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Government of Canada invests $1M in a COVID-19 evidence network to support decision-making
January 12, 2021
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To ensure decision-makers have access to the best COVID-19 science in a timely manner, the Government of Canada is investing $1M in the COVID-19 Evidence Network to support Decision-making (COVID-END)
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Understanding the impact of COVID-19 on women
December 30, 2020
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Dr. Innie Chen is leading research to understand the impact of COVID-19 on women, thanks to seed funding through The Ottawa Hospital Foundation’s COVID-19 Emergency Response Fund.
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COVID-19 and rheumatoid arthritis: using big data to understand risks and improve treatments
December 10, 2020
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Rheumatoid arthritis is an inflammatory disease that primarily affects the joints. Dr. Sibel Aydin is harnessing big data from ICES and the Ontario Best Practice Research Initiative to determine if people with rheumatoid arthritis are more or less li
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Can chest imaging diagnose COVID-19?
December 9, 2020
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An international team led by Dr. Matthew McInnes is regularly combing the latest research to find out whether chest imaging could be a useful tool for diagnosing COVID-19.
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World-first clinical trial aims to protect cancer patients from COVID-19
December 9, 2020
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Our researchers are leading the way in a world-first clinical trial to protect vulnerable cancer patients during the COVID-19 pandemic.
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The Ottawa Hospital contributes to ‘a beautiful evolution’ in HIV research and care
December 4, 2020
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In honour of World AIDS day, we take a look back at how The Ottawa Hospital played a major role in caring for patients with HIV, how it continues to lead life-saving research, and how it is transforming how HIV is managed today.
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Vaccines and viral immunotherapies: unique Canadian program provides training to manufacture biotherapeutics
November 21, 2020
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As COVID-19 highlights the urgent need to increase vaccine manufacturing around the world, a unique training program is bolstering Canada’s capacity to manufacture vaccines, as well as viral immunotherapies for cancer and other emerging biotherapeuti
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App could provide new way to track vaccine safety
November 17, 2020
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Vaccines are one of society’s greatest success stories, but like any treatment, there can be rare adverse events and they must be tested carefully. With a massive COVID-19 vaccination campaign on the horizon, Canadian researchers have launched a pilo
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$1M grant to support manufacturing of COVID-19 treatments and vaccines at The Ottawa Hospital and uOttawa
November 6, 2020
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Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $1,050,000 from the Canada Foundation for Innovation to support facilities for manufacturing innovative treatments and vaccines for COVID-19.
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The Ottawa Hospital and uOttawa launch new cancer immunotherapy research projects with funding from BioCanRx
September 22, 2020
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BioCanRx, Canada’s Immunotherapy Network, today announced funding of $10M for 14 cancer immunotherapy research projects and eight core and biomanufacturing facilities across the country. Researchers at The Ottawa Hospital (TOH) and the University of
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How to mitigate ICU drug shortages related to COVID-19
September 9, 2020
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As COVID-19 continues to disrupt global drug supplies, researchers at The Ottawa Hospital are playing a key role in developing and implementing mitigation strategies for intensive care units (ICUs).
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Canadian study compares COVID-19 spit test to traditional swab test
September 8, 2020
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A new study led by researchers at The Ottawa Hospital, University of Ottawa and the Public Health Agency of Canada’s National Microbiology Laboratory shows that a Canadian-made spit test can detect the COVID-19 virus.
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Algorithm helps prescribers choose more targeted antibiotics
August 27, 2020
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A study led by Dr. Derek MacFadden found that a combination of tools helped increase the number of patients receiving the most targeted and effective antibiotic for bacterial blood infections.
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Protecting cancer patients from COVID-19
July 8, 2020
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In the race to find new ways to prevent and treat COVID-19, Canadian researchers have launched an innovative clinical trial focussed on strengthening the immune system for one of the most vulnerable populations – cancer patients.
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Hyperbaric oxygen therapy for COVID pneumonia
June 26, 2020
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Astudy led by Dr. Sylvain Boet will test if hyperbaric oxygen therapy may be able to help some people with COVID-19 pneumonia.
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Preventing dangerous blood clots in COVID-19 patients
June 26, 2020
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Drs. Lana Castellucci, Marc Carrier and colleagues are contributing to an international clinical trial to find out whether a high dose of blood thinner can prevent dangerous blood clots in hospitalized COVID-19 patients.
