| NCT | Title | Condition | Status | Contact |
| NCT04417023 | B3 for NMD: Bench to Bedside and Back (NCT04417023) | Neuromuscular Disease | Recruiting | maduff@ohri.ca |
| NCT03936127 | Comparison of a Novel Transperineal Targeted Fusion Biopsy System to Conventional Transrectal Targeted Fusion Biopsy (NCT03936127) | Prostate Cancer | Recruiting | nschieda@toh.ca,baschwarz@toh.ca |
| NCT04136496 | Evaluation of a Novel Axillary Lymph Node Ink Localization Technique: A Feasibility Study (NCT04136496) | Breast Cancer,Axillary Lymphadenitis | Recruiting | nimikhael@ohri.ca |
| NCT05264285 | Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients (NCT05264285) | Acute Kidney Injury (AKI) | Recruiting | iwatpool@toh.ca |
| NCT03746925 | Comparing Short-term Outcomes After Direct Anterior and SuperPATH Hip Arthroplasty Approaches (NCT03746925) | Arthroplasty, Replacement, Hip | Recruiting | jdobransky@ohri.ca |
| NCT04871412 | The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage II (NCT04871412) | Lung Cancer,Gastric Cancer,Esophageal Cancer | Recruiting | afazekas@toh.ca |
| NCT05468281 | RAFF5 Proposal: Improve the Quality and Safety of Patients Seen in the Emergency Department for Acute Atrial Fibrillation and Flutter (NCT05468281) | Atrial Fibrillation,Atrial Flutter | Recruiting | skhaksari@ohri.ca |
| NCT05496309 | Causes and Mechanisms of Space Hemolysis at High Altitudes (NCT05496309) | Anemia,Weightlessness | Recruiting | gtrudel@toh.ca |
| NCT05852262 | High-dose Cephalexin for Cellulitis (HI-DOCC) (NCT05852262) | Cellulitis | Recruiting | kyadav@toh.ca,gsandino@ohri.ca |
| NCT05762601 | Cellular precOnditioning for Post-Surgical Myocardial Ischemic Complications - Observational Study (NCT05762601) | Cardiac Complication,Myocardial Infarction,Myocardial Ischemia,Myocardial Injury | Recruiting | |
| NCT05019963 | Enhancing COVID Rehabilitation With Technology (NCT05019963) | Covid19 | Recruiting | broward@ohri.ca |
| NCT04392921 | Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation (NCT04392921) | Atrial Fibrillation | Recruiting | aseely@ohri.ca |
| NCT05169112 | Impact of Hormonal Therapy on Prostate Cancer Recurrence After Radical Prostatectomy (NCT05169112) | Prostate Cancer | Recruiting | pjuneau@ohri.ca |
| NCT03787589 | Exercise in Patients With End Stage Kidney Disease (NCT03787589) | Renal Failure | Recruiting | |
| NCT04221295 | The PREPARE Trial: Exercise Before Surgery to Improve Recovery in Older People With Frailty (NCT04221295) | Frailty,Surgery--Complications,Disability Physical | Recruiting | emhladkowicz@toh.ca |
| NCT03677713 | Nasal Packing Following Endoscopic Endonasal Pituitary Resection (NCT03677713) | Pituitary Tumor | Recruiting | alasso@toh.ca |
| NCT02966886 | TSA Techniques in Glenohumeral OA (NCT02966886) | Osteoarthritis, Shoulder | Recruiting | plapner@toh.on.ca |
| NCT05206747 | Ottawa Sunglasses at Night for Mania Study (NCT05206747) | Mania,Sleep,Bipolar Disorder | Recruiting | jfiedorowicz@toh.ca |
| NCT04921137 | Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer (NCT04921137) | Breast Cancer | Recruiting | msavard@toh.ca |
| NCT04633525 | Defining Optimum Cup Orientation for Hip Replacements Taking Into Account the Individual's Anatomy and Movement Patterns (NCT04633525) | Hip Arthritis,Hip Osteoarthritis | Recruiting | meadufresne@ohri.ca |
| NCT03959709 | Pre-pectoral Versus Sub-pectoral Implant Placement in Immediate Breast Reconstruction (NCT03959709) | Mastectomy,Breast Cancer | Recruiting | |
