Find a clinical trial at The Ottawa Hospital

Clinical trials are used to determine the safety and effectiveness of treatments, devices and procedures. Participating in a clinical trial may or may not benefit you personally, but it will contribute to new knowledge that will help others.

How to use the tool:

  • Search for studies by disease or condition.
  • Bring what you find to your next appointment with your care team and ask them if you are eligible for the study.
  • If your care team think you may be eligible, you can ask them to refer you to the study team.

Please note:

  • We cannot guarantee a response from the person listed in the ‘Contact’ column. For best results, bring the information you find to your next appointment with your care team.
  • Information in this table comes from ClinicalTrials.gov, a resource provided by the U.S. National Library of Medicine, and is only available in English.


NCTTitleConditionStatusContact
NCT03787589Exercise in Patients With End Stage Kidney Disease (NCT03787589)Renal FailureRECRUITING 
NCT06067789The ALOFT Pilot Trial (NCT06067789)Vascular Diseases, Peripheral Artery Disease, SurgeryRECRUITINGemhladkowicz@toh.ca
NCT06042491The STRIVE Before Surgery Pilot Trial (NCT06042491)Surgery-Complications, Disability PhysicalRECRUITINGkbranje@ohri.ca
NCT05993013Improving Strength and Balance Through Exercise With LudoFit (NCT05993013)Accidental FallsRECRUITINGshhuang@toh.ca; tmackenzie@toh.ca
NCT05762601Cellular precOnditioning for Post-Surgical Myocardial Ischemic Complications - Observational Study (NCT05762601)Cardiac Complication, Myocardial Infarction, Myocardial Ischemia, Myocardial InjuryRECRUITING 
NCT05733416Intensive Cancer Screening After Cryptogenic Stroke (NCT05733416)Occult CancerRECRUITINGmdemetrof@ohri.ca
NCT05601427Intra-Operative Adductor Canal Blocks (NCT05601427)Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, AnesthesiaRECRUITINGshenke@ohri.ca
NCT05264285Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients (NCT05264285)Acute Kidney Injury (AKI)RECRUITINGiwatpool@toh.ca
NCT04754061PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL) (NCT04754061)Depression, Anxiety, Distress, EmotionalRECRUITINGjdownar@toh.ca
NCT04744675Peripheral Nerve Injections for CRPS (NCT04744675)Complex Regional Pain SyndromesRECRUITING 
NCT05173155Comparison of Direct Anterior Approach vs. Lateral Hemiarthroplasty for Femoral Neck Fracture Repair (NCT05173155)Hip FracturesRECRUITINGihorton@ohri.ca
NCT05169112Impact of Hormonal Therapy on Prostate Cancer Recurrence After Radical Prostatectomy (NCT05169112)Prostate CancerRECRUITINGpjuneau@ohri.ca
NCT05149911Effect of a Life Coaching Intervention on the Well-being and Distress of Physicians (NCT05149911)Distress, Emotional, BurnoutRECRUITINGsboet@toh.on.ca
NCT04921137Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer (NCT04921137)Breast CancerRECRUITINGmsavard@toh.ca
NCT04871412The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage II (NCT04871412)Lung Cancer, Gastric Cancer, Esophageal CancerRECRUITINGafazekas@toh.ca
NCT04671862Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis (NCT04671862)Mucositis Oral, Head and Neck Cancer, Radiation DermatitisRECRUITINGmgaudet@toh.ca; krdennis@toh.ca
NCT04661787Donation Advisor Clinical Decision Support Tool Study (NCT04661787)Organ DonationRECRUITINGaseely@ohri.ca
NCT04392921Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation (NCT04392921)Atrial FibrillationRECRUITINGaseely@ohri.ca
NCT04705896Albumin To Enhance Recovery After Acute Kidney Injury (NCT04705896)Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical IllnessRECRUITINGiwatpool@ohri.ca; hlanglois@ohri.ca
NCT04105179How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response (NCT04105179)Osteoarthritis, Knee, Inflammation KneesRECRUITING 
NCT04080466Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA (NCT04080466)Hip Dysplasia, Femoroacetabular Impingement, OsteoarthritisRECRUITINGckreviazuk@ohri.ca
NCT03936127Comparison of a Novel Transperineal Targeted Fusion Biopsy System to Conventional Transrectal Targeted Fusion Biopsy (NCT03936127)Prostate CancerRECRUITINGnschieda@toh.ca; baschwarz@toh.ca
NCT03806114Dislocation Precautions (NCT03806114)Arthroplasty, Hip Replacement, Arthroplasties, Hip Replacement, Health-Related Quality Of LifeRECRUITINGjdobransky@ohri.ca
NCT03746925Comparing Short-term Outcomes After Direct Anterior and SuperPATH Hip Arthroplasty Approaches (NCT03746925)Arthroplasty, Replacement, HipRECRUITINGjdobransky@ohri.ca
NCT03713255Mid-point Transverse Process to Pleura Block for Breast Cancer Surgery: A Randomized Controlled Trial (NCT03713255)Breast Cancer, Acute Pain, AnesthesiaRECRUITING 
NCT03677713Nasal Packing Following Endoscopic Endonasal Pituitary Resection (NCT03677713)Pituitary TumorRECRUITINGalasso@toh.ca
