Current Funding

Total funding: $173,000,000
Total lifetime funding as Principal Investigator or Co-Principal Investigator: $74,579,048
*unless otherwise stated, Dr. Fergusson's role is a Co-Investigator

04/2021-03/2026 Ontario SPOR SUPPORT Unit – Phase II
Principal Investigator: Dean Fergusson
Funder: Canadian Institute of Health Research and Strategy for Patient-Oriented Research (SPOR)
Total awarded: $34,200,000 ($2,500,000 Ottawa Methods Centre)

03/2021-03/2023 Preclinical multicenter studies of sepsis: assessing feasibility and team mental models
Principal Investigator: Manoj Lalu
Funder: New Frontiers in Research Fund
Total awarded: $250,000

12/2020-11/2021 Multicentre randomized clinical trial of hyperbaric oxygen therapy for COVID-19
Principal Investigator: Sylvain Boet
Funder: The Ottawa Hospital Academic Medical Organization (TOHAMO)
Total awarded: $100,000

10/2020-09/2022 Vascular events In noncardiac Surgery patients cOhort evaluatioN study-2 (VISION-2)
Principal Investigators: Michael McGillion, PJ Devereaux, Donald Scott, Elizabeth Peter, Thomas Doyle.
Funder: Canadian Institute of Health Research
Total awarded: $673,000 & In-kind, Industry and Partners contributions: $2,178,000

10/2020-09/2022 PREMISE: Intraoperative point-of-care hemoglobin testing and transfusion outcomes in non-cardiac surgery
Principal Investigator: Guillaume Martel
Funder: Canadian Blood Services
Total awarded: $392,974

10/2020-09/2022 Assessing the impact of donor and manufacturing characteristics on survival of transfused red blood cells
Principal Investigator: Alan Tinmouth
Funder: Canadian Blood Services
Total awarded: $90,935

10/2020-09/2021 A Framework for Accelerated Synthesis of Trial Evidence – FAST Evidence – to assess efficacy of mesenchymal stromal cells and convalescent plasma for COVID-19
Principal Investigator: David Allan
Funder: Canadian Blood Services
Total awarded: $25,000

10/2020-09/2021 Making Patient Partnerships A Reality in Very Early Phase Clinical Trials (MARVEL): Development of a patient engagement platform
Principal Investigator: Dean Fergusson
Funder: BioCanRx
Program: CSEI
Total awarded; $145,541

07/2020-06/2021 Identifying effect modifiers for CAR-T cell therapeutic efficacy
Principal Investigator: Dean Fergusson
Funder: BioCanRx
Total awarded: $100,058

07/2020-06/2021 Cellular precOnditioning for post-Surgical Myocardial Ischemic Complications (COSMIC)
Principal Investigators: Dean Fergusson, Manoj Lalu
Funder: Heart and Stroke
Total awarded: $40,000

06/2020-05/2021 Anticoagulation and Convalescent Plasma ICU Trials in REMAP-CAP
Principal Investigators: Alexis Turgeon, Ryan Zarychanski, Bojan Paunovic
Funder: Canadian Institutes of Health Research
Program: Operating Grant: COVID-19 Rapid Research Funding Opportunity
Total awarded: $2,176,566

06/2020-05/2021 A Randomized Open-Label Trial of CONvalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness (CONCOR-1)
Principal Investigators: Donald Arnold, Phillippe Begin, Jeannie Callum
Funder: Canadian Institutes of Health Research
Program: Operating Grant: COVID-19 Rapid Research Funding Opportunity
Total awarded: $2,972,273

06/2020-05/2021 Antithrombotic Therapy to Ameliorate Complications of COVID-19: The ATTACC Randomized Trial
Principal Investigators: Ewan Goligher, Patrick Lawler, Ryan Zarychanski
Funder: LifeArc Foundation, UK
Program: LifeArc COVID-19 Fund
Total award: £1,000,000 (approximately $1,700,000 CAD)

06/2020-07/2021 ATTACC (Anti Thrombotic Therapy to Ameliorate Complications of COVID-19: A randomized international, multi-centre, adaptive, controlled clinical trial
Principal Investigators: Ryan Zarychanski, Jorge Escobedo, Ewan Goligher, Patrick Lawler, Jose Nicolau
Funder: Canadian Institutes of Health Research
Program: Operating Grant: COVID-19 Rapid Research Funding Opportunity
Total awarded: $3,573,336

