Scientific Publications Database

Article Title: Mapping vitamin B-6 metabolism by hydrazoCEST magnetic resonance imaging
Authors: Brun, Emilie Marie Sophie Patit-Tha; Calvert, Nicholas David; Suchy, Mojmir; Kirby, Alexia; Melkus, Gerd; Garipov, Ruslan; Addison, Christina L.; Shuhendler, Adam J.
Journal: CHEMICAL COMMUNICATIONS Volume 57 Issue 83
Date of Publication:2021
Abstract:
A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5 '-phosphate, a key Vitamin B-6 metabolite necessary for >140 biotransformations was mapped by CEST-MRI in vitro and in vivo in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.