NCT04824144Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care (NCT04824144)Hyperactive Delirium, Delirium of Mixed OriginRECRUITING 
NCT03100110NeuroCognitive Communicator: Safety Study (NCT03100110)Motor Neuron Disease, Amyotrophic Lateral Sclerosis, TetraplegiaRECRUITINGrdoole@ohri.ca
NCT02966886TSA Techniques in Glenohumeral OA (NCT02966886)Osteoarthritis, ShoulderRECRUITINGplapner@toh.on.ca
NCT04574960Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL) (NCT04574960)Bladder Cancer, Bladder Urothelial CarcinomaRECRUITINGpjuneau@ohri.ca
NCT05955924Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial (NCT05955924)Non-melanoma Skin Cancer, Carcinoma, Squamous Cell, Carcinoma, Basal Cell, Keratinocyte CarcinomaRECRUITING 
NCT05029063Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters (NCT05029063)Venous Thromboembolism, CancerRECRUITINGapecarskie@ohri.ca; madhill@ohri.ca
NCT05206747Ottawa Sunglasses at Night for Mania Study (NCT05206747)Mania, Sleep, Bipolar DisorderRECRUITINGjfiedorowicz@toh.ca
NCT00800059Total Marrow Irradiation & Autologous Stem Cell Transplantation for Relapsed or Refractory Myeloma (NCT00800059)Multiple MyelomaRECRUITINGhatkins@ohri.ca
NCT05255003STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis (NCT05255003)Cancer-associated Thrombosis, ThrombocytopeniaRECRUITINGjbrinkhurst@ohri.ca
NCT05969275Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock (NCT05969275)Septic Shock, Sepsis, Pathologic Processes, Shock, Systemic Inflammatory Response Syndrome, Inflammation, InfectionsRECRUITINGUCCISS@ohri.ca
NCT03175718INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients (NCT03175718)Soft-tissue Sarcoma, Wound ComplicationRECRUITINGyalmosuli@ohri.ca
NCT05496309Causes and Mechanisms of Space Hemolysis at High Altitudes (NCT05496309)Anemia, WeightlessnessRECRUITINGgtrudel@toh.ca
NCT05487274TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion (NCT05487274)Osteoarthritis ShoulderRECRUITINGkmcilquham@ohri.ca
NCT05093075Therapeutic Plasma Exchange in Septic Shock: A Pilot Study (NCT05093075)Septic ShockRECRUITING 
NCT05306327Neurologic Physiology After Removal of Therapy (NeuPaRT) (NCT05306327)Determination of DeathRECRUITING 
NCT05325177PDA Treatment With Ibuprofen and Changes in Tissue Oxygenation. (NCT05325177)Patent Ductus Arteriosus After Premature BirthRECRUITING 
NCT05781113A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition (NCT05781113)Multiple SclerosisRECRUITINGgabose@toh.ca
NCT05513560RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (NCT05513560)Long COVID, Post COVID Condition, Post Acute Sequelae of COVID-19RECRUITING 
NCT05019963Enhancing COVID Rehabilitation With Technology (NCT05019963)Covid19RECRUITINGkwells@ohri.ca
NCT04935866Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study (NCT04935866)Traumatic Brain Injury, Subarachnoid Hemorrhage, Brain Injuries, Near-Infrared Spectroscopy, Intensive Care Neurological Disorder, AnemiaRECRUITING 
NCT03809884Dietary Counseling or Potassium Supplement to Increase Potassium Intake in Patients With High Blood Pressure (NCT03809884)HypertensionRECRUITINGjbiggs@ohri.ca
NCT05309226Cannabis Use in Pregnancy and Downstream Effects on Maternal and Infant Health (NCT05309226)Cannabis Use, Marijuana UseRECRUITINGsramlawi@ohri.ca; alyharvey@ohri.ca
NCT05677113A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver (NCT05677113)Colorectal Cancer, Liver MetastasesRECRUITINGroleclerc@ohri.ca
NCT05892666The Right Care, for the Right Patient, at the Right Time, by the Right Provider: A Value-based Comparison of the Management of Ambulatory Patients With Acute Health Concerns in walk-in Clinics, Primary Care Physician Practices and Emergency Departments (NCT05892666)Ambulatory Care, Emergency Services, Hospital, Quality of Care, CostsRECRUITINGjperry@ohri.ca
NCT01799967Minimally Invasive Surgery of the Gastro-esophageal Junction (NCT01799967)Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula, Zenker's DiverticulumRECRUITING 
NCT05899101The Impact of Opioid and Cannabis Exposure on Fetal Growth (NCT05899101)Pregnancy Related, Substance Use, Fetal Growth Retardation, Placenta DiseasesRECRUITING 
NCT04180722Transition to LIVE (Long-term In Home Ventilation Engagement) Study (NCT04180722)Long-term Ventilation at HomeRECRUITINGdmckim@toh.on.ca
NCT02869802Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic Analysis (NCT02869802)Cancer, Pancreatic CancerRECRUITING 
NCT05851547Dose Escalation For INtraprostatic LEsions (NCT05851547)Prostatic NeoplasmsRECRUITINGsgrimes@ohri.ca
NCT05754528Evaluating an Endocrine Therapy Dose-frequency Escalation Strategy and Its Effects on Tolerability and Compliance (NCT05754528)Breast CancerRECRUITINGlvandermeer@ohri.ca
