Benjamin Tsang profile picture

Contact Information

Benjamin Tsang, PhD
613-737-8899 x 72926

Ms. Terri van Gulik

ORCID logo


Selected Publications

Abedini MR, Wang PW, Huang YF, Cao MJ, Chou CY, Shieh DB and Tsang BK. Cell Fate Regulation by Gelsolin in Human Gynecologic Cancers. Proc. Nat. Acad. Sci. USA (2014, In Press).

Farrand L, Byun S, Kim JY, Im-Aram A, Lee JH, LimS, Lee KW, Suh JY, Lee HJ and Tsang BK. Piceatannol enhances cisplatin sensitivity in ovarian cancer through modulation of the p53 tumor suppressor pathway and induction of mitochondrial fission. J. Biol. Chem. 288: 23740-23750 (2013)

Abedini MR, Muller EJ, Brun J, Bergeron R, Gray DA, Tsang BK. Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells. Cancer Research 68(12): 4511-4517 (2008).

Kim JY, Xue K, Wang Q, Liu JY, Leader A, Han JY and Tsang BK. Chemerin Suppresses Ovarian Follicular Development and Its Potential Involvement in Follicular Arrest in Rats treated Chronically with Dihydrotestosterone. Endocrinology 154: 2912–2923 (2013).

Wang Q, Leader A and Tsang BK. Inhibitory role of prohibitin and chemerin in FSH-induced rat granulosa cell steroidogenesis. Endocrinology 154: 956-967 (2013).

Xue K, Liu JY, Murphy BR and Tsang BK. Orphan nuclear receptor NR4A1 is a negative regulator of DHT-induced rat preantral follicular growth. Molecular Endocrinology 26: 2004-2015 (2012)

All Other Publications

Wang PW, Abedini MR, Yang LX, Ding AA, Figeys D, Chang JY, Tsang BK, Shieh DB. Gelsolin regulates cisplatin sensitivity in human head-and-neck cancer. Int J Cancer. 2014 Apr 26. doi: 10.1002/ijc.28928. [Epub ahead of print]  

Farrand L, Kim JY, Byun S, Im-Aram A, Lee JH, Lee KW, Suh JY, Lee HJ and Tsang BK. Hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis inducing factor and X-linked inhibitor of apoptosis protein. J Biol Chem  2014 Jan 17;289(3):1723-31.  

Xue K, Kim JY, Liu JY, and Tsang BK Insulin-like 3-induced Rat Preantral Follicular Growth is mediated by Growth Differentiation Factor 9. Endocrinology  2014 Jan;155(1):156-67.  

Im-aram A, Farrand L, Bae SM, Song GH, Song YS, Han JY, and Tsang BK. The mTORC2 component Rictor confers cisplatin resistance in human ovarian cancer cells. PLOS ONE 8(9): e75455. doi:10.1371 (2013)

Farrand L, Kim JY, Im-Aram A, Suh JY, Lee HJ and Tsang BK. An improved quantitative approach for the assessment of mitochondrial fragmentation in chemoresistant ovarian cancer cells. PLOS ONE 8(9): e74008. doi:10.1371 (2013)

Orisaka M, Hattori K, Fukuda S, Mizutani T, Miyamoto K, Tsang BK, Kotsuji F and Yoshida Y. Dysregulation of ovarian follicular development:  LH decreases FSH sensitivity during preantral-early antral transition. Endocrinology 154: 2870-2880 (2013).

Hossain M, Cao M, Wang Q, Kim JY, Schellander K, Tesfaye D, and Tsang BK. Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model. J Ovarian Research 6: 36 (2013)

Wang Q, Leader A and Tsang BK. Fullicular stage-dependent regulation of apoptosis and steroidogenesis by prohibibitin in rat granulose cells. J Ovarian Research 6:23 (2013).

