The poster and complete program is also available as a PDF and can be found here.
| Friday, December 3, 2004 | ||
| 4:30-7:30 PM | REGISTRATION | The Westin Hotel |
| 6:30-7:30 PM | Wine and Cheese Reception, Poster Viewing | The Westin Hotel (Quebec & Nova Scotia Rooms) |
| 7:30 PM | Board buses to Canada Aviation museum | The Westin Hotel (Westin Main entrance) |
| 8:00-10:00 PM | Dinner and Speakers Clifford Chappel, Oakville, Ontario "Discovery and early characterization of the BB rat” |
Canada Aviation Museum |
| Saturday, December 4, 2004 (Provinces II) | ||
| 8:50-9:00 AM | Welcome and introductory remarks | Alex Rabinovitch, University of Alberta , Edmonton |
| The Immune Etiology of Diabetes | ||
| Chair: Hubert Kolb , Dusseldorf | ||
| 9:00-9:20 AM | Why study type 1 diabetes in rats ? | John Mordes, University of Massachusetts Medical School , Worcester |
| 9:20-9:40 AM | Immunopathogenesis of diabetes in BB rats |
Philippe Poussier , University of Toronto |
| 9:40-10:00 AM | The innate immune system in diabetes | Hubert Kolb, German Diabetes Center , Düsseldorf |
| 10:00-10:20 AM | What does IAN gene expression do for BB T cells ? | Donald Bellgrau, University of Colorado |
| 10:20-10:40 AM | BREAK | |
| The Role of the Target Tissue | ||
| Chair: Diane Finegood, Vancouver | ||
| 10:40-11:00 AM | Beta cell mass dynamics in early life | Diane Finegood, Simon Fraser University , Vancouver |
| 11:00-11:20 AM | Growth factors and beta cell regeneration | Wilma Suarez-Pinzon, University of Alberta , Edmonton |
| 11:20-11:40 AM | Sulfatide - an autoantigen in the islet ? | Karsten Buschard , Bartholin Institute, Copenhagen |
| 11:40-12:00 PM | Proteomic analyses of the islets | Thomas Sparre, Steno Diabetes Centre, Gentofte |
| 12:00-12:20 PM | Integrative biology of the pancreas in immune-mediated diabetes |
Hemmo Drexhage, Erasmus University, Rotterdam |
| 12:20-1:20 PM | LUNCH (Poster viewing, Quebec & Nova Scotia Rooms) | |
| Genetics, BB Congenics and Other Rat Models | ||
| Chair: Philippe Poussier , Toronto | ||
| 1:20-1:40 PM | New rat models for diabetic complications | Dennis Guberski, BRM Inc, Worcester |
| 1:40-2:00 PM | T-cell lymphopenia and the Ian-gene family | Helle Markholst, Novo Nordisk, Copenhagen |
| 2:00-2:20 PM | Congenic BB rats | Ake Lernmark , University of Washington, Seattle |
| 2:20-2:40 PM | IDDM4 rat diabetes locus and diabetes | John Mordes, University of Mass. Medical School, Worcester |
| 2:40-3:00 PM | BREAK | |
| Infectious Agents and Diabetes | ||
| Chair: Jan Rozing, Groningen | ||
| 3:00-3:20 PM | Virus-induced diabetes | Israel Mendez, Calgary |
| 3:20-3:40 PM | Toll-like receptors in KRV-induced diabetes | Danny Zipris, University of Mass. Medical School, Worcester |
| 3:40-4:00 PM | Cytomegalovirus-enhanced diabetes | Jan Rozing, University of Groningen , The Netherlands |
| Testing of Pharmacological and Other Interventions | ||
| Chair: Alex Rabinovitch, Edmonton | ||
| 4:00-5:00 PM | PANEL DISCUSSION: What are the most promising interventions and how can they be implemented?
