Hsiao-Huei Chen profile picture

Contact Information

Hsiao-Huei Chen, PhD
6135625800x8133
hchen@uottawa.ca

Publications

Selected Publications

* Corresponding author.
1. Hari A, Cruz SA, Qin Z, Couture P, Vilmundarson RO, Huang H, Stewart AFR, Chen HH*. IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care. Scientific Reports. 2017, doi: 10.1038/s41598-017-10349-3
(Impact Factor = 4.8)

2. Cruz SA, Hari A, Qin Z, Couture P, Huang H, Lagace DC, Stewart AFR, Chen HH*. Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury. Frontiers in Cellular Neuroscience. 2017 Jul 19;11:201. doi: 10.3389/fncel.2017.00201 (Impact Factor = 4.6)

3.  Almontashiri NA, Antoine A, Zhou X, Vilmundarson R, Zhang S, Hao K, Chen HH*, Stewart AFR*. 9p21.3 coronary artery disease risk variants disrupt TEAD transcription factor binding and TEAD-dependent TGFβ regulation of p16 expression in human aortic smooth muscle cells. Circulation. 2015 Nov 24;132(21):1969-78.
(Impact Factor = 19)

#  Editorial by MacRae CA, Pollak MR. Effect size does matter: the long road to mechanistic insight from genome wide association. Circulation, 2015 Oct 20. pii: CIRCULATIONAHA.115.019306.
(Impact Factor = 19)

4.  Chen HH*, Keyhanian K, Zhou X, Vilmundarson R, Almontashiri NA, Cruz SA, Pandey NR, Yap NL, Ho T, Stewart CA, Huang H, Hari A, Geoffrion M, McPherson R, Rayner K, Stewart AFR.  IRF2BP2 in macrophages controls inflammation and susceptibility to diet-induced obesity and atherosclerosis. Circulation Research. 2015;117:671-683. DOI: 10.1161/CIRCRESAHA.114.305777.        
(Impact Factor = 14) 

#   Featured as a Cover of the issue. Circulation Research. 2015;117 (September 25).

#   Editorial by Zhang H, Reilly MP. IRF2BP2: A New Player at the Crossroads of Inflammation and Lipid Metabolism. Circulation Research. 2015;117:656-658. DOI: 10.1161/CIRCRESAHA.115.307245.
(Impact Factor = 14) 

5.  Qin Z, Zhou X, Pandey NR, Vecchiarelli HA, Stewart CA, Zhang X, Lagace DC, Brunel JC, Béïque JC, Stewart AFR, Hill MN, Chen HH*.  Chronic Stress Induces Anxiety via an Amygdalar Intracellular Cascade that Impairs Endocannabinoid Signalling. Neuron. 2015  Mar 18;85(6):1319-1331. doi:10.1016/j.neuron.2015.02.015. Epub 2015 Mar 5.        
(Impact Factor = 16.4)

#   Featured & Reviewed in: Krishnan N, Tonks NK. Anxious moments for the protein tyrosine phosphatase PTP1B. Trends Neurosci. 2015 Jul 9. pii: S0166-2236(15)00151-4. doi: 10.1016/j.tins.2015.06.006. Epub ahead of print 
(Impact Factor = 15.6)

#   Editorial pick of  Science Signaling 2015 Mar 20, 8 (369), pp. ec68. http://stke.sciencemag.org/content/8/369/ec68.abstract
(Impact Factor = 6.3)     

6.  Chen HH, Stewart AFR. Making sense of GWAS: Integrating genetic variation with gene expression to derive functional mechanisms underlying disease risk. Circulation. 2015 Feb 10;131(6):519-21. Epub 2014 Dec 22.

(Impact Factor = 19)


7. Almontashiri NAM, Chen HH, Mailloux RJ, Tatsuta T, Teng ACT, Mahmoud AB, Ho T, Stewart NAS, Rippstein P, Harper ME, Roberts R, Christina Willenborg6 and Jeanette Erdmann6 for the CARDIoGRAM, consortium, Pastore A, McBride H, Langer T, Stewart AFR. SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS and associates with multiple clinical phenotypes. Cell Reports. (2014) 7(3):834-47. 
(Impact Factor = 7.2)

8. Zaman T, Zhou X, Pandey NR, Qin Z, Keyhanian K, Wen K, Courtney R, Stewart AFR, Chen HH*. LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia. Journal of Neuroscience. 34(1):140-8 (2014). 
(Impact Factor = 7.9)

9. Pandey NR, Zhou X, Qin Z, Zaman T, Gomez-Smith M, Kayhanin K, Anisman H, Brunel JM , Stewart AFR, Chen HH*. LMO4 is a metabolic responsive inhibitor of PTP1B that controls hypothalamic leptin signaling. Journal of Neuroscience. 33(31):12647-55 (2013). 
(Impact Factor = 7.9)