NCT05753618Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy (NCT05753618)Early-stage Breast CancerRECRUITINGlvandermeer@ohri.ca
NCT04228419TSA vs RSA in Glenohumeral Osteoarthritis (NCT04228419)Osteoarthritis of the ShoulderRECRUITING 
NCT05326334THERApeutic Outcomes Related to Gut microBIOME in Glioblastoma (GBM) Patients Receiving Chemo-radiation (THERABIOME-GBM) (NCT05326334)Glioblastoma, IDH-wildtypeRECRUITING 
NCT04928261Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy (NCT04928261)Breast CancerRECRUITINGlvandermeer@ohri.ca
NCT02281838The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II (NCT02281838)Intracerebral HemorrhageRECRUITINGddowlat@toh.on.ca
NCT04708509Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool (NCT04708509)Airway ExtubationRECRUITING 
NCT04549207Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer (NCT04549207)Breast Cancer, Castration-resistant Prostate CancerRECRUITING 
NCT05290857Anticoagulation After GI Bleeding Pilot Study and Registry (NCT05290857)GastroIntestinal Bleeding, Anticoagulant-induced BleedingRECRUITINGdsiegal@toh.ca
NCT05115617Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination Prospective Cohort Study (NCT05115617)SARS-CoV2 Infection, Covid19, Vaccine Reaction, Pregnancy Related, ImmunogenicityRECRUITINGsboyd@ohri.ca; alyharvey@ohri.ca
NCT04258475The Influence of Concurrent Oral Calcium Carbonate Supplementation on Steady State Pharmacokinetics of Oral Raltegravir. (NCT04258475)Calcium Supplementation in HIV Patients Using RaltegravirRECRUITINGnantremblay@toh.ca
NCT05954871Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer (NCT05954871)Colorectal Cancer, Non-Small Cell Lung CancerRECRUITING 
NCT05466838PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial (NCT05466838)Pancreatic InsufficiencyRECRUITING 
NCT03147859Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection (NCT03147859)HIV-infection/AIDSRECRUITINGbcameron@ohri.ca
NCT05078034HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT (NCT05078034)Acute Hypoxemic Respiratory FailureRECRUITINGaseely@toh.ca
NCT06168474Evaluating Simplified Layered Consent for Clinical Trials (NCT06168474)Staphylococcus Aureus BacteremiaRECRUITING 
NCT06043427Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma (NCT06043427)Gastroesophageal AdenocarcinomaRECRUITING 
NCT05096195PRevEnting FracturEs in REnal Disease 1 (NCT05096195)Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone DisorderRECRUITINGjudavis@toh.ca
NCT02236689Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement (NCT02236689)Tennis ElbowRECRUITING 
NCT05998642Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma (NCT05998642)Non-hodgkin LymphomaRECRUITING 
NCT04564079An Observational Study to Evaluate the Clinical Utility of the Oncomine Precision Assay Within the Exactis Network (NCT04564079)NSCLCRECRUITINGnatremblay@ohri.ca
NCT03663504Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (NCT03663504)Elective Colon SurgeryRECRUITING 
NCT04642430COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation (NCT04642430)Atrial FibrillationRECRUITINGlcastellucci@toh.ca; erithomas@toh.ca
NCT05804578Using a Blood Test to Monitor Metastatic Breast Cancer Treatment (NCT05804578)Metastatic Breast CancerRECRUITINGaawan@ohri.ca
NCT02975310In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps (NCT02975310)Sinusitis, Nasal PolypsRECRUITINGalasso@toh.ca
NCT05543941Evaluating XPERIENCEâ„¢ Advanced Surgical Irrigation (NCT05543941)Hip Osteoarthritis, Hip Arthritis, Knee Osteoarthritis, Knee ArthritisRECRUITINGshenke@ohri.ca
NCT05893147BALANCE+ Vanguard Phase (NCT05893147)Gram-negative BacteremiaRECRUITING 
NCT03765177CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies (NCT03765177)Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma, Chronic Lymphocytic LeukemiaRECRUITINGnkekre@toh.on.ca; vlopez@ohri.ca
NCT04624477Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer (NCT04624477)Papillary Thyroid Cancer, Papillary Thyroid Carcinoma, Papillary Microcarcinoma of the ThyroidRECRUITING 
NCT03481010Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology (NCT03481010)Hip DysplasiaRECRUITING 
NCT03715478Multi-Center Study of GSK2857916 in Combination With Pomalidomide and Dex (NCT03715478)Relapsed and/or Refractory Multiple MyelomaRECRUITING 
NCT04485195RAFF4 Trial: Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department (NCT04485195)Atrial FibrillationRECRUITINGistiell@ohri.ca; ericbrown@ohri.ca
NCT04224974Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia (NCT04224974)Acute LeukemiaRECRUITING 
NCT04624906Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia (NCT04624906)Waldenstrom MacroglobulinemiaRECRUITING 
NCT05395819Clinical Evaluation of Reverse Versus Anatomic Shoulder Arthroplasty Techniques in the Treatment of Osteoarthritis (NCT05395819)Shoulder OsteoarthritisRECRUITING 
