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Contact Information

Christopher Kennedy, PhD
613-562-5800 x8529

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Selected Publications

1 N. C. Read, . C. E. Holterman and C.R. Kennedy. Nox and renal disease. Clinical Science 2015; 128: 465-481.

2 C. E. Holterman, J. F. Thibodeau and C. R. Kennedy. NADPH oxidase 5 and renal disease. Curr Opin Nephrol Hypertens 2015; 24: 81-87.

3 C. R. Kennedy. Nitrate, Nitrite, and Nitric Oxide Find a Home in the Kidney by Offsetting Angiotensin II-Mediated Hypertension. Hypertension 2015; 65: 31-33.

4 D. Burger, J. F. Thibodeau, C. E. Holterman, K. D. Burns, R. M. Touyz and C. R. Kennedy. Urinary Podocyte Microparticles Identify Prealbuminuric Diabetic Glomerular Injury. J Am Soc Nephrol 2014 25: 1401-1407.

5 C. E. Holterman, J.-F. o. Thibodeau, C. Towaij, A. Gutsol, A. C. Montezano, R. J. Parks, M. E. Cooper, R. M. Touyz and C. R. J. Kennedy. Nephropathy and Elevated BP in Mice with Podocyte-Specific NADPH Oxidase 5 Expression. Journal of the American Society of Nephrology 2014 25: 784-797.

6 C. R. Kennedy. Nitrate, Nitrite, and Nitric Oxide Find a Home in the Kidney by Offsetting Angiotensin II-Mediated Hypertension. Hypertension 2014;

7 R. J. Mailloux, J. Y. Xuan, S. McBride, W. Maharsy, S. Thorn, C. E. Holterman, C. R. Kennedy, P. Rippstein, R. Dekemp, J. Da Silva, M. Nemer, M. Lou and M. E. Harper. Glutaredoxin-2 is Required to Control Oxidative Phosphorylation in Cardiac Muscle by Mediating Deglutathionylation Reactions. J Biol Chem 2014; 289: 14812-14828.

8 N. C. Read, A. Gutsol, C. E. Holterman, A. Carter, J. Coulombe, D. A. Gray and C. R. Kennedy. Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis. Biochim Biophys Acta 2014; 1842: 1028-1040.

9 D. Z. I. Cherney, B. Zinman, C. R. J. Kennedy, R. Moineddin, V. Lai, S. Yang, J. A. Miller, S. D. Prokopec, P. C. Boutros, J. W. Scholey and H. N. Reich. Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus. Kidney Int 2013; 84: 1246-1253.

10 C. M. Cuerrier, Y. X. Chen, D. Tremblay, K. Rayner, M. McNulty, X. Zhao, C. R. Kennedy, J. de BelleRoche, A. E. Pelling and E. R. O''Brien. Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions. PLoS One 2013; 8: e55867.

11 N. Drapeau, F. Lizotte, B. Denhez, A. Guay, C. R. Kennedy and P. Geraldes. Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes. Am J Physiol Endocrinol Metab 2013; 304: E1188-98.

12 C. Patrick, G. S. Wang, D. E. Lefebvre, J. A. Crookshank, B. Sonier, C. Eberhard, M. Mojibian, C. R. Kennedy, S. P. Brooks, M. L. Kalmokoff, M. Maglio, R. Troncone, P. Poussier and F. W. Scott. Promotion of autoimmune diabetes by cereal diet in the presence or absence of microbes associated with gut immune activation, regulatory imbalance, and altered cathelicidin antimicrobial Peptide. Diabetes 2013; 62: 2036-47.

13 M. Sedeek, A. Gutsol, A. C. Montezano, D. Burger, A. Nguyen Dinh Cat, C. R. Kennedy, K. D. Burns, M. E. Cooper, K. A. Jandeleit-Dahm, P. Page, C. Szyndralewiez, F. Heitz, R. L. Hebert and R. M. Touyz. Renoprotective effects of a novel Nox1/4 inhibitor in a momodel of type 2 diabetes. Clin Sci (Lond) 2013; 124(3): 191-202.

