Lynn Megeney profile picture

Contact Information

Lynn Megeney, PhD
Tel 613-737-8618
lmegeney@ohri.ca

Administrative Assistant
Amanda Cabeceiras
Tel 613-737-8899 ext 73841
acabeceiras@ohri.ca

Publications

Selected Publications

Fernando, P.S., Kelly, J.F., Balazsi, K., Slack, R.S., and Megeney, L.A. (2002). Caspase 3 activity is required for skeletal muscle differentiation. Proc.Natl.Acad.Sci.USA. 99. 11025-11030. 

Larsen, B.D., Rampalli, S., Burns, L., Dilworth, F.J. and Megeney, L.A. (2010). Caspase 3/Caspase activated DNase promote cell differentiation by inducing DNA strand breaks. Proc.Nat.Acad.Sci.USA. 107, 4230-4235. 

Lee, R.E., Brunette ,S., Puente, L.G. and Megeney, L.A. (2010). Metacaspase Yca1 is required for clearance of insoluble protein aggregates. Proc.Natl.Acad.Sci.USA.107, 13348-13353.

Putinski, C., Abdul-Ghani, M., Stiles, R., Brunette, S., Dick, S.A., Fernando, P.S., and Megeney, L.A. (2013). Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy. Proc.Natl.Acad.Sci.USA., 110, E4079-4087.

Dick, S.A. Chang, N.C., Dumont, N.A., Bell, R., Putinski, C., Kawabe, Y., Litchfield, D.W., Rudnicki, M.A. and Megeney, L.A. (2015). Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells.Proc.Natl.Acad.Sci.USA., 112, E5246-5252.

Al-Khalaf, M., Blake, L., Larsen, B.D., Bell, R.A., Brunette, S., Parks, R.J., Rudnicki, M.A., McKinnon, P.J., Dilworth, F.J. and Megeney, L.A. (2016).  Temporal activation of XRCC-1 mediated DNA repair is essential for muscle differentiation. Cell Discovery, 2, 15041.