Advanced Imaging Lab

Richard Aviv profile picture

Contact Information

Richard Aviv, MBChB, FRCR (UK), FRCPC, dABR
613 737-8899 ext 73040
raviv@toh.ca

Funding

2020 Oct – 2021 Oct Principal Investigator. Faculty of Medicine, Translational Research Grant (TRG). Hemorrhagic transformation of microinfarcts- an animal model. coPI Greg Silasi. $50000 [Grants]

2020 Oct -2021 Oct Supervisor: Trainee Scholarships for Stroke Research. Machine learning prediction of hematoma expansion in ICH. uOBMRI: Dr Paulo Cesar Puac Polanco $10000 CAD [Grants]

2020 Oct – 2023 Oct Co-PI. Longitudinal, Multicenter Study of Cortical Perfusion as Biomarkers of Cortical
Disease Severity and Cognitive Impairment in Multiple Sclerosis. Kuwait Foundation for the advancement of Sciences. PI: Armin Eilaghi $200000 [Grants]

2017 April – 2019 Apr Principal Investigator. VIPER-DCI Vascular-perfusion imaging for prediction and early recognition of DCI and relationship to clinical outcome. Alternate Funding Plan, Sunnybrook Health Sciences center. Collaborators: S Symons, L Da Costa. $60000 CAD [Grants]

2017 Mar – 2018 March Principal Investigator. Longitudinal, multicenter study of cortical perfusion and
microvascular reserve as biomarkers of disease severity and cognitive impairment in Multiple
Sclerosis. PSI Foundation $84000 [Grants]

2016 Dec – 2017 Dec Principal Investigator. VIPER-DCI Vascular-perfusion imaging for prediction and early recognition of DCI and relationship to clinical outcome. Discovery Phase Grant University of Toronto. $15000 CAD [Grants]

2016 Sep – 2022 Sep Principal Investigator. Testing existing and new therapeutic interventions in a
novel animal model of acute Spot Positive intracranial hemorrhage. Canadian Institutes of Health Research (CIHR). Operating Grant. Collaborator(s): Kullervo Hynynen, David Gladstone. $722454 [Grants]

2016 Sep – 2018 Sep Collaborator. Double-blind placebo controlled study of mixed-amphetamine salts, extended release (Adderall XR) for cognitive impairment in MS. Multiple Sclerosis Society of Canada. Operating Grant. PI: Sarah Morrow. Collaborator(s): Richard Aviv, Liesly Lee. 80,000 CAD. [Grants]

2016 May- 2017 May Collaborator. Establishing quantitative lipidomic biomarkers for multiple sclerosis patients and their relationship with cognitive impairment. Multiple Sclerosis Society. PI Ameer Taha. Collaborator(s): Richard Aviv, Walter Swardfager. US$29,834. [Grants]

2015 Jul – 2017 Jul Mentor and Co-Investigator. Quantitative blood oxygenation level dependent (qBOLD) MR imaging of glioblastoma multiforme for assessment of tumour hypoxia. RSNA. PI: Pejman Jabehdar Maralani. Collaborator(s): Richard Aviv (mentor), Todd Mainprize, Julia Keith, Bradley MacIntosh, Symon Graham. 210,000 CAD. [Grants]

2014 Jul – 2015 Jul Co-Investigator. Quantitative blood oxygenation level dependent (qBOLD) MR imaging of glioblastoma multiforme for assessment of tumour hypoxia. Brain Tumor Foundation of Canada. PI: Pejman Jabehdar Maralani. Collaborator(s): Richard Aviv (mentor), Todd Mainprize, Julia Keith, Bradley MacIntosh, Symon Graham. 24,956.6 CAD. [Grants]

2013 Sep – 2014 Sep Principal Investigator. Correlation of cortical perfusion and cognitive dysfunction between Multiple Sclerosis subtypes using a
novel quantitative perfusion sequence. Canadian Institutes of Health Research (CIHR). Operating Grant. Collaborator(s): Anthony Feinstein, Krista Lactot, Walter Swardfager. 77,402 CAD. [Grants]

2013 Mar – 2014 Mar Principal Applicant. Sunnybrook CTA Spot Sign in ICH. Online imaging training module. Knowledge dissemination, interobserver agreement and training efficacy assessment. Education Research and Scholarship Grant Competition. PI: Aviv, Richard. Collaborator(s): Thien Huynh. 9,895 CAD. [Grants]

