January 17, 2019

Dr. Jean SeelyAre you interested in participating in this study?

If you are a woman aged 45 to 74 who is planning to get a routine screening mammogram then you are eligible for this trial.

Please ask your doctor to fax a request to The Ottawa Hospital Breast Imaging Booking office at 613-761-4405, clearly indicating interest in the TMIST - MAC.22 study.

The TMIST Trial

The Tomosynthesis Mammographic Imaging Screening Trial (TMIST) is a randomized breast cancer screening trial that will help researchers learn about the best ways to find breast cancer in women who have no symptoms. It compares two approved types of digital mammography: standard digital mammography (2-D) with a newer technology called tomosynthesis mammography (3-D).

It is not known if the newer technology is more effective than conventional 2-D mammography at reducing life-threatening (advanced) breast cancers. The TMIST trial aims to find out.

What Participants Can Expect

Women who decide to participate in this trial will be involved through the end of the study in 2025. Once enrolled participants will be randomly assigned for either a 3-D or 2-D screening mammograms for five years. Each woman will need to agree to let her doctor tell her how often to get screened—either every year or every other year—based on her individual risks for developing breast cancer.

During the study, the results of every mammogram from every woman will be collected. Information about any medical follow-up, such as more imaging or a biopsy, will also be recorded. All women will be followed until the end of the study for breast cancer status, treatment, and results from treatment.

The Ottawa Hospital: Inspired by research. Driven by compassion 

The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care. See for more information about research at The Ottawa Hospital.

University of Ottawa: —A crossroads of cultures and ideas

The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe.

Media Contact

Amelia Buchanan
Senior Communication Specialist
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73687
Cell: 613-297-8315