Associate Scientist, Neuroscience
Ottawa Hospital Research Institute

Associate Professor, Neurology/Medicine
University of Ottawa

Director, Parkinson's Disease and Movement Disorders Clinic
Ottawa Hospital

Co-Director, Parkinson Research Consortium
University of Ottawa

Clinical research in movement disorders with a focus on Parkinson's disease.  Studies include both industry and investigator driven research exploring a wide variety of issues including clinical care models, biomarkers, observational studies, and the latest pharmacologic treatment options. Sponsors include CIHR, University of Ottawa Brain and Mind Research Institute, Michel J Fox Foundation, Parkinson Research Consortium, and the Ontario Brain Institute.

Dr. Grimes received his Doctorate in Medicine and completed his residency in Neurology at the University of Ottawa. He spent two years at the Toronto Hospital and the Centre for Research in Neurodegenerative Diseases as a research fellow in movement disorders and molecular genetics. He joined the Department of Medicine in Ottawa in 1999 and is the Director of the Parkinson’s Disease and Movement Disorders Clinic at The Ottawa Hospital.  He is a Professor of Medicine at the University of Ottawa. His major clinical interests are in the diagnosis and treatment of a wide variety of movement disorders with an emphasis on Parkinson’s disease and dystonia. H is recognized as a national expert in movement disorders having been the project leader and editor of the Canadian Guidelines on Parkinson’s Disease that were published in 2012 and it's update published in 2019 in the Canadian Medical Association Journal. He has received the Queen’s Golden Jubilee Medal and the Queen’s Diamond Jubilee Medal in recognition of his work in Parkinson’s disease being nominated by Parkinson Canada. In 2017, he received The Lifetime Achievement Award from the University of Ottawa to in recognize his significant contributions and achievement in the advancement of health outcomes and patient care. 

Brodsky M, Swope D, Grimes D.  Factors that affect the diffusion of botulinum toxins. Tremor Other Hyperkinet Mov (N Y). 2012;2. pii: tre-02-85-417-1. Epub 2012 Aug 6  PMID: 23440162

Grimes D, Gordon J, Snelgrove B, et al.  Canadian Guidelines on Parkinson's disease. Can J Neurol Sci. 2012;39:Suppl 4: S1-S30.  PMID: 23126020

Kitada T, Tomlinson JJ, Sio Ao H, Grimes DA, Schlossmacher MG. Considerations Regarding the Etiology and Future Treatment of Autosomal Recessive Versus Idiopathic Parkinson Disease. Curr Treat Options Neurol. 2012;14, (3):230-240, DOI: 10.1007/s11940-012-0175-8.  PMID: 22547255
 
Tahar AH, Chuang R, Steeves T, Jog M, Lang A, Grimes D.  Efficacy and Safety of T2000 in Older Patients with Essential Tremor.  Parkinsonism Relat Disord. 2012 Dec 17. PMID: 23254160

Sinha N, Grimes D, Rogaeva E, Tokuhiro S, Sato C, Woulfe J. Variant Alzheimer disease with spastic paraparesis and supranuclear gaze palsy.  Can J Neurol Sci. 2013 Mar;40(2):249-51.  PMID:23419577

Grimes, David A. Parkinson's Disease Compendium of Therapeutic Choices for its 7th Edition (2014), Editor Barbara Jovaisas

Ataxia; Huntington's; Parkinson's

Clinical research; Clinical trials; Patient decision aids