The poster and complete program is also available as a PDF and can be found here.

Friday, December 3, 2004
4:30-7:30 PM REGISTRATION The Westin Hotel
6:30-7:30 PM Wine and Cheese Reception, Poster Viewing The Westin Hotel (Quebec & Nova Scotia Rooms)
7:30 PM Board buses to Canada Aviation museum The Westin Hotel (Westin Main entrance)
8:00-10:00 PM Dinner and Speakers

Clifford Chappel, Oakville, Ontario
Errol Marliss, McGill University, Montreal

"Discovery and early characterization of the BB rat”

Canada Aviation Museum

Saturday, December 4, 2004 (Provinces II)
8:50-9:00 AM Welcome and introductory remarks Alex Rabinovitch, University of Alberta , Edmonton
The Immune Etiology of Diabetes  
  Chair: Hubert Kolb , Dusseldorf  
9:00-9:20 AM Why study type 1 diabetes in rats ?

John Mordes, University of Massachusetts Medical School , Worcester

9:20-9:40 AM

Immunopathogenesis of diabetes in BB rats

Philippe Poussier , University of Toronto
9:40-10:00 AM The innate immune system in diabetes Hubert Kolb, German Diabetes Center , Düsseldorf
10:00-10:20 AM What does IAN gene expression do for BB T cells ? Donald Bellgrau, University of Colorado
10:20-10:40 AM BREAK
The Role of the Target Tissue
  Chair: Diane Finegood, Vancouver  
10:40-11:00 AM Beta cell mass dynamics in early life Diane Finegood, Simon Fraser University , Vancouver
11:00-11:20 AM Growth factors and beta cell regeneration

Wilma Suarez-Pinzon, University of Alberta , Edmonton

11:20-11:40 AM Sulfatide - an autoantigen in the islet ? Karsten Buschard , Bartholin Institute, Copenhagen
11:40-12:00 PM Proteomic analyses of the islets Thomas Sparre, Steno Diabetes Centre, Gentofte
12:00-12:20 PM

Integrative biology of the pancreas in immune-mediated diabetes

Hemmo Drexhage, Erasmus University, Rotterdam
12:20-1:20 PM LUNCH (Poster viewing, Quebec & Nova Scotia Rooms)
Genetics, BB Congenics and Other Rat Models
    Chair: Philippe Poussier , Toronto  
1:20-1:40 PM New rat models for diabetic complications Dennis Guberski, BRM Inc, Worcester
1:40-2:00 PM T-cell lymphopenia and the Ian-gene family Helle Markholst, Novo Nordisk, Copenhagen
2:00-2:20 PM Congenic BB rats

Ake Lernmark , University of Washington, Seattle

2:20-2:40 PM IDDM4 rat diabetes locus and diabetes John Mordes, University of Mass. Medical School, Worcester
2:40-3:00 PM BREAK
Infectious Agents and Diabetes
  Chair: Jan Rozing, Groningen  
3:00-3:20 PM Virus-induced diabetes Israel Mendez, Calgary  
3:20-3:40 PM Toll-like receptors in KRV-induced diabetes Danny Zipris, University of Mass. Medical School, Worcester
3:40-4:00 PM Cytomegalovirus-enhanced diabetes

Jan Rozing, University of Groningen , The Netherlands

Testing of Pharmacological and Other Interventions
  Chair: Alex Rabinovitch, Edmonton  
4:00-5:00 PM PANEL DISCUSSION: What are the most promising interventions and how can they be implemented?

Panel: A. Lernmark, K. Buschard, J.Rozing, S. Chakrabarti , J. Mordes, D. Finegood, D. Hill

PANEL DISCUSSION: 3-5 minute presentations by each discussant, with discussion by the group

6:15 PM Board buses to Canadian Museum of Civilization, Hull, Quebcec The Westin Hotel (Westin Main entrance)
6:30-7:30 PM Reception Canadian Museum of Civilization, Canada Hall
7:30-10:00 PM Dinner and Speaker Canadian Museum of Civilization, Riverview Lounge
  Human: model of BB rat and NOD mouse diabetes?

David Serreze , The Jackson Laboratories, Bar Harbor

Sunday, December 5, 2004 (Two simultaneous sessions)
SESSION A (Provinces II Room)
Diet, Gut Immunity and Diabetes

Chair: Fraser Scott, Ottawa

8:30-8:50 AM Diet and dysfunctional metabolism Willy Malaisse , Brussels Free University
8:50-9:10 AM Wheat-related diabetes in rats and humans Fraser Scott, Ottawa Health Research Institute
9:10-9:30 AM NK cell defects in gut immune system Rita Bortell, University of Massachusetts Medical School, Worcester
9:30-9:50 AM Gut leakiness, tight junctions and diabetes Joe Neu, University of Florida, Gainesville
9:50-10:10 AM BREAK
New Models, New Technologies
  Chair: Helle Markholst, Copenhagen  
10:10-10:30 AM PAC transgenic rescue of lymphopenia and the involvement of IAN genes in T cell development Mike Michalkiewicz, Medical College of Wisconsin
10:30-10:50 AM The rat genome Anne Kwitek, Medical College of Wisconsin
10:50-11:10 AM Genetic variation in transcription factor Yy1 and type 1 diabetes Ingrid Kloting, University of Greifswald , Karlsburg, Germany
11:10-11:30 AM

“Mapping protein-protein interactions in yeast and in human”

Daniel Figeys, University of Ottawa

SESSION B (Ontario Room)
BB Rats as Models of Diabetic Complications
  Chair: Anders Sima , Detroit  
8:30-8:50 AM Diabetic retinopathy in the BB/Wor-rat S. Chakrabarti University of Western Ontario, London
8:50-9:10 AM Diabetic neuropathy in type 1 and type 2 BB-rats

Anders Sima , Wayne State University , Detroit

9:10-9:30 AM Diabetic encephalopathy – a new late complication in diabetes

Z. Li, Wayne State University, Detroit

9:30-9:50 AM Metabolic and Ion Fluxes in Diabetic BB rat heart R. Ramasamy, Columbia University, New York
9:50-10:10 AM BREAK
Metabolic and Other Lessons 
  Chair: Guoyao Wu, College Station (Texas)  
10:10- 10:30 AM Arginine and nitric oxide metabolism

Guoyao Wu , Texas A & M University, College Station

10:30-10:50 AM The effect of diabetes on fracture healing

S.S. Lin , New Jersey Medical School , Newark

10:50-11:10 AM BB rat diabetes effects on brain glucose and on the alpha cell

Rory McCrimmon, Yale School of Medicine , New Haven

11:10-11:30 AM Low protein diets, taurine and NOD diabetes

David Hill , Lawson Health Research Institute, London , Ontario

Plenary Session
 11:30-12:30 PM PANEL DISCUSSION: New Directions in Type 1 Diabetes Research
  Chair: Ake Lernmark , Seattle

Panel: H. Kolb, A. Rabinovitch, G. Wu, A. Sima, H. Markholst, P. Poussier, M. Michalkiewicz, D. Serreze

3-5 minute presentation by each panel member followed by Group Discussion – Rapporteur will capture key conclusions  

12:30-1:30 PM LUNCH (Poster viewing, Quebec & Nova Scotia Rooms)





Copyright 2004, All rights reserved