Dilworth Lab

Jeff Dilworth profile picture

Contact Information

Jeff Dilworth, PhD
613-737-8899 ext. 70339

Jeff Dilworth

Senior Scientist, Regenerative Medicine Program
Ottawa Hospital Research Institute
Professor, Department of Cellular and Molecular Medicine
University of Ottawa
Professor (Cross-Appointed), Department of Medicine
University of Ottawa
Professor (Cross-Appointed), Department of Surgery
University of Ottawa

Research Interests

Epigenetic regulation of gene expression during mammalian development and regeneration

Brief Biography

Dr Jeff Dilworth received his PhD in 1997 from Queen's University (Kingston, ON) for his research with Dr Glenville Jones examining the metabolism of vitamin D analogs, and how the altered stability of the drugs changed their perceived biological activity in cultured cells. He then carried our his post-doctoral training with Professor Pierre Chambon at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (Strasbourg, France) where he established a chromatin-based in vitro transcription system to characterize the mechanisms through which retinoic acid activates gene expression. As a research associate working with Dr. Stephen Tapscott at the Fred Hutchinson Cancer Research Center (Seattle, WA), he used his background in transcription and epigenetics to begin exploring the mechanisms regulating developmental gene expression programs.

In 2004, Dr Dilworth joined the Regenerative Medicine Program at the Ottawa Hospital Research Institute where he is currently a Senior Scientist within the Sprott Center for Stem Cell Research. His research team works to understand the epigenetic mechanisms controlling cell fate decisions during muscle regeneration, and the role of DNA-bound transcription factors in directing epigenetic enzymes to specific genes for activation of cell-specific gene expression programs. Dr Dilworth also serves as the Chair (Basic Science) of the Research Task Force for the Canadian Neuromuscular Disease Network.

Selected Publications

H. Faralli, C. Wang, A. Benyoucef, S. Sebastian, L. Zhuang, A. Chu, C. Palii, C. Liu, B. Camellato, M. Brand, K. Ge, and F.J. Dilworth. H3K27-demethylase activity of UTX/KDM6A is essential for skeletal muscle regeneration. Journal of Clinical Investigation 126: 1555-1565, 2016.

K. Singh, M. Cassano, E. Planet, S.Sebastian, S.M. Jang, G. Sohi, J. Choi, H.D. Youn, F.J. Dilworth*, and D. Trono*. KAP1 functions as a phosphorylation-inducible activator of MyoD function during skeletal muscle differentiation. Genes & Dev 29: 513-525, 2015. *Co-corresponding authors

S. Sebastian, H. Faralli, Z. Yao, P. Rakopoulos, C. Palii, Y. Cao, K. Singh, Q-C. Liu, A. Chu, A. Aziz, M. Brand, S.J. Tapscott, and F.J. Dilworth. Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation. Genes & Dev 27: 1247-1259, 2013.

Q-C. Liu, X. Zha, H. Faralli, H. Yin, C. Louis-Jeune, E. Perdiguero, E. Pranckeviciene, P. Munoz-Canoves, M. Rudnicki, M. Brand, C. Perez-Iratxeta, and F.J. Dilworth. Comparative expression profiling identifies differential roles for Myogenin and p38a MAPK signaling in myogenesis. J Mol Cell Biol. 4 : 386-397, 2012.

S. Seenundun, S. Rampalli, Q-C. Liu, A. Aziz, C. Palii, S.H. Hong, A. Blais, M. Brand, K. Ge, F.J. Dilworth. UTX-mediated demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO Journal 29: 1401-1411, 2010.

S. Rampalli, L. Li, E. Mak, K. Ge, M. Brand, S.J. Tapscott, and F.J. Dilworth. p38 MAPK signaling pathway regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation. Nature Struct Mol Biol 14: 1150-1156, 2007.