| NCT | Title | Condition | Status | Contact |
| NCT03787589 | Exercise in Patients With End Stage Kidney Disease (NCT03787589) | Renal Failure | RECRUITING | |
| NCT06641141 | The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (NCT06641141) | Gestational Diabetes Mellitus (GDM) | RECRUITING | rwhite@toh.ca |
| NCT06603870 | Secondary Prevention of VTE in Patients With Cancer and Catheter-Related Upper Extremity Deep Vein Thrombosis (NCT06603870) | Venous Thromboembolism, Cancer, Upper Extremity Deep Vein Thrombosis, Catheter-Related Infections | RECRUITING | kdanovitch@ohri.ca |
| NCT06503198 | The VICTORY Trial: Virtual, Innovative, Postsurgical Care To Optimize Return Home for Older People With frailtY (NCT06503198) | Surgery, Frailty | RECRUITING | emhladkowicz@toh.ca |
| NCT06462170 | Pancreatic Insulin Production Capacity (PIPC) - a Feasibility Study (NCT06462170) | Type 2 Diabetes | RECRUITING | |
| NCT06067789 | The ALOFT Pilot Trial (NCT06067789) | Vascular Diseases, Peripheral Artery Disease, Surgery | RECRUITING | emhladkowicz@toh.ca |
| NCT05993013 | Improving Strength and Balance Through Exercise With LudoFit (NCT05993013) | Accidental Falls | RECRUITING | shhuang@toh.ca; tmackenzie@toh.ca |
| NCT05849129 | Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer (NCT05849129) | Lung Cancer | RECRUITING | pwheatleyprice@toh.ca |
| NCT05762601 | Cellular precOnditioning for Post-Surgical Myocardial Ischemic Complications - Observational Study (NCT05762601) | Cardiac Complication, Myocardial Infarction, Myocardial Ischemia, Myocardial Injury | RECRUITING | |
| NCT05733416 | Intensive Cancer Screening After Cryptogenic Stroke (NCT05733416) | Occult Cancer | RECRUITING | mdemetrof@ohri.ca |
| NCT05601427 | Intra-Operative Adductor Canal Blocks (NCT05601427) | Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Anesthesia | RECRUITING | scosta@ohri.ca |
| NCT04754061 | PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL) (NCT04754061) | Depression, Anxiety, Distress, Emotional | RECRUITING | jdownar@toh.ca |
| NCT05173155 | Comparison of Direct Anterior Approach vs. Lateral Hemiarthroplasty for Femoral Neck Fracture Repair (NCT05173155) | Hip Fractures | RECRUITING | ihorton@ohri.ca |
| NCT05149911 | Effect of a Life Coaching Intervention on the Well-being and Distress of Physicians (NCT05149911) | Distress, Emotional, Burnout | RECRUITING | sboet@toh.on.ca |
| NCT04671862 | Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis (NCT04671862) | Mucositis Oral, Head and Neck Cancer, Radiation Dermatitis | RECRUITING | mgaudet@toh.ca; krdennis@toh.ca |
| NCT04080466 | Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA (NCT04080466) | Hip Dysplasia, Femoroacetabular Impingement, Osteoarthritis | RECRUITING | ckreviazuk@ohri.ca |
| NCT04824144 | Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care (NCT04824144) | Hyperactive Delirium, Delirium of Mixed Origin | RECRUITING | |
| NCT06421675 | Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple Myeloma (NCT06421675) | Refractory Multiple Myeloma | RECRUITING | |
| NCT02966886 | TSA Techniques in Glenohumeral OA (NCT02966886) | Osteoarthritis, Shoulder | RECRUITING | plapner@toh.on.ca |
| NCT06016387 | Tucatinib With Brain and/or Spinal XRT in Patients With HER2+ Metastatic Breast Cancer and LMD (NCT06016387) | HER2-positive Breast Cancer, LMD | RECRUITING | |
| NCT04871412 | The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III (NCT04871412) | Lung Cancer, Gastric Cancer, Esophageal Cancer | RECRUITING | afazekas@toh.ca |
| NCT04574960 | Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL) (NCT04574960) | Bladder Cancer, Bladder Urothelial Carcinoma | RECRUITING | pjuneau@ohri.ca |
| NCT05029063 | Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters (NCT05029063) | Venous Thromboembolism, Cancer | RECRUITING | apecarskie@ohri.ca; madhill@ohri.ca |
| NCT00800059 | Total Marrow Irradiation & Autologous Stem Cell Transplantation for Relapsed or Refractory Myeloma (NCT00800059) | Multiple Myeloma | RECRUITING | hatkins@ohri.ca |
| NCT06894576 | Development of a Risk Stratification Score for Recurrent Venous Thromboembolism and Treatment-related Clinically Relevant Bleeding in Patients With Cancer-associated Thrombosis (NCT06894576) | Cancer-associated Thrombosis | RECRUITING | hlanglois@ohri.ca |
| NCT05775965 | HIP Fracture Oral ThromboPROphylaxis (Hip PRO Pilot) (NCT05775965) | Hip Fractures | RECRUITING | medodd@ohri.ca |
| NCT06504342 | Clocks in Sync - Circadian Rhythm and Bipolar Mania (NCT06504342) | Bipolar Disorder, Mania | RECRUITING | jfiedorowicz@toh.ca |
| NCT06392776 | Early Diagnosis and Treatment of Undiagnosed Asthma or COPD: THE UCAP 2 TRIAL (NCT06392776) | COPD, Asthma | RECRUITING | kvandemheen@toh.ca |