Panel: A. Lernmark, K. Buschard, J.Rozing, S. Chakrabarti , J. Mordes, D. Finegood, D. Hill PANEL DISCUSSION: 3-5 minute presentations by each discussant, with discussion by the group |
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| 6:15 PM | Board buses to Canadian Museum of Civilization, Hull, Quebcec http://www.civilization.ca/ | The Westin Hotel (Westin Main entrance) |
| 6:30-7:30 PM | Reception | Canadian Museum of Civilization, Canada Hall |
| 7:30-10:00 PM | Dinner and Speaker | Canadian Museum of Civilization, Riverview Lounge |
| Human: model of BB rat and NOD mouse diabetes? | David Serreze , The Jackson Laboratories, Bar Harbor |
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| Sunday, December 5, 2004 (Two simultaneous sessions) | ||
| SESSION A (Provinces II Room) | ||
| Diet, Gut Immunity and Diabetes | ||
Chair: Fraser Scott, Ottawa |
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| 8:30-8:50 AM | Diet and dysfunctional metabolism | Willy Malaisse , Brussels Free University |
| 8:50-9:10 AM | Wheat-related diabetes in rats and humans | Fraser Scott, Ottawa Health Research Institute |
| 9:10-9:30 AM | NK cell defects in gut immune system | Rita Bortell, University of Massachusetts Medical School, Worcester |
| 9:30-9:50 AM | Gut leakiness, tight junctions and diabetes | Joe Neu, University of Florida, Gainesville |
| 9:50-10:10 AM | BREAK | |
| New Models, New Technologies | ||
| Chair: Helle Markholst, Copenhagen | ||
| 10:10-10:30 AM | PAC transgenic rescue of lymphopenia and the involvement of IAN genes in T cell development | Mike Michalkiewicz, Medical College of Wisconsin |
| 10:30-10:50 AM | The rat genome | Anne Kwitek, Medical College of Wisconsin |
| 10:50-11:10 AM | Genetic variation in transcription factor Yy1 and type 1 diabetes | Ingrid Kloting, University of Greifswald , Karlsburg, Germany |
| 11:10-11:30 AM | “Mapping protein-protein interactions in yeast and in human” |
Daniel Figeys, University of Ottawa |
| SESSION B (Ontario Room) | ||
| BB Rats as Models of Diabetic Complications | ||
| Chair: Anders Sima , Detroit | ||
| 8:30-8:50 AM | Diabetic retinopathy in the BB/Wor-rat | S. Chakrabarti University of Western Ontario, London |
| 8:50-9:10 AM | Diabetic neuropathy in type 1 and type 2 BB-rats | Anders Sima , Wayne State University , Detroit |
| 9:10-9:30 AM | Diabetic encephalopathy – a new late complication in diabetes | Z. Li, Wayne State University, Detroit |
| 9:30-9:50 AM | Metabolic and Ion Fluxes in Diabetic BB rat heart | R. Ramasamy, Columbia University, New York |
| 9:50-10:10 AM | BREAK | |
| Metabolic and Other Lessons | ||
| Chair: Guoyao Wu, College Station (Texas) | ||
| 10:10- 10:30 AM | Arginine and nitric oxide metabolism | Guoyao Wu , Texas A & M University, College Station |
| 10:30-10:50 AM | The effect of diabetes on fracture healing | S.S. Lin , New Jersey Medical School , Newark |
| 10:50-11:10 AM | BB rat diabetes effects on brain glucose and on the alpha cell | Rory McCrimmon, Yale School of Medicine , New Haven |
| 11:10-11:30 AM | Low protein diets, taurine and NOD diabetes | David Hill , Lawson Health Research Institute, London , Ontario |
| Plenary Session | ||
| 11:30-12:30 PM | PANEL DISCUSSION: New Directions in Type 1 Diabetes Research | |
| Chair: Ake Lernmark , Seattle | ||
Panel: H. Kolb, A. Rabinovitch, G. Wu, A. Sima, H. Markholst, P. Poussier, M. Michalkiewicz, D. Serreze 3-5 minute presentation by each panel member followed by Group Discussion – Rapporteur will capture key conclusions |
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| 12:30-1:30 PM | LUNCH (Poster viewing, Quebec & Nova Scotia Rooms) | |