All Other Publications

11 J. F. Thibodeau, R. Nasrallah, A. Carter, Y. He, R. Touyz, R. L. Hebert and C. R. Kennedy. PTGER1 Deletion Attenuates Renal Injury in Diabetic MoModels. Am J Pathol 2013 183: 1789-802.

12 D. Burger, D. G. Kwart, A. C. Montezano, N. C. Read, C. R. J. Kennedy, C. S. Thompson and R. M. Touyz. Microparticles Induce Cell Cycle Arrest Through Redox-Sensitive Processes in Endothelial Cells: Implications in Vascular Senescence. Journal of the American Heart Association 2012; 1: e001842.

13 R. Nadarajah, R. Milagres, M. Dilauro, A. Gutsol, F. Xiao, J. Zimpelmann, C. Kennedy, J. Wysocki, D. Batlle and K. D. Burns. Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice. Kidney Int 2012; 82: 292-303.

14 F. Xiao, S. Hiremath, G. Knoll, J. Zimpelmann, K. Srivaratharajah, D. Jadhav, D. Fergusson, C. R. Kennedy and K. D. Burns. Increased urinary angiotensin-converting enzyme 2 in renal transplant patients with diabetes. PLoS One 2012; 7: e37649.

15 A. V. Cybulsky and C. R. J. Kennedy. Podocyte injury associated with mutant alpha-actinin-4. Journal of Signal Transduction 2011; 2011: 1-11.

16 A. V. Cybulsky, T. Takano, J. Papillon, J. Guillemette, A. M. Herzenberg and C. R. Kennedy. Podocyte Injury and Albuminuria in Mice with Podocyte-Specific Overexpression of the Ste20-Like Kinase, SLK. Am J Pathol 2010; 177: 2290-99.

17 W. H. Faour, J. F. Thibodeau and C. R. Kennedy. Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes. Cell Signal 2010; 22: 1222-30.

18 C. R. Kennedy. What Type of VEGF Do You Need? J Am Soc Nephrol 2010; 21: 1410-12.

19 M. Sedeek, G. E. Callera, A. Montezano, A. Gutsol, F. Heitz, C. Szyndralewiez, P. Page, C. R. Kennedy, K. D. Burns, R. M. Touyz and R. L. Hebert. Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney - implications in type 2 diabetic nephropathy. Am J Physiol Renal Physiol 2010; 299: F1348-58.

20 E. M. Stitt-Cavanagh, W. H. Faour, K. Takami, A. Carter, B. Vanderhyden, Y. Guan, A. Schneider, M. D. Breyer and C. R. Kennedy. A Maladaptive Role for EP4 Receptors in Podocytes. J Am Soc Nephrol 2010; 21: 1678-90.

21 D. Z. Cherney, J. W. Scholey, J. Zhou, J. Zimpelmann, C. Kennedy, K. D. Burns, V. Lai and J. A. Miller. Endothelial nitric oxide synthase gene polymorphisms and the renal hemodynamic response to L-arginine. Kidney Int 2009; 75: 327-32.

22 A. V. Cybulsky, T. Takano, J. Papillon, K. Bijian, J. Guillemette and C. R. Kennedy. Glomerular epithelial cell injury associated with mutant alpha-actinin-4. Am J Physiol Renal Physiol 2009; 297: F987-95.

23 R. L. Konger, S. D. Billings, N. C. Prall, T. M. Katona, S. C. Dasilva, C. R. Kennedy, S. Badve, S. M. Perkins and P. T. Lacelle. The EP(1) subtype of prostaglandin E(2) receptor: Role in keratinocyte differentiation and expression in non-melanoma skin cancer. Prostaglandins Leukot Essent Fatty Acids 2009; 81: 279-90.

24 J. L. Michaud, M. Hosseini-Abardeh, K. Farah and C. R. Kennedy. Modulating alpha-actinin-4 dynamics in podocytes. Cell Motil Cytoskeleton 2009; 66: 166-78.