| NCT03031873 | Evaluation of Susceptibility-weighted Magnetic Resonance Imaging and 4d-time-resolved Magnetic Resonance Angiography in Brain Arteriovenous Malformations (NCT03031873) | Arteriovenous Malformations | Recruiting | baschwarz@toh.ca |
| NCT00800059 | Total Marrow Irradiation & Autologous Stem Cell Transplantation for Relapsed or Refractory Myeloma (NCT00800059) | Multiple Myeloma | Recruiting | hatkins@ohri.ca |
| NCT05487274 | TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion (NCT05487274) | Osteoarthritis Shoulder | Recruiting | kmcilquham@ohri.ca |
| NCT03809884 | Dietary Counseling or Potassium Supplement to Increase Potassium Intake in Patients With High Blood Pressure (NCT03809884) | Hypertension | Recruiting | jbiggs@ohri.ca |
| NCT01799967 | Minimally Invasive Surgery of the Gastro-esophageal Junction (NCT01799967) | Achalasia,Paraesophageal Hernia,GERD,Epiphrenic Diverticula,Zenker's Diverticulum | Recruiting | |
| NCT05101928 | Ozurdex Monotherapy Trial (NCT05101928) | Uveitis, Posterior,Uveitis, Intermediate,Panuveitis | Recruiting | mlalonde@ohri.ca |
| NCT04080466 | Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA (NCT04080466) | Hip Dysplasia,Femoroacetabular Impingement,Osteoarthritis | Recruiting | ckreviazuk@ohri.ca |
| NCT03663504 | Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (NCT03663504) | Elective Colon Surgery | Recruiting | |
| NCT03713255 | Mid-point Transverse Process to Pleura Block for Breast Cancer Surgery: A Randomized Controlled Trial (NCT03713255) | Breast Cancer,Acute Pain,Anesthesia | Recruiting | |
| NCT04708509 | Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool (NCT04708509) | Airway Extubation | Recruiting | |
| NCT02236689 | Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement (NCT02236689) | Tennis Elbow | Recruiting | |
| NCT05754528 | Evaluating an Endocrine Therapy Dose-frequency Escalation Strategy and Its Effects on Tolerability and Compliance (NCT05754528) | Breast Cancer | Recruiting | lvandermeer@ohri.ca |
| NCT05753618 | Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy (NCT05753618) | Early-stage Breast Cancer | Recruiting | lvandermeer@ohri.ca |
| NCT04549207 | Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer (NCT04549207) | Breast Cancer,Castration-resistant Prostate Cancer | Recruiting | |
| NCT03147859 | Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection (NCT03147859) | HIV-infection/AIDS | Recruiting | bcameron@ohri.ca |
| NCT05066347 | REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT (NCT05066347) | Syncope | Recruiting | Bhghaedi@ohri.ca,pnguyen@ohri.ca |
| NCT04781725 | INVINCIBLE TRIAL: Intratumoral INT230-6 in Breast Cancer (NCT04781725) | Breast Cancer | Recruiting | aarnaout@toh.on.ca |
| NCT04661787 | Donation Advisor Clinical Decision Support Tool Study (NCT04661787) | Organ Donation | Recruiting | aseely@ohri.ca |
| NCT05198869 | SpotLight-19 Research & Development Study (NCT05198869) | Screening | Recruiting | |
| NCT04671862 | Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis (NCT04671862) | Mucositis Oral,Head and Neck Cancer,Radiation Dermatitis | Recruiting | mgaudet@toh.ca,krdennis@toh.ca |
| NCT04105179 | How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response (NCT04105179) | Osteoarthritis, Knee,Inflammation Knees | Recruiting | |
| NCT03806114 | Dislocation Precautions (NCT03806114) | Arthroplasty, Hip Replacement,Arthroplasties, Hip Replacement,Health-Related Quality Of Life | Recruiting | jdobransky@ohri.ca |
