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Contact Information

Ran Klein, PhD


ORCID logo https://orcid.org/0000-0002-4357-3779


Selected Publications

  1. Salman O*, Klein R, Anatomical Region Identification in Medical x-ray Computed Tomography (CT) Scans: Development and Comparison of Alternative Data-Analysis and Vision-Based Methods, Neural Computing and Applications [Online First 2020]
  2. Gabrani-Juma H*, Zuckier LS, Klein R, Development and validation of the Lesion Synthesis Toolbox and the Perception Study Tool for quantifying observer limits-of-detection of lesions in positron emission tomography, J Med Imaging, [Online First 2020]
  3. Manwell S*, Klein R, Xu To, deKemp RA, Clinical comparison of the Positron Emission Tracking (PeTrack) algorithm with the Real-Time Position Management System for respiratory gating in cardiac positron emission tomography, Med Phys, [In Press 2020].
  4. Currie G, Hawk KE, Rohrer E, Vial A, Klein R, Machine Learning and Deep Learning in Medical Imaging: Intelligent Imaging, J Med Image and Rad Sci, 2019;450(4):477-87.
  5. Klein R, Razavi S*, Memon R*, Zuckier L, An electronic 99mTc-DTPA Glomerular Filtration Rate spreadsheet with novel embedded quality assurance features, Nuc Med Comm. 2019;40(1):30-40.
  6. Ocneanu A*, deKemp R, Renaud JM, Adler A, Beanlands RSB, Klein R, Optimally repeatable kinetic model variant for myocardial blood flow measurements with 82Rb PET. Computational and Mathematical Methods in Nuclear Medicine, 2017: 6810626, 11 pages.
  7. Klein R, Ocneanu A*, Renaud JM, Ziadi MC, Beanlands RSB, deKemp RA, Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification with 82Rb dynamic PET imaging, J Nucl Cardiol, [In press].
  8. Gabrani-Juma H*, Clarkin OJ, Pourmoghaddas A, Driscoll B, Wells RG, deKemp RA, Klein R, Validation of a multimodality flow phantom and its application for assessment of dynamic SPECT and PET technologies, IEEE-Trans Med Imag, 2017;36(1):132-41.
  9. Hunter CRRN, Klein R, Beanlands RS, deKemp RA, Patient Body Motion Effects on the Quantification of Regional Myocardial Blood Flow with Dynamic PET Imaging, Med Phys, 2016;43(4):1829-40.
  10. deKemp RA, Renaud JM, Klein R, Beanlands RS, Radionuclide tracers for myocardial perfusion imaging and blood flow quantification. Cardiol Clinics, 2016;34(1):37-46.
  11. Wells RG, Timmins R, Klein R, Lockwood J, Marvin B, deKemp RA, Wei L, Ruddy TD, Dynamic SPECT measurement of absolute myocardial blood flow in a porcine model, J Nucl Med, 2014;55(10):1685-91.
  12. Klein R, Hung G-U, Wu T-C, Li D, deKemp RA, Hsu B, Feasibility and Operator Variability of Myocardial Blood Flow and Reserve Measurements with 99mTc-Sestamibi Quantitative Dynamic SPECT-CT Imaging. J. Nucl. Cardiol., 2014;21(6):1075-88.
  13. Klein R, Beanlands RS, Wassenaar RW, Thorn S, Lamoureux M, DaSilva JN, Adler A, deKemp RA, Kinetic model based factor analysis of dynamic sequences of cardiac positron emission tomography. Med. Phys., 2010;37(8):3995-4010.
  14. Klein R, Adler A, Beanlands RS, deKemp RA, Precision-controlled elution of a 82Sr/82Rb generator for cardiac perfusion imaging with positron emission tomography. Phys. Med. Biol., 2007;52(3):659-673.

All Other Publications

  1. Thorn S, Barlow S, Feher A, Stacy M, Doviak H, Jacobs J, Zellars K, Renaud J, Klein R, deKemp R, Khakoo A, Lee TW, Spinale F, Sinusas A, Application of Hybrid MMP-Targeted and Dynamic 201Tl SPECT/CT Imaging for Evaluation of Early Post Myocardial Infarction Remodeling, Circ Cardiovascular Imaging, 12(11):e009055.