10. Qin Z, Zhou X, Gomez-Smith M, Pandey NR, Lee KF, Lagace DC, Béïque J-C, Chen HH*. LMO4 regulates calcium-induced calcium release and synaptic plasticity in the hippocampus. Journal of Neuroscience. 32(12):4271-83 (2012).
(Impact Factor = 7.9)

11. Teng AC, Almontashiri NAM, Cheng BLM, Lou P, Ozmizrak P, Chen HH, Stewart AFR. Identification of a Phosphorylation-dependent Nuclear Localization Motif in Interferon Regulatory Factor 2 Binding Protein 2. PLos ONE. 6(8):e24100 (2011).
(Impact Factor = 4.5)

12. Qin Z, Pandey NR, Zhou X, Stewart CA, Hari A, Huang H, Stewart AFR, Brunel JM, Chen HH*. Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound. Biochem Biophys Res Commun. 2015 Jan 23. pii: S0006-291X(15)00062-5. doi: 10.1016/j.bbrc.2015.01.040. Epub ahead of print 
(Impact Factor = 2.8) 


13. Pandey NR, Zhou X, Zaman T, Cruz SA, Qin Z, Lu M, Keyhanian K, Brunel JM, Stewart AFR, Chen HH*. LMO4 is required to maintain hypothalamic insulin signaling. Biochem Biophys Res Commun. (2014) 450(1):666-72. 
(Impact Factor = 2.8)

14. Almontashiri NAM, Ghasemzadeh N, Roberts R, Quyyumi AA, Chen HH*, Stewart AFR*. Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies. PLos ONE, (2014) 9(9):e106294.
(Impact Factor = 4.5)

15. Chen HH, Almontashiri N, Antoine D, Stewart AFR. (2014) Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion? Curr Cardiol Rep. 2014 Jul;16(7):502. doi: 10.1007/s11886-014-0502-7.

16. Almontashiri NAM, Fan M, Cheng B, Chen HH, Roberts R, Stewart AFR. Interferon gamma activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype. The Journal of the American College of Cardiology,  61(2):143-7 (2013). 
(Impact Factor = 14.2)

17. Zhou X, Gomez-Smith M, Qin Z, Duquette PM, Rai PS, Cardenas-Blanco A, Harper M-E, Tsai E, Anisman H, Chen HH*. Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism. Cellular & Molecular Life Sciences,(2012) 69(5):819-28.
(Impact Factor = 6.6)

18. Duquette PM, Zhou X, Yap NL, MacLaren EJ, Lu JJ, Wallace VA, Chen HH*. Loss of LMO4 in the Retina Leads to Reduction of GABAergic Amacrine Cells and Functional Deficits. PLoS ONE, 5(10):e13232 (2010).
(Impact Factor = 4.5)

19. Teng A, Kuraitis D, Dugan S, Belanger MI, Cheng B, Crowson M, Guo X, Burgon PG, Suuronen EJ, Chen HH, Stewart, AF. IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression. FASEB J. 24(12):4825-34 (2010).
(Impact Factor = 6.3)

20. Gomez-Smith M, Qin Z, Zhou X, Schock SC, Chen HH*. LIM domain only 4 protein promotes granulocyte colony stimulating factor-induced signaling in neurons. Cellular & Molecular Life Sciences. 67(6):949-57 (2010).
(Impact Factor = 7.0)

21. Schock SC, Xu J, Duquette PM, Qin Z, Rai PS, Lewandowski AJ, Thompson CS, Seifert EL, Harper M, Chen HH*. Rescue of neurons from ischemic injury by PPARγ requires a novel essential cofactor LMO4. Journal of Neuroscience. 28: 12433-12444 (2008).
(Impact Factor = 8.1)

22. Chen HH*, Schock SC, Xu J, Safarpour F, Thompson CS, Stewart AF. Extracellular ATP-dependent upregulation of the transcription cofactor LMO4 promotes neuron survival from hypoxia. Experimental Cell Research. 313: 3106-16 (2007).
(Impact Factor = 3.9)

23. Chen HH*, Xu J, Safarpour F, Stewart AFR. LMO4 mRNA stability is regulated by extracellular ATP in F11 cells. Biochem Biophys Res Commun. 357: 56-61 (2007).
(Impact Factor = 2.8)

24. Chen HH, Stewart AF. (2007)  Characterization of Cardiac Gene Promoter Activity: Reporter Constructs and Heterologous Promoter Studies. Methods Mol Biol (2007) 366:217-25. 