| NCT03100110 | NeuroCognitive Communicator: Safety Study (NCT03100110) | Motor Neuron Disease, Amyotrophic Lateral Sclerosis,Tetraplegia | Recruiting | rdoole@ohri.ca |
| NCT05326334 | THERApeutic Outcomes Related to Gut microBIOME in Glioblastoma (GBM) Patients Receiving Chemo-radiation (THERABIOME-GBM) (NCT05326334) | Glioblastoma, IDH-wildtype | Recruiting | |
| NCT05255003 | STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis (NCT05255003) | Cancer-associated Thrombosis,Thrombocytopenia | Recruiting | jbrinkhurst@ohri.ca |
| NCT03506867 | A Healthy People Initiative: Building the Socio-Economic Capital of Low Income Population At-Risk for HIV and Hepatitis-C (NCT03506867) | Nicotine Dependence,Substance Use Disorders | Recruiting | spakhale@toh.ca |
| NCT05029063 | Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters (NCT05029063) | Venous Thromboembolism,Cancer | Recruiting | crockwell@ohri.ca,madhill@ohri.ca |
| NCT04500626 | Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients (NCT04500626) | Covid19 | Recruiting | sboet@toh.on.ca,josburns@ohri.ca |
| NCT05781113 | A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition (NCT05781113) | Multiple Sclerosis | Recruiting | gabose@toh.ca |
| NCT05309226 | Cannabis Use in Pregnancy and Downstream Effects on Maternal and Infant Health (NCT05309226) | Cannabis Use,Marijuana Use | Recruiting | sramlawi@ohri.ca,alyharvey@ohri.ca |
| NCT04935866 | Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study (NCT04935866) | Traumatic Brain Injury,Subarachnoid Hemorrhage,Brain Injuries,Near-Infrared Spectroscopy,Intensive Care Neurological Disorder,Anemia | Recruiting | |
| NCT03765177 | CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies (NCT03765177) | Acute Lymphoblastic Leukemia,Non-Hodgkin's Lymphoma,Chronic Lymphocytic Leukemia | Recruiting | nkekre@toh.on.ca,aliblack@ohri.ca |
| NCT03175718 | INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients (NCT03175718) | Soft-tissue Sarcoma,Wound Complication | Recruiting | yalmosuli@ohri.ca |
| NCT04907279 | Aripiprazole Once-Monthly in Hospitalized Patients (INITIATE) (NCT04907279) | Schizophrenia,Schizo Affective Disorder,Bipolar I Disorder | Recruiting | |
| NCT04257227 | Transcranial Magnetic Stimulation for Psychological Distress in Patients With Advanced Illness (NCT04257227) | Depressive Symptoms,Depression, Anxiety,Psychological Distress,Terminal Illness | Recruiting | jdownar@toh.ca |
| NCT04080934 | Breaststroke Swimming After Breast Cancer Treatment/Surgery as a Means of Treatment for Seroma, Lymphedema, and Chronic Arm and Chest Pain (NCT04080934) | Lymphedema,Seroma,Pain, Postoperative,Pain, Chest | Recruiting | |
| NCT04163081 | The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments (NCT04163081) | Nicotine Dependence, Cigarettes,Nicotine Withdrawal | Recruiting | akapur@ohri.ca |
| NCT04228419 | TSA vs RSA in Glenohumeral Osteoarthritis (NCT04228419) | Osteoarthritis of the Shoulder | Recruiting | |
| NCT02975310 | In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps (NCT02975310) | Sinusitis,Nasal Polyps | Recruiting | alasso@toh.ca |
| NCT04970771 | Solving Wellness: An Initiative to Enhance Canadian Healthcare Provider Wellness (NCT04970771) | Stress,Burnout, Professional,Burnout | Recruiting | |
| NCT04642430 | COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation (NCT04642430) | Atrial Fibrillation | Recruiting | lcastellucci@toh.ca,vebates@ohri.ca |
