Daniel Coutu profile picture

Contact Information

Daniel Coutu, PhD
613-798-5555; 79048

ORCID logo https://orcid.org/0000-0002-4641-0115


Selected Publications

1: Coutu DL, Kokkaliaris KD, Kunz L, Schroeder T. Multicolor quantitative
confocal imaging cytometry. Nat Methods. 2018 Jan;15(1):39-46. doi:
10.1038/nmeth.4503. Epub 2017 Nov 13. PubMed PMID: 29320487.

2: Coutu DL, Kokkaliaris KD, Kunz L, Schroeder T. Three-dimensional map of
nonhematopoietic bone and bone-marrow cells and molecules. Nat Biotechnol. 2017
Dec;35(12):1202-1210. doi: 10.1038/nbt.4006. Epub 2017 Nov 13. PubMed PMID:

3: Hoppe PS, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Moritz
N, Endele M, Filipczyk A, Gambardella A, Ahmed N, Etzrodt M, Coutu DL, Rieger MA,
Marr C, Strasser MK, Schauberger B, Burtscher I, Ermakova O, Bürger A, Lickert H,
Nerlov C, Theis FJ, Schroeder T. Early myeloid lineage choice is not initiated by
random PU.1 to GATA1 protein ratios. Nature. 2016 Jul 14;535(7611):299-302. doi:
10.1038/nature18320. PubMed PMID: 27411635.

4: Hoppe PS, Coutu DL, Schroeder T. Single-cell technologies sharpen up mammalian
stem cell research. Nat Cell Biol. 2014 Oct;16(10):919-27. doi: 10.1038/ncb3042.
Review. PubMed PMID: 25271480.

5: Coutu DL, Schroeder T. Probing cellular processes by long-term live
imaging--historic problems and current solutions. J Cell Sci. 2013 Sep 1;126(Pt
17):3805-15. doi: 10.1242/jcs.118349. Epub 2013 Aug 13. Review. PubMed PMID:

All Other Publications

6: Bourgine PE, Klein T, Paczulla AM, Shimizu T, Kunz L, Kokkaliaris KD, Coutu
DL, Lengerke C, Skoda R, Schroeder T, Martin I. In vitro biomimetic engineering
of a human hematopoietic niche with functional properties. Proc Natl Acad Sci U S
A. 2018 Jun 4. pii: 201805440. doi: 10.1073/pnas.1805440115. [Epub ahead of
print] PubMed PMID: 29866839.

7: Hastreiter S, Skylaki S, Loeffler D, Reimann A, Hilsenbeck O, Hoppe PS, Coutu
DL, Kokkaliaris KD, Schwarzfischer M, Anastassiadis K, Theis FJ, Schroeder T.
Inductive and Selective Effects of GSK3 and MEK Inhibition on Nanog Heterogeneity
in Embryonic Stem Cells. Stem Cell Reports. 2018 May 10. pii:
S2213-6711(18)30187-5. doi: 10.1016/j.stemcr.2018.04.019. [Epub ahead of print]
PubMed PMID: 29779897.

8: Coutu DL, Mahfouz W, Loutochin O, Galipeau J, Corcos J. Tissue engineering of
rat bladder using marrow-derived mesenchymal stem cells and bladder acellular
matrix. PLoS One. 2014 Dec 1;9(12):e111966. doi: 10.1371/journal.pone.0111966.
eCollection 2014. PubMed PMID: 25437001; PubMed Central PMCID: PMC4249849.

9: Coutu DL, Galipeau J. Molecular and endocrine mechanisms underlying the
stem cell theory of aging. In: Adult stem cells (K.Turksen ed.). 2014.

10: Despars G, Carbonneau CL, Bardeau P, Coutu DL, Beauséjour CM. Loss of the
osteogenic differentiation potential during senescence is limited to bone
progenitor cells and is dependent on p53. PLoS One. 2013 Aug 29;8(8):e73206. doi:
10.1371/journal.pone.0073206. eCollection 2013. PubMed PMID: 24009740; PubMed
Central PMCID: PMC3756945.

11: Romieu-Mourez R, Coutu DL, Galipeau J. The immune plasticity of mesenchymal
stromal cells from mice and men: concordances and discrepancies. Front Biosci
(Elite Ed). 2012 Jan 1;4:824-37. Review. PubMed PMID: 22201917.

12: Coutu DL, François M, Galipeau J. Mesenchymal stem cells and tissue repair.
In: Regenerative therapy using blood-derived stem cells (David Allan and Dirk Strunk, eds) 2012.

13: Coutu DL, Galipeau J. Roles of FGF signaling in stem cell self-renewal,
senescence and aging. Aging (Albany NY). 2011 Oct;3(10):920-33. Review. PubMed
PMID: 21990129; PubMed Central PMCID: PMC3229969.

14: Coutu DL, François M, Galipeau J. Inhibition of cellular senescence by
developmentally regulated FGF receptors in mesenchymal stem cells. Blood. 2011
Jun 23;117(25):6801-12. doi: 10.1182/blood-2010-12-321539. Epub 2011 Apr 28.
PubMed PMID: 21527526.

15: Coutu DL, Cuerquis J, El Ayoubi R, Forner KA, Roy R, François M, Griffith M,
Lillicrap D, Yousefi AM, Blostein MD, Galipeau J. Hierarchical scaffold design
for mesenchymal stem cell-based gene therapy of hemophilia B. Biomaterials. 2011
Jan;32(1):295-305. doi: 10.1016/j.biomaterials.2010.08.094. PubMed PMID:

16: Lamont EW, Coutu DL, Cermakian N, Boivin DB. Circadian rhythms and clock genes
in psychotic disorders. Isr J Psychiatry Relat Sci. 2010;47(1):27-35. Review.
PubMed PMID: 20686197.

17: Coutu DL, Yousefi AM, Galipeau J. Three-dimensional porous scaffolds at the
crossroads of tissue engineering and cell-based gene therapy. J Cell Biochem.
2009 Oct 15;108(3):537-46. doi: 10.1002/jcb.22296. Review. PubMed PMID: 19681040.

18: Copland IB, Lord-Dufour S, Cuerquis J, Coutu DL, Annabi B, Wang E, Galipeau
J. Improved autograft survival of mesenchymal stromal cells by plasminogen
activator inhibitor 1 inhibition. Stem Cells. 2009 Feb;27(2):467-77. doi:
10.1634/stemcells.2008-0520. PubMed PMID: 19338064.

19: Kucic T, Copland IB, Cuerquis J, Coutu DL, Chalifour LE, Gagnon RF, Galipeau
J. Mesenchymal stromal cells genetically engineered to overexpress IGF-I enhance
cell-based gene therapy of renal failure-induced anemia. Am J Physiol Renal
Physiol. 2008 Aug;295(2):F488-96. doi: 10.1152/ajprenal.00044.2008. Epub 2008 Jun
4. PubMed PMID: 18524862.

20: Coutu DL, Wu JH, Monette A, Rivard GE, Blostein MD, Galipeau J. Periostin, a
member of a novel family of vitamin K-dependent proteins, is expressed by
mesenchymal stromal cells. J Biol Chem. 2008 Jun 27;283(26):17991-8001. doi:
10.1074/jbc.M708029200. Epub 2008 Apr 30. PubMed PMID: 18450759.

21: Lamont EW, Coutu DL, Cermakian N, Boivin DB. The role of circadian clock
genes in mental disorders. Dialogues.Clin.Neurosci. 2007;9:333-342.