Xiaohui Zha profile picture

Contact Information

Xiaohui Zha, Ph.D.
613-737-8899 x73268
Xzha@ohri.ca

Fax: 613-737-8803

Xiaohui Zha

Senior Scientist, Chronic Disease Program
Ottawa Hospital Research Institute
Associate Professor, Department of Medicine & Department of Biochemistry, Microbiology and Immunology
University of Ottawa

Research Interests

Cholesterol regulation and transport
Membrane nano-domains
ATP-binding cassette transporter proteins
Atherosclerosis and macrophage inflammation

Brief Biography

Dr. Zha obtained her Ph.D. in Chemistry from Cornell University (Ithaca, NY) with Dr. George Morrison, studying secondary ion mass spectrometry. She then pursued postdoctoral research in cell biology with Dr. Fred Maxfield at Columbia University in New York City, where she used advanced fluorescent microscopy to study cellular membrane dynamics. It is during this period that she developed interests in cholesterol and, particularly, how cholesterol disregulation impacts on human diseases such as atherosclerosis, inflammation and metabolic syndromes.

Selected Publications

1.   L. Ma, F. Dong, M. Zaid, A. Kumar and X. Zha. “ABCA1 Enhances TLR4-Stimulated IL-10 Secretion through PKA Activation.” J. Biol. Chem., 2012, 23;287(48):40502-12

2.  L.T. Ma, F. Dong, M. Denis, Y. Feng, M.D. Wang and X. Zha. “Ht31, a PKA anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ABCA1”. J. Biol. Chem., 2011, 286, 3370-3378.

3. M. Denis, Y. D. Landry and X. Zha. “ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments.” J. Biol. Chem., 2008, 283, 16178-86.

4. Y. Landry, M. Denis, S. Nandi, S. Bell, A. M. Vaughan and X. Zha; “ABCA1 expression disrupts raft membrane microdomains through its ATPase fueled functions”. J. Biol. Chem., 2006, 281, 36091-101.

5. A. Ridsdale, M. Denis, P. Gougeon, J. K. Ngsee, J.F. Presley and X. Zha; “Cholesterol is required for efficient ER-Golgi transport of secretory membrane proteins”. Mol. Biol. Cell. 2006, 17, 1593-605.

Diseases, conditions and populations of interest


Vascular, heart and metabolic disease



Research and clinical approaches


Molecular and cellular biology