NCT04543110Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC (NCT04543110)Bladder CancerRECRUITINGcaproulx@ohri.ca
NCT06129084A Study to Compare the Results of FGFR Testing by Either ctDNA Blood Testing or Standard Tumor Tissue Testing (NCT06129084)Metastatic Bladder Cancer, Metastatic Urothelial CarcinomaRECRUITINGsgrimes@toh.ca
NCT05605509RP-6306 in Patients With Advanced Cancer (NCT05605509)Advanced CancerRECRUITING 
NCT05101928Ozurdex Monotherapy Trial (NCT05101928)Uveitis, Posterior, Uveitis, Intermediate, PanuveitisRECRUITINGmmuir@ohri.ca
NCT05066347REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT (NCT05066347)SyncopeRECRUITINGpnguyen@ohri.ca
NCT05194072A Study of SGN-B7H4V in Advanced Solid Tumors (NCT05194072)Ovarian Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms, Triple Negative Breast Neoplasms, HER2 Negative Breast Neoplasms, Hormone Receptor Positive Breast Neoplasms, Endometrial Neoplasms, Carcinoma, Non-Small-Cell Lung, Cholangiocarcinoma, Gallbladder Carcinoma, Adenoid Cystic CarcinomaRECRUITING 
NCT05258578Tele-BARICARE to Manage COVID-19-Related Distress (NCT05258578)Obesity, Bariatric Surgery Candidate, Mental Health Disorder, Eating DisordersRECRUITINGdasandre@toh.ca
NCT04319627Statins for Venous Event Reduction in Patients With Venous Thromboembolism (NCT04319627)Venous Thromboembolism, Blood Clot, Post Thrombotic SyndromeRECRUITINGjbrinkhurst@ohri.ca
NCT05371808Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: (NCT05371808)Chronic Lymphocytic Leukemia, Small Lymphocytic LymphomaRECRUITING 
NCT04448184Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial) (NCT04448184)Hematologic NeoplasmsRECRUITINGatinmouth@ohri.ca
NCT04521413Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies (NCT04521413)Advanced Solid MalignanciesRECRUITING 
NCT05364749Selective CT for Anticoagulated Head Injured Patients (NCT05364749)Head Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Traumatic, Blunt Head InjuryRECRUITING 
NCT05601440Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer (NCT05601440)Breast CancerRECRUITING 
NCT04335292Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer With Osimertinib Third-line Rechallenge (NCT04335292)Non-Small Cell Lung CancerRECRUITING 
NCT04093167Study of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC (NCT04093167)Non-Small Cell Lung CancerRECRUITING 
NCT04874038Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) (NCT04874038)Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, ChronicRECRUITING 
NCT06204809Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants With Myotonic Dystrophy Type 1 (NCT06204809)Myotonic Dystrophy 1RECRUITING 
NCT03559114PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST) (NCT03559114)Traumatic Brain InjuryRECRUITINGrporteous@ohri.ca; smiezitis@ohri.ca
NCT05246098REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI (NCT05246098)Respiratory Disease, COVID-19, Viral InfectionRECRUITINGaseely@toh.ca
NCT04138706Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection (NCT04138706)Clostridium Difficile InfectionRECRUITINGmaidris@ohri.ca
NCT04580225Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE) (NCT04580225)Wrist Arthritis, Wrist Arthropathy, Scapholunate Advanced Collapse, Scaphoid Nonunion, Post-traumatic; Arthrosis, Arthritis, Musculoskeletal Diseases, Joint DiseasesRECRUITINGnagrawal@ohri.ca
NCT04548661Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (NCT04548661)Surgical Site InfectionRECRUITINGjaboukhalil@toh.ca
NCT04274530Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial (NCT04274530)Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed, Fractures, OpenRECRUITING 
NCT04415060SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival (NCT04415060)Covid19, Hypoxic Respiratory FailureRECRUITINGjhaines@toh.ca; iwatpool@toh.ca
NCT02960087Phase II High Dose Brachytherapy and Low Dose Rate Brachytherapy as Monotherapy in Localized Prostate Cancer (NCT02960087)Prostate CarcinomaRECRUITING 
NCT03948074Cannabis For Cancer-Related Symptoms (NCT03948074)Pain, Nausea, Anxiety, Sleep DisturbanceRECRUITINGsdownar@ohri.ca
NCT04260802A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802)Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder CancerRECRUITINGdjonker@toh.ca
NCT06078553A Natural History Study in Participants With DOK7 Congenital Myasthenic Syndromes (CMS) (NCT06078553)Congenital Myasthenic SyndromeRECRUITING 
NCT05707208A Randomized, Controlled Study of Repeat Dose Sustained Release Lidocaine for Treatment of Chronic Scrotal Pain (NCT05707208)Chronic PainRECRUITINGamanross@toh.ca
NCT02675569ACCESS HD: Comparing Catheters to Fistulas in Elderly Patients Starting Hemodialysis (NCT02675569)End-stage Kidney FailureRECRUITINGshiremath@toh.on.ca; jbiggs@ohri.ca
