Scientific Publications Database

Article Title: Oncolytic viruses: cytolytic agents, replicating immunotherapeutics or both?
Authors: Chen, Ashley T.; Samson, Briana L. R.; Crupi, Mathieu J. F.; Bell, John C.
Journal: FUTURE VIROLOGY Volume 13 Issue 7
Date of Publication:2018
Abstract:
Cancer cells have distinct hallmarks that promote growth and metastasis, but at the same time enhance their susceptibility to viral infection [1]. As a result, oncolytic viruses (OVs) possess an intrinsic ability or can be engineered to selectively target, replicate in and kill cancer cells, while leaving healthy cells unharmed. Oncolysis allows for amplification of the initial viral load due to viral replication and subsequent spread of infectious particles to neighboring cells upon cell lysis. In addition to this direct cytotoxic effect, OVs can be armed with therapeutic transgenes to take advantage of antigen release and presentation, as well as to potentiate immune responses and infiltration within the tumor microenvironment (TME) [2,3].