Manoj Lalu profile picture

Contact Information

News

Are EVs travelling to injured lungs?
March 15, 2024 - Tiny particles called extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have shown clear potential to treat several lung diseases in animal models by reducing inflammation. However, there has been debate about where MSC-EVs ...
ELEVATE seed grants to help researchers at The Ottawa Hospital improve treatment for inflammatory and immune conditions
February 21, 2024 - The Ottawa Hospital’s Research Institute is awarding four ELEVATE seed grants to help researchers understand the role of inflammation and the immune system in various diseases and develop better treatments.
Powering up the body’s EVs
November 9, 2023 - Dr. Alvin Tieu is receiving the Worton Researcher in Training Award from The Ottawa Hospital for his multidisciplinary research on life-threatening lung diseases
Meet Dr. Manoj Lalu, the clinician-scientist bringing lab discoveries to patients every day
March 16, 2023 - From looking at how we can use stem cells to treat diseases like sepsis to dealing with patients directly in the ICU and OR, Dr. Lalu is making an impact behind the scenes and beyond.
Researchers at The Ottawa Hospital co-lead $39M Accelerating Clinical Trials (ACT) Consortium
January 19, 2023 - The new Accelerating Clinical Trials (ACT) Consortium, co-led by The Ottawa Hospital, aims to transform Canada’s clinical trials landscape by removing barriers, streamlining approvals, enhancing support and facilitating the engagement and ...
“Dream team” of researchers tackles leading cause of vision loss
July 27, 2022 - Dr. Catherine Tsilfidis has assembled a world-class team to bring discoveries with game-changing potential to patients with retinal disease
Researchers at The Ottawa Hospital awarded 19 CIHR grants worth more than $12 million
July 20, 2022 - These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, ...
First made-in-Canada CAR-T cell therapy for cancer shows promise in clinical trial
June 17, 2022 - More than a dozen people with cancer who had exhausted all treatment options are alive and cancer-free today thanks to a pioneering Canadian clinical trial of a highly personalized kind of immunotherapy.
Ottawa Hospital researchers awarded $1.85M from Stem Cell Network
May 12, 2022 - Four research teams at The Ottawa Hospital have been awarded a total of $1.85 million to harness stem cells and regenerative medicine to develop new therapies for septic shock, bone and joint conditions, and newborn lung damage, while also ...
Researchers at The Ottawa Hospital awarded five grants for high risk, high reward and interdisciplinary research
April 4, 2022 - The New Frontiers in Research Fund (NFRF) 2021 Exploration competition has awarded $25 million to support 102 research teams across Canada that bring diverse disciplines together in pursuit of breakthrough ideas and high-reward outcomes.
Tiny particles hold promise for treating acute and chronic lung disease
February 17, 2022 - A meta-analysis of lab studies found that tiny particles called extracellular vesicles (EVs) released by mesenchymal stem/stromal cells (MSCs) have clear potential for treating acute lung injury,
Study explores patient engagement in lab research
January 6, 2022 - A study found that engaging patients in laboratory research is possible, and can benefit both the patients and the researchers.
Virtual care with remote monitoring catches drug errors and reduces patient pain
November 4, 2021 - The use of take-home technology by patients following non-elective surgery resulted in significantly greater detection and correction of drug errors, and reduced pain, according to a study published in The BMJ.
$2.4 M grant to help researchers develop gene and cell therapies for a leading cause of blindness
September 15, 2021 - A team led by Dr. Catherine Tsilfidis has received $2.4 M from the Ontario Research Fund to develop treatments for retinal diseases, a leading cause of blindness.
Nothing about me, without me: Engaging patients in clinical trials
August 13, 2021 - It seems obvious – blindingly so – that patients, traditionally the subjects of clinical trials, should be involved as partners from the beginning. The benefits for patients are clear – an increased sense of control and the ability to learn about ...
Researchers at The Ottawa Hospital awarded three grants for high risk, high reward and interdisciplinary research
May 31, 2021 - The New Frontiers in Research Fund (NFRF) 2020 Exploration competition brings diverse disciplines together in pursuit of breakthrough ideas and high-reward outcomes.
One small step for blood cancer patients, one giant step for Canadian cancer patients of all stripes
February 25, 2021 - The Canadian-Led Immunotherapies in Cancer (CLIC) research program is building Canada’s capacity for innovation in CAR-T therapy, with support from BioCanRx, The Ottawa Hospital, BC Cancer and the Ontario Institute for Cancer Research
Blueprint Excelerator helps move discoveries from the bench to the bedside
November 6, 2020 - The Blueprint Translational Research Group was established in 2016 at The Ottawa Hospital, in collaboration with the Ottawa Methods Centre. Co-led by Dr. Dean Fergusson and Dr. Manoj Lalu, Blueprint developed an innovative model called the ...
The Ottawa Hospital and uOttawa launch new cancer immunotherapy research projects with funding from BioCanRx
September 22, 2020 - BioCanRx, Canada’s Immunotherapy Network, today announced funding of $10M for 14 cancer immunotherapy research projects and eight core and biomanufacturing facilities across the country. Researchers at The Ottawa Hospital (TOH) and the University ...
