Current Funding

Total lifetime funding as Principal Investigator or Co-Principal Investigator: $145,001,238
Total lifetime funding as Co-Investigator: $217,015,899
*unless otherwise stated, Dr. Fergusson's role is a Co-Investigator

04/2025-03/2028 Developing evidence-informed patient engagement guidance for economic evaluations (DEEP-ENGAGE)
Principal Investigators: Thavorn, Kednapa; Graham, ID; Hutton, BE; Presseau, J; Smith, MM
Funder: Canadian Institutes of Health Research / Program: Project Grant

04/2025-03/2027 STRIVE before surgery trial: a pragmatic multicenter randomized trial of Structured TRaining to Improve fitness in a Virtual Environment before surgery
Principal Investigators: McIsaac, Daniel I; Gillis, CA; Hallet, J; Kidd, GD; Lee, SM; Mayson, KV; Taljaard, M; Tandon, P; Wallace, T; Wijeysundera, DN
Funder: Canadian Institutes of Health Research / Program: Project Grant – Patient-Oriented Research – Implementation Science

04/2025-03/2028 Optimizing Patient-centred outcomes Using opioid minimization Strategies (OPUS) Pilot Trial
Principal Investigators: Verret, Michael; Fergusson, Dean A; Lalu, Manoj M; Turgeon, Alexis F
Funder: Canadian Institutes of Health Research / Program: Project Grant

02/2025-01/2026 Empowering communities: developing strategies to improve uptake of the CARE project
Principal Investigators: Manoj Lalu, Dawn Richards, Laurie Proulx
Funder: Ontario SPOR SUPPORT Unit’s (OSSU) / Program - EMPOWER VIII Project Opportunity

10/2024-09/2025 Accelerating and standardizing assessment of acute lung injury using an artificial intelligence based approach
Principal Investigators: Manoj Lalu, Arvind S. Mer, Patricia C Liaw
Funder: Canadian Institutes of Health Research / Program: Project Grant

10/2024-09/2028 Establishing An International Core Outcome Set for Subarachnoid Hemorrhage (SAH) - What and How to Measure Outcomes in SAH Research
Principal Investigators: English, Shane W; Marti, Maria Luisa; Presseau, Justin; Shea, Beverley J; Andersen, Christopher R
Funder: Canadian Institutes of Health Research / Program: Project Grant

 10/2024-09/2028 Effects of donor-recipient sex-matched versus sex-mismatched red blood cell transfusion on outcomes in critically ill adult patients
Principal Investigators: Dean Fergusson, Michelle Zeller
Funder: Canadian Institutes of Health Research / Program: Project Grant

04/2024-03/2027 Reconnecting care partners to persons living with dementia through primary care surveillance data
Principal Investigators: Neil Drummond, Claire Webster, Annie Robitaille
Funder: Canadian Institutes of Health Research / Program: Operating Grant, Eval. of Dementia Programs, Services, & Care Models 

03/2024-03/2026 Harnessing the power of cell therapy for severe lung injury: assessing feasibility and understanding reproducibility.
Principal Investigators: Manoj Lalu, Kelly Cobey
Funder: New Frontiers in Research Fund / Program: Exploration

04/2024-03/2029 BRAINapt: TBI International Adaptive Platform Trial
Principal Investigators: Alexis Turgeon, Shane English, Francois Lauzier, Michelle McDonald, Lynne Moore, Jay Park, Ryan Zarychanski
Funder: Canadian Institutes of Health Research / Program: Project Grant

04/2024-03/2028 Virtual, Innovative, postsurgical Care To Optimize Return home for older people with frailtY: the VICTORY randomized trial
Principal Investigators: Sylvie Aucoin, Alan Forster, Michael Jack, Gurlavine Kidd, Manoj Lalu, Jordan Leitch, Michael McGillion, Daniel McIsaac, Kednapa Thavorn
Funder: Canadian Institutes of Health Research / Program: Operating Grant: SPOR Innovative Clinical Trial Multi-Year Grant

04/2023-01/2025 AAVenger-B: Adeno-Associated Virus Engineered Gene Epithelial progenitor cell Regeneration for surfactant proteinB deficiency
Prinicipal Investigator: Dean Fergusson
Funder: Stem Cell Network / Program: Impact Awards: Ethical, Legal, Social Implications

04/2023-01/2025 Developing guidance to translate promising cell therapies to early phase clinical trials
Prinicipal Investigators: Dean Fergusson, Manoj Lalu
Funder: Stem Cell Network / Program: Impact Awards: Ethical, Legal, Social Implications 

10/2022-03/2025 The effects of an intraoperative targeted low-splanchnic blood volume restrictive fluid management strategy compared to a liberal one on postoperative outcomes in liver transplantation - the REFIL (REstrictive Fluid management In Liver transplantation) pilot multicenter randomized controlled trial
Prinicipal Investigators: Dean Fergusson, François M Carrier, Michael Chasse
Funder: Canadian Institutes of Health Research / Program: Project Grant

10/2022-09/2025 Patient engagement in basic science: co-development and pilot evaluation of a novel framework
Prinicipal Investigators: Dean Fergusson, Manoj Lalu, Dawn Richards
Funder: Canadian Institutes of Health Research / Program: Project Grant

09/2022-08/2025 PREVENT GU: Prevention of thromboembolism with rivaroxaban in GU cancer patients receiving chemotherapy: A Randomized Placebo-Controlled, Double-Blind Clinical Trial
Principal Investigators: Luke Lavallée, Dominick Bossé, Rodney Breau, Marc Carrier
Funder: Canadian Institutes of Health Research / Program: Project Grant