  2. Klein R, deKemp RA, 82Rb is the best flow tracer for high-volume sites, Annals of Nuc Cardiol 2019;5(1):53-62.
  3. Sriperumbuduri S, Dent R, Malcolm J, Hiremath S, Klein R, White CA; Akbari A, Accurate GFR in obesity – Protocol for a systematic review, Sys Review, 2019:8;147.
  4. Pfau D, Thorn SL, Zhang J, Mikush N, Renaud JM, Klein R, deKemp RA, Wu X, Hu X, Sinusas AJ, Young LH, Tirziu D, Angiotensin receptor neprilysin inhibitor attenuates myocardial remodeling and improves infarct perfusion in experimental heart failure. Scientific Reports, 2019;9(1):5791.
  5. Robin P, Klein R, Gardner J, Ziebarth B, Bazarjani S, Razavi S*, Zuckier LS, Zeng W, Quantitative analysis of technetium-99m-sestamibi uptake and washout in parathyroid scintigraphy supports dual mechanisms of lesion conspicuity. Nuc Med Comm., 2019;40(5):469-76.
  6. Hunter CRRN, Klein R, Alessio A, deKemp RA, Correction for Rigid Patient body motion correction for dynamic cardiac PET-CT by attenuation-emission alignment according to projection consistency conditions. Med. Phys. 2019;46(4):1697-1706.
  7. Klein R, Nadouri D*, Osler E*, Johnson C, Dent S, Dwivedi G, Diastolic dysfunction can precede systolic dysfunction on MUGA in cancer patients receiving trastuzumab based therapy. Nuc Med Comm. 2019;40(1):22-29.
  8. Ahmadi A, Klein R, Lewin HS, Beanlands RSB, deKemp RA, Rubidium-82 Generator Yield and Efficiency for PET Perfusion Imaging: Comparison of Two Clinical Systems, J Nucl Card, [In Press 2020].
  9. Ahmadi A, Renaud JM, Promislow S, Burwash IG, Dwivedi G, Klein R, Zelt JGE, deKemp RA, Beanlands RS, Mielniczuk LM, Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodelling and decreased event-free survival in heart failure patients, J Nucl Card, [In Press 2020]
  10. Klein R, Celiker-Guler E, Rotstein BH, deKemp RA, PET and SPECT Tracers for Myocardial Perfusion Imaging, Sem in Nucl Med, 2020;50(3):208-18.
  11. Abele JT, Raubenheimer M, Bain VG, Wandzilak G, AlHulaimi N, Coulden R, deKemp RA, Klein R, Williams RG, Warshawski RS, Lalonde LD, Quantitative blood flow evaluation of vasodilation-stress compared with dobutamine-stress in patients with end-stage liver disease using 82Rb PET/CT. J Nuc Cardiol. 2018;19(11) [Epub ahead of print].
  12. Klein R, Initial steps to tracer kinetic modeling and MBF quantification, Annals of Nuc Cardiol.Annals of Nuc Cardiol., 2018:4(1):68-73.
  13. Pelletier-Galarneau M, Martineau P, Klein R, Henderson M, Zuckier LS, Reproducibility of Radioactive Iodine Uptake (RAIU) Measurements, J Appl Clin Med Phys, 2018:19(1):239-42.
  14. Razavi S*, Ziebarth B, Zuckier L, Klein R, Zeng W, Dual time-point quantitative SPECT-CT parathyroid imaging using a single computed tomography: feasibility and operator variability, Nuc Med Comm. 2018;39:3-9.
  15. Pelletier-Galarneau M, deKemp RA, Hunter C, Klein R, Klein M, Ironstone J, Fisher JA, Ruddy TD, Effects of hypercapnia on myocardial blood flow in healthy human subjects, J Nucl Med, 2018:59(1):100-6.
  16. Ohira H, Mc Ardle B, Nery P, deKemp RA, Renaud J, Klein R, Clarkin O, MacDonald K, Leung E, Beanlands R, Birnie D., Inter- and intra- observer agreement of FDG-PET/CT image interpretation in patients referred for assessment of cardiac sarcoidosis, J Nuc Med 2017;58:1324-9.
