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Hsiao-Huei Chen, PhD


Saviour siblings: surprising discovery reveals the staying power of stem cells from older brothers
December 14, 2022 - The researchers believe this is the first example of this kind of “saviour sibling” effect to rescue a lethal genetic deficit.
Researchers at The Ottawa Hospital awarded 19 CIHR grants worth more than $12 million
July 20, 2022 - These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, ...
Could a drug that controls appetite also treat schizophrenia and Alzheimer’s? Mouse studies show promise.
September 8, 2021 - Two recent studies suggest that the drug trodusquemine has the potential to treat symptoms of both schizophrenia and Alzheimer’s disease. This is because the drug targets an enzyme called PTP1B, which plays a role in both diseases
Study in mice reveals possible new target to treat schizophrenia
March 10, 2021 - The enzyme PTP1B may be a new target for treating schizophrenia, according to a study published in Neuropsychopharmacology.
Study in mice reveals possible new target to treat autism
March 2, 2020 - The enzyme PTP1B may be a new target for treating autism spectrum disorder, according to a study published in Nature Communications.
Study in mice reveals a new target to treat Alzheimer’s disease
January 23, 2020 - A new study has found that PTP1B, an enzyme that counteracts insulin and plays an important role in obesity and diabetes, is also a target for treating Alzheimer’s disease. Blocking PTP1B in mouse models of Alzheimer’s restored their spatial ...
Researchers get $745,000 boost from NSERC
May 29, 2019 - Four scientists from The Ottawa Hospital, affiliated with the University of Ottawa, were successful in the recent discovery grant competition from the Natural Sciences and Engineering Research Council of Canada (NSERC).
Researchers awarded $1.7 M to tackle stroke and heart attack from multiple angles
October 2, 2018 - Five groups from The Ottawa Hospital, affiliated with the University of Ottawa, were successful in the Heart and Stroke Foundation's recent grant competition. Drs. Dar Dowlatshahi, Tim Ramsay and Elizabeth Rochon were awarded $290,000* to test ...
Top Research Papers from The Ottawa Hospital 2015-2017
June 7, 2018 - Did you know that researchers at The Ottawa Hospital publish an average of four new scientific papers every single day? Our research is advancing science and improving health on a massive scale – both at home and around the world. The list below ...
Could a skin cancer drug help treat stroke?
April 18, 2018 - Dr. Hsiao-Huei Chen and her team discovered that a drug used to treat skin cancer reduced brain damage after stroke in animal models. While a lack of blood flow that supplies oxygen and nutrients is the first thing to kill brain cells after a strok
Extra maternal care prevents brain inflammation and reduces anxiety in mice
September 22, 2017 - New research led by Dr. Hsiao-Huei Chen reveals that a protein called IRF2BP2 plays an important role in controlling anxiety in mice by influencing microglia, known as the immune system of the brain. Microglial cells can do many things, including fig
Research suggests new anti-inflammatory approach for treating stroke
July 28, 2017 - Every 10 minutes, someone in Canada suffers a stroke, usually because of a clot blocking blood flow to the brain. While lack of blood is the first thing to kill brain cells, collateral damage from immune cells trying to clean up the mess (inflammat
The Ottawa Hospital awarded 18 research grants from the Canadian Institutes of Health Research, worth $10.7 million
May 19, 2017 - Eighteen research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded nearly $11 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). This represents a suc
Do the body’s own marijuana-like compounds play a role in schizophrenia? $150,000 grant will help researchers find out.
June 1, 2016 - Dr. Hsiao-Huei Chen was awarded $150,000 from the Ontario Mental Health Foundation to test whether blocking an enzyme called PTP1B can alleviate schizophrenia-like behaviors in mouse models of the condition. Schizophrenia is a debilitating mental
Research solves mystery of genetic risk factor for heart disease
November 4, 2015 - A study led by Drs. Hsiao-Huei Chen and Alexandre Stewart has finally solved a long-standing mystery of heart disease. More than eight years ago, Dr. Stewart discovered that people with variations in a certain region of DNA (called 9p21.3) have a 21%
Novel genetic variant affects inflammation and may increase heart disease risk by 50%
August 26, 2015 - Inflammation can help the body fight infection, clean up damaged tissue and heal injuries, but too much inflammation can contribute to problems such as plaque build-up in the blood vessels and heart disease. Dr. Hsiao-Huei Chen and colleagues have
Drug to control appetite could also fight anxiety: Ottawa study
March 5, 2015 - Did you know that our body produces its own marijuana-like compound to protect us against anxiety? A study led by Ottawa researchers published today in Neuron reveals a new biological pathway that regulates anxiety and obesity and suggests that a ...