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Breast cancer

The Ottawa Hospital is conducting cutting-edge research to improve our understanding of breast cancer and develop better treatments. This page includes selected news stories about our breast cancer research, links to researchers working in this area and related resources. Learn more below.

Research News


Breast cancer rates rising among Canadian women in their 20s, 30s and 40s Breast cancer rates rising among Canadian women in their 20s, 30s and 40s
April 26, 2024 - Researchers highlight need for immediate shift in public health policy as early detection is key to reducing breast cancer death and complications.
A passion for medicine sparked by a grandmother and Star Trek A passion for medicine sparked by a grandmother and Star Trek
December 15, 2023 - Meet Dr. Jean Seely — breast radiologist and researcher
Breast cancer screening before age 50 linked with better survival Breast cancer screening before age 50 linked with better survival
August 4, 2023 - Canadian provinces and territories that allowed women 40-49 to self-refer for organized breast cancer screening programs with annual mammograms had better survival and lower breast cancer mortality rates compared with those that did not, according to
Show more news stories


Researchers


Name Scientific appointment Diseases, conditions and populations of interest Research and clinical approaches
Addison, Christina
PhD
Senior Scientist
(CR)
Bone and joint degeneration, Cancer, Lung cancer, Lung disease, Pancreatic cancer, Prostate cancer, Breast cancer Basic research, Clinical research, Cohort studies, Disease models, Drug development, Genetics, Imaging, Model organisms, Translational research, Molecular and cellular biology
Ardolino, Michele
PhD
Senior Scientist
(CR)
Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma Basic research, Cancer immunotherapy, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Awan, Arif Ali
MD
Clinician Investigator
(CR)
Breast cancer
Bissell, Mary Beth
MSc, MD, FRCPC
Clinician Investigator
(CR)
Breast cancer, Cancer, COVID-19, Population health, Women's health Clinical research
Clemons, Mark
MB BS, BMedSci, MSc, MD, FRCP, FRCPC
Scientist
(CR)
Breast cancer, Cancer Basic research, Clinical research, Clinical trials, Health research methods, Knowledge translation and implementation research
Hutton, Brian
MSc, PhD
Senior Scientist
(MIR)
Addiction, Anxiety, Breast cancer, Depression, Health equity, Health in disadvantaged peoples, Maternal and fetal health, Mental health, Population health, Suicide, Cancer Clinical research, Cohort studies, Epidemiology, Health research methods, Health services research, Patient safety, Public health, Rapid reviews, Biostatistics, Clinical trials, Systematic reviews
Ilkow, Carolina
PhD
Senior Scientist
(CR)
Breast cancer, COVID-19, Ovarian cancer, Pancreatic cancer Basic research, Cancer biotherapeutics, Cancer immunotherapy, Extracellular vesicles / exosomes, Gene therapy, Immunization, Immunotherapy, Molecular and cellular biology, Oncolytic viruses, Translational research, Viral therapy
Morgan, Scott
MD, MSc, FRCPC
Clinician Investigator
(CR)
Bladder cancer, Breast cancer, Cancer, Prostate cancer Biomarkers, Clinical research, Clinical trials, Cohort studies, Imaging, Systematic reviews
Sabourin, Luc
PhD
Senior Scientist
(CR)
Breast cancer, Muscular dystrophy, Skin cancer Basic research, Disease models, Drug development, Gene expression, Genetics, Molecular and cellular biology, Proteomics, Stem cells, Transgenic/knockout models
Seely, Jean
MDCM, FRCPC
Clinician Investigator
(CR)
Breast cancer, Cancer, Health equity, Population health, Women's health Clinical trials, Cohort studies, Health technology, Imaging, Patient engagement, Public health, Quality Improvement, Surgery
Srikanthan, Amirrtha
MD, MHSc, FRCPC, DRCPSC (AYA Oncology)
Clinician Investigator
(CR)
Breast cancer, Cancer, Gastrointestinal stromal tumours (GIST), Soft tissue sarcoma Clinical research, Health promotion, Patient engagement, Surveys
Wilkinson, Anna
MD
Clinician Investigator
(CR)
Breast cancer




Clinical Trials

The following list of clinical trials is pulled from ClinicalTrials.gov using the search terms "Breast cancer” and “Ottawa Hospital.” More advanced search options are available. If you find a clinical trial that interests you, you can bring the information to the next appointment with your care team and ask if you are eligible for the study. If so, they may be able to refer you to the study team. Visit ohri.ca/patients to learn more about participating in research and clinical trials.