  17. Klein R, Ametepe ES, Yam Y, Dwivedi G, Chow BJ, Cardiac CT Assessment of Left-Ventricular Mass in Mid-Diastasis and its Prognostic Value, Eur Heart J Cardiovascular Imaging, 2017;18(1):95-102.
  18. deKemp RA, Renaud JM, Klein R, Beanlands RS, Radionuclide tracers for myocardial perfusion imaging and blood flow quantification. Cardiol Clinics, 2016;34(1):37-46.
  19. Ohira H, Birnie DH, Pena E, Bernick J, Mc Ardle B, Leung E, Wells, GA, Yoshinaga K, Tsujino I, Sato T, Manabe O, Oyama-Manabe N, Nishimura M, Tamaki N, Dick A, Dennie C, Klein R, Renaud J, deKemp RA, Ruddy TD, Chow BJW, Davies R, Hessian R, Liu P, Beanlands RSB, Nery PB, Comparison of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) and cardiac magnetic resonance (CMR) in corticosteroid-naive patients with conduction system disease due to cardiac sarcoidosis. EJNMMI 2016;43(2):259-69.
  20. Jones C, Klein R, Can PET be performed without an attenuation scan? J Nucl Cardiol, [Online ahead of print]
  21. Klein R, Editorial: Derivation of respiratory gating signals from ECG signals. J Nucl Cardiol, 2016;23(1):84-6.
  22. Ohira H, deKemp R, Pena E, Davies RA, Stewart DJ, Chandy G, Contreras-Dominguez V, Dennie C, Mc Ardle B, Klein R, Renaud J, DaSilva J, Pugliese C, Dunne R, Beanlands R, Mielniczuk LM, Shifts in myocardial fatty acid and glucose metabolism in pulmonary arterial hypertension: A potential mechanism for a maladaptive right ventricular response, Eur Heart J Cardiovascular Imaging, [Online ahead of print].
  23. Dunet V, Klein R, Allenbach G, Renaud J, deKemp RA, Prior JO, Myocardial blood flow quantification by Rb-82 cardiac PET/CT: A detailed reproducibility study between two semi-automatic analysis programs. J Nucl Cardiol. 2015 [Epub ahead of print]
  24. Arasaratnam P, Ayoub C, Klein R, deKemp R, Beanlands RS, Chow BJW, Positron Emission Tomography Myocardial Perfusion Imaging for Diagnosis and Risk Stratification in Obese Patients. Cur Cardiovascular Imag Rep, 2014;8:9304.
  25. Croteau E, Renaud JM, Archer C, Klein R, DaSilva JN, Ruddy TD, Beanlands RSB, deKemp RA, Beta2-adrenergic stress for in-vivo assessment of nitric-oxide-mediated coronary endothelial-dependent vasodilator function using micro-PET blood flow imaging in mice, Eur J Nucl Med Research, 2014;4(1):68
  26. Orton EJ, Al Harbi I, Klein R, Benalands RSB, deKemp RA, Wells, RG, Detection and severity classification of extra-cardiac interference in 82Rb PET myocardial perfusion imaging, Med Phys, 2014;41(10):102501.
  27. Nesterov SV, Deshayes E, Sciagrà R, Settimo L, Declerck JM, Pan XB, Yoshinaga K, Katoh C, Slomka PJ, Germano G, Han C, Aalto V, Alessio AM, Ficaro EP, Lee BC, Nekolla SG, Gwet KL, deKemp RA, Klein R, Dickson J, Case JA, Bateman T, Prior JO, Knuuti JM, Quantification of Myocardial Blood Flow in Absolute Terms Using 82Rb PET Imaging. Results of the RUBY-10 Study, J Am Coll Cardiol Img, 2014;7(11):1119-27.
  28. Chow BJ, Green RE, Coyle D, Laine M, Hanninen H, Leskinen H, Rajda M, Larose E, Hartikainen J, Hedman M, Mielniczuk L, O'Meara E, deKemp RA, Klein, R, Paterson I, White JA, Yla-Herttuala S, Leber A, Tandon V, Lee T, Al-Hesayen A, Hessian R, Dowsley T, Kass M, Kelly C, Garrard L, Tardif JC, Knuuti J, Beanlands RS, Wells GA, & IMAGE-HF Investigators, Computed tomographic coronary angiography for patients with heart failure (CTA-HF): A randomized controlled trial (IMAGE HF project 1-C). Trials, 2013;14:443.