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Using big data to find promising drugs for COVID-19
June 26, 2020
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Dr. Derek MacFadden and his colleagues plan to identify promising drugs to treat COVID-19 by analyzing past data from 3,000 Ontario patients treated for other kinds of coronavirus infections.
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Understanding the impact of COVID-19 on pregnant women and babies
June 25, 2020
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Very little is known about how COVID-19 affects pregnant women and their babies. Drs. Darine El-Chaâr, Marc-André Langlois and their team plan to address this knowledge gap through several large studies. Dr Langlois’s team will be responsib
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Harnessing cancer-fighting viruses to develop a COVID-19 vaccine
June 25, 2020
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Drs. Carolina Ilkow, John Bell and colleagues are harnessing their expertise in making oncolytic (cancer-fighting) viruses to develop a vaccine against COVID-19, in partnership with scientists and clinicians in Canada and around the world.
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Using cell therapy to calm the immune system in critically ill patients
June 25, 2020
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Drs. Duncan Stewart, Shane English, Dean Fergusson and colleagues will launch a randomized, controlled clinical trial in several centres across Canada to test MSCs in people with severe COVID-19.
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The Ottawa Hospital awarded $4.7 million for COVID-19 research from the Canadian Institutes of Health Research
June 25, 2020
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Researchers at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded $4.7 million from the Canadian Institutes of Health Research (CIHR) for four research projects that could transform our understanding of COVID-19 and lead
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Helping COVID-19 survivors stay healthy
June 23, 2020
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Drs. Sara J. Abdallah and Juthaporn Cowan will study the long-term effects of COVID-19 in survivors, checking in on them three, six and 12 months after they were initially infected.
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TOHAMO awards $1.2M for COVID-19 research projects
June 12, 2020
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Could artificial intelligence help predict which COVID-19 patients will become gravely ill? Could a home-based spit test diagnose COVID-19? Could virtual care after surgery reduce patient returns to hospital?
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Can virtual care after surgery reduce patient returns to hospital? Research study now open in Ottawa
June 10, 2020
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COVID-19 has accelerated the adoption of all kinds of virtual health care, from phone and video appointments to tools that monitor symptoms remotely. The Ottawa Hospital continues to be at the forefront of this trend with the launch of an innovative
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Using lab-grown human tissues to identify possible treatments
June 8, 2020
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Dr. William Stanford and his colleagues are using human tissue models to understand why COVID-19 makes some patients severely ill.
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Stopping COVID-19 with behavioral science and artificial intelligence
June 8, 2020
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Dr. Justin Presseau and colleagues plan to use state-of-the-art behavioural science and artificial intelligence to develop an app that can help people reduce how much they touch their eyes, nose and mouth.
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Understanding the challenge of COVID-19 for Ottawa’s most vulnerable people
June 8, 2020
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Dr. Smita Pakhale and her colleagues will harness the trust and engagement they have built with Ottawa’s most marginalized communities over the last 10 years through community-based participatory action research to examine how COVID-19 has impacted t
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Mobile reporting of adverse events from a pandemic COVID-19 vaccine
June 8, 2020
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Dr. Kumanan Wilson and his colleagues will harness their electronic vaccine-tracking platform CANImmunize to let Canadians report potential adverse events from a COVID-19 vaccine through their mobile device.
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Could blood plasma shore up our COVID defenses?
June 5, 2020
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A team led by Dr. Alan Tinmouth and Dr. Dean Fergusson is part of a collaboration aiming to settle the long-standing question of whether “convalescent” blood plasma from recovered patients can be used to treat actively sick ones.
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Creating a new mouse model to study COVID-19 lung disease
June 4, 2020
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Researchers are working to develop a mouse model of COVID-19 that mimics the severe lung disease seen in humans. The lack of good, accessible animal models of this disease is severely limiting research around the world.
