Knowledge Synthesis Group

About Us


The Knowledge Synthesis (KS) Group, led by Dr. Brian Hutton (and previously by Dr. David Moher), joined the Ottawa Hospital Research Institute (OHRI) in 2008. It is an academic research group located at the Centre for Practice-Changing Research, Ottawa, Canada and is affiliated with the University of Ottawa. It works closely with the Ottawa Methods Centre (OHRI) and is engaged exclusively in knowledge synthesis and related methods research. The KS Group is committed to developing high quality knowledge syntheses such as systematic reviews; meta-analyses; network meta-analyses; scoping reviews; rapid reviews; and health technology assessments. It has garnered international recognition having conducted research for and training to local, provincial, national and international stakeholders.

The KS Group is involved in a variety of national and international research initiatives including CIHR’s Drug Safety and Effectiveness Network, for which the group operates as a Collaborating Center for Systematic Reviews and Network Meta-Analysis; and the Public Health Agency of Canada’s Task Force on Preventive Health Care, for which the group is a designated Evidence Synthesis Research Center. The KS Group is also currently the coordinating center for the Cochrane Rapid Reviews Methods Group, which is focused upon establishing best methods for the conduct and reporting of rapid reviews. Other research initiatives include the Consolidated of Reporting Initiatives for Randomized Controlled Trials (CONSORT) group and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) group.

The KS group also works closely with the OHRI’s Centre for Journalology (, which provides internal and external outreach and consulting to help researchers improve the reporting quality and dissemination of their research. The Centre is also actively involved in research on topics which include publication models and predatory journals, peer and editorial review, reporting guideline development, and incentives and rewards in academic publishing.


As mentors and global leaders in the science and conduct of clinical and methodological research, the Knowledge Synthesis (KS) Group strives to improve healthcare through evidence-based research syntheses by fostering excellence through innovation, collaboration, professionalism and transparency.


ChalmersPrior to 2009, the KS Group was formerly the Chalmers Research Group, established in 1998 at the Children’s Hospital of Eastern Ontario Research Institute (CHEO RI). The group was named after Dr. Thomas C. Chalmers, a highly respected and accomplished physician, researcher and administrator, who was an acknowledged leader in the design, conduct and evaluation of clinical trials and systematic reviews. Dr Chalmers went on to publish several hundred articles in his lifetime, including a landmark paper on the development of evidence-based medicine. The KS Group endeavors to continue Dr. Chalmers’ legacy in the quest for excellence in health research.