NCT02999022Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) (NCT02999022)FracturesRECRUITINGspapp@toh.ca; medodd@ohri.ca
NCT03297606Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (NCT03297606)Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid TumorsRECRUITING 
NCT05714891Neoadjuvant Platform Trial in Non-Small Cell Lung Cancer (NCT05714891)NSCLCRECRUITING 
NCT04812366Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer (NCT04812366)Prostate CancerRECRUITINGpjuneau@ohri.ca
NCT05428735The DRAGON 2 Trial (NCT05428735)Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR)RECRUITING 
NCT05795699A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD) (NCT05795699)Fuchs Endothelial Corneal DystrophyRECRUITING 
NCT05840224Study of GS-4528 in Adults With Solid Tumors (NCT05840224)Solid TumorRECRUITING 
NCT02906943Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943)Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary CancerRECRUITINGhanzhang@ohri.ca; kchristink@toh.ca
NCT03569826Canadian Network for Autoimmune Liver Disease (NCT03569826)Primary Bilary Cirrhosis (PBC), Autoimmune Hepatitis, Overlap SyndromeRECRUITINGangcheung@toh.ca; mmuir@toh.ca
NCT04304651Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism (NCT04304651)Embolism and ThrombosisRECRUITINGadelluc@toh.ca; mcarrier@toh.ca
NCT05809999IBD Neoplasia Surveillance RCT (NCT05809999)Colonic Neoplasms, Inflammatory Bowel Diseases, DysplasiaRECRUITING 
NCT04558593Surveillance of Complex Renal Cysts - The SOCRATIC Study (NCT04558593)Complex Renal CystRECRUITING 
NCT03419689Study Looking at Biomarkers in Ovarian Cancer (NCT03419689)Gynecologic CancerRECRUITINGjweberpals@toh.ca
NCT03718260PSMA-PET Registry for Recurrent Prostate Cancer (NCT03718260)Recurrent Prostate CancerRECRUITINGdyachnin@ohri.ca
NCT04609566Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors (NCT04609566)Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and NeckRECRUITING 
NCT02355171Personalize My Treatment (PMT) Registry (NCT02355171)CancerRECRUITINGnatremblay@ohri.ca
NCT04680442Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction (NCT04680442)Breast Cancer, Heart FailureRECRUITINGkelross@ohri.ca
NCT05180097Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma (NCT05180097)Hodgkin LymphomaRECRUITING 
NCT03847649A Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies (NCT03847649)CancerRECRUITING 
NCT05032196Study of WVE-003 in Patients With Huntington's Disease (NCT05032196)Huntington DiseaseRECRUITINGtanthompson@ohri.ca
NCT05487235A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05487235)Advanced Solid Tumors, Metastatic Solid TumorsRECRUITING 
NCT05481151A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV (NCT05481151)Polycythemia VeraRECRUITINGdmaassen@ohri.ca
NCT04182776Fragility Fractures of the Pelvis (FFP) (NCT04182776)Pelvic FractureRECRUITING 
NCT03838718REtroperitoneal SArcoma Registry: an International Prospective Initiative (NCT03838718)Retroperitoneal SarcomaRECRUITINGcnessim@toh.ca
NCT05114096Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) (NCT05114096)Preterm Birth, Premature Birth, Complication of Prematurity, Obstetric Labor, Premature, Pregnancy ComplicationsRECRUITING 
NCT03944798Surveillance AFter Extremity Tumor surgerY (NCT03944798)Soft Tissue Sarcoma, Lung MetastasesRECRUITING 
NCT06143046A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus in Pregnant Women and in Infants Born to Vaccinated Mothers (NCT06143046)Respiratory Syncytial VirusRECRUITING 
NCT05907304A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations (NCT05907304)Advanced or Metastatic Solid TumorsRECRUITING 
NCT05913687Automated Imaging Differentiation of Parkinsonism (NCT05913687)Parkinson Disease, Multiple System Atrophy, Parkinson Variant, Progressive Supranuclear PalsyRECRUITINGtanthompson@ohri.ca
NCT02436707Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma (NCT02436707)LymphomaRECRUITING 
NCT03449381This Study Aims to Find the Best Dose of BI 907828 (Brigimadlin) in Patients With Different Types of Advanced Cancer (Solid Tumors) (NCT03449381)NeoplasmsRECRUITING 
NCT04401475A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients With COVID-19 (NCT04401475)COVID-19, ARDSRECRUITING 
NCT05848713AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia (NCT05848713)Community-acquired PneumoniaRECRUITING 
NCT03636295Low INR to Minimize Bleeding With Mechanical Valves Trial (NCT03636295)Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve ReplacementRECRUITING 
NCT02632448A Study of LY2880070 in Participants With Advanced or Metastatic Cancer (NCT02632448)Solid Tumors, Colorectal Cancer, Breast Cancer, Ovarian Cancer, Colon Cancer, Rectal Cancer, Neoplasms, Endometrial Cancer, Soft Tissue Sarcoma, Triple Negative Breast Cancer, Pancreas Cancer, Pancreatic CancerRECRUITING 
