Fresh blood not better, clinical trial shows

October 8, 2012

Ottawa — In a finding that runs counter to commonly held beliefs about fresh being better, a clinical trial published today by the Journal of the American Medical Association shows that acutely ill premature babies who received fresher blood did not fare better than those who received the current standard of care. There was no difference between the two approaches with respect to major organ injury, mortality and infection.

"Before now, most of the literature on the subject suggested that fresh red blood cells are better," says lead author Dr. Dean Fergusson, who heads up the Clinical Epidemiology Program at the Ottawa Hospital Research Institute and is an associate professor at the University of Ottawa.
"However, the effect of fresher blood on clinical outcomes had never been examined using a randomized clinical trial in human patients, which is considered the gold standard in medical science. Now it has, and we found the standards currently in place are no different for this highly vulnerable population of pre-term infants than a policy and system that would favour fresh blood."

Previous observational studies of patient outcomes used already existing clinical data, which is problematic for a number of key reasons. Determining the average age of blood and its impact for those transfused more than once is very difficult because the age of red blood cells used in each transfusion could range dramatically within the acceptable shelf life of 42 days.

Called the ARIPI Randomized Trial, which stands for Age of Red Blood Cells in Premature Infants, this study involved 377 babies weighing less than 1,250 grams and requiring red blood cell transfusions. Randomly, they either received blood that had been stored a week or less, or received the current standard of practice used by blood banks. It turned out that there was no difference in outcome between the two groups.

"Over the years, the number of retrospective studies showing possible harm from older blood has created pressure to change the management of the blood supply to provide fresher transfusion products," says Dr. Dana Devine, Vice President, Medical, Scientific & Research Affairs of Canadian Blood Services. "This is a huge undertaking that would require many more donations than we currently have and greatly increase the cost of operating the blood system.

"To have this particular human clinical trial saying otherwise is important because it is the first such study using the highest level of evidence, the randomized controlled trial, and it was done in a very vulnerable patient population."

The findings of this trial, which took place between May 2006 and June 2011, could not have happened without the hundreds of parents who consented to enroll their children in the study.

"For the families, it's a difficult decision at a difficult time to allow their tiny and fragile child to be a part of a clinical trial. On behalf of the entire team involved in this trial, I salute and thank the families for allowing us to make this important finding," says Dr. Nicole Rouvinez-Bouali, an academic neonatologist at the Children's Hospital of Eastern Ontario.

The ARIPI trial included six Canadian hospitals: The Ottawa Hospital, Children's Hospital of Eastern Ontario (Ottawa), Jewish General Hospital (Montreal), Royal University Hospital (Saskatoon), Children's and Women's Health Centre of British Columbia (Vancouver), and CHU Sainte-Justine (Montreal).

The article is titled "Effects of Fresh Red Blood Cell Transfusions on Clinical Outcomes in Premature, Very Low-Birth-Weight Infants" and was published online by the Journal of the American Medical Association on Oct. 8, 2012.

Funding for the ARIPI Randomized Trial was provided by the Canadian Institutes of Health Research.


Media Contacts:

Paddy Moore
Manager, Communications and Public Relations,
Ottawa Hospital Research Institute
613-798-5555 ext. 73687
613-794-6912 (cell)

Adrienne Vienneau
Director, Communications and Public Relations
Children's Hospital of Eastern Ontario, Research Institute
613-737-7600 x4144
613-513-8437 (cell)

Paul McGrath
Public Affairs Manager
Canadian Blood Services
709-690-0484 (cell)

Néomie Duval
Media Relations Officer
University of Ottawa
613-562-5800 x2981
613-863-7221 (cell)

About the Ottawa Hospital Research Institute (OHRI)
The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff conducting research to improve the understanding, prevention, diagnosis and treatment of human disease. Research at OHRI is supported by The Ottawa Hospital

About the CHEO Research Institute
Established in 1984, the CHEO Research Institute coordinates the research activities of the Children's Hospital of Eastern Ontario (CHEO) and is one of the institutes associated with the University of Ottawa teaching hospitals. The Research Institute brings together health professionals from within CHEO to share their efforts in solving pediatric health problems. It also promotes collaborative research outside the hospital with partners from the immediate community, industry and the international scientific world. For more information, please visit

About Canadian Blood Services
Canadian Blood Services is a national, not-for-profit charitable organization that manages the supply of blood and blood products in all provinces and territories outside of Quebec. Canadian Blood Services also oversees the OneMatch Stem Cell and Marrow Network, and provides national leadership for organ and tissue donation and transplantation. Canadian Blood Services operates 42 permanent collection sites and more than 20,000 donor clinics annually. The provincial and territorial Ministries of Health provide operational funding to Canadian Blood Services. The federal government, through Health Canada, is responsible for regulating the blood system.

About the University of Ottawa
The University of Ottawa is committed to research excellence and encourages an interdisciplinary approach to knowledge creation, which attracts the best academic talent from across Canada and around the world. It is an important stakeholder in the National Capital Region’s economic development.