Albert Lab

Albert Lab

Paul Albert profile picture

Contact Information

Paul Albert, PhD
613-562-5800 8307

OHRI (Neuroscience)
451 Smyth Road
Ottawa, ON K1H-8M5

ORCID logo


Selected Publications

Five Key Publications

Albert lab members in bold
Publications archived at: ResearchGate

1. Vahid-Ansari F, Zahrai A, Daigle M, Albert PR (2024) Chronic Desipramine Reverses Deficits in Cell Activity, Norepinephrine Innervation, and Anxiety-Depression Phenotypes in Fluoxetine-Resistant cF1ko Mice. J Neurosci 44. PDF

2. Turcotte-Cardin V, Vahid-Ansari F, Luckhart C, Daigle M, Geddes SD, Tanaka KF, Hen R, James J, Merali Z, Beique JC, Albert PR (2019) Loss of adult 5-HT1A autoreceptors results in a paradoxical anxiogenic response to antidepressant treatment. J Neurosci 39, 1334-46. PDF

3. Vahid-Ansari F, Daigle M, Manzini MC, Tanaka KF, Hen R, Geddes SD, Beique JC, James J, Merali Z, Albert PR. (2017) Abrogated Freud-1/CC2D1A repression of 5-HT1A autoreceptors induces fluoxetine-resistant anxiety/depression-like behavior. J Neurosci 37, 11967-11978. PDF

4. Zahrai A, Vahid-Ansari F, Daigle M, Albert PR (2020) Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression. Transl Psychiatry 10:334. PDF

5. Vahid-Ansari F and Albert PR (2018) Chronic fluoxetine induces activity changes in recovery from post-stroke anxiety, depression and cognitive impairment. Neurotherapeutics 15, 200-215. PDF.

All Other Publications

Selected Publications

1. Galaraga K, Rogaeva A, Biniam N, Daigle M, Albert PR (2024) CaMKIV-mediated phosphorylation inactivates Freud-1/CC2D1A for calcium-dependent 5-HT1A receptor gene induction. Int J Mol Sci 25. Doi: 10.3390/ijms25116194  PDF

2. Harkin EF, Nasrallah G, Le François B, Albert PR (2023) Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β. Int J Mol Sci 24:15620.  Doi: 10.3390/ijms242115620 PDF 

3. Vahid-Ansari F, Albert PR (2021) Rewiring of the Serotonin System in Major Depression.  Frontiers in Psychiatry 12: 2275 PDF
4. Albert PR, Le Francois B, Vahid-Ansari F (2019) Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm. J Psychiatry Neurosci 44: 164-76. PDF

5. Albert PR, Vahid-Ansari F (2019) The 5-HT1A receptor: Signaling to behavior. Biochimie 161: 34-45.
6. Le Francois B, Zhang L, Mahajan GJ, Stockmeier CA, Friedman E, Albert PR (2018) A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression. J Neurosci 38:8200-8210. PDF

7. Luckhart C, Philippe TJ, Le François B, Vahid-Ansari F, Geddes SD, Beique JC, Lagace DC, Daigle M, Albert PR (2016) Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice. Mol Brain 9: 77, 1-10. doi: 10.1186/s13041-016-0254-y

8. Vahid-Ansari F, Lagace DC, Albert PR (2016) Persistent post-stroke depression in mice following unilateral medial prefrontal cortex stroke. Transl Psychiatry 6: e863.

9. Albert PR, Vahid-Ansari F, Luckhart C (2014) Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Front Behav Neurosci 8, 199.

10. Le François B, Soo J, Millar AM, Daigle M, Le Guisque AM, Leman S, Minier F, Belzung C, Albert PR (2015) Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site. Neurobiol Dis 82: 332-41.

11. Albert PR (2015) Why is depression more prevalent in women? J Psychiatry Neurosci 40: 219-21.

12. Czesak M*, Le François B*, Millar AM, Deria M, Daigle M, Visvader JE, Anisman H, Albert PR (2012) Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) gene knock-out mice. J Biol Chem 287, 6615-6627.

13. Hadjighassem MR, Szewczyk B, Austin MC, Daigle M, Stockmeier CA, Albert PR (2009) Human Freud-2/CC2D1B: a novel repressor of post-synaptic 5-HT1A receptor expression. Biol Psychiatry 66, 214-222.

14. Kushwaha, N., Harwood, S.C., Wilson, A.M., Berger, M., Tecott, L.H., Roth, B.L. and Albert, P.R. (2006) Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine(1A) (5-HT1A) receptor for G-protein coupling. Mol. Pharmacol. 69, 1518-26.

15. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Basak A, Kushwaha N, Sequeira A, Morris SJ, Ou X, and Albert PR (2003) Impaired repression at a 5-hydroxytryptamine 1A receptor polymorphism associated with major depression and suicide. J Neuroscience 23, 8788-8799.

PubMed Listings

For more publications use this PubMed ID link.