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Cancer biotherapeutics

Biologically based therapeutics, which include oncolytic viruses and immune cell therapies, are among the most promising cancer treatments to emerge over the last decade. While different biotherapeutics function in different ways, one thing they have in common is the ability to mobilize and activate the body's natural defence mechanisms (the immune system) to attack cancer cells. Researchers at The Ottawa Hospital are leading the way in this area of research, with a number of world-first clinical trials and projects.

Research News


The promise of CAR-T therapy for cancer: meta-analysis shows the big picture
August 14, 2019 - CAR-T therapy, which uses a patient’s own genetically modified immune cells, is one of the most exciting advances in cancer treatment. To get a big picture view of the field, Drs. Manoj Lalu and Dean Fergusson led a team that analyzed data from nearl
Dr. John Bell wins public and patient engagement award
April 15, 2019 - Dr. John Bell won the inaugural European Society for Gene and Cell Therapy Public and Patient Engagement Award.
Patients and clinical trial experts key to upcoming made-in-Canada CAR-T clinical trial
March 1, 2019 - Researchers at The Ottawa Hospital and the University of Ottawa are known around the world for their expertise in designing and leading clinical trials, and they're now applying this knowledge to create a made-in-Canada approach for CAR-T cell cl
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Researchers


Name Scientific appointment Diseases, conditions and populations of interest Research and clinical approaches
Atkins, Harold
MD, FRCPC
Scientist
(Cancer Therapeutics)
Autoimmune disease, Autoimmune diseases of the nervous system, Blood cancer, Cancer, Multiple sclerosis, Myasthenia gravis, Stiff person syndrome Basic research, Cancer biotherapeutics, Cancer immunotherapy, Cell therapy, Clinical trials, Immunotherapy, Oncolytic viruses, Regenerative medicine, Stem cells, Translational research, Transplantation, Viral therapy
Auer, Rebecca
MD, MSc, FRCSC
Scientist
(Cancer Therapeutics)
Cancer, Colorectal cancer, Ovarian cancer, Pancreatic cancer Basic research, Cancer biotherapeutics, Cancer immunotherapy, Cell therapy, Clinical research, Clinical trials, Immunotherapy, Molecular and cellular biology, Oncolytic viruses, Peri-operative medicine, Quality Improvement, Surgery, Translational research, Viral therapy
Bell, John
PhD
Senior Scientist
(Cancer Therapeutics)
Cancer Basic research, Cancer biotherapeutics, Cancer immunotherapy, Immunotherapy, Oncolytic viruses, Translational research, Viral therapy
Diallo, Jean-Simon
PhD
Scientist
(Cancer Therapeutics)
Cancer, Infectious disease Basic research, Cancer biotherapeutics, Cancer immunotherapy, Drug development, Gene therapy, Immunization, Immunotherapy, Molecular and cellular biology, Oncolytic viruses, Translational research, Viral therapy
Ilkow, Carolina
PhD
Scientist
(Cancer Therapeutics)
Breast cancer, Ovarian cancer, Pancreatic cancer Basic research, Cancer biotherapeutics, Cancer immunotherapy, Gene therapy, Immunotherapy, Molecular and cellular biology, Oncolytic viruses, Viral therapy
Kekre, Natasha
BSc, MD, MPH, FRCPC
Associate Scientist
(Clinical Epidemiology)
Blood cancer, Cancer Cancer biotherapeutics, Cancer immunotherapy, Cell therapy, Clinical trials, Epidemiology, Immunotherapy, Stem cells, Translational research, Transplantation, Viral therapy
Lorimer, Ian
PhD
Senior Scientist
(Cancer Therapeutics)
Brain and neuromuscular disease, Brain cancer, Cancer Basic research, Cancer biotherapeutics, Cell therapy, Disease models, Molecular and cellular biology, Translational research
Vanderhyden, Barbara
PhD
Senior Scientist
(Cancer Therapeutics)
Cancer, Infertility, Ovarian cancer, Women's health Basic research, Bioinformatics, Biomarkers, Cancer biotherapeutics, Disease models, Drug development, Epigenetics, Gene expression, Genomics, Immunotherapy, Model organisms, Molecular and cellular biology, Oncolytic viruses, Stem cells, Transgenic/knockout models, Translational research, Viral therapy