| NCT06103500 | Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis (NCT06103500) | Sepsis, Bacterial Infections, Community-Acquired Infections, Hospital Infection | RECRUITING | dmacfadden@toh.ca |
| NCT05255003 | STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis (NCT05255003) | Cancer-associated Thrombosis, Thrombocytopenia | RECRUITING | jbrinkhurst@ohri.ca |
| NCT05920343 | VTE Prevention With Rivaroxaban in Genitourinary Cancer Patients Receiving Systemic Therapy (NCT05920343) | Venous Thromboembolism, Urologic Cancer | RECRUITING | lulavallee@toh.ca; dyachnin@toh.ca |
| NCT05969275 | Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock (NCT05969275) | Septic Shock, Sepsis, Pathologic Processes, Shock, Systemic Inflammatory Response Syndrome, Inflammation, Infections | RECRUITING | UCCISS@ohri.ca |
| NCT03175718 | INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients (NCT03175718) | Soft-tissue Sarcoma, Wound Complication | RECRUITING | yalmosuli@ohri.ca |
| NCT05487274 | TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion (NCT05487274) | Osteoarthritis Shoulder | RECRUITING | kmcilquham@ohri.ca |
| NCT05325177 | PDA Treatment With Ibuprofen and Changes in Tissue Oxygenation. (NCT05325177) | Patent Ductus Arteriosus After Premature Birth | RECRUITING | |
| NCT05781113 | A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition (NCT05781113) | Multiple Sclerosis | RECRUITING | |
| NCT05306327 | Neurologic Physiology After Removal of Therapy (NeuPaRT) (NCT05306327) | Determination of Death | RECRUITING | |
| NCT04935866 | Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study (NCT04935866) | Traumatic Brain Injury, Subarachnoid Hemorrhage, Brain Injuries, Near-Infrared Spectroscopy, Intensive Care Neurological Disorder, Anemia | RECRUITING | |
| NCT05677113 | A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver (NCT05677113) | Colorectal Cancer, Liver Metastases | RECRUITING | roleclerc@ohri.ca |
| NCT05093075 | Therapeutic Plasma Exchange in Septic Shock: a Pilot Study (NCT05093075) | Septic Shock | RECRUITING | |
| NCT05169112 | Impact of Hormonal Therapy on Prostate Cancer Recurrence After Radical Prostatectomy (NCT05169112) | Prostate Cancer | RECRUITING | rbreau@ottawahospital.on.ca; pjuneau@ohri.ca |
| NCT01799967 | Minimally Invasive Surgery of the Gastro-esophageal Junction (NCT01799967) | Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula, Zenker's Diverticulum | RECRUITING | |
| NCT05892666 | The Right Care, for the Right Patient, at the Right Time, by the Right Provider: A Value-based Comparison of the Management of Ambulatory Patients With Acute Health Concerns in walk-in Clinics, Primary Care Physician Practices and Emergency Departments (NCT05892666) | Ambulatory Care, Emergency Services, Hospital, Quality of Care, Costs | RECRUITING | jperry@ohri.ca |
| NCT04180722 | Transition to LIVE (Long-term In Home Ventilation Engagement) Study (NCT04180722) | Long-term Ventilation at Home | RECRUITING | dmckim@toh.on.ca |
| NCT06296173 | Open Lung Protective Extubation Following General Anesthesia (NCT06296173) | Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury, Atelectasis | RECRUITING | dmcisaac@toh.ca; mlalu@toh.ca |
| NCT06511258 | The STRIVE Before Surgery Trial (NCT06511258) | Surgery-Complications, Disability Physical | RECRUITING | emhladkowicz@toh.ca |
| NCT02869802 | Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic Analysis (NCT02869802) | Cancer, Pancreatic Cancer | RECRUITING | |
| NCT05851547 | Dose Escalation For INtraprostatic LEsions (NCT05851547) | Prostatic Neoplasms | RECRUITING | sgrimes@ohri.ca |
| NCT05753618 | Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy (NCT05753618) | Early-stage Breast Cancer | RECRUITING | lvandermeer@ohri.ca |
| NCT04228419 | TSA vs RSA in Glenohumeral Osteoarthritis (NCT04228419) | Osteoarthritis of the Shoulder | RECRUITING | |
| NCT06570473 | Feasibility Trial for a Right Ventricular Failure Platform Trial (NCT06570473) | Pulmonary Hypertension, Right Ventricular Dysfunction, Right Heart Failure | RECRUITING | |
| NCT05326334 | THERApeutic Outcomes Related to Gut microBIOME in Glioblastoma (GBM) Patients Receiving Chemo-radiation (THERABIOME-GBM) (NCT05326334) | Glioblastoma, IDH-wildtype | RECRUITING | |
| NCT04928261 | Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy (NCT04928261) | Breast Cancer | RECRUITING | lvandermeer@ohri.ca |
| NCT05955924 | Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial (NCT05955924) | Non-melanoma Skin Cancer, Carcinoma, Squamous Cell, Carcinoma, Basal Cell, Keratinocyte Carcinoma | RECRUITING | clennox@ohri.ca |
| NCT04258475 | The Influence of Concurrent Oral Calcium Carbonate Supplementation on Steady State Pharmacokinetics of Oral Raltegravir. (NCT04258475) | Calcium Supplementation in HIV Patients Using Raltegravir | RECRUITING | nantremblay@toh.ca |
