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Contact Information

Deborah Siegal, MD MSc FRCPC
613-737-8899 x78804

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Deborah Siegal

Scientist, Inflammation & Chronic Disease
Ottawa Hospital Research Institute
Associate Professor, Department of Medicine
University of Ottawa
Associate Professor, School of Epidemiology and Public Health
University of Ottawa

Research Interests

  1. Management of anticoagulant-related bleeding.
  2. Restarting anticoagulants after bleeding
  3. Perioperative management of anticoagulation for urgent surgery
  4. Ischemic stroke in patients with cancer

Brief Biography

Dr. Deborah Siegal MD MSc FRCPC is a hematologist (thrombosis medicine) and clinician-scientist, Associate Professor of Medicine and School of Epidemiology and Public Health at the University of Ottawa, and Associate Scientist at the Ottawa Hospital Research Institute. She holds a Tier 2 Canada Research Chair in Anticoagulant Management of Cardiovascular Disease. Dr. Siegal received a B.Sc. in Physiology (McGill University, 1998), M.Sc. in Pharmacology (University of Toronto, 2001), M.D. (Queen’s University, 2009), and M.Sc. in Health Research Methodology (McMaster University, 2017). 

Selected Publications

Little DHW, Cerasuolo J, Perez R, Douketis J, Holbrook A, Sutradhar R, Paterson M, Gomes T, Siegal DM. Resumption of Anticoagulant Therapy After Anticoagulant-Related Bleeding: A Population-Based Cohort Study. CMAJ. 2021 Mar 1;193(9):E304-E309.2.

Little DHW, Pinto T, Xenodemetropoulos T, Douketis J, Dionne J, Holbrook A, Siegal DM. Management of Antithrombotic Therapy After Gastrointestinal Bleeding: A Mixed Methods Study of Healthcare Providers. J Thromb Haemost. 2021 Jan;19(1):153-160.

Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, Mathur VS, Castillo J, Bronson MD, Leeds JM, Mar FA, Gold A, Crowther MA. Andexanet for Reversal of Factor Xa Inhibitor Activity. N Engl J Med. 2015 Dec 17;373(25):2413-24.

Connolly SJ, Crowther M, Eikelboom JW, Gibson CM, Curnutte JT, Lawrence JH, Yue P, BronsonMD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen AT, Beyer-Westendorf J,Albaladejo P, Lopez-Sendon J, Demchuk AM, Pallin DJ, Concha M, Goodman S, Leeds J, Souza S,Siegal DM, Zotova E, Meeks B, Ahmad S, Nakamya J, Milling TJ Jr; ANNEXA-4 Investigators. Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors. N Engl J Med.2019 Apr 4;380(14):1326-1335.

Siegal D, Yudin J, Kaatz, Douketis JD, Lim W, Spyropoulos AC. Periprocedural heparin bridging inpatients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding andthromboembolic rates. Circulation. 2012 Sep 25;126(13):1630-9.

Research and clinical approaches