2013 Jan – 2013 Dec Principal Investigator. Developing a focused ultrasound animal model of hemorrhagic stroke. Physicians Services Incorporated Foundation (The) (PSI). Resident research award. Collaborator(s): Thien Huyhn, Kullervo Hynynen, Dan Dumont, Paul Van Slyke. 20,000 CAD. [Grants]

2013 Jan – 2013 Dec Co-Investigator. Early Prediction of Response for Brain Metastases Following Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiosurgery Using Perfusion and Apoptosis Quantification MRI. Tiffin trust. PI: Arjun Saghal. Collaborator(s): Greg Stanicz, Richard Aviv. 50,000 CAD. [Grants]

2012 Jul – 2015 Jun Co-Investigator. Predicting intracerebral hemorrhage expansion using the dynamic CT-angiography spot sign. Heart and Stroke Foundation of Ontario (HSFO). Grant-in-Aid. PI: D Dowlatshahi. Collaborator(s): S Chakraborty ,R I Aviv, D Dowlatshahi. 96,720 CAD. [Grants]

2012 Jan – 2013 Jan Co-Investigator. Systematic reviews of the evidence that tests for chronic cerebrospinal venous
insufficiency (CCSVI) are valid and reproducible, that CCSVI is associated with multiple sclerosis, and of the
benefits and harms of endovascular therapy for multiple sclerosis. Canadian Institutes of Health Research (CIHR). Knowledge Synthesis Grant. PI: Andreas Laupacis. Collaborator(s): R Aviv, J Burton, A Dueck, T Feasby, L Perrier, J Spears, S Strauss, K Thorpe. 99,300 CAD. [Grants]

2011 Jul – 2013 Jun Principal Investigator. A novel animal model of contrast extravasation in intracranial hemorrhage. Heart and Stroke Foundation of Canada (HSFC). Grant-in-Aid. Collaborator(s): Kullervo Hynynen, Dan Dumont, Paul Van Slyke. 140,000 CAD. [Grants]

2011 Apr – 2012 Apr Supervisor. Development of a real-time clinical tool for predicting the tissue fate in ischemic stroke. Mathematics of Information Technology and Complex Systems (MITACS). MITACS Elevate Industrial Fellowship Program. PI: Richard Aviv. 35,000 CAD. [Research Fellowships]

2011 Jan – 2012 Jan Co-Investigator. Systematic reviews of the evidence that tests for chronic cerebrospinal venous
insufficiency (CCSVI) are valid and reproducible, that CCSVI is associated with multiple sclerosis, and of the
benefits and harms of endovascular therapy for multiple sclerosis. Canadian Institutes of Health Research (CIHR). Knowledge Synthesis Grant. PI: Andreas Laupacis. Collaborator(s): R Aviv, J Burton, A Dueck, T Feasby, L Perrier, J Spears, S Strauss, K Thorpe. 99,300 CAD. [Grants]

2010 Oct – 2012 Oct Co-Principal Investigator. The SPOTLIGHT Study: A Multicentre Image-Guided Emergency Treatment Protocol for Patients
with Intracerebral Hemorrhage. Ontario Stroke Network (OSN) Ministry of Health and Long-Term Care Research Program. Collaborator(s): Gladstone G, Aviv R, Demchuk A. 92,186.25 CAD. [Grants]

2010 Jul – 2015 Jul Principal Investigator. The Spot Sign Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy ‘SPOTLIGHT’ study. Canadian Institutes of Health Research (CIHR). Collaborator(s): Gladstone G, Aviv R (Co-primary applicant), Demchuk A. 1,708,141 CAD. [Grants]

2010 – 2013 Co-Investigator. Cardiac Monitoring for Stroke Prevention: The EMBRACE Study Program. Canadian Stroke Network. PI: Gladstone DJ. Collaborator(s): Dorian P, O’Donnell M, Spring M, Mamdani M, Thorpe K, Laupacis A, Kapral M, Aviv R, Blakely J, Cote R, Sharma M, Shuaib A. 952,718 CAD. [Grants]

2009 Aug – 2012 Jul Co-Investigator. Utility of a 30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation After a Cerebral Ischemic Event (EMBRACE): A Cluster Randomized Trial. Heart and Stroke Foundation and Canadian Stroke Network. PI: Gladstone D. 1,463,000 CAD. [Clinical Trials]
To evaluate the utility of a novel diagnostic tool for detecting occult AF in patients with a recent ischemic stroke or TIA. The ultimate goal of this secondary stroke prevention research is to prevent recurrent strokes (both fatal and non-fatal, disabling strokes) by improving the identification, and consequently the treatment, of patients with AF.