| NCT04543110 | Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC (NCT04543110) | Bladder Cancer | Recruiting | caproulx@ohri.ca |
| NCT04894448 | Immunogenicity of COVID-19 Vaccination in PLWH (NCT04894448) | HIV Infections | Recruiting | |
| NCT05115617 | Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination Prospective Cohort Study (NCT05115617) | SARS-CoV2 Infection,Covid19,Vaccine Reaction,Pregnancy Related,Immunogenicity | Recruiting | sboyd@ohri.ca,alyharvey@ohri.ca |
| NCT03949387 | Functional Electrical Stimulation Cycling for Managing Mobility Disability in People With Multiple Sclerosis (NCT03949387) | Multiple Sclerosis | Recruiting | |
| NCT03297359 | WAVe Study - Weight Adjusted Dalteparin for Patients Over 90 kg With Acute Cancer Associated Venous Thromboembolism (NCT03297359) | Cancer,Venous Thromboembolism,Obesity | Recruiting | |
| NCT02281838 | The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II (NCT02281838) | Intracerebral Hemorrhage | Recruiting | ddowlat@toh.on.ca |
| NCT04549662 | The HepatoPancreaticoBiliary Resection Arginine Immunomodulation (PRIMe) Trial (NCT04549662) | Hepatopancreaticobiliary (HPB) Malignancy,Surgery | Recruiting | gumartel@toh.ca,leamonette@ohri.ca |
| NCT03639064 | Cannabis Oil for Pain in Parkinson's Disease (NCT03639064) | Parkinson Disease | Recruiting | |
| NCT04319627 | Statins for Venous Event Reduction in Patients With Venous Thromboembolism (NCT04319627) | Venous Thromboembolism,Blood Clot,Post Thrombotic Syndrome | Recruiting | jbrinkhurst@ohri.ca |
| NCT03481010 | Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology (NCT03481010) | Hip Dysplasia | Recruiting | |
| NCT04824144 | Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care (NCT04824144) | Hyperactive Delirium,Delirium of Mixed Origin | Recruiting | |
| NCT04485195 | RAFF4 Trial: Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department (NCT04485195) | Atrial Fibrillation | Recruiting | istiell@ohri.ca,ericbrown@ohri.ca |
| NCT03266783 | Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism (NCT03266783) | Venous Thromboembolism | Recruiting | lcastellucci@toh.ca,vebates@ohri.ca |
| NCT03309579 | SAHaRA: A Randomized Controlled Trial (NCT03309579) | Subarachnoid Hemorrhage, Aneurysmal | Recruiting | senglish@ohri.ca |
| NCT05258578 | Tele-BARICARE to Manage COVID-19-Related Distress (NCT05258578) | Obesity,Bariatric Surgery Candidate,Mental Health Disorder,Eating Disorders | Recruiting | dasandre@toh.ca |
| NCT04448184 | Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial) (NCT04448184) | Hematologic Neoplasms | Recruiting | atinmouth@ohri.ca |
| NCT05809999 | IBD Neoplasia Surveillance RCT (NCT05809999) | Colonic Neoplasms,Inflammatory Bowel Diseases,Dysplasia | Recruiting | |
| NCT03103932 | Biomarker Guided Discharge of Heart Failure Patients (NCT03103932) | Heart Failure; With Decompensation | Recruiting | |
| NCT04224974 | Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia (NCT04224974) | Acute Leukemia | Recruiting | |
| NCT04318665 | Early Diagnosis of Mortality Using Admission CT Perfusion in Severe Traumatic Brain Injury Patients (ACT-TBI Study) (NCT04318665) | Traumatic Brain Injury | Recruiting | |
| NCT05605509 | RP-6306 in Patients With Advanced Cancer (NCT05605509) | Advanced Cancer | Recruiting | |
| NCT05707208 | A Randomized, Controlled Study of Repeat Dose Sustained Release Lidocaine for Treatment of Chronic Scrotal Pain (NCT05707208) | Chronic Pain | Recruiting | amanross@toh.ca |
