Ottawa Methods Center (OMC)

REthinking Clinical Trials (REaCT) Program

Scientific Lead: Dr. Dean Fergusson

What is the most efficient way to answer the most important questions to improve care for cancer patients? Rethinking Clinical Trials (REaCT) Program answers this question with eight key principles. As described in the Journal of Oncology Practice, REaCT involves comparing different approved treatment strategies rather than developing new ones. It also involves a streamlined process for obtaining oral (rather than written) patient consent, immediate randomization into treatment groups using a mobile device and simplified data collection. Their first trial, which compares two strategies to prevent chemotherapy-related infections in breast cancer patients, has recruited nearly 500 patients in just over 18 months, at a small fraction of the cost of most cancer clinical trials.
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