05/2020-04/2024 An innovative registry-based trials platform to improve clinical care, outcomes, and health policy for children with treatable rare diseases
Principal Investigator: Elizabeth Potter
Funder: Canadian Institutes of Health Research
Program: SPOR Innovative Clinical Trial Multi-Year Grant
Total awarded: $688,502

04/2020-04/2021 Cellular Immuno-Therapy for COVID-19 induced Acute Respiratory Distress Syndrome: the CIRCA-19 Trial.
Principal Investigator: Duncan Stewart
Funder: Stem Cell Network
Program: COVID-19 Rapid Response Initiative
Total awarded: $300,000

03/2020-03/2022 University of Ottawa Excelerator: Enhancing impact through translational and clinical research
Principal Investigators: Dean Fergusson, Manoj Lalu
Funder: University of Ottawa, Faculty of Medicine
Total awarded: $121,000

04/2020-03/2021 Patient and Public Involvement in Preclinical Laboratory Research: A Scoping Review
Principal Investigators: Dean Fergusson, Manoj Lalu
Funder: Canadian Institutes of Health Research
Total awarded: $76,500

04/2020-03/2024 Using behavioural science to understand and improve participation in clinical trials: A theory-based research project.
Principal Investigators: Jamie Brehaut; Principal Knowledge User: Susan Marlin
Funder: Canadian Institutes of Health Research
Total awarded: $963,900

10/2019-09/2022 Platelet Transfusions in Hematopoietic Stem Cell Transplantation - The PATH Phase III Trial
Principal Investigators: Alan Tinmouth, Dawn Maze, Jason Tay
Funder: Canadian Institutes of Health Research
Total awarded: $1,507,050

10/2019-09/2022 TRICS IV - Restrictive versus Liberal Transfusion in Younger Patients Undergoing Cardiac Surgery
Principal Investigators: Dean Fergusson, David Mazer, Bruno da Costa, Peter Juni, Nadine Shehata, Subodh Verma, Richard Whitlock
Funder: Canadian Institutes of Health Research
Total awarded: $2,190,000

10/2019-09/2021 Translation of Highly Promising Basic Science Research into Clinical Applications: A Systematic Review
Principal Investigators: Dean Fergusson & Manoj Lalu
Funder: Canadian Institutes of Health Research
Total awarded: $122,400

10/2019-09/2021 Length of storage of red blood cell units as a risk factor for hospital-acquired infections: an individual patient data meta-analysis
Principal Investigators: Dean Fergusson & Patricia Fontela
Funder: Canadian Institutes of Health Research
Total awarded: $110,000 

06/2019-05/2021 Clinical Impact of Red Cell Storage Age: Individual Patient Data Meta-Analysis of Four Recent Large Randomized Trials
Principal Investigators: Marie Steiner, Susan Assmann
Funder: National Institutes of Health (National Heart, Lung, and Blood Institute)
Total awarded: $133,418 US 

06/2019-05/2023 Integrating clinical data systems to improve the capacity, performance, and value of Manitoba’s healthcare system
Principal Investigators: Ryan Zarychanski, Paul Komenda, Marshall Pitz
Funder: Canadian Institute of Health Research (CIHR); SPOR iCT Rewarding Success
CIHR Funds Awarded: $2,400,000

04/2019-03/2021 Using real-world data and iterative economic evaluation to prioritize resource allocation for care and research in adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia
Principal Investigators: Kednapa Thavorn, Natasha Kekre, Harry Atkins
Funder: Ontario Institute for Cancer Research: OICR-CCO Health Services Research Network
Total awarded: $284,955

01/2019-01/2024 Cam type femoroacetabular impingement (FAI) is a cause of hip pain in the young adult and a precursor to osteoarthritis (OA)
Principal Investigators: Paul Beaule, Mario Lamontagne, Gerd Melkus, Andrew Speirs
Funder: Canadian Institute of Health Research
Total awarded: $711,450

01/2019-07/2022 PREPARE Trial: a parallel arm multicenter randomized trial of frailty-focused PReoperative Exercise to decrease PostoperAtive complication Rates and disability scorEs
Principal Investigators: Dean Fergusson, Daniel McIsaac, Rachel Khadaroo, John Muscedere, Monica Taljaard
Funder: Canadian Institute of Health Research
Total awarded: $1,136,025