NCT04633655International CIPN Assessment and Validation Study (NCT04633655)Chemotherapy-induced Peripheral Neuropathy, Quality of LifeRECRUITINGkrdennis@toh.ca
NCT03784755Local Ablative Therapy For Hormone Sensitive Oligometastatic Prostate Cancer (NCT03784755)Prostate Cancer MetastaticRECRUITING 
NCT03261102TDM Guided Early Optimization of ADAL in Crohn's Disease (NCT03261102)Crohn Disease, Drug Monitoring, Inflammatory Bowel DiseasesRECRUITINGmetessier@ohri.ca
NCT04635891Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) (NCT04635891)FSHDRECRUITINGjemacgregor@ohri.ca; szakutney@ohri.ca
NCT04449874A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874)Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid TumorsRECRUITING 
NCT04263038Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism (NCT04263038)Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases, Cardiovascular Diseases, Respiratory Tract Diseases, Venous Thromboembolism, Anticoagulant-induced Bleeding, BleedingRECRUITING 
NCT05571839A Study of SGN-BB228 in Advanced Melanoma and Other Solid Tumors (NCT05571839)Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, MesotheliomaRECRUITING 
NCT03778502DOAC in Unusual Site Venous Thrombosis (NCT03778502)Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis, Retinal Vein ThrombosisRECRUITING 
NCT04743765HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial (NCT04743765)Hip Fractures, Myocardial InjuryRECRUITING 
NCT02855476HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease (NCT02855476)Huntington's DiseaseRECRUITINGjading@toh.ca
NCT04853576A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY) (NCT04853576)Sickle Cell Disease, HemoglobinopathiesRECRUITING 
NCT05773274Comparing Retreatment of 177Lu-DOTATATE PRRT Versus Everolimus in Patients With Metastatic Unresectable Midgut Neuroendocrine Tumors, NET RETREAT Trial (NCT05773274)Metastatic Midgut Neuroendocrine Tumor, Metastatic Midgut Neuroendocrine Tumor G1, Metastatic Midgut Neuroendocrine Tumor G2, Unresectable Midgut Neuroendocrine TumorRECRUITING 
NCT05171049A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE (NCT05171049)Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary EmbolismRECRUITING 
NCT04035005A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (NCT04035005)Multiple Sclerosis, Primary ProgressiveRECRUITING 
NCT06179160A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation (NCT06179160)Solid TumorsRECRUITING 
NCT04151342CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS) (NCT04151342)Cancer, Malignancies Multiple, Malignant Solid Tumor, Cancer, Therapy-Related, Molecular Sequence Variation, Genetic Alteration, Gene Fusion, Receptor Tyrosine Kinase Gene Mutation, RTK Family Gene Mutation, Ras (Kras or Nras) Gene MutationRECRUITING 
NCT03266783Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism (NCT03266783)Venous ThromboembolismRECRUITINGlcastellucci@toh.ca; erithomas@toh.ca
NCT04683848Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury (NCT04683848)Spinal Cord InjuryRECRUITING 
NCT02821013Duration of Anti-PD-1 Therapy in Metastatic Melanoma (NCT02821013)Unresectable/Metastatic MelanomaRECRUITING 
NCT03674307Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates (NCT03674307)Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related ComplicationRECRUITINGerithomas@toh.ca; miricci@ohri.ca
NCT05730036A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma (NCT05730036)Relapsed Refractory Multiple Myeloma (RRMM)RECRUITING 
NCT05253651A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (NCT05253651)Colorectal NeoplasmsRECRUITING 
NCT05151172EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial) (NCT05151172)Acute Ischemic StrokeRECRUITINGmdemetrof@ohri.ca
NCT03573089Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE) (NCT03573089)Kidney Failure, Chronic, HyperphosphatemiaRECRUITINGshiremath@toh.ca
NCT04530123Dose-Ranging Study of the Efficacy and Safety of TAK-101 for Prevention of Gluten-Specific T Cell Activation in Participants With Celiac Disease on a Gluten-Free Diet (NCT04530123)Celiac DiseaseRECRUITINGrsy@toh.on.ca
NCT03975647A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer (NCT03975647)HER2-positive Breast CancerRECRUITING 
NCT05538130A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130)Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal CancerRECRUITING 
NCT04228991Hypofractionated LocoRegional Radiotherapy in Breast Cancer (NCT04228991)Breast Neoplasms, Radiotherapy, LymphedemaRECRUITING 
NCT02468024JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024)Non-Small Cell Lung CancerRECRUITINGsgilbert@toh.ca; afazekas@toh.ca
