Scientific Publications Database

Article Title: Periadventitial tissue examination in temporal artery biopsies for suspected giant cell arteritis: a case series and literature review
Authors: McDonald, Heather M.; Farmer, James P.; Blanco, Paula L.
Journal: CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE Volume 54 Issue 5
Date of Publication:2019
Abstract:
Objective: Giant cell arteritis (GCA) is a systemic vasculitis, affecting medium-and large-sized vessels. Temporal artery biopsies (TABs) are currently the benchmark for diagnosing suspected cases of GCA. Often, the temporal artery is skeletonized, and surrounding soft tissue is discarded at the time of biopsy. The purpose of this study was to identify cases in which diagnoses were made through examination of periadventitial soft tissue in nonskeletonized TABs.Design: Retrospective observational case series and literature review.Participants: Six patients were recruited on a case-by-case basis. Inclusion criteria: bilateral TABs for suspected GCA and periadventitial findings leading to appropriate diagnosis. Exclusion criteria: none.Methods: A retrospective chart review was performed to collect patient demographics and clinical information in 2 academic institutions in Ontario, Canada. The primary outcome measure was identification of histopathological diagnoses made through examination of periadventitial soft tissue in TABs performed for suspected GCA.Results: Two patients were diagnosed with GCA, one of which had a concurrent diagnosis of chronic lymphocytic leukemia. Four patients were diagnosed with small vessel vasculitis, 3 of which were antineutrophil cytoplasmic antibody-related vasculitides. All patients had evidence of a disease limited to the periadventitial tissue of the TAB. The results are limited by the study's size.Conclusions: This case series demonstrates that other serious conditions may declare themselves with symptoms similar to that of GCA. We recommend that surgeons perform a nonskeletonized TAB in all cases of suspected GCA and that pathologists adequately examine the periadventitial tissue in these biopsies to ensure appropriate diagnosis.