Researchers at The Ottawa Hospital awarded three grants for high risk, high reward and interdisciplinary research

May 31, 2021

Principal Investigators on the projects include (clockwise from top left): Drs. Richard Aviv, Manoj Lalu, Jenna Evans, Eve Tsai, Jing Wang Principal Investigators on the projects include (clockwise from top left): Drs. Richard Aviv, Manoj Lalu, Jenna Evans, Eve Tsai, Jing Wang The New Frontiers in Research Fund (NFRF) 2020 Exploration competition has awarded $14.5 million to support 117 research projects across Canada that bring diverse disciplines together in pursuit of breakthrough ideas and high-reward outcomes. The NFRF program, a federal research funding initiative, mobilizes cutting-edge interdisciplinary, international, and transformative research that strengthens Canadian innovation and benefits Canadians.

Researchers at The Ottawa Hospital, affiliated with uOttawa, were awarded three grants in the competition. Each grant is worth $250,000 and includes collaborators from multiple institutions. The grants include:

A pilot study of Hyperacute mEchAnicaL endoscopic Minimally invasive surgical (MIS) intracranial hemorrhage Evacuation (HEALME)
This vanguard proposal assesses, for the first time, the feasibility and socioeconomic impact of a time-based approach to the treatment of intracranial hemorrhage (ICH) emphasizing hyperacute(<8hrs) intervention with a new minimally invasive surgical (MIS) technique.

Principal Investigator: Richard Aviv
Co-Investigator: Dar Dowlatshahi
Collaborators: Shamy, Michel; Budiansky, Adele; Miller, Elka; Lalu, Manoj; Wong, Alex; Thavorn, Kednapa; Melkus, Gerd; Schwarz, Betty Anne; Ramsay, Tim

Preclinical multicenter studies of sepsis: assessing feasibility and team mental models
The primary objectives of our proposed project are to a) assess the feasibility of a multicenter preclinical study to evaluate the sex-dependent response to antibiotic therapy in sepsis and b) examine where mental model convergences and divergences are occurring in team members' conceptions of their tasks and roles. Our project represents a paradigm shift in clinical translation and vigorous understanding of disease and discoveries. 

Principal Investigators: Manoj Lalu, Jenna Evans
Co-Investigators: Dean Fergusson, Agnes Grudniewicz, Asher Mendelson, Braedon McDonald, Alison Fox-Robichaud, Kimberly Macala
Collaborators: Stephane Bourque, Sean Gill, Janet Sunohara-Neilson, Patricia Liaw, Gedisminas Cepinskas

A clinically-applicable biomaterial-guided local drug delivery system to promote post-stroke brain regeneration and functional recovery
This proposal leverages the expertise of an interdisciplinary team of neurobiologists, biomedical engineers and neurosurgeons to develop a local drug delivery system to specifically target in situ the stroke lesion site for regeneration that limit adverse systemic effects on other organs.

Principal Investigators: Jing Wang, Eve Tsai
Collaborator: Xudong Cao

The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation. 

Media Contact 
Jenn Ganton