Publications

Full Systematic Reviews

  • A systematic review on the efficacy and safety of low molecular weight heparin as an anticancer therapeutic in preclinical animal models. PMID 32683148
  • The efficacy and safety of low molecular weight heparin administration to improve survival of cancer patients: a systematic review and meta-analysis. PMID 32369854
  • Neuroprotection by remote ischemic conditioning in rodent models of focal ischemia: a systematic review and meta-analysis. PMID 33405011
  • The effects of resistant starches on inflammatory bowel disease in preclinical and clinical settings: a systematic review and meta-analysis. PMID 33167889
  • An analysis of mesenchymal stem cell-derived extracellular vesicles for preclinical use. PMID 32697573
  • From the lab to patients: a systematic review and meta-analysis of mesenchymal stem cell therapy for stroke. PMID: 31654281
  • Post-operative shared-care for patients undergoing non-cardiac surgery: a systematic review and meta-analysis. PMID 31290119
  • Risks and benefits of chimeric antigen receptor t-cell (CAR-T) therapy in cancer: a systematic review and meta-analysis. PMID 30948292
  • Identifying stroke therapeutics from preclinical models: a protocol for a novel application of network meta-analysis. PMID 30906535
  • Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review. PMID 30841915
  • A systematic review of the impact of surgical special care units on patient outcomes and health care resource utilization. PMID 30676348
  • Safety and efficacy of adult stem cell therapy for acute myocardial infarction and ischemic heart failure (SafeCell Heart): a systematic review and meta-analysis. PMID 30255989
  • MSC-derived extracellular vesicles in preclinical animal models of bone injury: a systematic review and meta-analysis. PMID 34313927
  • Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta-analysis. PMID 34596349

Systematic Review Protocols

  • Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol. PMID 31831057
  • Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in patients with haematological and solid malignancies: protocol for a systematic review and meta-analysis. PMID 29288188
  • Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol. PMID: 29116020
  • Mesenchymal stromal cells as a therapeutic intervention for COVID-19: a living systematic review and meta-analysis protocol. PMID 34526123
  • Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol. PMID 34127055
  • Identifying effect modifiers of CAR-T cell therapeutic efficacy: a systematic review and individual patient data meta-analysis protocol. PMID 36653879

Addressing Rigour and Reproducibility in Preclinical (Lab Based) Research

  • Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol. PMID 33123348
  • Assessing the completeness of reporting in preclinical oncolytic virus therapy studies. PMID 31276026
  • Reporting preclinical anesthesia study (REPEAT): evaluating the quality of reporting in the preclinical anesthesiology literature. PMID 31120888
  • Surrogate humane endpoints in small animal models of acute lung injury: a modified Delphi consensus study of researchers and laboratory veterinarians. PMID 33332817
  • Epidemiology and reporting characteristics of preclinical systematic reviews. PMID 33951050
  • A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies. PMID 36892457
  • Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies. PMID 36603053

Qualitative Research

  • What are potential barriers and enablers to patient and physician participation in Canadian cell therapy trials for stroke? A stakeholder interview study. PMID 32198301
  • So you want to give stem cells to babies? Neonatologists and parent's views to optimize clinical trials. PMID 31005276
  • Navigating choice in the face of uncertainty: using a theory informed qualitative approach to identifying potential patient barriers and enablers to participating in an early phase chimeric antigen receptor T (CAR-T) cell therapy trial. PMID 33741670
  • Understanding potential barriers and enablers to a perioperative early phase cell therapy trial. PMID 35396169
  • Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies. PMID 36603053

Cohort Studies

  • Building Canadian capacity for CAR-T cells in relapsed/refractory acute lymphoblastic leukemia: a retrospective cohort study. PMID 32688454
  • Risk factors for failure to rescue in myocardial infarction after noncardiac surgery: a cohort study. PMID 32349069
  • Association between frailty and patient outcomes after cancer surgery: a population-based cohort study. PMID 35034792

Patient Engagement

  • Partnering with patients to get better outcomes with chimeric antigen receptor T-cell therapy: towards engagement of patients in early phase trials. PMID 33072399
  • Patient engagement in preclinical laboratory research: A scoping review. PMID 34280783
  • Making Patient Partnerships a Reality in Very Early Phase Clinical TriaLs (MARVEL)
  • Recognizing patient partner contributions to health research: a mixed methods research protocol. PMID 35668479
  • Building a platform for meaningful patient partnership to accelerate "bench-to-bedside" translations of promising new therapies. PMID 35467515
  • Intraoperative pharmacologic opioid minimization strategies and patient-centred outcomes after surgery: a scoping review protocol. PMID 36858477
  • Engaging patients in anesthesiology research: a rewarding frontier. PMID 36959493

Miscellaneous

  • Systematic review and narrative review lead experts to different cancer trial predictions: a randomized trial. PMID 33346013
  • Sex and gender-dependent differences in clinical and preclinical sepsis. PMID 33399356