Note that ClinicalTrials.gov is hosted by the U.S. National Library of Medicine and is only available in English. Please note that we cannot guarantee a response from the person listed in the ‘Contact’ column.

NCTTitleConditionStatusContact
NCT05646862A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy (NCT05646862)Breast CancerRECRUITING 
NCT02632448A Study of LY2880070 in Participants With Advanced or Metastatic Cancer (NCT02632448)Solid Tumors, Colorectal Cancer, Breast Cancer, Ovarian Cancer, Colon Cancer, Rectal Cancer, Neoplasms, Endometrial Cancer, Soft Tissue Sarcoma, Triple Negative Breast Cancer, Pancreas Cancer, Pancreatic CancerRECRUITING 
NCT03975647A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer (NCT03975647)HER2-positive Breast CancerRECRUITING 
NCT04260802A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802)Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder CancerRECRUITING 
NCT04549207Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer (NCT04549207)Breast Cancer, Castration-resistant Prostate CancerRECRUITING 
NCT03233191Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer (NCT03233191)Breast ScreeningRECRUITING 
NCT04928261Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy (NCT04928261)Breast CancerRECRUITING 
NCT05754528Evaluating an Endocrine Therapy Dose-frequency Escalation Strategy and Its Effects on Tolerability and Compliance (NCT05754528)Breast CancerRECRUITING 
NCT04921137Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer (NCT04921137)Breast CancerRECRUITINGmsavard@toh.ca
NCT05753618Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy (NCT05753618)Early-stage Breast CancerRECRUITINGlvandermeer@ohri.ca
NCT05696626Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation (NCT05696626)Metastatic Breast CancerRECRUITING 
NCT04228991Hypofractionated LocoRegional Radiotherapy in Breast Cancer (NCT04228991)Breast Neoplasms, Radiotherapy, LymphedemaRECRUITING 
NCT05601440Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer (NCT05601440)Breast CancerRECRUITING 
NCT03713255Mid-point Transverse Process to Pleura Block for Breast Cancer Surgery: A Randomized Controlled Trial (NCT03713255)Breast Cancer, Acute Pain, AnesthesiaRECRUITING 
NCT02906943Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943)Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary CancerRECRUITING 
NCT04874038Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) (NCT04874038)Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, ChronicRECRUITING 
NCT03488693Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (NCT03488693)Breast CancerRECRUITING 
NCT04680442Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction (NCT04680442)Breast Cancer, Heart FailureRECRUITING 
NCT05840211Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy (NCT05840211)Locally Advanced or Unresectable Metastatic Breast Cancer, Stage IV Breast CancerRECRUITING 
NCT05382286Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382286)Triple Negative Breast Cancer, PD-L1 PositiveRECRUITING 
NCT05382299Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382299)Triple Negative Breast Cancer, PD-L1 NegativeRECRUITING 
NCT05548127TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A) (NCT05548127)Breast CancerRECRUITING 
NCT05573555TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) (NCT05573555)Breast CancerRECRUITING 
NCT05804578Using a Blood Test to Monitor Metastatic Breast Cancer Treatment (NCT05804578)Metastatic Breast CancerRECRUITINGaawan@ohri.ca


Publications

The following research publications are pulled from PubMed using the search terms "Breast cancer" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19.
2024-06-28

Evaluation of Unsolicited Feedback from Patients with Cancer and Their Families as a Strategy to Improve Cancer Care Delivery.
2024-05-24

Auditing Abbreviated Breast MR Imaging: Clinical Considerations and Implications.
2024-05-23

Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial.
2024-05-22

Development and application of a weighted change score to evaluate interventions for vasomotor symptoms in patients with breast cancer using regression trees: a cohort study.
2024-05-20

Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer.
2024-05-11

Antipsychotic Use and Risk of Breast Cancer in Women With Severe Mental Illness: Replication of a Nationwide Nested Case-Control Database Study.
2024-04-30

The Efficacy of Fat Grafting on Treating Post-Mastectomy Pain with and without Breast Reconstruction: A Systematic Review and Meta-Analysis.
2024-04-26

Perspectives on shorter durations of anti-HER2 therapy in early-stage HER2-positive breast cancer: a patient survey.
2024-04-26

Lymphovenous Bypass for Immediate Lymphatic Reconstruction in Breast Cancer Patients Undergoing Axillary Lymph Node Dissection: Minimizing the Risk of Upper Extremity Lymphedema.
2024-04-25

View more on PubMed