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Studying the immune response of COVID-19 patients in the ICU
June 4, 2020
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A study led by Dr. Shirley Mei will examine why some people get severely ill and die of COVID-19, while others experience only mild symptoms
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Experimental Stem Cell Therapy a Potential Weapon in COVID-19 Fight
May 28, 2020
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Ottawa-based researchers pivot at lightning speed to launch study on treating related respiratory failure
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COVID-19 research on cell therapy, drug screening and marginalized populations funded through Ontario’s Rapid Research Fund
May 21, 2020
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Researchers from The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded almost $2 million from Ontario’s COVID-19 Rapid Research Fund for three research projects that could help in the fight against the virus. These three pr
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Thanking the heroes behind clinical trials
May 20, 2020
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COVID-19 has put a special focus on the importance of clinical trials in finding ways to diagnose, treat and prevent this new infection, but clinical trials have always been essential to improving care and saving lives at The Ottawa Hospital. Six cli
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COVID-19 Evidence Network to support decision-making
May 11, 2020
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To help leaders around the world respond to unprecedented challenges related to COVID-19, Drs. Jeremy Grimshaw and John Lavis are co-leading The COVID-19 Evidence Network to support Decision-making (COVID-END). Partners in the network include experts
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COVID-19 research moving at ‘lightning speed’, thanks to generous community support
May 8, 2020
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Researchers at The Ottawa Hospital are working around the clock to advance more than 50 potentially life-saving research projects to support the world-wide effort to find better ways to treat and prevent COVID-19. Now, nine of these projects have bee
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Researchers use lab-grown human tissues to understand secrets of COVID-19 infection, identify possible treatments
April 29, 2020
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A team of Ontario researchers is using 3D lab-grown human tissue models to understand why COVID-19 makes some patients severely ill. They also hope to identify drugs that can reduce the severity of the infection.
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Cancer-killing viruses provide inspiration for COVID-19 vaccine
April 28, 2020
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While physical distancing has slowed the spread of COVID-19, the vast majority of people around the world remain susceptible to the virus. That’s why most experts believe we won’t be able to fully find a new normal until a vaccine is developed. At T
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Clinical trial to test plasma from recovered COVID-19 patients as possible treatment
April 28, 2020
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Researchers, clinicians and patients at The Ottawa Hospital will be contributing to the global effort to determine if plasma from people who have recovered from COVID-19 (called convalescent plasma) could be an effective treatment for actively infect
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Harnessing stem cells and regenerative medicine to fight COVID-19
April 23, 2020
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Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $490,000 from the Stem Cell Network for two research projects that could help in the fight against COVID-19. These peer-reviewed grants are part of an overall investm
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Should I leave my retirement or long-term care home due to COVID-19? New tools can help with tough decisions
April 22, 2020
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Researchers from The Ottawa Hospital, the University of Ottawa, the Champlain Local Health Integration Network?and the National Institute of Ageing have developed tools to help seniors decide if they should temporarily move out of their retirement, a
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How are you coping during COVID-19?
April 20, 2020
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COVID-19 is changing core aspects of people’s lives in a unique manner. Social interactions, family and work are all affected. Researchers want to understand the impacts of these changes and determine what helps people cope.? They have launched a stu
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Don’t change blood pressure medication because of fear of COVID-19
April 17, 2020
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Viruses get inside our cells by latching onto specific proteins on the cell surface. In the case of COVID-19, the virus latches onto a protein that normally controls blood pressure. In fact, common blood pressure medications increase the level of thi
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New COVID-19 projections show how physical distancing can make a huge difference in Ottawa
April 8, 2020
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Researchers from The Ottawa Hospital and the University of Ottawa, in partnership with Ottawa Public Health, have created a new interactive Ottawa COVID-19 website, that predicts various scenarios around the number of hospitalizations and deaths in O
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Researchers join the fight against COVID-19
April 2, 2020
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As hospitals and communities band together to fight COVID-19, researchers at The Ottawa Hospital are harnessing their unique expertise and resources to help.
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A COVID-19 palliative care pandemic plan: An essential tool
March 31, 2020
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Palliative care physicians have created a coronavirus disease 2019 (COVID-19) palliative care plan as an essential tool to provide care and help manage scare resources during the pandemic. The plan, which focuses on 8 critical elements -- "stuff
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Nothing to sniff at: Screening platform identifies drugs that could fight the common cold
January 10, 2020
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A team led by Dr. Robin Parks has developed a new way to identify drugs that may be good candidates for treating the common cold. While many products can treat cold symptoms, there is currently no way to treat the viruses that causes the disease, suc
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New scientist profile: Dr. Krishan Yadav aims to improve care for skin infections
December 11, 2019
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Dr. Krishan Yadav wants to find the best way to treat the patients with skin infections he sees in the emergency department. Currently there is little evidence on how best to treat common skin infections such as cellulitis.