| NCT05290857 | Anticoagulation After GI Bleeding Pilot Study and Registry (NCT05290857) | GastroIntestinal Bleeding, Anticoagulant-induced Bleeding | RECRUITING | dsiegal@toh.ca |
| NCT05115617 | Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination Prospective Cohort Study (NCT05115617) | SARS-CoV2 Infection, Covid19, Vaccine Reaction, Pregnancy Related, Immunogenicity | RECRUITING | sboyd@ohri.ca; alyharvey@ohri.ca |
| NCT06004739 | Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection (NCT06004739) | Infectious Disease | RECRUITING | |
| NCT03147859 | Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection (NCT03147859) | HIV-infection/AIDS | RECRUITING | bcameron@ohri.ca |
| NCT05078034 | HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT (NCT05078034) | Acute Hypoxemic Respiratory Failure | RECRUITING | aseely@toh.ca |
| NCT04762134 | Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO) (NCT04762134) | Bacterial Sexually Transmitted Diseases | RECRUITING | |
| NCT06168474 | Evaluating Simplified Layered Consent for Clinical Trials (NCT06168474) | Staphylococcus Aureus Bacteremia | RECRUITING | |
| NCT02236689 | Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement (NCT02236689) | Tennis Elbow | RECRUITING | |
| NCT06844227 | Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual) (NCT06844227) | Atrial Fibrillation (AF) | RECRUITING | samuelhamilton@ohri.ca |
| NCT05506904 | Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support (NCT05506904) | Airway Extubation | RECRUITING | aseely@toh.ca |
| NCT04642430 | COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation (NCT04642430) | Atrial Fibrillation | RECRUITING | lcastellucci@toh.ca; erithomas@toh.ca |
| NCT05804578 | Using a Blood Test to Monitor Metastatic Breast Cancer Treatment (NCT05804578) | Metastatic Breast Cancer | RECRUITING | aawan@ohri.ca |
| NCT02975310 | In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps (NCT02975310) | Sinusitis, Nasal Polyps | RECRUITING | alasso@toh.ca |
| NCT03765177 | CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies (NCT03765177) | Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia | RECRUITING | nkekre@toh.on.ca; vlopez@ohri.ca |
| NCT05543941 | Evaluating XPERIENCEâ„¢ Advanced Surgical Irrigation (NCT05543941) | Hip Osteoarthritis, Hip Arthritis, Knee Osteoarthritis, Knee Arthritis | RECRUITING | shenke@ohri.ca |
| NCT03663504 | Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (NCT03663504) | Elective Colon Surgery | RECRUITING | |
| NCT03481010 | Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology (NCT03481010) | Hip Dysplasia | RECRUITING | |
| NCT06131840 | A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors (NCT06131840) | Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Stomach Neoplasms, Pancreatic Ductal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small Cell Lung Carcinoma | RECRUITING | |
| NCT06454188 | A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis (NCT06454188) | Psoriatic Arthritis, Spondyloarthritis, Axial | RECRUITING | hkarkat@ohri.ca |
| NCT05998642 | Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma (NCT05998642) | Non-hodgkin Lymphoma | RECRUITING | |
| NCT04705896 | Albumin To Enhance Recovery After Acute Kidney Injury (NCT04705896) | Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness | RECRUITING | iwatpool@ohri.ca; hlanglois@ohri.ca |
| NCT04224974 | Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia (NCT04224974) | Acute Leukemia | RECRUITING | |
| NCT05395819 | Clinical Evaluation of Reverse Versus Anatomic Shoulder Arthroplasty Techniques in the Treatment of Osteoarthritis (NCT05395819) | Shoulder Osteoarthritis | RECRUITING | |
| NCT05066347 | REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT (NCT05066347) | Syncope | RECRUITING | pnguyen@ohri.ca |
| NCT05258578 | Tele-BARICARE to Manage COVID-19-Related Distress (NCT05258578) | Obesity, Bariatric Surgery Candidate, Mental Health Disorder, Eating Disorders | RECRUITING | dasandre@toh.ca |
| NCT04319627 | Statins for Venous Event Reduction in Patients With Venous Thromboembolism (NCT04319627) | Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome | RECRUITING | jbrinkhurst@ohri.ca |
| NCT04045587 | International Severe Asthma Registry: Canadian Cohort (NCT04045587) | Severe Asthma | RECRUITING | kvandemheen@ohri.ca |
| NCT05605509 | RP-6306 in Patients With Advanced Cancer (NCT05605509) | Advanced Cancer | RECRUITING | |
| NCT06129084 | A Study to Compare the Results of FGFR Testing by Either CtDNA Blood Testing or Standard Tumor Tissue Testing (NCT06129084) | Metastatic Bladder Cancer, Metastatic Urothelial Carcinoma | RECRUITING | sgrimes@toh.ca |
| NCT04448184 | Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial) (NCT04448184) | Hematologic Neoplasms | RECRUITING | atinmouth@ohri.ca |
| NCT04521413 | Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies (NCT04521413) | Advanced Solid Malignancies | RECRUITING | |