25 J. L. Michaud, E. Stitt-Cavanaugh, N. Endlich, K. Endlich, Y. De Repentigny, R. Kothary and C. R. Kennedy. Mice with podocyte-specific overexpression of wild type alpha-actinin-4 are healthy controls for K256E-alpha-actinin-4 mutant transgenic mice. Transgenic Res 2009; 19: 285-9.

26 M. Sedeek, R. L. Hebert, C. R. Kennedy, K. D. Burns and R. M. Touyz. Molecular mechanisms of hypertension: role of Nox family NADPH oxidases. Curr Opin Nephrol Hypertens 2009; 18: 122-7.

27 E. Stitt-Cavanaugh, MacLoed, L., and Kennedy, C.R.J. The Podocyte in Diabetic Kidney Disease. TheScientificWorld 2009; 9: 1127-39.

28 W. H. Faour, K. Gomi and C. R. Kennedy. PGE(2) induces COX-2 expression in podocytes via the EP(4) receptor through a PKA-independent mechanism. Cell Signal 2008; 20: 2156-64.

29 J. Sequeira, G. Boily, S. Bazinet, S. Saliba, X. He, K. Jardine, C. Kennedy, W. Staines, C. Rousseaux, R. Mueller and M. W. McBurney. sirt1-null mice develop an autoimmune-like condition. Exp Cell Res 2008; 314: 3069-74.

30 H. Cheng, S. Wang, Y. I. Jo, C. M. Hao, M. Zhang, X. Fan, C. Kennedy, M. D. Breyer, G. W. Moeckel and R. C. Harris. Overexpression of cyclooxygenase-2 predisposes to podocyte injury. J Am Soc Nephrol 2007; 18: 551-9.

31 D. Z. Cherney, J. W. Scholey, D. C. Cattran, A. K. Kang, J. Zimpelmann, C. Kennedy, V. Lai, K. D. Burns and J. A. Miller. The effect of oral contraceptives on the nitric oxide system and renal function. Am J Physiol Renal Physiol 2007; 293: F1539-44.

32 C. R. Kennedy, H. Xiong, S. Rahal, J. Vanderluit, R. S. Slack, Y. Zhang, Y. Guan, M. D. Breyer and R. L. Hebert. Urine concentrating defect in prostaglandin EP1-deficient mice. Am J Physiol Renal Physiol 2007; 292: F868-75.

33 J. L. Michaud and C. R. Kennedy. The podocyte in health and disease: insights from the mouse. Clin Sci (Lond) 2007; 112: 325-35.

34 J. L. Michaud, K. M. Chaisson, R. J. Parks and C. R. Kennedy. FSGS-associated alpha-actinin-4 (K256E) impairs cytoskeletal dynamics in podocytes. Kidney Int 2006; 70: 1054-61.

35 J. A. Miller, D. Z. Cherney, J. A. Duncan, V. Lai, K. D. Burns, C. R. Kennedy, J. Zimpelmann, W. Gao, D. C. Cattran and J. W. Scholey. Gender differences in the renal response to renin-angiotensin system blockade. J Am Soc Nephrol 2006; 17: 2554-60.

36 S. Rahal, L. I. McVeigh, Y. Zhang, Y. Guan, M. D. Breyer and C. R. Kennedy. Increased severity of renal impairment in nephritic mice lacking the EP1 receptor. Can J Physiol Pharmacol 2006; 84: 877-85.

37 K. Bijian, T. Takano, J. Papillon, L. Le Berre, J. L. Michaud, C. R. Kennedy and A. V. Cybulsky. The Actin Cytoskeleton Regulates Extracellular Matrix-Dependent Survival Signals in Glomerular Epithelial Cells. Am J Physiol Renal Physiol 2005;
38 S. B. Ahmed, A. K. Kang, K. D. Burns, C. R. Kennedy, V. Lai, D. C. Cattran, J. W. Scholey and J. A. Miller. Effects of oral contraceptive use on the renal and systemic vascular response to angiotensin II infusion. J Am Soc Nephrol 2004; 15: 780-6.

