Michael Rudnicki, PhD, FRSC
Tel: (613) 739-6740
Fax: (613) 739-6294
613-737 8899 ext. 76330
Senior Scientist and Director of the Regenerative Medicine Program and the
Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute
Professor, Department of Medicine and Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa
Canada Research Chair in Molecular Genetics
Scientific Director, Stem Cell Network
Stem Cell Biology, Myogenesis, Satellite Cells, Molecular Biology, Transcriptional Regulation, Transcriptional Networks, Gene Expression, Signal Transduction, Differentiation, Molecular Genetics.
Biographical Sketch and Research Interests
Dr. Michael Rudnicki is a Senior Scientist and the Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research at the Ottawa Hospital Research Institute. He is Professor in the Department of Medicine at the University of Ottawa. Dr. Rudnicki is the Scientific Director of the Canadian Stem Cell Network. Dr. Rudnicki is a Fellow of the Royal Society of Canada, and holds the Canada Research Chair in Molecular Genetics. He is an Associate Editor of Cell Stem Cell and the Journal of Cell Biology, and is Co-Editor in Chief of Skeletal Muscle. He has organized international research conferences as one of the founding directors of the Society for Muscle Biology.
Dr Rudnicki's laboratory works to understand the molecular mechanisms that regulate the determination, proliferation, and differentiation of stem cells during embryonic development and during tissue regeneration. The lab has conducted leading studies into both embryonic myogenesis and the function of muscle stem cells (satellite cells) in adult regenerative myogenesis. In particular, they have worked extensively to understand the molecular mechanisms that regulate the function of satellite cells in skeletal muscle. Towards this end, the lab employs molecular genetic and genomic approaches to determine the function and roles played by regulatory factors. They identified Pax7 as a transcription factor required for the specification of satellite cells, and identified Wnt7a signaling as playing an important role in muscle stem cell function. His research has been published in scientific journals that include Cell, Nature Cell Biology, Cell Stem Cell, Genes & Development, and PLoS Biology.
Satellite stem cells undergoing a symmetric division on a cultured myofiber
- Megeney, L.A., Kablar, B., Garrett, K., Anderson, J.E., and Rudnicki,
M.A. (1996). MyoD is required for myogenic stem cell function in adult
skeletal muscle. Genes Dev. 10: 1173-1183.
- Seale, P., Sabourin, L.A., Girgis-Gabardo, A., Mansouri, A., Gruss, P., and
Rudnicki, M.A. (2000). Pax7 is required for the specification
of myogenic satellite cells. Cell 102: 777-786.
- Polesskaya, A., Seale, P., and Rudnicki, M.A. (2003). Wnt
signaling induces the myogenic specification of resident CD45+ adult stem cells
during muscle regeneration. Cell 113:841-852.
- Kuang, S. Charge, S.B., Seale, P., Huh, M., and Rudnicki, M.A.
(2006). Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J.
Cell Biol. 172:103-113.
- Kuang., K., Kuroda, K.,, Le Grand, F., and Rudnicki, M.A.
(2007). Asymmetric self-renewal and commitment of satellite stem cells in
muscle. Cell 129(5):999-1010.
- McKinnell, I.W., Ishibashi, J., Greenblatt, Le Grand, F., Punch, V.J.G.,
Addicks, G.C., Jack F Greenblatt, J.F., Dilworth, F.J., and Rudnicki,
M.A. (2008). Pax7 activates myogenic genes by recruitment of a histone
methyltransferase complex. Nature Cell Biology 10(1):77-84.
- Le Grand, F., Scimè, A., Jones, A.E., and Rudnicki, M.A.
(2009). The planar cell polarity pathway regulates the symmetric expansion of
satellite stem cells . Cell Stem Cell 4(6):535-547.
- von Maltzahn, J., Bentzinger, C.F., and Rudnicki, M.A. (2011).
Non-canonical Wnt7a/Fzd7 signalling activates the Akt/mTor anabolic growth
pathway in skeletal muscle. Nature Cell Biology 14(2):186-191.
