Ian Lorimer profile picture

Contact Information

Ian Lorimer, PhD

Ottawa Hospital Research Institute
Centre for Cancer Therapeutics
501 Smyth Road
Box 926
Ottawa, ON
K1H 8L6

ORCID logo https://orcid.org/0000-0002-2128-348X


Selected Publications

Jacques FH, Nicholas G, Lorimer IAJ, Sikati Foko V, Prevost J, Dumais N, Milne K, Nelson BH, Woulfe J, Jansen G, Apedaile BE (2021) The SEJ study: Avelumab in newly diagnosed glioblastoma, Neuro-oncology Advances, accepted for publication

Lavictoire SJ, Jomaa D, Gont A, Jardine K, Cook DP, Lorimer IAJ (2021) Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma, Journal of Biological Chemistry, accepted for publication

Ramanathan A and Lorimer IAJ (2021) Engineered cells as glioblastoma therapeutics, Cancer Gene Therapy, March 22, doi: 10.1038/s41417-021-00320-w. 

Lorimer IAJ (2019) Aberrant Rac pathway signalling in glioblastoma, Small GTPases, published online May 6, 1-15

Lavictoire SJ, Gont A, Julian L, Stanford WL, Vlasschaert C, Gray D, Jomaa D, Lorimer IAJ (2018) Engineering PTEN-L for cell-mediated delivery, Molecular Therapy – Methods and Clinical Development, 9: 12-22

Kumar R, Gont A, Perkins T, Hanson JEL, Lorimer IAJ (2017) Induction of senescence in primary glioblastoma cells by serum and TGFb, Scientific Reports, 7: 2156

Gont A, Daneshmand M, Woulfe J, Lavictoire SJ, Lorimer IAJ (2017) PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion, Oncotarget, 8: 8559-8573

Jahani-Asl A, Yin H, Soleimani VD, Chang NC, Sincennes M-C, Luchman HA, Puram SV,
Scott AM, Lorimer IAJ, Ligon KL, Weiss S, Rudnicki MA, Bonni A (2016) EGFRvIII Requires OSMR as a Co-Receptor to Drive Glioblastoma Tumorigenesis, Nature Neuroscience, 19:798-806

Restall IJ, Parolin DAE, Daneshmand M, Hanson JEL, Simard MA, Fitzpatrick ME, Kumar R, Lavictoire SJ, Lorimer IAJ (2015) PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma, Cell Cycle, 14: 2938-48

Lorimer IAJ (2015) Atypical PKCι as a target for glioblastoma therapy. Current Cancer Drug Targets 15:136-44

Gont A, Hanson JEL, Lavictoire SJ, Daneshmand M, Nicholas G, Woulfe J, Kassam A, Da Silva VF, Lorimer IAJ (2014) Inhibition of glioblastoma malignancy by Lgl1, Oncotarget, 5, 11541-51

Karapetis C , Jonker D, Daneshmand M, Hanson J, Marginean C, O'Callaghan C, Tebbutt N, Price T, Tu D, Simes J, Zalcberg J, Lorimer IAJ (2014) BRAF, PIK3CA and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer: results from NCIC CTG / AGITG CO.17, Clinical Cancer Research, 20, 744-53  

Liwak U, Jordan LE, Von-Holt SD, Singh P, Hanson JE, Lorimer IA, Roncaroli F, Holcik M (2013) Loss of PDCD4 contributes to enhanced chemoresistance in glioblastoma multiforme through de-repression of Bcl-xL translation. Oncotarget, 4, 1365-72

Goss GD, O'Callaghan C, Lorimer I, Tsao MS, Masters GA, Jett J, Edelman MJ, Lilenbaum R, Choy H, Khuri F, Pisters K, Gandara D, Kernstine K, Butts C, Noble J, Hensing TA, Rowland K, Schiller J, Ding K, Shepherd FA (2013) Gefitinib versus Placebo in Completely Resected Non-Small Cell Lung Cancer, Results of the NCIC CTG BR19 Study. J. Clin. Oncology, 31, 3320-6

Gont A, Hanson JEL, Lavictoire SJ, Parolin DAE, Daneshmand M, Restall IJ, Soucie M, Nicholas G, Woulfe J, Kassam A, Da Silva VF and Lorimer IAJ (2013) PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1. Oncotarget, 4, 1266-1279

Daneshmand D, Hanson JEL, Nabavi M, Hilton JF, Vandermeer L, Kanji F, Dent SF, Clemons M, Lorimer IAJ (2012) Detection of PIK3CA mutations in breast cancer bone metastases, ISRN Oncology, 492578. Epub 2012 Aug 30

All Other Publications

Hilton J, Weberpals J, Lorimer I, Amin S, Islam S, Daneshmand M, Hanson J, Mallick R, Verma S (2012) BRCA1 protein levels and PI3K3CA mutations as predictive biomarkers for response to neoadjuvant chemotherapy in locally advanced breast cancer: an exploratory analysis, Oncology Letters, Oncol Lett 4: 141-145, 2012

Vickers MV, Bar J, Gorn-Hundermann I, Yarom N, Daneshmand M, Hanson J, Addison CL, Asmis TR, Jonker DJ, Maroun J, Lorimer IAJ, Goss GG and Dimitroulakos J (2012) Stage-dependent differential expression of microRNAs in colorectal cancer: potential role as markers of metastatic disease. Clinical and Experimental Metastasis, 29:123-32

Paget JA, Restall IJ, Daneshmand M, Mersereau JA, Simard MA, Parolin DAE, Lavictoire SJ, Amin MS, Islam S and Lorimer IAJ (2012) Repression of cancer cell senescence by PKCi, Oncogene, 31: 3584-96

Proctor CJ and Lorimer IAJ (2011) Modelling the role of the Hsp70/Hsp90 system in the maintenance of protein homeostasis, PLoS ONE, 6: e22038

Baldwin RM, Barrett GM, Parolin DAE, Gillies JK, Paget JA, Lavictoire SJ, Gray DA and Lorimer IAJ (2010) Coordination of glioblastoma cell motility by protein kinase C iota, Molecular Cancer, 9:233

Listings from The Ottawa Hospital Library

This lists the 5 most recent publications in The Ottawa Hospital's Library database from this researcher.This database only starts tracking a researcher's publications once they start working at the Ottawa Hospital Research Institute.
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PubMed Listings

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