Scientific Publications Database

Article Title: Oncolytic Viruses: The Best is Yet to Come
Authors: Lemay, Chantal G.; Keller, Brian A.; Edge, Robert E.; Abei, Masato; Bell, John C.
Journal: CURRENT CANCER DRUG TARGETS Volume 18 Issue 2
Date of Publication:2018
Abstract:
Oncolytic viruses are a promising anti-cancer platform, achieving significant pre-clinical and clinical milestones in recent years. A full arsenal of selective, safe, and effective viruses has been developed with some emerging pre-clinical research focusing on optimizing these therapies in the face of remaining challenges, both in the bloodstream and in the tumour microenvironment. Herein we discuss the recent progress in pre-clinical virotherapy research to address these challenges, with special focus on innovative strategies that seek to complement the current strengths of virotherapy, ensuring an optimal multi-faceted attack on cancer. This review highlights the research areas that we believe provide the most potential to increase the efficacy of this exciting biotherapy platform: cell carriers, tumour vascular destruction, microenvironment modulation, combination therapies, and virus-mediated anti-tumour immune responses.