| NCT06532565 | Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors (NCT06532565) | Advanced Solid Tumors | RECRUITING | |
| NCT05364749 | Selective CT for Anticoagulated Head Injured Patients (NCT05364749) | Head Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Traumatic, Blunt Head Injury | RECRUITING | |
| NCT05371808 | Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: (NCT05371808) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | RECRUITING | |
| NCT04335292 | Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer with Osimertinib Third-line Rechallenge (NCT04335292) | Non-Small Cell Lung Cancer | RECRUITING | |
| NCT04093167 | Study of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC (NCT04093167) | Non-Small Cell Lung Cancer | RECRUITING | |
| NCT03559114 | PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST) (NCT03559114) | Traumatic Brain Injury | RECRUITING | rporteous@ohri.ca; smiezitis@ohri.ca |
| NCT06345079 | Cessation of Somatostatin Analogues After PRRT in Mid, Hind-Gut and Pancreatic Neuroendocrine Tumours (NCT06345079) | Neuroendocrine Tumors | RECRUITING | rgoodwin@toh.ca |
| NCT04548661 | Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (NCT04548661) | Surgical Site Infection | RECRUITING | jaboukhalil@toh.ca |
| NCT03948074 | Cannabis For Cancer-Related Symptoms (NCT03948074) | Pain, Nausea, Anxiety, Sleep Disturbance | RECRUITING | sdownar@ohri.ca |
| NCT04260802 | A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802) | Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder Cancer | RECRUITING | djonker@toh.ca |
| NCT04874038 | Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) (NCT04874038) | Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, Chronic | RECRUITING | |
| NCT04415060 | SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival (NCT04415060) | Covid19, Hypoxic Respiratory Failure | RECRUITING | jhaines@toh.ca; iwatpool@toh.ca |
| NCT02999022 | Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) (NCT02999022) | Fractures | RECRUITING | spapp@toh.ca; medodd@ohri.ca |
| NCT05601440 | Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer (NCT05601440) | Breast Cancer | RECRUITING | |
| NCT06208735 | CLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies (NCT06208735) | B-Cell Leukemia, Non-Hodgkin's Lymphoma, B-cell Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Primary Mediastinal Large B-cell Lymphoma (PMBCL), Mantle Cell Lymphoma, B-cell Lymphoma | RECRUITING | vlopez@ohri.ca |
| NCT04580225 | Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE) (NCT04580225) | Wrist Arthritis, Wrist Arthropathy, Scapholunate Advanced Collapse, Scaphoid Nonunion, Post-traumatic; Arthrosis, Arthritis, Musculoskeletal Diseases, Joint Diseases | RECRUITING | hghaziasgar@ohri.ca |
| NCT05246098 | REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI (NCT05246098) | Respiratory Disease, COVID-19, Viral Infection | RECRUITING | aseely@toh.ca |
| NCT06736704 | SNV4818 in Participants With Advanced Solid Tumors (NCT06736704) | Advanced Solid Tumors | RECRUITING | |
| NCT03297606 | Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (NCT03297606) | Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors | RECRUITING | |
| NCT06462183 | Study of Safety and Efficacy of RGT-61159 in Adults with Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC) (NCT06462183) | Adenoid Cystic Carcinoma, Colorectal Cancer | RECRUITING | |
| NCT05114096 | Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) (NCT05114096) | Preterm Birth, Premature Birth, Complication of Prematurity, Obstetric Labor, Premature, Pregnancy Complications | RECRUITING | |
| NCT02906943 | Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943) | Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary Cancer | RECRUITING | hanzhang@ohri.ca; kchristink@toh.ca |
| NCT06537609 | A Platform Trial for Gram Negative Bloodstream Infections (NCT06537609) | Gram-negative Bacteremia | RECRUITING | |
| NCT05840224 | Study of GS-4528 in Adults With Solid Tumors (NCT05840224) | Solid Tumor | RECRUITING | |
| NCT03569826 | Canadian Network for Autoimmune Liver Disease (NCT03569826) | Primary Bilary Cirrhosis (PBC), Autoimmune Hepatitis, Overlap Syndrome | RECRUITING | angcheung@toh.ca; mmuir@toh.ca |
| NCT04304651 | Screening for Occult Malignancy in Patients with Unprovoked Venous Thromboembolism (NCT04304651) | Embolism and Thrombosis | RECRUITING | adelluc@toh.ca; mcarrier@toh.ca |
| NCT05809999 | IBD Neoplasia Surveillance RCT (NCT05809999) | Colonic Neoplasms, Inflammatory Bowel Diseases, Dysplasia | RECRUITING | |
| NCT03419689 | Study Looking at Biomarkers in Ovarian Cancer (NCT03419689) | Gynecologic Cancer | RECRUITING | jweberpals@toh.ca |
| NCT03718260 | PSMA-PET Registry for Recurrent Prostate Cancer (NCT03718260) | Recurrent Prostate Cancer | RECRUITING | dyachnin@ohri.ca |