NCT04675294Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03) (NCT04675294)Head and Neck Cancer, Head and Neck Squamous Cell CarcinomaRECRUITING 
NCT05625412A Study of BMS-986360/CC-90001 Alone and in Combination With Chemotherapy or Nivolumab in Advanced Solid Tumors (NCT05625412)Advanced Solid TumorsRECRUITING 
NCT05775289A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer (NCT05775289)Non-small Cell Lung CancerRECRUITING 
NCT05581004A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05581004)Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma, TNBC, Esophageal Cancer, Gastric Cancer, Cervical Cancer, Urothelial Carcinoma, Clear Cell RCC, HCCRECRUITING 
NCT05376891Met Non Small Cell Cancer Registry (MOMENT) (NCT05376891)CancerRECRUITINGpwheatleyprice@toh.ca
NCT02735707Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (NCT02735707)Community-acquired Pneumonia, Influenza, COVID-19RECRUITING 
NCT05686070A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke (NCT05686070)Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke, High-risk Transient Ischemic AttackRECRUITING 
NCT03127631A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (NCT03127631)Prostate Cancer, Cardiovascular DiseaseRECRUITINGdyachnin@toh.ca
NCT01574053Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort (NCT01574053)Huntington's DiseaseRECRUITINGjading@toh.ca
NCT05171075A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE (NCT05171075)Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary EmbolismRECRUITING 
NCT05819359Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD (NCT05819359)Parkinson's DiseaseRECRUITING 
NCT05548127TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A) (NCT05548127)Breast CancerRECRUITING 
NCT03969953Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease (NCT03969953)Chronic Kidney Diseases, Dialysis-dependent Kidney Failure, Cardiovascular DiseaseRECRUITING 
NCT05355701A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701)Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, GliomaRECRUITING 
NCT03496883Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial (NCT03496883)Intracerebral HemorrhageRECRUITINGddowlat@toh.ca
NCT04895709A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors (NCT04895709)Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast NeoplasmsRECRUITING 
NCT05573555TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) (NCT05573555)Breast CancerRECRUITING 
NCT05257083A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (NCT05257083)Multiple MyelomaRECRUITING 
NCT05696626Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation (NCT05696626)Metastatic Breast CancerRECRUITING 
NCT04477785PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort (NCT04477785)Parkinson DiseaseRECRUITING 
NCT05090566MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma (NCT05090566)Multiple MyelomaRECRUITING 
NCT05650632A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma (NCT05650632)Multiple MyelomaRECRUITING 
NCT06084936A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma (NCT06084936)LymphomaRECRUITING 
NCT05430971Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry (NCT05430971)Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)RECRUITING 
NCT03020303Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease (NCT03020303)Endstage Renal DiseaseRECRUITINGdzimmerman@toh.on.ca
NCT04167527Endovascular Therapy for Low NIHSS Ischemic Strokes (NCT04167527)Cerebral IschemiaRECRUITING 
NCT05379595A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (NCT05379595)Advanced or Metastatic Colorectal CancerRECRUITING 
NCT05625399A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma (NCT05625399)MelanomaRECRUITING 
NCT04894591To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC) (NCT04894591)Extensive-stage Small-cell Lung CancerRECRUITING 
NCT03151629International Registry for Men With Advanced Prostate Cancer (IRONMAN) (NCT03151629)Prostate CancerRECRUITING 
NCT05933057Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy (NCT05933057)Duchenne Muscular DystrophyRECRUITING 
NCT05137119Staphylococcus Aureus Network Adaptive Platform Trial (NCT05137119)Staphylococcus Aureus BacteremiaRECRUITING 
NCT05811351A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) (NCT05811351)Geographic AtrophyRECRUITING 
NCT05909904Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma (NCT05909904)Head and Neck Squamous Cell Carcinoma, Head and Neck CancerRECRUITING 
NCT03860883Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (NCT03860883)Cutaneous Melanoma, Stage IIRECRUITINGcnessim@toh.ca
NCT04663308A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) (NCT04663308)Primary Sclerosing CholangitisRECRUITING 
NCT05184712Phase 3 Clinical Study of AK112 for NSCLC Patients (NCT05184712)Non-Squamous Non-small Cell Lung CancerRECRUITING 
