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New model may lead to better treatments for depression after stroke
September 14, 2016
Dr.
Paul Albert
and his team have developed a new animal model to help test treatments for depression after stroke
.
Between 20 to 80 percent of stroke patients will be diagnosed with depression, which greatly impacts both their quality of life and ability to recover. Only a third of these patients will see complete relief with antidepressants, and it is hard to develop better treatments because the basic cause is still unknown. Current animal models of post-stroke depression have some mobility problems, which makes it difficult for researchers to tell if their behaviours are symptoms of depression. The model mice created by Dr. Albert and his team, described recently in
Translational
Psychiatry, consistently have long-term depression and no such mobility issues. They are using these mice to examine the effectiveness of exercise (a part of rehabilitation) and SSRIs, one of the most commonly prescribed antidepressants, for treating post-stroke depression. These studies will lead to a better understanding of what causes this condition and how these treatments work.
Authors:
F. Vahid-Ansari, D.C. Lagace, Albert P.R.
Funders:
Canadian Institutes of Health Research, Canadian Partnership for Stroke Recovery
The Ottawa Hospital: Inspired by research. Driven by compassion
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care. See www.ohri.ca for more information about research at The Ottawa Hospital.
University of Ottawa
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
For further information, please contact
Amelia Buchanan
Senior Communication Specialist
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73687
Cell: 613-297-8315
ambuchanan@ohri.ca
Tags:
Depression
,
Mental health
,
Stroke