Albert Lab

Paul Albert profile picture

Contact Information

Paul Albert, PhD
613-562-5800 8307

OHRI (Neuroscience)
451 Smyth Road
Ottawa, ON K1H-8M5

ORCID logo


Selected Publications

Five Key Publications

Albert lab members in bold
Publications archived at: ResearchGate

1. Turcotte-Cardin V, Vahid-Ansari F, Luckhart C, Daigle M, Geddes SD, Tanaka KF, Hen R, James J, Merali Z, Beique JC, Albert PR (2019) Loss of adult 5-HT1A autoreceptors results in a paradoxical anxiogenic response to antidepressant treatment. J Neurosci 39, 1334-46. PDF

2. Le François B, Zhang L, Mahajan GJ, Stockmeier C, Friedman E, Albert PR (2018) A novel alternative splicing mechanism that enhances human 5-HT1A receptor RNA stability is altered in major depression. J Neurosci 38, 8200-10. PDF

3. Vahid-Ansari F, Daigle M, Manzini MC, Tanaka KF, Hen R, Geddes SD, Beique JC, James J, Merali Z, Albert PR. (2017) Abrogated Freud-1/CC2D1A repression of 5-HT1A autoreceptors induces fluoxetine-resistant anxiety/depression-like behavior. J Neurosci 37, 11967-11978. PDF

4. Zahrai A, Vahid-Ansari F, Daigle M, Albert PR (2020) Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression. Transl Psychiatry 10:334. PDF

5. Vahid-Ansari F and Albert PR (2018) Chronic fluoxetine induces activity changes in recovery from post-stroke anxiety, depression and cognitive impairment. Neurotherapeutics 15, 200-215. PDF.

All Other Publications

Selected Publications

1. Vahid-Ansari F, Albert PR (2021) Rewiring of the Serotonin System in Major Depression.  Frontiers in Psychiatry 12: 2275 PDF
2. Hayley S, Hakim AM, Albert PR (2021) Depression, dementia and immune dysregulation. Brain 144: 746-760. PDF
3. Albert PR, Le Francois B, Vahid-Ansari F (2019) Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm. J Psychiatry Neurosci 44: 164-76. PDF

4. Albert PR, Vahid-Ansari F (2019) The 5-HT1A receptor: Signaling to behavior. Biochimie 161: 34-45.

5. Seyedabadi M, Ghahremani MH, Albert PR (2019) Biased signaling of G protein coupled receptors (GPCRs): molecular determinants of GPCR/transducer selectivity and therapeutic potential. Pharmacol Ther. 200:148-178. 

6. Souslova T, Mirédin K, Millar AM and Albert PR (2017) Recruitment by the repressor Freud-1 of histone deacetylase-Brg1 chromatin remodeling complexes to strengthen HTR1A gene repression. Mol Neurobiol 54, 8263-8277

7. Luckhart C, Philippe TJ, Le François B, Vahid-Ansari F, Geddes SD, Beique JC, Lagace DC, Daigle M, Albert PR (2016) Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice. Mol Brain 9: 77, 1-10. doi: 10.1186/s13041-016-0254-y

8. Vahid-Ansari F, Lagace DC, Albert PR (2016) Persistent post-stroke depression in mice following unilateral medial prefrontal cortex stroke. Transl Psychiatry 6: e863.

9. Albert PR, Vahid-Ansari F, Luckhart C (2014) Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Front Behav Neurosci 8, 199.

10. Le François B, Soo J, Millar AM, Daigle M, Le Guisque AM, Leman S, Minier F, Belzung C, Albert PR (2015) Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site. Neurobiol Dis 82: 332-41.

11. Albert PR (2015) Why is depression more prevalent in women? J Psychiatry Neurosci 40: 219-21.

12. Czesak M*, Le François B*, Millar AM, Deria M, Daigle M, Visvader JE, Anisman H, Albert PR (2012) Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) gene knock-out mice. J Biol Chem 287, 6615-6627.

13. Hadjighassem MR, Szewczyk B, Austin MC, Daigle M, Stockmeier CA, Albert PR (2009) Human Freud-2/CC2D1B: a novel repressor of post-synaptic 5-HT1A receptor expression. Biol Psychiatry 66, 214-222.

14. Kushwaha, N., Harwood, S.C., Wilson, A.M., Berger, M., Tecott, L.H., Roth, B.L. and Albert, P.R. (2006) Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine(1A) (5-HT1A) receptor for G-protein coupling. Mol. Pharmacol. 69, 1518-26.

15. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Basak A, Kushwaha N, Sequeira A, Morris SJ, Ou X, and Albert PR (2003) Impaired repression at a 5-hydroxytryptamine 1A receptor polymorphism associated with major depression and suicide. J Neuroscience 23, 8788-8799.

16. *Ou X-M, *Lemonde S, Jafar-Nejad H, Bown CD, Goto A, Rogaeva, A and Albert, PR (2003) Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene. J. Neuroscience 23, 7415-25. *co-first authors

PubMed Listings

For more publications use this PubMed ID link.