Scientific Publications Database

Article Title: Regression of Sebaceous Carcinoma of the Eyelid after a Small Incisional Biopsy: Report of Two Cases
Authors: Brownstein, Seymour; Mehta, Sonul; Nijhawan, Navdeep; Allaire, Guy; Tuan Quynh Tram Nguyen; Tang, Tina; Jiang, Kailun; Saleh, Solin; Kalin-Hajdu, Evan; Bruen, Robbin; Oestrelcher, James
Journal: OCULAR ONCOLOGY AND PATHOLOGY Volume 5 Issue 4
Date of Publication:2018
Abstract:
Purpose: To report 2 cases of regression of sebaceous carcinoma of the eyelid after a small incisional biopsy. Methods: Clinical, imaging, and histopathological findings are presented, with a literature review on regressing ocular tumors. Results: Our first patient was a 79-year-old man who presented with a 10-month history of progressive left upper eyelid ptosis caused by an eyelid tumor with orbital involvement and confirmed on magnetic resonance imaging. Our second patient was a 70-year-old woman who presented with ptosis with a left upper eyelid mass. Both patients underwent a small incisional biopsy of their lesion. The histopathological diagnoses in both cases were consistent with sebaceous carcinoma. Both patients refused exenteration. Follow-up clinical examination and imaging disclosed total regression of the ptosis and of the neoplasm with no sign of recurrence in both patients over a 4-year period for Case 1 and a 7-year period for Case 2. Conclusion: Regression following incisional biopsy of basal cell, squamous cell, and Merkel cell carcinoma, including of the eyelid, is well documented. To the best of our knowledge, our 2 cases of sebaceous carcinoma are the first to be reported with total involution clinically and on imaging of the tumor following partial incisional biopsy.