25. Chen HH, Mullett SJ, Stewart AFR. Vgl-4, a novel member of the Vestigial-like family of transcription cofactors, regulates a1-adrenergic activation of gene expression in cardiac myocytes. Journal of Biological Chemistry. 279:30800-30806 (2004).
(Impact Factor = 6.3)

26. Chen HH, Maeda T, Mullett SJ, Stewart AFR. The transcription cofactor Vgl-2 is required for skeletal muscle differentiation. Genesis. 39: 273-279 (2004).
(Impact Factor = 2.8)

27. Chen HH, Baty C, Maeda T, Saba S, Ueyama T, Brooks S, Baker LC, Gursoy E, Salama G, London B, and Stewart AFR. Transcription Enhancer Factor-1-Related Factor-Transgenic Mice Develop Cardiac Conduction Defects Associated With Altered Connexin Phosphorylation. Circulation. 110, 2980-2987 (2004).
(Impact Factor = 15.3)

28. MacGowan GA, Evans C, Hu TCC, Debrah D, Mullett S, Chen HH, McTiernan C, Stewart AFR, Koretsky AP, and Schroff SG. Troponin I protein kinase C phosphorylation sites and ventricular function. Cardiovascular Research. 63: 245-255 (2004).
(Impact Factor = 4.5)

29. Chen HH, Arber, S., and Frank, E.  (2003).  Development of the monosynaptic stretch reflex circuit. Cur. Opinion in Neurobiol. 13, 96-102.
(Impact Factor = 7.6)

30. Chen HH, Tourtellotte WG and Frank E. Muscle spindle-derived neurotrophin 3 (NT3) regulates synaptic connectivity between muscle sensory and motor neurons. Journal of Neuroscience. 23: 3512-3519 (2002).
(Impact Factor = 8.0)

31. Maeda T, Sepulveda J, Chen HH, and Stewart AFR. α1-Adrenergic activation of the cardiac ankyrin repeat protein gene in cardiac myocytes. Gene. 297: 1-9. (2002)
(Impact Factor = 2.8)

32. Chen HH, Yip JW, Stewart, AFR and Frank E. Differential expression of a transcription regulatory factor, the LIM-domain only 4 protein LMO4, in muscle sensory neurons. Development. 129: 4879-4889 (2002).
(Impact Factor = 7.9)

33. Chen HH, and Frank, E.  (1999).  Development and specification of muscle sensory neurons.  Cur. Opinion in Neurobiol.  9, 405-409. 
(Impact Factor = 7.6)

34. Chen HH, Mack LM, Choi SY, Ontell M, Kochanek S. and Clemens PR. DNA from both high-capacity and first-generation adenoviral vectors remains intact in skeletal muscle. Hum. Gene Therapy. 10: 365-373 (1999).
(Impact Factor = 5.8)

35. Stewart AFR, Suzow J, Kubota T, Ueyama T, and Chen HH. Transcription Factor RTEF-1 Mediates ?1-Adrenergic Reactivation of the Fetal Gene Program in Cardiac Myocytes. Circulation Research. 83: 43-49 (1998).
(Impact Factor = 9.2)

36. Chen HH, Mack LM, Kelly R, Ontell M, Kochanek S and Clemens PR. Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc. Natl. Acad. Sci. USA. 94:1645-1650 (1997).
(Impact Factor = 10.9)

37. Clemens PR, Kochanek S, Sunada Y, Chan S, Chen HH, Campbell KP and Caskey CT. In vivo muscle gene transfer of full-length dystrophin with an adenoviral vector that lacks all viral genes. Gene Therapy. 3: 965-972. (1996).
(Impact Factor = 5.9)

38. Kochanek S, Clemens PR, Mitani K, Chen HH, Chan S and Caskey CT. A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and b-galactosidase. Proc. Natl. Acad. Sci. USA. 93: 5731-5736 (1996),
(Impact Factor = 10.9)

39. Grubman MJ, Piccone ME, Chen HH and Roos RP. Construction of a chimeric Theiler''''s murine encephalomyelitis virus containing the Lb gene of foot-and-mouth disease virus. Virology. 226: 135-139 (1996).
(Impact Factor = 3.2)

40. Chen HH, Kong WP, and Roos RP. The leader peptide of Theiler''''''''s murine encephalomyelitis virus is a zinc-binding protein. J. Virol. 69: 8076-8078 (1995. 
(Impact Factor = 3.6)

41. Chen HH, Kong WP, Ward PL and Roos RP. A picornaviral protein synthesized out of frame with the polyprotein plays a role in a virus-induced immune-mediated demyelinating disease. Nature Medicine. 1: 927-931 (1995).
(Impact Factor = 27.9)

PubMed Listings

For more publications use this PubMed ID link.