Michael Rudnicki, OC, PhD, FRSC

mrudnicki@ohri.ca
Tel: (613) 739-6740
Fax: (613) 739-6294

Assistant:
Sandy Martino
smartino@ohri.ca
613-737 8899 ext. 76330

Senior Scientist and Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute

Professor, Department of Medicine and Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa

Canada Research Chair in Molecular Genetics

Scientific Director, Stem Cell Network

Research Interests

Stem Cell Biology, Myogenesis, Satellite Cells, Molecular Biology, Transcriptional Regulation, Transcriptional Networks, Gene Expression, Signal Transduction, Differentiation, Molecular Genetics.

Biographical Sketch and Research Interests

Dr. Michael Rudnicki is a Senior Scientist and the Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research at the Ottawa Hospital Research Institute. He is Professor in the Department of Medicine at the University of Ottawa. Dr. Rudnicki is the Scientific Director of the Canadian Stem Cell Network. Dr. Rudnicki is an Officer of the Order of Canada, a Fellow of the Royal Society of Canada, and holds the Canada Research Chair in Molecular Genetics. He is an Associate Editor of Cell Stem Cell and the Journal of Cell Biology, and is Co-Editor in Chief of Skeletal Muscle. He has organized international research conferences as one of the founding directors of the Society for Muscle Biology.
Dr Rudnicki's laboratory works to understand the molecular mechanisms that regulate the determination, proliferation, and differentiation of stem cells during embryonic development and during tissue regeneration. The lab has conducted leading studies into both embryonic myogenesis and the function of muscle stem cells (satellite cells) in adult regenerative myogenesis. In particular, they have worked extensively to understand the molecular mechanisms that regulate the function of satellite cells in skeletal muscle. Towards this end, the lab employs molecular genetic and genomic approaches to determine the function and roles played by regulatory factors. They identified Pax7 as a transcription factor required for the specification of satellite cells, and identified Wnt7a signaling as playing an important role in muscle stem cell function. His research has been published in scientific journals that include Cell, Nature Cell Biology, Cell Stem Cell, Genes & Development, and PLoS Biology.


Satellite stem cells undergoing a symmetric division on a cultured myofiber

Selected  Publications

  1. Megeney, L.A., Kablar, B., Garrett, K., Anderson, J.E., and Rudnicki, M.A. (1996). MyoD is required for myogenic stem cell function in adult skeletal muscle. Genes Dev. 10: 1173-1183.
  2. Seale, P., Sabourin, L.A., Girgis-Gabardo, A., Mansouri, A., Gruss, P., and Rudnicki, M.A. (2000). Pax7 is required for the specification of myogenic satellite cells. Cell 102: 777-786.
  3. Polesskaya, A., Seale, P., and Rudnicki, M.A. (2003). Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell 113:841-852.
  4. Kuang, S. Charge, S.B., Seale, P., Huh, M., and Rudnicki, M.A. (2006). Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J. Cell Biol. 172:103-113.
  5. Kuang., K., Kuroda, K.,, Le Grand, F., and Rudnicki, M.A. (2007). Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell 129(5):999-1010.
  6. McKinnell, I.W., Ishibashi, J., Greenblatt, Le Grand, F., Punch, V.J.G., Addicks, G.C., Jack F Greenblatt, J.F., Dilworth, F.J., and Rudnicki, M.A. (2008). Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex. Nature Cell Biology 10(1):77-84.
  7. Le Grand, F., Scimè, A., Jones, A.E., and Rudnicki, M.A. (2009). The planar cell polarity pathway regulates the symmetric expansion of satellite stem cells . Cell Stem Cell 4(6):535-547.
  8. von Maltzahn, J., Bentzinger, C.F., and Rudnicki, M.A. (2011). Non-canonical Wnt7a/Fzd7 signalling activates the Akt/mTor anabolic growth pathway in skeletal muscle. Nature Cell Biology 14(2):186-191.
  9. Soleimani, V.D., Yin, H., Jahani-Asl, A., Ming, H., Kockx, C.E.M., van IJcken, W.F.J., Grosveld, F., and Rudnicki, M.A. (2012) Snail regulates MyoD binding-site occupancy to direct enhancer switching and differentiation-specific transcription in myogenesis.  Molecular Cell 47(3):457-68.
  10. Kawabe, Y., Wang, Y.X., McKinnell, I.W., Bedford, M.T., and Rudnicki, M.A. (2012) Carm1 regulates activation of transcription by Pax7 through asymmetric satellite stem cell divisions. Cell Stem Cell 11(3):333-45.
Most Recent Publications (provided by The Ottawa Hospital Library Database)