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Taking CANImmunize to the next level
October 1, 2019
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CANImmunize, an award-winning vaccine-tracking platform developed by researchers at The Ottawa Hospital, is transitioning into a startup company. The popular app-based platform will continue to digitally transform the delivery of immunization service
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Unravelling the mystery of how one gene contributes to Parkinson’s, Crohn’s and leprosy
September 25, 2019
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Researchers have struggled for years to understand how mutations in one gene, called LRRK2, can increase the risk of three very different diseases: Parkinson’s (a brain disease), Crohn’s (a gut disease) and leprosy (a peripheral nervous system diseas
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The next frontier in HIV research: Ottawa scientists to play key role in new $17M prevention and cure studies
August 14, 2019
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Despite great strides in HIV research, over 75,000 Canadians are living with HIV and approximately seven more contract it every day. And this incurable virus continues to take a huge toll around the world. The Government of Canada recently announced
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The Ottawa Hospital awarded 13 grants worth $11.2 million from Canadian Institutes of Health Research
July 26, 2019
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Researchers at The Ottawa Hospital have been awarded 13 grants worth a total of $11.2 million from the Canadian Institutes of Health Research (CIHR). The new projects focus on areas such as cancer immunotherapy, hepatitis C infection, blood clots, ar
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New scientist profile: Dr. Derek MacFadden helps prescribers fight antibiotic resistance
June 26, 2019
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Ninety percent of antibiotics are prescribed outside of hospitals, and a third are unnecessary. Dr. Derek MacFadden’s research aims to help prescribers choose the right antibiotic for the bacteria they’re fighting instead of using broad-spectrum anti
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$950,000 to help develop stem cell treatments for septic shock, lung injury and muscle degeneration
May 17, 2019
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Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks to four new peer-reviewed research grants from the Ontario Institute for Regenerative Medici
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Ottawa researchers working with World Health Organization to improve response to public health emergencies
April 4, 2019
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In response to the SARS outbreak, the threat of influenza pandemics, and the changing nature of public health emergencies, the World Health Organization released the revised International Health Regulations (IHR(2005)). These regulations are the most
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Immunization tracking brought into the digital age
November 30, 2018
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Building on successful public health reporting pilot projects in Ottawa and Kingston, Ontarians will soon be able to use CANImmunize to immediately see and download their own, and their families’ official immunization records held by the province. CA
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Experimental contraceptive could give women the power to prevent pregnancy and STIs
November 30, 2018
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While condoms are the gold standard for preventing pregnancy and Sexually Transmitted Infections (STIs), there is a need around the world for solutions that can be used independently by women. New research led by Dr. Nongnuj Tanphaichitr brings a pot
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Standardizing digital vaccination records in Canada: team behind CANImmunize launches Canadian Vaccine Catalogue
July 12, 2018
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As provinces and territories across Canada work to digitize vaccination records, a team of Canadian physicians, researchers and policy-makers has released the first version of the Canadian Vaccine Catalogue (CVC). This comprehensive, standards-based
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Using viruses to fight viruses: new approach eliminates “dormant” HIV-infected cells
December 18, 2017
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While Ottawa researchers are known for their work on cancer-fighting viruses, one team is applying these viruses to a new target: HIV.
Researchers at The Ottawa Hospital and the University of Ottawa have discovered that the Maraba virus, or MG1, c
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Stem cells for septic shock: world-first trial establishes safety, sets stage for larger trial
November 2, 2017
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Stem cells are usually thought of as the building blocks of the body – able to give rise to all our cells and organs. But Dr. Lauralyn McIntyre, Dr. Duncan Stewart, Dr. Dean Fergusson and their colleagues are testing the idea that certain stem cells
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HIV kept at bay with single injection every 8 weeks
August 17, 2017
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Over the last two decades, HIV has been transformed from a death sentence into a chronic, treatable disease, requiring just a single pill a day to keep the virus at bay for most people. A study co-authored by Dr. Jonathan Angel has now paved the wa
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New treatment for our sickest patients comes closer to reality
June 30, 2017
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The Ottawa Hospital was one of the top sites for enrolling patients in an international clinical trial of a promising new treatment for shock. The study, published in the New England Journal of Medicine, shows that a naturally-occurring protein calle
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Dr. Gonzalo Alvarez presents Taima TB research program to parliamentarians
June 5, 2017
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Dr. Gonzalo Alvarez was on Parliament Hill today presenting the Taima TB research program to the Parliamentary Health Research Caucus on Indigenous Health Research in Canada.