| NCT04558593 | Surveillance of Complex Renal Cysts - the SOCRATIC Study (NCT04558593) | Complex Renal Cyst | RECRUITING | |
| NCT05428735 | The DRAGON 2 Trial (NCT05428735) | Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR) | RECRUITING | |
| NCT04812366 | Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer (NCT04812366) | Prostate Cancer | RECRUITING | pjuneau@ohri.ca |
| NCT04680442 | Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction (NCT04680442) | Breast Cancer, Heart Failure | RECRUITING | kelross@ohri.ca |
| NCT04065269 | ATr Inhibitor in Combination With Olaparib/Durvalumab (MEDI4736) in Gynaecological Cancers With ARId1A Loss or no Loss (NCT04065269) | Gynaecological Cancers | RECRUITING | |
| NCT03847649 | A Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies (NCT03847649) | Cancer | RECRUITING | |
| NCT06078553 | A Natural History Study in Participants With DOK7 Congenital Myasthenic Syndromes (CMS) (NCT06078553) | Congenital Myasthenic Syndrome | RECRUITING | |
| NCT04182776 | Fragility Fractures of the Pelvis (FFP) (NCT04182776) | Pelvic Fracture | RECRUITING | |
| NCT06043427 | Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma (NCT06043427) | Gastroesophageal Adenocarcinoma | RECRUITING | |
| NCT06204809 | Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants with Myotonic Dystrophy Type 1 (NCT06204809) | Myotonic Dystrophy 1 | RECRUITING | |
| NCT03838718 | REtroperitoneal SArcoma Registry: an International Prospective Initiative (NCT03838718) | Retroperitoneal Sarcoma | RECRUITING | cnessim@toh.ca |
| NCT05686317 | ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System (NCT05686317) | Heart Failure | RECRUITING | |
| NCT05180097 | Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma (NCT05180097) | Hodgkin Lymphoma | RECRUITING | |
| NCT06411288 | Global Study of Del-desiran for the Treatment of DM1 (NCT06411288) | DM1, Myotonic Dystrophy, Myotonic Dystrophy 1, Myotonia, Myotonic Dystrophy Type 1 (DM1), Dystrophy Myotonic, Myotonic Disorders, Steinert Disease, Steinert, Myotonic Muscular Dystrophy | RECRUITING | |
| NCT02632448 | A Study of LY2880070 in Participants With Advanced or Metastatic Cancer (NCT02632448) | Solid Tumors, Colorectal Cancer, Breast Cancer, Ovarian Cancer, Colon Cancer, Rectal Cancer, Neoplasms, Endometrial Cancer, Soft Tissue Sarcoma, Triple Negative Breast Cancer, Pancreas Cancer, Pancreatic Cancer | RECRUITING | |
| NCT04633655 | International CIPN Assessment and Validation Study (NCT04633655) | Chemotherapy-induced Peripheral Neuropathy, Quality of Life | RECRUITING | krdennis@toh.ca |
| NCT04421820 | BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours (NCT04421820) | Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma | RECRUITING | saali@ohri.ca; roleclerc@ohri.ca |
| NCT05848713 | AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia (NCT05848713) | Community-acquired Pneumonia | RECRUITING | |
| NCT06182774 | Fixed Duration vs Continuous Daratumumab in Transplant Ineligible Older Adults With Newly Diagnosed Multiple Myeloma (NCT06182774) | Multiple Myeloma | RECRUITING | |
| NCT04449874 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874) | Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors | RECRUITING | |
| NCT06384352 | A Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients with Advanced Solid Tumors (NCT06384352) | Advanced Solid Tumors | RECRUITING | junakamura@ohri.ca |
| NCT04263038 | Clinical Surveillance Vs. Anticoagulation for Low-risk Patients with Isolated Subsegmental Pulmonary Embolism (NCT04263038) | Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases, Cardiovascular Diseases, Respiratory Tract Diseases, Venous Thromboembolism, Anticoagulant-induced Bleeding, Bleeding | RECRUITING | |
| NCT04635891 | Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) (NCT04635891) | FSHD | RECRUITING | jemacgregor@ohri.ca; szakutney@ohri.ca |
| NCT06662786 | A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer (NCT06662786) | Colorectal Neoplasms | RECRUITING | |
| NCT06586515 | MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors (NCT06586515) | Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer | RECRUITING | |
| NCT05204888 | MyAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home (NCT05204888) | COPD | RECRUITING | kvandemheen@ohri.ca |
| NCT05171049 | A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE (NCT05171049) | Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism | RECRUITING | |
| NCT02855476 | HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease (NCT02855476) | Huntington's Disease | RECRUITING | jading@toh.ca |
| NCT04743765 | HIP Fracture Accelerated Surgical TreaTment and Care TracK 2 Trial (NCT04743765) | Hip Fractures, Myocardial Injury | RECRUITING | |
