Scientist, Cancer Therapeutics, Ottawa Hospital Research Institute
Assistant Professor, Department of Medicine, University of Ottawa
Keywords: angiogenesis, tumorigenesis, signal transduction, proteomics, resistance
Current Research Projects
Our laboratory focuses on two main themes, angiogenesis in tumor growth and cancer biomarker discovery. We have actively been investigating the role of the extracellular matrix (ECM) in modulating the angiogenic response in tumors and inducing resistance to common anti-cancer treatments. As the ECM present in tumors is vastly different then that found in normal tissue counterparts understanding the effects of ECM on endothelial cell and tumor cell biology is extremely important. To this end we are also investigating the molecular events elicited in cells by ECM interactions including the role of focal adhesion kinase and integrin linked kinase signal transduction pathways. Our laboratory is also attempting to identify biomarkers correlating with cancer disease presence, prognosis and recurrence using a proteomic approach. We are currently screening patient sera using the Ciphergen ProteinChip Biology System to identify unique proteins that correlate with the factors of interest and are subsequently validating the identified markers using alternative approaches that would be clinically applicable.
Recent Publications
Addison CL , Nör JE, Linn SA, Polverini PJ, Delaney CE. 2005. The Response of VEGF-stimulated Endothelial Cells to Angiostatic Molecules is Substrate-Dependent. BMC Cell Biology, in press.
Addison CL, Belperio, JA, Burdick MD, Strieter RM. 2004 . Overexpression of the Duffy Antigen Receptor for Chemokines (DARC) by NSCLC Tumor Cells Results in Increased Tumor Necrosis. BMC Cancer. 4(1):28
Ehlert, JE, Addison, CL , Burdick MD, Kunkel SL, Strieter RM. 2004 . Identification and Partial Characterization of a Variant of Human CXCR3 Generated by Post-translational Exon Skipping . J. Immunol. 173(10):6234-6240.
Nor JE, Peters MC, Christensen JB, Sutorik MM, Linn S, Khan MK, Addison CL , Mooney DJ, Polverini PJ. 2001. Engineering and characterization of functional human microvessels in immunodeficient mice. Lab Invest. 81(4):453-63.
Addison CL , Burdick MD, Xue YY, Morris SB, Buechi L, Walz A, Strieter RM. 2000 . The CXC Chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine induced angiogenic activity. J.Immmunol. 165:5269-5277.
General Campus
(see 