  29. Chow BJW, Green RE, Coyle D, Laine M, Hanninen H, Leskinen H, Rajda M, Larose E, Hartikainen J, Hedman M, Mielniczuk L, O’Meara E, deKemp RA, Klein R, Paterson I, White JA, Yla-Herttuala S, Leber A, Tandon V, Lee T, Al-Hesayen A, Hessian R, Dowsley T, Kass M, Kelly C, Garrard L, Tardif JC, Knuuti J, Beanlands RS, Wells GA, Computed Tomographic Coronary Angiography for Patients with Heart Failure (CTA-HF): A Randomized Controlled Trial. (IMAGE HF Project 1-C), Trials 2013;14:443.
  30. Tahari AK, Lee A, Rajaram M, Fukushima K, Lodge MA, Lee BC, Ficaro EP, Nekolla S, Klein R, deKemp RA, Wahl RL, Bengel FM, Bravo PE, Absolute myocardial blood flow quantification with 82-Rb PET/CT: Comparison of different software packages and methods. Eur J of Nucl Med and Mol Imaging, 2014;41(1):126-135.
  31. McArdle BA, Birnie DH, Klein R, deKemp RA, Leung E, Renaud J, DaSilva J, Wells GA, Beanlands RS, Nery PB, Is There an Association Between Clinical Presentation and the Location and Extent of Myocardial Involvement of Cardiac Sarcoidosis as Assessed by 18F- Fluorodoexyglucose Positron Emission Tomography? Circ Cardiovasc Imagin., 2013;6(5):617-26.
  32. Thackeray JT, Renaud JM, Kordos M, Klein R, deKemp RA, Beanlands RS, DaSilva JN, Test-Retest repeatability of quantitative measurements of cardiac [11c]meta-hydroxyephedrine in rats by small animal positron emission tomography. Nuc. Med. Biol., 2013;40(5):676-681.
  33. Paterson I, Wells GA, Ezekowitz JA, White JA, Friedrich MG, Mielniczuk LM, O'Meara E, Chow B, deKemp RA, Klein R, Dennie C, Dick A, Coyle D, Dwivedi G, Rajda M, Wright GA, Laine M, Hanninen H, Larose E, Connelly K, Leung-Poi H, Howarth A, Davies RA, Duchesne L, Yla-Herttuala S, Saraste A, Farand P, Garrard L, Tardif J-C, Arnold M, Knuuti J, Beanlands R, Chan KL, Routine versus selective cardiac magnetic resonance in non-ischemic heart failure - OUTSMART-HF: study protocol for a randomized controlled trial (IMAGE-HF (heart failure) project 1-B). Trials, 2013;14:332.
  34. Thorn SL, deKemp R, Dumouchel T, Klein R, Renaud JM, Wells G, Gollob M, Beanlands RS, DaSilva JN, Repeatable Non-Invasive Imaging of FDG PET in the mouse myocardium: Evaluation of tracer kinetics in a Type 1 Diabetes model. J. Nucl. Med, 2013;54(9):1637-44.
  35. Pourmoghaddas A, Klein R, deKemp RA, Wells, RG, Respiratory phase alignment improves blood-flow quantification in Rb82 PET myocardial perfusion imaging. Med. Phys., 2013;40(2):022503.
  36. deKemp R, Declerck J, Klein R, Nakazato R, Pan X-B, Nakazato R, Tonge C, Aumugam P, Berman DS, Germano G, Beanlands RS, Slomka PJ, Multisoftware reproducibility study of stress and rest myocardial blood flow assessed with 3D dynamic PET/CT and a 1-tissue-compartment model of 82Rb kinetics. J. Nucl. Med. 2013;54(4):571-7.
  37. Dwivedi G, AlShehri H, deKemp RA, Ali I, Alghamdi AA, Klein R, Scullion A, Ruddy TD, Beanlands RS, Chow BJW, Scar Imaging using multislice computed tomography versus metabolic imaging by F-18 FDG positron emission tomography: A pilot study. Int. J. Cardiol., 2013;168(2):739-745.