NCT05132582A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer (NCT05132582)HER2 Positive Breast CancerRECRUITING 
NCT06254482An Extension Study to Evaluate the Long-Term Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) (NCT06254482)Huntington DiseaseRECRUITING 
NCT05382299Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382299)Triple Negative Breast Cancer, PD-L1 NegativeRECRUITING 
NCT05488314A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer (NCT05488314)Carcinoma, Non-Small-Cell LungRECRUITING 
NCT05382286Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382286)Triple Negative Breast Cancer, PD-L1 PositiveRECRUITING 
NCT03968393Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery (NCT03968393)Stroke, Atrial FibrillationRECRUITING 
NCT05502341Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen (NCT05502341)HIV-1-infectionRECRUITING 
NCT05217446A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer (NCT05217446)Metastatic Colorectal CancerRECRUITING 
NCT05327530A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley) (NCT05327530)Locally Advanced or Metastatic Urothelial CarcinomaRECRUITING 
NCT05325866A Study Evaluating Bemarituzumab in Solid Tumors With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (NCT05325866)Solid TumorsRECRUITING 
NCT04951622A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis (NCT04951622)Myasthenia GravisRECRUITING 
NCT05445778Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA) (NCT05445778)Ovarian Cancer, Peritoneal Cancer, Fallopian Tube CancerRECRUITINGjweberpals@toh.ca
NCT04728893Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (NCT04728893)Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic LeukaemiaRECRUITING 
NCT04529122A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test (NCT04529122)Solid TumoursRECRUITING 
NCT05646862A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy (NCT05646862)Breast CancerRECRUITING 
NCT04961567A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus (NCT04961567)Lupus Erythematosus, SystemicRECRUITING 
NCT04031677Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (NCT04031677)Retroperitoneal Sarcoma, Liposarcoma, LeiomyosarcomaRECRUITING 
NCT06032546A Study to Assess Change in Disease Activity, Adverse Events, and How the Drug Moves Through the Body in Adult Participants Living With Human Immunodeficiency Virus (HIV) Receiving Intravenous (IV) Infusion of Budigalimab and/or ABBV-382 (NCT06032546)Human Immuno-deficiency Virus (HIV) DiseaseRECRUITING 
NCT05827016A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma (NCT05827016)Multiple MyelomaRECRUITING 
NCT03950076EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF) (NCT03950076)Intracranial Hemorrhages, Atrial FibrillationRECRUITING 
NCT04589845Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study (NCT04589845)Solid TumorsRECRUITING 
NCT05840211Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy (NCT05840211)Locally Advanced or Unresectable Metastatic Breast Cancer, Stage IV Breast CancerRECRUITING 
NCT05358717A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) (NCT05358717)Huntington DiseaseRECRUITING 
NCT05052801Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (NCT05052801)Gastric Cancer, Gastroesophageal Junction AdenocarcinomaRECRUITING 
NCT06136559A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011) (NCT06136559)Chronic Lymphocytic Leukemia, Small Lymphocytic LymphomaRECRUITING 
NCT05523167A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy. (NCT05523167)Active Idiopathic Inflammatory Myopathy, Myositis, Dermatomyositis, Polymyositis, Immune-Mediated Necrotizing Myopathy, Antisynthetase SyndromeRECRUITING 
NCT03233191Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer (NCT03233191)Breast ScreeningRECRUITING 
NCT04340141Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer (NCT04340141)Pancreatic Adenosquamous Carcinoma, Resectable Pancreatic Adenocarcinoma, Pancreatic CancerRECRUITING 
NCT04513717Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial (NCT04513717)Metastatic Malignant Neoplasm in the Bone, Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8RECRUITING 
NCT04269902Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study (NCT04269902)Chronic Lymphocytic Leukemia, Small Lymphocytic LymphomaRECRUITING 
NCT00887146Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma (NCT00887146)Brain and Central Nervous System TumorsRECRUITING 
NCT03488693Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (NCT03488693)Breast CancerRECRUITING 
NCT03486873Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) (NCT03486873)Solid Tumors, Hematologic MalignanciesRECRUITING 
NCT00781612A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies (NCT00781612)Neoplasm MetastasisRECRUITING