Scientist, Chronic Disease Program
Ottawa Hospital Research Institute
Dr. MacPherson has an active practice in infectious diseases with a particular interest in HIV and other sexually transmitted infections. Dr. MacPherson's main research interest is in understanding how HIV disables the immune system and he currently directs a basic science laboratory investigating specifically the role of interleukin-7 in HIV infection. Dr. MacPherson is also the principle investigator on a number of clinical research projects including smoking cessation, gay men's health, cardiovascular risk factors in HIV+ individuals and treatment of infectious syphilis. Current research grants include:
Addressing Health Inequities and Improving Health Outcomes among Gay Men
The Effects of Statin Therapy on Coronary Flow Reserve and Inflammatory Markers in HIV-Positive Patients
Interleukin-7 Regulation of Cytotoxic CD8 T-Cell Activity in HIV patients
Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis
A Pilot Study to Assess the Effectiveness and Health Benefits of an Innovative Smoking Cessation Intervention for HIV+ Patients at The Ottawa Hospital Clinic
Dr. MacPherson received his PhD from the University of California at Berkeley in 1991 and his MD from McMaster University in 1998. He completed his residency in internal medicine at the University of Toronto and subspecialty training in infectious diseases at the University of Ottawa. Dr MacPherson runs an active practice in infectious diseases with a particular interest in HIV and other sexually transmitted infections. Dr MacPherson is a Clinician Scientist who works as a staff physician in the Division of Infectious Diseases at the Ottawa Hospital General Campus and a research scientist at the Ottawa Hospital Research Institute (Chronic Disease Program)where he is involved in both clinical and fundamental research projects. Dr. MacPherson is also an Associate Professor in the Department of Medicine, and the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa .
IL-7 receptor recovery on CD8 T-cells isolated from HIV+ patients is inhibited by the HIV Tat protein.
Faller EM, McVey MJ, MacPherson PA. PLoS One. 2014 Jul 17;9(7):e102677
Heart failure in HIV infection: focus on the role of atherosclerosis.
Ng B, MacPherson P, Haddad T, Dwivedi G. Curr Opin Cardiol. 2014 Mar;29(2):174-9.
Neurocognitive and psychiatric changes as the initial presentation of neurosyphilis.
Costiniuk CT, MacPherson PA.
CMAJ. 2013 Apr 2;185(6):499-503.
IL-7 downregulates IL-7Rα expression in human CD8 T cells by two independent mechanisms.
Ghazawi FM, Faller EM, Sugden SM, Kakal JA, MacPherson PA. Immunol Cell Biol. 2013 Feb;91(2):149-58.
Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradation.
Faller EM, Sugden SM, McVey MJ, Kakal JA, MacPherson PA.. J Immunol. 2010 Sep 1;185(5):2854-66.
Diseases, conditions and populations of interest
Anxiety; Depression; HIV; Infectious disease; Men's health; Other; Sexually transmitted diseases
Research and clinical approaches
Behaviour; Cohort studies; Epidemiology; Health promotion; Health services research; Knowledge translation and implementation research; Prevention; Psychology; Qualitative methods; Surveys