- Soleimani, V.D., Yin, H., Jahani-Asl, A., Ming, H., Kockx, C.E.M., van IJcken,
W.F.J., Grosveld, F., and Rudnicki, M.A. (2012) Snail regulates
MyoD binding-site occupancy to direct enhancer switching and
differentiation-specific transcription in myogenesis. Molecular Cell
- Kawabe, Y., Wang, Y.X., McKinnell, I.W., Bedford, M.T., and Rudnicki, M.A. (2012) Carm1 regulates activation of transcription by Pax7 through asymmetric satellite stem cell divisions. Cell Stem Cell 11(3):333-45.
Wang YX;Bentzinger CF;Rudnicki MA;, (2013 May), Treating muscular dystrophy by stimulating intrinsic repair, Regen Med, Vol.8, Issue 3, 237-240
Campbell PA;Rudnicki MA;, (2013 Mar 14), Oct4 Interaction with Hmgb2 Regulates Akt Signaling and Pluripotency, Stem Cells, Vol.31, Issue 6, 1107-1120 -> view abstract
Bentzinger CF;Wang YX;von MJ;Soleimani VD;Yin H;Rudnicki MA;, (2013 Jan 3), Fibronectin regulates Wnt7a signaling and satellite cell expansion, Cell Stem Cell, Vol.12, Issue 1, 75-87 -> view abstract
Wang YX;Bentzinger CF;Rudnicki MA;, (2013 Jan 1), Molecular regulation of determination in asymmetrically dividing muscle stem cells, Cell Cycle, Vol.12, Issue 1, 3-4
Yin H;Price F;Rudnicki MA;, (2013 Jan), Satellite cells and the muscle stem cell niche, Physiol Rev, Vol.93, Issue 1, 23-67 -> view abstract
Neuwirt H;Eder IE;Puhr M;Rudnicki M;, (2013 Jan), SOCS-3 is downregulated in progressive CKD patients and regulates proliferation in human renal proximal tubule cells in a STAT1/3 independent manner18, Lab Invest, Vol.93, Issue 1, 123-134 -> view abstract
Yin H;Pasut A;Soleimani VD;Bentzinger CF;Antoun G;Thorn S;Seale P;Fernando P;van IW;Grosveld F;Dekemp RA;Boushel R;Harper ME;Rudnicki MA;, (2013 Feb 5), MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16, Cell Metab, Vol.17, Issue 2, 210-224 -> view abstract
Pasut A;Jones AE;Rudnicki MA;, (2013), Isolation and Culture of Individual Myofibers and their Satellite Cells from Adult Skeletal Muscle, J Vis Exp, Vol.22, Issue 73, e50074 -> view abstract
Parker MH;von MJ;Bakkar N;Al-Joubori B;Ishibashi J;Guttridge D;Rudnicki MA;, (2013), Retraction: MyoD-dependent regulation of NF-kappaB activity couples cell-cycle withdrawal to myogenic differentiation, Skelet Muscle, Vol.3, Issue 1, 15
Bentzinger CF;Wang YX;von MJ;Rudnicki MA;, (2013), The emerging biology of muscle stem cells: Implications for cell-based therapies, Bioessays, Vol.35, Issue 3, 231-241 -> view abstract
Current Lab Members
Gregory Addicks PhD candidate
Andrew Jones PhD candidate
Alessandra Pasut PhD candidate
Yu Xin (Will) Wang PhD candidate
Florian Bentzinger Postdoctoral fellow
Natasha Chang Postdoctoral fellow
Nicolas Dumont - Postdoctoral Fellow
Melanie Lacaria Postdoctoral fellow
Marie-Claude Sincennes Postdoctoral fellow
Johnathan Smid Postdoctoral fellow
Vahab Soleimani Postdoctoral fellow
Julia von Maltzahn Postdoctoral fellow
Hang Yin Postdoctoral fellow
Sharlene Faulkes Research Associate
Hong Ming - Technician
Jennifer Ritchie - Technician
David Wilson - Technician
Fan Xiao Technician