Scientific Publications Database

Article Title: Targeted agents for HER2-positive breast cancer in older adults: current and future perspectives
Authors: Soto-Perez-De-Celis, Enrique; Loh, Kah Poh; Baldini, Capucine; Battisti, Nicolo Matteo Luca; Chavarri-Guerra, Yanin; De Glas, Nienke A.; Hsu, Tina; Hurria, Arti
Journal: EXPERT OPINION ON INVESTIGATIONAL DRUGS Volume 27 Issue 10
Date of Publication:2018
Abstract:
Introduction: One-third of breast cancer (BC) cases worldwide occur in women aged 65years and older, with 10 to 15% overexpressing the human epidermal growth factor receptor 2 (HER2). Although several HER2-targeted therapies have been developed, the lack of data regarding their use in older patients hampers evidence-based decision-making for this population.Areas Covered: We review current evidence on the efficacy and safety of HER2-targeted therapies in older adults with BC, focusing on approved therapies such as trastuzumab, lapatinib, pertuzumab, ado-trastuzumab-emtansine, and neratinib. Additionally, we discuss drugs under development to target the HER2-receptor, and to overcome resistance to existing therapies. Finally, we highlight the cardiotoxicity of HER2-targeted drugs among older adults.Expert Opinion: Older adults are underrepresented in trials of HER2-targeted therapies in BC. We propose strategies to increase recruitment of older adults in clinical trials in order to increase the evidence base to treat this growing population.