| NCT06157892 | A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors (NCT06157892) | Breast Neoplasms, Gastroesophageal Junction Adenocarcinoma, HER2 Low Breast Neoplasms, HER2 Positive Breast Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms, Metastatic Breast Cancer, Metastatic Gastric Cancer, Advanced Breast Cancer, Advanced Gastric Cancer | RECRUITING | |
| NCT04151342 | CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS) (NCT04151342) | Cancer, Malignancies Multiple, Malignant Solid Tumor, Cancer, Therapy-Related, Molecular Sequence Variation, Genetic Alteration, Gene Fusion, Receptor Tyrosine Kinase Gene Mutation, RTK Family Gene Mutation, Ras (Kras or Nras) Gene Mutation | RECRUITING | |
| NCT02821013 | Duration of Anti-PD-1 Therapy in Metastatic Melanoma (NCT02821013) | Unresectable/Metastatic Melanoma | RECRUITING | |
| NCT03674307 | Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates (NCT03674307) | Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication | RECRUITING | erithomas@toh.ca; miricci@ohri.ca |
| NCT05253651 | A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (NCT05253651) | Colorectal Neoplasms | RECRUITING | |
| NCT03636295 | Low INR to Minimize Bleeding with Mechanical Valves Trial (NCT03636295) | Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement | RECRUITING | |
| NCT03573089 | Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE) (NCT03573089) | Kidney Failure, Chronic, Hyperphosphatemia | RECRUITING | shiremath@toh.ca |
| NCT06613685 | Study of Oral Weekly GS-1720 and GS-4182 Compared With Biktarvy in People With HIV-1 Who Have Not Been Treated (NCT06613685) | HIV-1-infection | RECRUITING | |
| NCT05843578 | STENOVA - A Study to Evaluate Safety, Tolerability, PK and PD of AGMB-129 in Patients With Fibrostenotic Crohn's Disease (NCT05843578) | Fibrostenotic Crohn's Disease | RECRUITING | |
| NCT06179160 | A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation (NCT06179160) | Solid Tumors | RECRUITING | |
| NCT02468024 | JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024) | Non-Small Cell Lung Cancer | RECRUITING | sgilbert@toh.ca; afazekas@toh.ca |
| NCT06384261 | A Study Comparing Venetoclax and Azacitidine Plus Cusatuzumab to Venetoclax and Azacitidine in Newly Diagnosed AML Ineligible for Intensive Therapy (NCT06384261) | Leukemia, Myeloid, Acute | RECRUITING | hcarr@ohri.ca |
| NCT05407636 | Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD (NCT05407636) | AMD, nAMD, Wet Age-related Macular Degeneration, wAMD, WetAMD, CNV | RECRUITING | |
| NCT04228991 | Hypofractionated LocoRegional Radiotherapy in Breast Cancer (NCT04228991) | Breast Neoplasms, Radiotherapy, Lymphedema | RECRUITING | |
| NCT03093116 | A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements (NCT03093116) | Locally Advanced Solid Tumors, Metastatic Solid Tumors | RECRUITING | |
| NCT05581004 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05581004) | Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma, TNBC, Esophageal Cancer, Gastric Cancer, Cervical Cancer, Colorectal Cancer, Urothelial Carcinoma, Clear Cell RCC, HCC | RECRUITING | |
| NCT05376891 | Met Non Small Cell Cancer Registry (MOMENT) (NCT05376891) | Cancer | RECRUITING | pwheatleyprice@toh.ca |
| NCT05464030 | Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01) (NCT05464030) | Colorectal Cancer | RECRUITING | |
| NCT06608927 | Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (NCT06608927) | Metastatic Pancreatic Ductal Adenocarcinoma | RECRUITING | |
| NCT05090566 | MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma (NCT05090566) | Multiple Myeloma | RECRUITING | |
| NCT06298552 | A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients with Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis (NCT06298552) | Generalized Myasthenia Gravis | RECRUITING | |
| NCT05538130 | A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130) | Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer | RECRUITING | |
| NCT05355701 | A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701) | Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma | RECRUITING | |
| NCT03127631 | A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (NCT03127631) | Prostate Cancer, Cardiovascular Disease | RECRUITING | dyachnin@toh.ca |
| NCT01574053 | Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort (NCT01574053) | Huntington's Disease | RECRUITING | jading@toh.ca |
| NCT02735707 | Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (NCT02735707) | Community-acquired Pneumonia, Influenza, COVID-19 | RECRUITING | |
| NCT05171075 | A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE (NCT05171075) | Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism | RECRUITING | |
| NCT03969953 | Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease (NCT03969953) | Chronic Kidney Diseases, Dialysis-dependent Kidney Failure, Cardiovascular Disease | RECRUITING | |