09/2022-02/2027 A Randomized Controlled Non-Inferiority Trial to Assess the Utility of Non-
Targeted Biopsies for Colorectal Neoplasia Detection in Adult Inflammatory Bowel Disease
Principal Investigators: Dean Fergusson, Sanjay Murthy
Funder: Canadian Institutes of Health Research / Program: Project Grant

07/2022-06/2025 Exergaming registry-based trial promoting physical activity in children and adolescents with spinal muscular atrophy
Principal Investigators: Maryam Oskoui, Maureen M Smith, Alan C Evans, Yasser Iturria Medina, Danielle Levac, Elizabeth K Potter
Funder: Canadian Institutes of Health Research / Program: Operating Grant - Clinical Trials Projects

07/2022-06/2025 The Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (CLEAN Wound) Trial
Principal Investigators: Paul J Karanicolas, Jad Abou Khalil, David E Smith, Melanie E Tsang, Stephanie Mason
Funder: Canadian Institutes of Health Research / Program: Operating Grant - Clinical Trials Projects

07/2022-06/2025 Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
Principal Investigators: Dean Fergusson, Natasha Kekre, Christopher Bredeson, Terry A Hawrysh, Kevin A Hay, Rob Holt, Jennifer L Quizi, Kednapa Thavorn
Funder: Canadian Institutes of Health Research / Program: Operating Grant - Clinical Trials Projects

07/2022-06/2025 The Safety and Efficacy of Adalimumab for Pain Reduction in Individuals with Mucopolysaccharidoses: A Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Trial
Principal Investigators: John J Mitchell, Maureen M Smith, Michal Inbar- Feigenberg, Shailly Jain, Lynda Polgreen, Elizabeth K Potter
Funder: Canadian Institutes of Health Research / Program: Operating Grant - Clinical Trials Projects

07/2022-06/2025 A Phase I trial of single domain antibody-based CD22 chimeric antigen receptor (CAR)-T cells for the treatment of relapsed/refractory CD22+ B-cell acute lymphoblastic leukemia
Principal Investigators: Kevin A Hay, Terry A Hawrysh, Natasha Kekre, Joerg
Krueger, Amanda Li, David Szwajcer
Funder: Canadian Institutes of Health Research / Program: Operating Grant - Clinical Trials Projects

07/2022-06/2025 A Training Platform in Pragmatic Registry-Based Trials: Connecting Canada's Health, Data, and Biomanufacturing Sectors
Principal Investigators: Amit Garg, Jeremy Grimshaw, Lauralyn McIntyre, Justin Presseau, Monica Taljaard, et al.
Funder: Canadian Institutes of Health Research / Program: Training Grant - Clinical Trials Training Platforms

07/2022-06/2025 Canadian Network for Statistical Training in Trials (CANSTAT)
Principal Investigators: Sameer Parpia, Shirin Golchi, Anna Heath, Shun Fu Lee, Tolulope Sajobi, Kevin Thorpe, Hubert H Wong
Funder: Canadian Institutes of Health Research / Program: Training Grant - Clinical Trials Training Platforms

07/2022-06/2025 Accelerating Clinical Trials (ACT) – Canada
Principal Investigators: PJ Devereaux, Dean Fergusson, et al.
Funder: Canadian Institutes of Health Research / Program: Team Grant - Pan Canadian Clinical Trials Consortium

07/2022-06/2025 Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock: A Phase II RCT
Principal Investigators: Dean Fergusson, Lauralyn McIntyre, Alison Fox- Robichaud, Asher A Mendelson, Duncan J Stewart, Keith R Walley
Funder: Canadian Institutes of Health Research / Program: Clinical Trials Award Program

07/2022-06/2025 Canadian Consortium of Clinical Trial Training (CANTRAIN) platform: enhancing career preparedness in RCT research targeting different audiences across the continuum
Principal Investigators: Dean Fergusson, Jean Bourbeau, etc al.
Funder: Canadian Institutes of Health Research / Program: Training Grant - Clinical Trials Training Platforms

04/2022-03/2025 Umbilical Mesenchymal Stem Cells as Cellular Immunotherapy for Septic Shock (UC-CISS): A Phase II RCT
Principal Investigator: Lauralyn McIntyre
Funder: Stem Cell Network

04/2022-01/2025 Engaging patients in laboratory-based cell therapy research: Co-production and field testing of a framework
Principal Investigators: Dean Fergusson, Manoj Lalu
Funder: Stem Cell Network / Program: Translation & Society Team Award

03/2022-02/2028 DRAGON 2 - An international multicenter randomized controlled trial to compare combined Portal and Hepatic Vein Embolization (PVE/HVE) with PVE alone in liver surgery
Prinicipal Investigators: Dean Fergusson, Guillaume Martel
Funder: Canadian Institutes of Health Research / Program: Project Grant

10/2021-09/2026 Perioperative pharmacologic opioid minimization strategies and patient- centred outcomes after surgery
Prinicipal Investigators: Michael Verret Supervisors: Dean Fergusson, Manoj M Lalu Funder: Canadian Institutes of Health Research / Program: CIHR Fellowship

04/2021-03/2026 Ontario SPOR SUPPORT Unit – Phase II
Principal Investigator: Dean Fergusson
Funder: Canadian Institute of Health Research and Strategy for Patient- Oriented Research (SPOR)