Researchers get $558K boost from Heart and Stroke Foundation

June 15, 2017

Two scientists from The Ottawa Hospital and the University of Ottawa were successful in the Heart and Stroke Foundation’s recent grant-in-aid grant competition. Dr. Baptiste Lacoste was awarded $259,000* to test whether drugs that are already used to treat pulmonary hypertension may also reduce damage to the brain blood vessels and speed up recovery after a stroke in animal models. Dr. Lacoste has previously found that these drugs can keep blood vessels in the brain from leaking. The current clot-busting drugs used after stroke have serious side effects, and are only given to 10 percent of patients. Dr. Bernard Thébaud was awarded $299,000** to study the effectiveness of endothelial colony forming cells (ECFCs) from umbilical cord blood to treat pulmonary hypertension in newborns. ECFCS can reproduce very quickly and have been shown to help form blood vessels after being transplanted in animal models. The team will test whether these cells can promote lung growth in animal models of newborn pulmonary hypertnesion, determine the optimal dose and examine the long-term safety and efficacy of this treatment.

*Co-applicants: Marie-Ève Tremblay, Jean-Claude Béïque Collaborators : Dale Corbett, Gregory Cron, Diane Lagace, Kathleen M. MacLeod

** Collaborators: Mervin Yoder, Dylan Burger, Daphne Merkus, Duncan Stewart

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