| NCT06088979 | A Study to Investigate Efficacy and Safety of TOUR006 in Participants 18 to 80 Years of Age With Thyroid Eye Disease (NCT06088979) | Thyroid Eye Disease | RECRUITING | |
| NCT03496883 | Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial (NCT03496883) | Intracerebral Hemorrhage | RECRUITING | ddowlat@toh.ca |
| NCT05573555 | TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) (NCT05573555) | Breast Cancer | RECRUITING | |
| NCT06206837 | A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer. (NCT06206837) | Breast Cancer | RECRUITING | |
| NCT04477785 | PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort (NCT04477785) | Parkinson Disease | RECRUITING | |
| NCT05257083 | A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (NCT05257083) | Multiple Myeloma | RECRUITING | |
| NCT04895709 | A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors (NCT04895709) | Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms | RECRUITING | |
| NCT05696626 | Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation (NCT05696626) | Metastatic Breast Cancer | RECRUITING | |
| NCT05379595 | A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (NCT05379595) | Advanced or Metastatic Colorectal Cancer | RECRUITING | |
| NCT05430971 | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry (NCT05430971) | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) | RECRUITING | |
| NCT05933057 | Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy (NCT05933057) | Duchenne Muscular Dystrophy | RECRUITING | |
| NCT03151629 | International Registry for Men With Advanced Prostate Cancer (IRONMAN) (NCT03151629) | Prostate Cancer | RECRUITING | |
| NCT05137119 | Staphylococcus Aureus Network Adaptive Platform Trial (NCT05137119) | Staphylococcus Aureus Bacteremia | RECRUITING | |
| NCT05243797 | Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation (NCT05243797) | Multiple Myeloma | RECRUITING | |
| NCT05384626 | A Study of NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1) (NCT05384626) | Locally Advanced Solid Tumor, Metastatic Solid Tumor | RECRUITING | |
| NCT06483334 | A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04) (NCT06483334) | Metastatic Urothelial Carcinoma, Locally Advanced Urothelial Carcinoma | RECRUITING | |
| NCT06084936 | A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma (NCT06084936) | Lymphoma | RECRUITING | |
| NCT06012435 | A Study of Sigvotatug Vedotin Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer (NCT06012435) | Carcinoma, Non-Small-Cell Lung | RECRUITING | |
| NCT06846671 | A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors (NCT06846671) | CLL, Chronic Lymphocytic Leukemia | RECRUITING | |
| NCT03860883 | Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (NCT03860883) | Cutaneous Melanoma, Stage II | RECRUITING | cnessim@toh.ca |
| NCT05773274 | Comparing Retreatment of 177Lu-DOTATATE PRRT Versus Everolimus in Patients With Metastatic Unresectable Midgut Neuroendocrine Tumors, NET RETREAT Trial (NCT05773274) | Metastatic Midgut Neuroendocrine Tumor, Metastatic Midgut Neuroendocrine Tumor G1, Metastatic Midgut Neuroendocrine Tumor G2, Unresectable Midgut Neuroendocrine Tumor | RECRUITING | |
| NCT05382299 | Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382299) | Triple Negative Breast Cancer, PD-L1 Negative | RECRUITING | |
| NCT05650632 | A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma (NCT05650632) | Multiple Myeloma | RECRUITING | |
| NCT03968393 | Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery (NCT03968393) | Stroke, Atrial Fibrillation | RECRUITING | |
| NCT06435429 | A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer (NCT06435429) | Metastatic HER2-positive Breast Cancer | RECRUITING | |
| NCT06064877 | A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma (NCT06064877) | Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma | RECRUITING | |
| NCT04613596 | Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 (NCT04613596) | Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer | RECRUITING | |
| NCT04951622 | A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis (NCT04951622) | Myasthenia Gravis | RECRUITING | |
| NCT04663308 | A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) (NCT04663308) | Primary Sclerosing Cholangitis | RECRUITING | |
| NCT05325866 | A Study Evaluating Bemarituzumab in Solid Tumors With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (NCT05325866) | Solid Tumors | RECRUITING | |
| NCT05730036 | A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma (NCT05730036) | Relapsed Refractory Multiple Myeloma (RRMM) | RECRUITING | |
| NCT04486378 | A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients with CtDNA-positive, Resected Stage II (high Risk) and Stage III Colorectal Cancer (NCT04486378) | Colorectal Cancer Stage II, Colorectal Cancer Stage III | RECRUITING | |
