Gage Lab

Blair Gage profile picture

Contact Information

Blair Gage, PhD
613-737-8899, x 70339
bgage@ohri.ca

Sandy Martino
Research Administrative Assistant
Tel:613-737-8899x76330
Email: smartino@ohri.ca



ORCID logo https://orcid.org/0000-0002-6601-6369

Publications

Selected Publications


1.     Gage BK, Liu JC, Innes BT, MacParland SA, McGilvray ID, Bader GD, Keller GM. Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem Cell-Derived Venous Angioblasts. Cell Stem Cell. (2020) 27(2): 254-269 e259. Article.
  • This study established the core mouse model used in the Gage lab where mouse liver vasculature (LSECs) are replaced by functionally mature hPSC-derived LSECs.
  • Exploration of published scRNAseq data of hPSC-LSECs can be found collaboratively here with Dr. Gary Bader (U of Toronto).

2. Gage BK, Merlin S, Olgasi C, Follenzi A, Keller GM. Therapeutic Correction of Hemophilia A by Transplantation of hPSC-derived Liver Sinusoidal Endothelial Cell Progenitors. Cell Rep. (2022) 39(1): 110621. Article.
  • This study developed a new higher yield differentiation protocol to make hPSC-derived venous endothelial cells with enhanced liver engraftment potential.
  • In collaboration with Dr. Antonia Follenzi (Università, del Piemonte Orientale, Italy), this study also revealed that hPSC-VEC cell therapy can functionally correct severe bleeding phenotypes seen in Hemophilia A mice paving the way for future cell therapy development.


All Other Publications


Please see my Google Scholar account.

Please see my ORCID. 0000-0002-6601-6369

PubMed Listings

For more publications use this PubMed ID link.