11/2018-04/2021 Rapid correction of vitamin D deficiency in pediatric critical illness: a phase III multicentre randomized controlled trial
Principal Investigator: Dayre McNally
Funder: Physicians’ Services Incorporated Foundation (PSI)
Total awarded: $249,000

10/2018-09/2023 Rapid correction of vitamin D deficiency in pediatric critical illness: A phase III multicentre randomized controlled trial
Principal Investigator: Dayre McNally
Funder: Canadian Institute of Health Research
Total awarded: $983,026

10/2018-09/2022 Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Comparative Effectiveness Trial (FLUID)
Principal Investigators: Dean Fergusson, Lauralyn McIntyre, Monica Taljaard
Funder: Canadian Institute of Health Research
Total awarded: 374,851

04/2018-03/2022 PRICE 2: A phase 3 randomized controlled trial of phlebotomy resulting in controlled hypovolemia to prevent blood loss in major hepatic resections
Principal Investigator: Guillaume Martel
Funder: Canadian Institute of Health Research
Total funding: $497,252

04/2018-03/2022 Microbiome-Based Precision Medicine in Inflammatory Bowel Disease
Principal Investigators: Alan Stintzi & David Mack
Funder: Genome Canada
Total funding: $4,469,716

04/2018-03/2021 Understanding decision making in organ donation: a national study
Principal Investigators: Michaël Chassé, Kimberly Jordison, Justin Presseau
Funder: Canadian Institute of Health Research
Total awarded: $669,375

04/2018-03/2023 Endothelial Progenitor Cell Exosomes and MicroRNA Transfer as Therapy for Acute Kidney Injury
Principal Investigator: Kevin Burns
Funder: Canadian Institute of Health Research
Total awarded: $742,050

04/2017-03/2021 Developing a framework for the ethical design and conduct of pragmatic trials to improve the quality and value of health care systems and practices
Principal Investigators: Dean Fergusson, Monica Taljaard, Charles Weijer Principal Knowledge User: Terry Klassen
Funder: Canadian Institute of Health Research
Total awarded: $780,300

04/2017-03/2022 Aneurysmal Subarachnoid Hemorrhage - Red Blood Cell Transfusion and Outcome (SAHaRA):A Randomized Controlled Trial
Principal Investigator: Shane English
Funder: Canadian Institute of Health Research
Total awarded: $1,384,650

08/2016-07/2023 An epidemiologic research program to improve maternal and child health
Principal Investigators: Shi Wu Wen and Mark Walker
Funder: Canadian Institute of Health Research
Program: Foundation Scheme
Total awarded: $9,876,973

07/2016-06/2021 Optimal Practices in Critical Care Neurology and Trauma
Principal Investigator: Alexis Turgeon
Funder: Canadian Institute of Health Research
Program: Foundation Scheme
Total awarded: $1,891,003

07/2016-06/2021 Transfusion in Traumatic Brain Injury Trial (TSiTBI Trial)
Principal Investigators: Dean Fergusson, Francois Lauzier
Funder: Canadian Institute of Health Research
Program: Project Grant
Total awarded: $1,490,000

07/2015-06/2022 Predicting and preventing the major vascular complications of surgery.
Program Leader: PJ Devereaux
Role: Co-investigator
Funder: CIHR
Program: Foundation Scheme
Total awarded: $8,439,205

07/2015-06/2022 Promoting implementation of evidence-based care
Program Leader: Jeremy Grimshaw
Role: Co-investigator
Funder: Canadian Institute of Health Research
Program: Foundation Scheme
Total awarded: $2,128,006

07/2015-06/2022 Clinical translation of stem cell-based therapies for neonatal lung diseases
Program Leader: Bernard Thebaud
Role: Co-investigator
Funder: Canadian Institute of Health Research
Program: Foundation Scheme
Total awarded: $5,250,000

07/2015-06/2022 A Research Program to Improve Patient Outcomes in Kidney Transplantation
Program Leader: Gregory Knoll
Role: Co-investigator
Funder: Canadian Institute of Health Research
Program: Foundation Scheme
Total awarded: $3,871,800