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Senior Scientist and Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute
Professor, Department of Medicine and Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa
Canada Research Chair in Molecular Genetics
Scientific Director, Stem Cell Network
Howard Hughes Medical Institute International Research Scholar
Research Interests
Stem Cells, Myogenesis, Embryogenesis, Molecular Biology, Transcriptional Regulation, Transcriptional Networks, Gene Expression, Cell Cycle, Cell Differentiation, Molecular Genetics.
Biographical Sketch and Research Interests
Dr. Michael Rudnicki is a Senior Scientist and the Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research at the Ottawa Hospital Research Institute. He is a Professor in the Department of Medicine at the University of Ottawa. Dr. Rudnicki is the Scientific Director of the Canadian Stem Cell Network and the International Regulome Consortium.
Dr. Rudnicki received his Ph.D. at the University of Ottawa in 1988 with Dr. Michael McBurney where he examined the control of gene expression during embryonal carcinoma cell differentiation. Dr. Rudnicki trained at the post-doctoral level at the Massachusetts Institute of Technology in the Whitehead Institute with Dr. Rudolf Jaenisch. His post-doctoral studies involved the genetic dissection of the function of the MyoD-family of transcription factors by gene targeting. Dr. Rudnicki was appointed Assistant Professor at McMaster University in 1992. In 2000, he moved to Ottawa to join the Ottawa Hospital Research Institute.
Dr. Rudnicki is a Fellow of the Royal Society of Canada, he holds the Canada Research Chair in Molecular Genetics, and is an International Research Scholar of the Howard Hughes Medical Institute. He is an Associate Editor of Journal of Cell Biology and Cell Stem Cell, and has organized international research conferences as one of the founding directors of the Society for Muscle Biology. He holds operating grants from the National Institutes of Health, the Canadian Institutes of Health Research, the Muscular Dystrophy Association, and Genome Canada.
Dr Rudnicki's laboratory works to understand the molecular mechanisms that regulate the determination, proliferation, and differentiation of stem cells during embryonic development and during tissue regeneration. The lab has conducted extensive studies into both embryonic myogenesis and the function of stem cells in adult skeletal muscle. Towards this end, the lab employs molecular genetic and genomic approaches to determine the function and roles played by regulatory factors. They identified Pax7 as a transcription factor required for the specification of satellite cells, and identified Wnt signaling as playing an important role in the myogenic specification of adult stem cells. His research has been published in scientific journals that include Cell, Genes & Development, Nature Cell Biology and PLoS Biology.
Major Awards/Affiliations
National Cancer Institute of Canada Research Scientist Award (1993 - 1999).
Medical Research Council of Canada, Research Scholarship Award (1993, Declined)
Medical Research Council of Canada, Research Scientist Award (1999 - 2004).
Premier's Research Excellence Award (1999 - 2004).
Canada Research Chair in Molecular Genetics (2001 - 2008).
International Research Scholar of the Howard Hughes Medical Institute (2001 - present).
Fellow of the Royal Society of Canada (2006 - present).
Active Research Funding:
"Genomic analysis of Rb-family function in myogenesis"
Canadian Institutes of Health Research
10/01/04 - 09/30/09
"Genetic regulation of skeletal muscle repair"
National Institutes of Health, Operating Grant
04/01/2005-03/30/2010
"Molecular regulation of satellite cell function"
Muscular Dystrophy Association
01/01/05-12/31/07
"Cell therapy for muscular disease"
The Stem Cell Network
09/01/05-03/31/08
"Satellite stem cells from skeletal muscle for the treatment of
neuromuscular disease"
Canadian Institutes of Health Research
10/01/06 - 09/30/11
"Genomic investigation of transcriptional regulation in
embryonic stem cells"
Canadian Institutes of Health Research
10/01/06 - 09/30/11
"Defining the molecular determinants of myogenic commitment"
Howard Hughes Medical Institute International Research Scholar
01/01/07 - 12/30/11
Most Recent Publications (provided by The Ottawa Hospital Library Database)
Joe AW;Yi L;Natarajan A;Le GF;So L;Wang J;Rudnicki MA;Rossi FM;, (2010 Feb), Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis, Nat Cell Biol, Vol.12, Issue 2, 153-163 -> view abstract
Abou-Khalil R;Le GF;Pallafacchina G;Valable S;Authier FJ;Rudnicki MA;Gherardi RK;Germain S;Chretien F;Sotiropoulos A;Lafuste P;Montarras D;Chazaud B;, (2009 Sep 4), Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal, Cell Stem Cell, Vol.5, Issue 3, 298-309 -> view abstract
Le GF;Jones AE;Seale V;Scime A;Rudnicki MA;, (2009 Jun 5), Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells, Cell Stem Cell, Vol.4, Issue 6, 535-547 -> view abstract
Gillespie MA;Le GF;Scime A;Kuang S;von MJ;Seale V;Cuenda A;Ranish JA;Rudnicki MA;, (2009 Dec 28), p38-{gamma}-dependent gene silencing restricts entry into the myogenic differentiation program, Journal of Cell Biology, Vol.187, Issue 7, 991-1005 -> view abstract
Muro EM;McCann JA;Rudnicki MA;ndrade-Navarro MA;, (2009), Use of SNP-arrays for ChIP assays: computational aspects, Methods Mol Biol, Vol.567, 145-154 -> view abstract
Willemse L;Lyall D;Rudnicki M;, (2008 Sep), Catalyzing stem cell research, Regeneracion Medica, Vol.3, Issue 5, 761-764 -> view abstract
Parise G;McKinnell IW;Rudnicki MA;, (2008 May), Muscle satellite cell and atypical myogenic progenitor response following exercise, Muscle Nerve, Vol.37, Issue 5, 611-619 -> view abstract
Kuang S;Gillespie MA;Rudnicki MA;, (2008 Jan 10), Niche regulation of muscle satellite cell self-renewal and differentiation, Cell Stem Cell, Vol.2, Issue 1, 22-31 -> view abstract
McKinnell IW;Ishibashi J;Le Grand F;Punch VG;Addicks GC;Greenblatt JF;Dilworth FJ;Rudnicki MA;, (2008 Jan), Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex, Nature Cell Biology, Vol.10, Issue 1, 77-84 -> view abstract
Kuang S;Rudnicki MA;, (2008 Feb), The emerging biology of satellite cells and their therapeutic potential. [Review] [122 refs], Trends in Molecular Medicine, Vol.14, Issue 2, 82-91 -> view abstract
Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).
Lab Personnel
Mark Gillespie
Jonathan Smid
Vincent Punch
Pearl Campbell
Feodor Price
Negin Shahid
Vanessa Seale
Ban Al-Joubouri
Greg Addicks
Dr. Anthony Scime
Dr. Kazuki Kuroda
Dr. Iain McKinnell
Dr. Shihuan Kuang
Dr. Fabien Legrand
Dr. Yoichi Kawabe
Dr. Vahab Soleimani
Nancy Ringuette
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