| NCT04803747 | A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery (NCT04803747) | Major Non-cardiac Surgeries | Recruiting | emhladkowicz@toh.ca,nkhalil@ohri.ca |
| NCT02869802 | Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic Analysis (NCT02869802) | Cancer,Pancreatic Cancer | Recruiting | |
| NCT04304651 | Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism (NCT04304651) | Embolism and Thrombosis | Recruiting | adelluc@toh.ca,mcarrier@toh.ca |
| NCT02821013 | Duration of Anti-PD-1 Therapy in Metastatic Melanoma (NCT02821013) | Unresectable/Metastatic Melanoma | Recruiting | |
| NCT03850847 | Understanding Decision Making in the Intensive Care Unit: a National Study (NCT03850847) | Organ Donation | Recruiting | |
| NCT04624477 | Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer (NCT04624477) | Papillary Thyroid Cancer,Papillary Thyroid Carcinoma,Papillary Microcarcinoma of the Thyroid | Recruiting | |
| NCT05601440 | Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer (NCT05601440) | Breast Cancer | Recruiting | |
| NCT03260478 | HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial (NCT03260478) | Traumatic Brain Injury,Transfusion | Recruiting | |
| NCT05371808 | Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: (NCT05371808) | Chronic Lymphocytic Leukemia,Small Lymphocytic Lymphoma | Recruiting | |
| NCT04260802 | A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802) | Cancer,Neoplasms,Metastatic Cancer,Triple Negative Breast Cancer,Gastric Cancer,Cervical Cancer,Ovarian Cancer,Hepatocellular Carcinoma,Squamous Cell Carcinoma of Head and Neck,Urothelial Carcinoma,Urothelial Neoplasm,Non Small Cell Lung Cancer,Renal Cell Carcinoma,Locally Advanced Solid Tumor,Locally Advanced Malignant Neoplasm,Squamous Cell Carcinoma,Sarcoma,Merkel Cell Carcinoma,Bladder Cancer | Recruiting | djonker@toh.ca |
| NCT04180722 | Transition to LIVE (Long-term In Home Ventilation Engagement) Study (NCT04180722) | Long-term Ventilation at Home | Recruiting | dmckim@toh.on.ca |
| NCT02999022 | Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) (NCT02999022) | Fractures | Recruiting | spapp@toh.ca,medodd@ohri.ca |
| NCT05306327 | Neurologic Physiology After Removal of Therapy (NeuPaRT) (NCT05306327) | Determination of Death | Recruiting | |
| NCT05899101 | The Impact of Opioid and Cannabis Exposure on Fetal Growth (NCT05899101) | Pregnancy Related,Substance Use,Fetal Growth Retardation,Placenta Diseases | Recruiting | |
| NCT04794569 | Tinzaparin Lead-In to Prevent the Post-Thrombotic Syndrome (NCT04794569) | Deep Vein Thrombosis,Post Thrombotic Syndrome | Recruiting | adelluc@toh.ca,dawarner@ohri.ca |
| NCT04263038 | Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism (NCT04263038) | Pulmonary Embolism,Embolism,Embolism and Thrombosis,Lung Diseases,Cardiovascular Diseases,Respiratory Tract Diseases,Venous Thromboembolism,Anticoagulant-induced Bleeding,Bleeding | Recruiting | |
| NCT04223505 | Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus (NCT04223505) | Atrial Fibrillation | Recruiting | |
| NCT04330690 | Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial (NCT04330690) | COVID-19 | Recruiting | senglish@ohri.ca,iwatpool@ohri.ca,rporteous@ohri.ca |
| NCT04743765 | HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial (NCT04743765) | Hip Fractures,Myocardial Injury | Recruiting | kmcilquham@ohri.ca |
