David Courtman profile picture

Contact Information

David Courtman, PhD
613-737-8899 x79181
dcourtman@ohri.ca

ORCID logo https://orcid.org/0000-0002-6403-271X

What We Do

Our lab is developing novel stem and progenitor cell-based gene therapies for use in early phase human trials. Clinically applicable cell therapies are developed in a dedicated Good Manufacturing Practice facility and tested for safety, identity, and potential therapeutic efficacy. In addition we use both in vitro and in vivo models to explore the biological mechanisms of disease progression in vascular and pulmonary diseases.

Selected Publications

Vaka R, Khan S, Ye B, Risha Y, Parent S, Courtman DW, Stewart DJ, Davis DR. Direct comparison of different therapeutic cell types susceptibility to inflammatory cytokines associated with COVID-19 acute lung injury. Stem Cell Res Ther. 2022 Jan 15;13(1):20.

Yuan Y, Khan S, Stewart DJ, Courtman DW. Engineering blood outgrowth endothelial cells to optimize endothelial nitric oxide synthase and extracellular matrix production for coating of blood contacting surfaces. Acta Biomater. 2020 Jun;109:109-120.

McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, Schlosser K, Fergusson DA; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial. Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347.

Granton J, Langleben D, Kutryk MB, Camack N, Galipeau J, Courtman DW, Stewart DJ. Endothelial NO-synthase gene-enhanced progenitor cell therapy for pulmonary arterial hypertension: The PHACeT Trial. Circ Res. 2015 Sept 11;117(7):645-54.

Yuan Y, Altalhi WA, Ng JJ, Courtman DW. Derivation of human peripheral blood derived endothelial progenitor cells and the role of osteopontin surface modification and eNOS transfection. Biomaterials. 2014 Jan;35(1):133-42.

Ormiston ML, Deng YP, Rundle N, Bendjelloul F, Tsoporis JN, Parker TG, Stewart DJ, Courtman DW. A lymphocyte-dependent mode of action of imatinib mesylate in experimental pulmonary hypertension. Am J Pathol. 2013 May:182(5):1541-51.

Suen RS, Rampersad SN, Stewart DJ, Courtman DW. Differential roles of endothelin-1 angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice. Am J Pathol. 2011 Sep;179(3):1549-59.

Hakimzadeh N, Stewart DJ, Courtman DW. The role of transglutaminase 2 and osteopontin in matrix protein supplemented microencapsulation of marrow stromal cells. Biomaterials. 2010 Dec;31(35):9256-65.

Karoubi G, Ormiston ML, Stewart DJ, Courtman DW. Single-cell hydrogel encapsulation for enhanced survival of human marrow stromal cells. Biomaterials. 2009 Oct;30(29):5445-55.

Meet the Courtman Lab


GMP
Staff:
Samantha Hodgins, Quality & Operations Manager
Saad Khan, Production & Process Development Manager
Kristi Campbell, Quality Assurance Associate II
William Wallace, Quality Assurance Associate I
Angus Macaulay, Manufacturing Associate III
Mfoniso Thompson, Manufacturing Associate III
Anna Blinder, Manufacturing Associate I
Momina Ejaz, Manufacturing Associate I
Jennifer Hauteclocque, Manufacturing Associate I
Trang Nguyen, Manufacturing Associate I
Liam Cassin, Facility Technician