Han YY, Xia GL and Tsang BK. Regulation of Cyclin D2 Expression and Degradation by Follicle Stimulating Hormone during Rat Granulosa Cell Proliferation in vitro. Biol Reprod.  2013 Mar 7;88(3):57.

Kobayashi N, Abedini MR, Sakuragi N and Tsang BK. PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation. J Ovarian Research 2013 Jan 26;6:7.  

Du MR, Qiu Q, Gruslin A, Gordon J, Li DJ and Tsang BK. SB225002 promotes mitotic catastrophe in chemo-sensitive and –resistant ovarian cancer cells independent of p53 status in vitro. PLOS ONE 2013;8(1):e54572. 

Wang Q, Leader A and Tsang BK. Inhibitory role of chemerin and prohibitin on FSH-induced steroidogenesis. Endocrinology 154: 956-967 (2012).  

Ali AY, Farrand L, Kim JY, Byun S, Suh JY, Lee HJ and Tsang BK. Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum. Ann NY Acad Sci 1271: 58-67 (2012)  

Wang Q, Kim JY, Xue K, Liu JY, Leader A and Tsang BK. Chemerin, a novel regulator of follicular growth and steroidogenesis and its potential involvement in the pathogenesis of PCOS. Endocrinology 153: 5600-5611 (2012).

Woo MG, Xue K, Liu JY, McBribe H. and Tsang BK. Calpain-mediated processing of p53-associated, Parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol. Chem. 287: 3963–3975 (2012)  

Ali AY, Abedini MR, Tsang BK.  The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation.  Oncogene 2011:  2175-2186 (2012)

 Zhang C, Xia G, Tsang BK.  Interaction of thyroid hormone and FSH in the regulation of rat granulose cell apoptosis.  Frontiers Biosci (Elite Ed.) Jun 1; 3:1401-1413 (2011).  

Al-Bahlani S, Fraser M, Wong AY, Sayan BS, Bergeron R, Melino G, Tsang BK. P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.  Oncogene Oct 13;30(41):4219-4230 (2011). 

Haider M, Qiu Q, Bani-Yaghoub M, Tsang BK, Gruslin A.  Characterization and role of NUMB in the human extravillous trophopblast.  Placenta Jun;32(6):441-449 (2011).

Leung EL, Wong JC, Johlfs MG, Tsang BK, Fiscus RR.  Protein kinase G type 1alpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation. Mol Cancer Res. 8(4): 578-591 (2010).

Jiang JY, Xiong HL, Cao MJ, Xia XH, Sirard M-A, Tsang BK Granulosa cell gene   expression associated with oocyte developmental competence. J Ovarian Research 3:6, 2010.  

Fu JJ, Lv XY, Lin HY, Wu L, Wang R,  Zhou Z, Zhang BH, Tsang BK, Zhu C, Wang HM. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells.  J Biol. Chem. 285(14): 10870-10879 2010.  

Abedini MR, Muller EJ, Bergeron R, Gray DA, Tsang BK. Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein.  Oncogene 29: 11-25 (2010).

Leung EL, Wong JC, Johlfs MG, Tsang BK and Fiscus RR. Protein kinase G type 1alpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation. Mol. Can. Res. 8(4): 578-591 (2010)

Qiu Q, Yan XY, Bell M, Di JM, Tsang BK and Gruslin A. Mature IGF-II prevents the formation of “big” IGF-II/IGFBP-2 complex in the human circulation. Growth Horm. IGF Res. 2010 Apr;20(2): 110-117.  

Kobayashi N, Orisaka M, Cao MJ, Kotsuji F, Leader A, Sakuragi N, and Tsang, BK. Growth differentiation factor-9 mediates the interaction between FSH and thyroid hormone in the regulation of rat preantral follicular development. Endocrinology 150: 5566-5574(2009).

Orisaka M, Jiang J-Y, Orisaka S, Kotsuji F and Tsang BK. Growth Differentiation Factor-9 promotes preantral follicle development through up-regulation of androgen production. Endocrinology 150: 2740-2748 (2009).