Taima TB Summary
The challenge
Despite the ongoing efforts of d
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Could stem cells heal premature lungs, fight infections, build muscles and strengthen bones?
May 25, 2017
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Ottawa researchers closer to finding out, thanks to $1.5 million from the Ontario Institute for Regenerative Medicine
Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to huma
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The Ottawa Hospital awarded 18 research grants from the Canadian Institutes of Health Research, worth $10.7 million
May 19, 2017
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Eighteen research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded nearly $11 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). This represents a suc
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Government of Canada Supports Latent Tuberculosis Study
March 24, 2017
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Tuberculosis (TB) is preventable and curable, yet it remains one of the most common infectious diseases worldwide. In Canada, rates of TB are low; however, there is greater incidence among Canadian Indigenous people and among foreign-born individuals
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Ottawa researchers develop rapid review process to help WHO respond to global threats
December 22, 2016
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Ms. Chantelle Garritty and collaborators in the Knowledge Synthesis Group have developed a process to help the World Health Organization (WHO) quickly create guidelines during global emergencies.
During an outbreak of a new disease, WHO needs to a
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Dr. Paul MacPherson awarded Research Chair in Gay Men’s Health from Ontario HIV Treatment Network
September 7, 2016
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Gay men make up 58 percent of the people living with HIV in Ontario. Although overall rates of new HIV infections are declining, gay men accounted for 60 percent of new diagnoses in 2015, highlighting the continuing risk of infection within this co
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Researchers find compound that can protect mice from Ebola
July 27, 2016
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Drs. Michel Chrétien (OHRI Emeritus Scientist), Majambu Mbikay and colleagues from the National Microbiology Laboratory in Winnipeg have found a compound that can protect mice from the Ebola virus, even when given as little as 30 minutes before i
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Ottawa research informs international Ebola guideline
June 14, 2016
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Should clinicians wear double gloves or single gloves when caring for Ebola patients? What about full gowns versus coveralls? After Ebola broke out in West Africa in late 2013, the World Health Organization (WHO) asked Dr. David Moher and his tea
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Two lives forever changed by 30 years of HIV drug research
April 22, 2016
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Yves Brunet has taken part in 15 HIV drug trials at The Ottawa Hospital since the 1980s. Thanks to research, daily treatments have commuted a sentence of certain death from AIDS into a manageable condition.
Yves Brunet and Andy Collins were di
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Landmark trial could expand revolutionary treatments to all hepatitis C patients
February 3, 2016
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New targeted treatments have revolutionized care for hepatitis C, offering cure rates of close to 100 percent for people infected with the most common strain of the virus. Dr. Curtis Cooper and his team have played a major role in the research th
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Dr. Robin Parks awarded $790,000 from CIHR to study common cold virus
December 16, 2015
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An average person will suffer around 400 colds in his or her lifetime and these colds account for 40% of all workplace absenteeism. Colds can also have much more serious consequences in people with compromised immune systems, as well as the very youn
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New treatments cure hepatitis C in patients co-infected with HIV
July 29, 2015
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Around the world, between 4 and 5 million people are infected with both HIV and the hepatitis C virus. These patients have high rates of liver disease. Until now, effective treatment for co-infected patients has been difficult since the interferon-
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How does the liver affect the immune system? $175,000 grant to help find answers
June 10, 2015
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Dr. Angela Crawley has been awarded a $175,000 grant from the Natural Sciences and Engineering Research Council of Canada to study how cells in the liver can influence the immune response. This project focuses on a kind of cell called a macrophage, w
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DNA test slashes wait times for tuberculosis diagnosis in Iqaluit
March 23, 2015
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Study results prompt Government of Nunavut to fund TB test's continued use
Tuberculosis continues to be a significant public health concern in Canada's North, where testing for TB takes far longer than in the country's major centres. A paper just
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Flu shots decrease overall risk of acquiring Guillain-Barré Syndrome
January 19, 2015
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Drs. Kumanan Wilson and Steven Hawken published a paper this week that examines whether the flu shot increases or decreases the risk of getting Guillain-Barré Syndrome (GBS), a rare but serious autoimmune condition.
Recent studies have associated
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