2009 Jul – 2011 Jun Co-Investigator. Refinement of a point of care, electronic testing tool for the longitudinal stroke assessments. Heart and Stroke Foundation of Canada (HSFC). PI: Ween J. 160,000 CAD. [Grants]

2009 Mar – 2014 Feb Principal Investigator. Prediction of Hemorrhagic Transformation of Ischemic Stroke with CT Perfusion Derived Blood-Brain-Barrier Permeability Surface Area Product. Heart and Stroke Foundation of Canada (HSFC). Grant-in-Aid Application. Collaborator(s): Lee TY, Aviv R, (Co primary applicants), Sandra Black, David Gladstone, Sean Symons (Co-Applicants). 600,000 CAD. [Grants]

2009 Jan – 2010 Principal Applicant. “The SPOT Sign for Predicting and Treating ICH Growth Study (STOP-IT Study): Educational Imaging Module”. SHUTC Academic Trust Fund Application. 9,100. [Grants]

2009 Jan – 2009 Dec Principal Investigator. Regional cortical cerebral quantitative MRI perfusion correlation with neurocognition in multiple sclerosis. Physicians Services Incorporated Foundation (The) (PSI). 62,000 CAD. [Grants]

2008 Oct – 2009 Sep Principal Investigator. MRI derived cortical cerebral blood flow correlation with cognitive impairment. Mulitple Sclerosis Scientific Research Foundation. Collaborator(s): Aviv R, Feinstein A. 35,000 CAD. [Grants]

2008 Jul – 2011 Jun Co-Investigator. The Effect of IDO Activation and Lesion Characteristics on Depressive Symptoms Post Stroke. Heart and Stroke Foundation of Canada (HSFC). PI: Lanctôt KL. 286,198 CAD. [Grants]

2008 – 2013 Collaborator. Canadian Atherosclerosis Imaging Network (CAIN). Canadian Institutes of Health Research (CIHR). Collaborator(s): Tardif JC, Moody A, Spence D, Frayne R, Fenster A, Chow B, Friedrich M, Beanlands R, Rutt B, Black S. 10,000,000 CAD. [Grants]

2008 – 2011 Collaborator. An fMRI Study of the Neural and Clinical Implications of Pediatric Sports-Related Concussion. Canadian Institutes of Health Research (CIHR). PI: Keightley M. 335,910 CAD. [Grants]

2008 – 2010 Co-Investigator. The spot sign for predicting and treating ICH growth study (STOP-IT STUDY): A US and Canadian Collaborative application. SPOTRIAS (NINDS-funded). PI: Flaherty M. 2,143,287 CAD. [Grants]

2008 – 2009 Principal Investigator. Radiation reduction from an extended dynamic contrast enhanced CT protocol (CT Perfusion). Alternative Funding Plan. Phase III Innovation projects. 70,287 CAD. [Grants]

2006 Oct – 2007 Sep Principal Investigator. CT Permeability Imaging in Acute Stroke. Canadian Stroke Consortium (CSC). Collaborator(s): Aviv R, Lee T, Black S. 40,000 CAD. [Grants]
A prospective study of CT permeability in stroke as a predictor of intracranial hemorrhage.

2006 Oct – 2007 Sep Co-Investigator. Predicting Hematoma growth and outcome in Intracerebral hemorrhage using contrast bolus CT (PREDICT) study. Canadian Stroke Consortium (CSC). PI: Demchuck A. 40,000 CAD. [Grants]
A Prospective Cohort Study Evaluating Use of CT Bolus Studies in Predicting Hematoma Growth and Functional Outcome in Spontaneous Intracerebral Hemorrhage Patients Within 6 Hours of Symptom Onset.

2006 Jul – 2008 Jun Co-Investigator. The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression. Heart and Stroke Foundation of Canada (HSFC). Collaborator(s): Lanctôt KL, Herrmann N, Black SE, Sahlas DJ, Gladstone D, Ween JE, Aviv R. 108,715 CAD. [Grants]

2004 Sep – 2007 Mar Collaborator. The ABC- Database. Ministry of Health and long term care. PI: Ween J. 600,000 CAD. [Grants]
Collaborative development of a stroke and cognition assessment Battery.