Bentzinger CF;Rudnicki MA;, (2014 Mar 4), Rejuvenating aged muscle stem cells, Nat Med, Vol.20, Issue 3, 234-235

vonMaltzahn J.;Jones AE;Parks RJ;Rudnicki MA;, (2013 Oct 8), Pax7 is critical for the normal function of satellite cells in adult skeletal muscle, Proc Natl Acad Sci U S A, Vol.110, Issue 41, 16474-16479 -> view abstract

vonMaltzahn J.;Zinoviev R;Chang NC;Bentzinger CF;Rudnicki MA;, (2013 Nov 29), A truncated Wnt7a retains full biological activity in skeletal muscle, Nat Commun, Vol.4, 2869 -> view abstract

Bentzinger CF;Wang YX;Dumont NA;Rudnicki MA;, (2013 Nov 15), Cellular dynamics in the muscle satellite cell niche, EMBO Rep, Vol.14, Issue 12, 1062-1072 -> view abstract

Wang YX;Bentzinger CF;Rudnicki MA;, (2013 May), Treating muscular dystrophy by stimulating intrinsic repair, Regen Med, Vol.8, Issue 3, 237-240

Campbell PA;Rudnicki MA;, (2013 Mar 14), Oct4 Interaction with Hmgb2 Regulates Akt Signaling and Pluripotency, Stem Cells, Vol.31, Issue 6, 1107-1120 -> view abstract

Bentzinger CF;Wang YX;von MJ;Soleimani VD;Yin H;Rudnicki MA;, (2013 Jan 3), Fibronectin regulates Wnt7a signaling and satellite cell expansion, Cell Stem Cell, Vol.12, Issue 1, 75-87 -> view abstract

Wang YX;Bentzinger CF;Rudnicki MA;, (2013 Jan 1), Molecular regulation of determination in asymmetrically dividing muscle stem cells, Cell Cycle, Vol.12, Issue 1, 3-4

Yin H;Price F;Rudnicki MA;, (2013 Jan), Satellite cells and the muscle stem cell niche, Physiol Rev, Vol.93, Issue 1, 23-67 -> view abstract

Neuwirt H;Eder IE;Puhr M;Rudnicki M;, (2013 Jan), SOCS-3 is downregulated in progressive CKD patients and regulates proliferation in human renal proximal tubule cells in a STAT1/3 independent manner18, Lab Invest, Vol.93, Issue 1, 123-134 -> view abstract

Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).

Current Lab Members

Gregory Addicks – PhD candidate
Alessandra Pasut – PhD candidate
Yu Xin (Will) Wang – PhD candidate
William Chen - MSc candidate
Natasha Chang – Postdoctoral fellow
Jose Manuel Hernandez Hernandez - Postdoctoral Fellow
Nicolas Dumont - Postdoctoral fellow Melanie Lacaria – Postdoctoral fellow
Marie-Claude Sincennes – Postdoctoral fellow
Johnathan Smid – Postdoctoral fellow
Sharlene Faulkes – Research Associate
Hong Ming - Technician
Jennifer Ritchie - Technician
David Wilson - Technician
Fan Xiao – Technician