| NCT04529122 | A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test (NCT04529122) | Solid Tumours | RECRUITING | |
| NCT04728893 | Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (NCT04728893) | Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia | RECRUITING | |
| NCT05668988 | A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28) (NCT05668988) | Non-small Cell Lung Cancer | RECRUITING | |
| NCT06578247 | Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML (NCT06578247) | Leukemia | RECRUITING | |
| NCT04994717 | Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia (NCT04994717) | Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL) | RECRUITING | |
| NCT04961567 | A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus (NCT04961567) | Lupus Erythematosus, Systemic | RECRUITING | |
| NCT04589845 | Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study (NCT04589845) | Solid Tumors | RECRUITING | |
| NCT04031677 | Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (NCT04031677) | Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma | RECRUITING | |
| NCT06047080 | An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma (NCT06047080) | Large B-Cell Lymphoma | RECRUITING | |
| NCT05827016 | A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma (NCT05827016) | Multiple Myeloma | RECRUITING | |
| NCT05445778 | Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (NCT05445778) | Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer | RECRUITING | jweberpals@toh.ca |
| NCT06136624 | Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) (NCT06136624) | Prostate Cancer Metastatic | RECRUITING | |
| NCT06428409 | A Clinical Study of MK-2870 Alone or With Chemotherapy to Treat Gastrointestinal Cancers (MK-9999-02A) (NCT06428409) | Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer | RECRUITING | |
| NCT06205485 | Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer (NCT06205485) | Rectal Cancer | RECRUITING | |
| NCT06107426 | Real-World Study of ABBV-951 Subcutaneous Infusion to Assess Change in Disease Activity in Adult Participants With Parkinson's Disease (NCT06107426) | Parkinson's Disease (PD) | RECRUITING | |
| NCT05523167 | A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy. (NCT05523167) | Active Idiopathic Inflammatory Myopathy, Myositis, Dermatomyositis, Polymyositis, Immune-Mediated Necrotizing Myopathy, Antisynthetase Syndrome | RECRUITING | |
| NCT05946213 | Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer (NCT05946213) | Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8 | RECRUITING | |
| NCT06136559 | A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011) (NCT06136559) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | RECRUITING | |
| NCT05111574 | Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery (NCT05111574) | Anal Melanoma, Bladder Melanoma, Cervical Melanoma, Esophageal Melanoma, Gallbladder Melanoma, Head and Neck Mucosal Melanoma, Mucosal Melanoma, Mucosal Melanoma of the Urinary System, Nasopharyngeal Mucosal Melanoma, Oral Cavity Mucosal Melanoma, Penile Mucosal Melanoma, Rectal Melanoma, Recurrent Mucosal Melanoma, Sinonasal Mucosal Melanoma, Urethral Melanoma, Vaginal Melanoma, Vulvar Melanoma | RECRUITING | |
| NCT06393374 | Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012) (NCT06393374) | Triple-Negative Breast Cancer | RECRUITING | |
| NCT05624996 | Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer (NCT05624996) | Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8 | RECRUITING | |
| NCT05050162 | Comparing Cisplatin Every Three Weeks to Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer (NCT05050162) | Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma, Advanced Laryngeal Squamous Cell Carcinoma, Advanced Oropharyngeal Squamous Cell Carcinoma, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8, Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | RECRUITING | |
| NCT04340141 | Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer (NCT04340141) | Pancreatic Adenosquamous Carcinoma, Resectable Pancreatic Adenocarcinoma, Pancreatic Cancer | RECRUITING | |
| NCT04513717 | Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial (NCT04513717) | Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8 | RECRUITING | |
| NCT05174169 | Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (NCT05174169) | Stage III Colon Cancer | RECRUITING | |
| NCT04269902 | Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study (NCT04269902) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | RECRUITING | |
| NCT03488693 | Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (NCT03488693) | Breast Cancer | RECRUITING | |
| NCT03486873 | Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) (NCT03486873) | Solid Tumors, Hematologic Malignancies | RECRUITING | |
