinions in Cardiology, 21(4): 376-384, 2006.

Teichert-Kuliszewska K, Kutryk MJB, Kuliszewski MA, Karoubi G, Courtman DW, Zucco L, Granton J, Stewart DJ: Bone Morphogenic Protein Receptor-2 Signaling Promotes Pulmonary Arterial Endothelial Cell Survival: Implications of Loss-of-Function. Circ. Res., 98(2): 209-17, February, 2006.

Zhao YD, Courtman DW, Deng Y, Kugathasan L, Han RNN, Zhang Q, Trogadis J, Ng DS, Stewart DJ: Rescue of Monocrotaline-Induced Pulmonary Arterial Hypertension Using Bone Marrow-Derived Endothelial Progenitor Cells. Circulation Research, 96(4):442-450, 2005.