The Ottawa Hospital awarded six CIHR grants worth $2.6 million
September 7, 2020 - Could a common diabetes drug help prevent ovarian cancer? Can a tailored screening program help prevent eye disease in immigrants? Is sepsis different in females versus males, and if so, can this help us develop better treatments? These are just ...
TOHAMO awards $1.2M for COVID-19 research projects
June 12, 2020 - Could artificial intelligence help predict which COVID-19 patients will become gravely ill? Could a home-based spit test diagnose COVID-19? Could virtual care after surgery reduce patient returns to hospital?
Can virtual care after surgery reduce patient returns to hospital? Research study now open in Ottawa
June 10, 2020 - COVID-19 has accelerated the adoption of all kinds of virtual health care, from phone and video appointments to tools that monitor symptoms remotely. The Ottawa Hospital continues to be at the forefront of this trend with the launch of an ...
Creating a new mouse model to study COVID-19 lung disease
June 4, 2020 - Researchers are working to develop a mouse model of COVID-19 that mimics the severe lung disease seen in humans. The lack of good, accessible animal models of this disease is severely limiting research around the world.
Harnessing stem cells and regenerative medicine to fight COVID-19
April 23, 2020 - Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $490,000 from the Stem Cell Network for two research projects that could help in the fight against COVID-19. These peer-reviewed grants are part of an overall ...
Researchers join the fight against COVID-19
April 2, 2020 - As hospitals and communities band together to fight COVID-19, researchers at The Ottawa Hospital are harnessing their unique expertise and resources to help.
The Ottawa Hospital awarded nine grants worth $5.6 million from Canadian Institutes of Health Research
February 3, 2020 - How can we treat depression when nothing else is working? How can heart growth be both good and bad? How can we increase patient participation in clinical trials? These are just a few of the big questions that researchers at The Ottawa Hospital ...
To help protect research, experts agree on a definition of predatory publishing
January 15, 2020 - Leading scholars and publishers from The Ottawa Hospital’s Centre for Journalology, the University of Ottawa’s Telfer School of Management, and other institutions from around the world have agreed on a consensus definition of predatory publishing.
Ottawa a “hotbed of patient partnerships in research”
September 27, 2019 - The Ontario SPOR Support Unit’s summer newsletter showcases how Ottawa has become a “hotbed of patient partnerships in research.” Three stories demonstrate how researchers at The Ottawa Hospital are partnering with patients and caregivers to ...
The promise of CAR-T therapy for cancer: meta-analysis shows the big picture
August 14, 2019 - CAR-T therapy, which uses a patient’s own genetically modified immune cells, is one of the most exciting advances in cancer treatment. To get a big picture view of the field, Drs. Manoj Lalu and Dean Fergusson led a team that analyzed data from ...
Clinicians at The Ottawa Hospital launch 14 innovative projects to improve health-care delivery, thanks to funding from TOHAMO and The Ottawa Hospital’s Research Institute
March 22, 2019 - The Ottawa Hospital Academic Medical Organization (TOHAMO) has awarded $1.169 million in Innovation Grants to 14 teams, with supporting funds provided by the Ottawa Hospital Research Institute.
Patients and clinical trial experts key to upcoming made-in-Canada CAR-T clinical trial
March 1, 2019 - Researchers at The Ottawa Hospital and the University of Ottawa are known around the world for their expertise in designing and leading clinical trials, and they're now applying this knowledge to create a made-in-Canada approach for CAR-T ...
Researchers to advance science and improve health with new CIHR funding
February 14, 2019 - Researchers at The Ottawa Hospital, affiliated with the University of Ottawa, are playing a lead role in nine new projects funded by the Canadian Institutes of Health Research (CIHR). These projects will advance science and improve health in ...
Predatory journals: researchers propose solutions to stop the “corruption of science”
December 4, 2017 - The team of researchers behind a landmark study on predatory journals has now outlined the first concrete steps that stakeholders can take to combat the growing influence of these journals. Their pioneering work is published in Nature Human Behavior.
Predatory journals a global problem: Investigation in Nature reveals high income countries not immune
September 6, 2017 - A massive investigation published in Nature shows that contrary to popular belief, a majority of papers in suspected biomedical predatory journals (57 percent) are from high or upper middle income countries, with many coming from prestigious institut
Ottawa researchers to play lead role in new cancer immunotherapy studies
February 15, 2017 - BioCanRx funds research into CAR-T and virus-infected cell therapy Researchers from The Ottawa Hospital and the University of Ottawa will play a lead role in cutting-edge research on cancer immunotherapy, thanks to five new peer-reviewed researc
Researchers use rigorous approach to establish the strength of lab data to inform stem cell clinical trial
December 7, 2016 - While many exciting discoveries are made in laboratories every year, few ever become successful human treatments. This may be because often the decision to start a human trial is based on a few laboratory studies instead of considering all the av