  38. O'Meara E, Mielniczuk LM, Wells G, deKemp R, Klein R, Coyle D, McArdle B, Patterson I, White JA, Arnold M, Friedrich M, Larose E, Dick A, Chow B, Dennie C, Haddad H, Ruddy T, Ukkonen H, Wisenberg G, Cantin B, Pibarot P, Freeman M, Turcotte E, Connelly K, Clarke J, Williams K, Racine N, Garrard L, Tardif JC, DaSilva J, Knuuti J, Beanlands R, Alternative imaging modalities in ischemic heart failure (AIMI-HF): Study protocol for a randomized controlled trial. IMAGE HF Project I-A, Trials, 2013;14:218.
  39. Efseaff M, Klein R, Beanlands RSB, deKemp RA, Short-term repeatability of resting myocardial blood flow measurements using rubidium-82 PET imaging. J. Nucl. Cardiol., 2012:19(5);997-1006.
  40. Lamoureux M, Thorn S, Dumouchel T, Klein R, Renaud JM, Mason S, Lortie M, DaSilva JN, Beanlands RS, deKemp RA, Uniformity and repeatability of normal resting myocardial blood flow in rats with [13N]-ammonia and small animal PET. Nucl. Med. Commun., 2012;33:917-25.
  41. Katoh C, Yoshinaga K, Klein R, Kasai K, Manabe O, deKemp RA, Tamaki N, Quantification of Regional Myocardial Blood Flow Estimation with Three-dimensional Dynamic Rubidium-82 PET and modified spillover correction Model. J. Nucl. Cardiol., 2012;19:763-74.
  42. Yoshinaga K, Katoh C, Manabe O, Klein R, Naya M, Sakakibara M, Yamada S, deKemp RA, Tsutsui H, Tamaki N, Incremental diagnostic value of regional myocardial blood flow quantification over relative perfusion imaging with generator-produced rubidium-82 PET. Circ J., 2011;75(11):2628-34.
  43. Yoshinaga K, Manabe O, Katoh C, Chen L, Klein R, Naya M, deKemp RA, Williams K, Beanlands RSB, Tamaki N, Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET. Eur. J. Nucl. Med. Mol. Imaging, 2010;37(12):2233-41.
  44. Klein R, Beanlands RS, deKemp RA, Quantification of Myocardial Blood Flow and Flow Reserve - Technical Aspects. J. Nucl. Cardiol., 2010;17(4):555-570.
  45. Klein R, Renaud JM, Ziadi MC, Thorn SL, Adler A, Beanlands RS, deKemp RA, Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using Rubdium-82 PET and a highly automated analysis program. J. Nucl. Cardiol., 2010;17(4):600-616.
  46. Yoshinaga K, Klein R, Tamaki N, Generator Produced Rubidium-82 Positron Emission Tomography Myocardial Perfusion Imaging – From Basic Aspects to Clinical Applications. J. Of Cardiol., 2010;55(2):163-173.
  47. Lekx KS, deKemp RA, Beanlands RSB, Wisenberg G, Wells RG, Stodilka RZ, Lortie M, Klein R, Zabel P, Kovacs MS, Sykes J, Prato FS, Quantification of regional myocardial blood flow in a canine model of stunned and infarcted myocardium: comparison of rubidium-82 positron emission tomography with microspheres. Nucl. Med. Commun., 2010;31(1):67-74.
  48. Lekx KS, deKemp RA, Beanlands RSB, Wisenberg G, Wells G, Stodilka RZ, Lortie M, Klein R, Zabel P, Kovacs MS, Sykes J, Prato FS, 3D versus 2D dynamic 82Rb myocardial blood flow imaging in a canine model of stunned and infarcted myocardium. Nucl. Med. Commun., 2010;31(1):75-81.
  49. Lortie M, Beanlands RS, Yoshinaga K, Klein R, DaSilva JN, deKemp RA, Quantification of myocardial blood flow with 82Rb dynamic PET imaging. Eur. J. Nucl. Med. and Mol. Imaging., 2007;34(11):1765-74.

PubMed Listings

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