Fu JJ, Lin P, Lv XY, Yan XJ, Wang HX, Zhu C, Tsang BK, Yu XG and Wang HM. Low molecular mass polypeptide-2 in human extravillous trophoblast: over-expression in hydatidiform mole and possible role in trophoblast cell invasion.  Placenta 30(4):305-312 (2009).

Orimoto AM, Dumaresq-Doiron K, Jiang JY, Tanphaichitr N, Tsang BK and Carmona E. Mammalian hyaluronidase induces ovarian granulosa cell apoptosis and is involved in the induction of follicular atresia. Endocrinology 150:5566-5574 (2009).  

Abedini MR, Muller EJ, Brun J, Bergeron R, Gray DA and Tsang BK. Cisplatin induces p53-dependent FLICE-like inhibitory protein (FLIP) ubiquitination in ovarian cancer cells. Cancer Research 68: 4511-4517 (2008).  

Leung LH, Fraser M, Fiscus RR and Tsang BK. Cisplatin alters nitric oxide synthase levels in human ovarian cancer cells: involvement in p53 regulation and cisplatin resistance. Br. J. Cancer 98, 1803-1809 (2008).  

Gregory-Bass RC, Olatinwo M , Xu W, Matthews R,  Stiles JK,  Thomas K, Liu D, Tsang BK and Thompson WE. Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis. Internat. J. Cancer 122: 1923-1930 (2008).

Yang X, Fraser M, Abedini MR, Bai T and Tsang BK. Regulation of AIF-Mediated, Cisplatin-Induced Apoptosis by Akt. Br. J. Cancer 98: 803-808 (2008).

Fraser M, Bai T and Tsang BK. Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function. Internat. J Cancer. 122:534-546 (2008).  

Wang HM and Tsang BK. Nodal signaling and Apoptosis. Reproduction 133: 1-8 (2007).  

Craig J, Orisaka M, Wang HM, Orisaka S, Thompson W, Zhu C, Kotsuji F and Tsang BK. Gonadotropin and intra-ovarian signals regulating follicle development and atresia: the delicate balance between life and death. Frontiers in Bioscience 12: 3628-3639 (2007).

Bissonette F, Cohen J, Collins J, Cowan L, Dales S, Dills S, Greene C, Gysler M, Hanck B, Hughes E, Leader A, McDonald S, Marrin M, Martin R, Min J, Mortimer D, Mortimer S, Smith J, Tsang BK, Van Vugt D and Yuzpe A (in alphabetical order). Incidence and complications of multiple gestation in Canada: proceedings of an expert meeting. Reproductive BioMedicine Online. Vol 14, No 6, 773-790 (2007).  

Qiu Q, Jiang JY, Bell M, Tsang BK and Gruslin A. Activation of endoproteolytic processing of IGF-II in fetal, early postnatal and pregnant rats and persistence of circulating levels in postnatal life. Endocrinology 148: 4803- 4811 (2007).

Jahani-Asl A, Basak A and Tsang BK. Caspase-3-mediated cleavage of Akt: involvement of non-consensus sites and influence of phosphorylation. FEBB Letters. 581: 2883-2888 (2007).  

Wu A, Anupriwan A, Iamsaard S, Chakrabandhu K, Santos DC, Rupar T, Tsang  BK, Carmona E and Tanphaichitr N. Sperm Surface Arylsulfatase A Can Disperse the Cumulus Matrix of Cumulus Oocyte Complexes. J. Cell Physiol. 213: 201-211 (2007).

Listings from The Ottawa Hospital Library

This lists the 24 most recent publications in The Ottawa Hospital's Library database from this lab.This database only starts tracking a researcher's publications once they start working at the Ottawa Hospital Research Institute.
More publications may be available in The Ottawa Hospital Library database.

PubMed Listings

For more publications use this PubMed ID link.