39 L. C. Martineau, L. I. McVeigh, B. J. Jasmin and C. R. Kennedy. p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: implications for the actin cytoskeleton. Am J Physiol Renal Physiol 2004; 286: F693-701.

40 L. I. Lemieux, S. S. Rahal and C. R. Kennedy. PGE2 reduces arachidonic acid release in murine podocytes: evidence for an autocrine feedback loop. Am J Physiol Cell Physiol 2003; 284: C302-9.

41 J. L. Michaud, L. I. Lemieux, M. Dube, B. C. Vanderhyden, S. J. Robertson and C. R. Kennedy. Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant alpha-actinin-4. J Am Soc Nephrol 2003; 14: 1200-11.

42 R. M. Breyer, C. R. Kennedy, Y. Zhang, Y. Guan and M. D. Breyer. Targeted gene disruption of the prostaglandin E2 EP2 receptor. Adv Exp Med Biol 2002; 507: 321-6.

43 R. M. Breyer, C. R. Kennedy, Y. Zhang and M. D. Breyer. Structure-function analyses of eicosanoid receptors. Physiologic and therapeutic implications. Ann N Y Acad Sci 2000; 905: 221-31.

44 X. Li, Y. Okada, C. C. Pilbeam, J. A. Lorenzo, C. R. Kennedy, R. M. Breyer and L. G. Raisz. Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro. Endocrinology 2000; 141: 2054-61.

45 C. R. Kennedy, Y. Zhang, S. Brandon, Y. Guan, K. Coffee, C. D. Funk, M. A. Magnuson, J. A. Oates, M. D. Breyer and R. M. Breyer. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med 1999; 5: 217-20.

46 A. C. Chan, M. Wagner, C. Kennedy, E. Chen, O. Lanuville, V. A. Mezl, K. Tran and P. C. Choy. Vitamin E up-regulates arachidonic acid release and phospholipase A2 in megakaryocytes. Mol Cell Biochem 1998; 189: 153-9.

47 A. C. Chan, Wagner, M., Kennedy, C., Mroske, C., Proulx, P.,Laneuville, O., Tran, K., and P. C. Choy. Vitmain E upregulates phospholipase A2, arachidonic acid release and cyclooxygenase in endothelial cells. . Akt. Ernähr.-Med 1998; 22: 152-159.

48 C. Kennedy, P. R. Proulx and R. L. Hebert. Bradykinin-induced translocation of cytoplasmic phospholipase A2 in MDCK cells. Can J Physiol Pharmacol 1997; 75: 563-7.

49 C. R. Kennedy, R. L. Hebert, M. T. Do and P. R. Proulx. Bradykinin-stimulated arachidonic acid release from MDCK cells is not protein kinase C dependent. Am J Physiol 1997; 273: C1605-12.

50 M. A. Lal, C. R. Kennedy, P. R. Proulx and R. L. Hebert. Bradykinin-stimulated cPLA2 phosphorylation is protein kinase C dependent in rabbit CCD cells. Am J Physiol 1997; 273: F907-15.

51 C. R. Kennedy, P. R. Proulx and R. L. Hebert. Role of PLA2, PLC, and PLD in bradykinin-induced release of arachidonic acid in MDCK cells. Am J Physiol 1996; 271: C1064-72.

52 C. R. Kennedy, P. R. Proulx and R. L. Hebert. Regulation of bradykinin-stimulated phospholipase C and arachidonic acid release by protein kinase A in MDCK-D1 cells. Biochim Biophys Acta 1995; 1258: 206-14.

53 C. Kennedy, R. Slack, L. X. Ding, H. Aubry and P. Proulx. Transfer of arachidonyl groups within the lipids of two human neuroblastoma cell lines. Biochim Biophys Acta 1994; 1211: 326-34.

Chapters in Books

1. Targeted Gene Disruption of the Prostaglandin E2 EP2 Receptor, in Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury. Edited by Honn et al., Kluwer Academic/Plenum Publishers, 2002.

2. Angiotensin II as a Mediator of Renal Tubular Transport, in Contributions to Nephrology, Karger, 2001.

PubMed Listings

For more publications use this PubMed ID link.