| NCT05171075 | A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE (NCT05171075) | Venous Thromboembolism,Deep Venous Thrombosis,Pulmonary Embolism | Recruiting | |
| NCT04702945 | Canadian COVID-19 Emergency Department Registry (NCT04702945) | Covid-19 | Recruiting | |
| NCT03385655 | Prostate Cancer Biomarker Enrichment and Treatment Selection (NCT03385655) | Prostate Cancer | Recruiting | |
| NCT05032495 | Patient Engagement Study to Evaluate the Use of Biological Therapies for Cardiac Arrhythmias (NCT05032495) | Arrythmia | Recruiting | |
| NCT05176639 | A Safety, Tolerability and Efficacy Study of VRDN 001 in Healthy Volunteers and Persons With Thyroid Eye Disease (TED) (NCT05176639) | Thyroid Eye Disease | Recruiting | |
| NCT05913687 | Automated Imaging Differentiation of Parkinsonism (NCT05913687) | Parkinson Disease,Multiple System Atrophy, Parkinson Variant,Progressive Supranuclear Palsy | Recruiting | tanthompson@ohri.ca |
| NCT05716334 | Biosimilars of Rituximab in ANCA-associated Vasculitis Compared to the Originator (NCT05716334) | ANCA-associated Vasculitis,Granulomatosis With Polyangiitis,Microscopic Polyangiitis | Recruiting | |
| NCT02960087 | Phase II High Dose Brachytherapy and Low Dose Rate Brachytherapy as Monotherapy in Localized Prostate Cancer (NCT02960087) | Prostate Carcinoma | Recruiting | |
| NCT04564079 | An Observational Study to Evaluate the Clinical Utility of the Oncomine Precision Assay Within the Exactis Network (NCT04564079) | NSCLC | Recruiting | natremblay@ohri.ca |
| NCT05840224 | Study of GS-4528 in Adults With Solid Tumors (NCT05840224) | Solid Tumor | Recruiting | |
| NCT03718260 | PSMA-PET Registry for Recurrent Prostate Cancer (NCT03718260) | Recurrent Prostate Cancer | Recruiting | dyachnin@ohri.ca |
| NCT05466838 | PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial (NCT05466838) | Pancreatic Insufficiency | Recruiting | |
| NCT04580225 | Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE) (NCT04580225) | Wrist Arthritis,Wrist Arthropathy,Scapholunate Advanced Collapse,Scaphoid Nonunion,Post-traumatic; Arthrosis,Arthritis,Musculoskeletal Diseases,Joint Diseases | Recruiting | nagrawal@ohri.ca |
| NCT03261102 | TDM Guided Early Optimization of ADAL in Crohn's Disease (NCT03261102) | Crohn Disease,Drug Monitoring,Inflammatory Bowel Diseases | Recruiting | metessier@ohri.ca |
| NCT04415060 | SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival (NCT04415060) | Covid19,Hypoxic Respiratory Failure | Recruiting | jhaines@toh.ca,iwatpool@toh.ca |
| NCT04472910 | GATA6 Expression as a Predictor of Response to Peri-Operative Chemotherapy in Resectable Pancreatic Adenocarcinoma (NCT04472910) | Resectable Pancreatic Cancer | Recruiting | |
| NCT05137119 | Staphylococcus Aureus Network Adaptive Platform Trial (NCT05137119) | Staphylococcus Aureus Bacteremia | Recruiting | |
| NCT03070522 | Prednisone in Cystic Fibrosis Pulmonary Exacerbations (NCT03070522) | Cystic Fibrosis Pulmonary Exacerbation | Recruiting | byazji@ohri.ca,iseguin@toh.ca |
| NCT05892666 | The Right Care, for the Right Patient, at the Right Time, by the Right Provider: A Value-based Comparison of the Management of Ambulatory Patients With Acute Health Concerns in walk-in Clinics, Primary Care Physician Practices and Emergency Departments (NCT05892666) | Ambulatory Care,Emergency Services, Hospital,Quality of Care,Costs | Recruiting | jperry@ohri.ca |
| NCT04035005 | A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (NCT04035005) | Multiple Sclerosis, Primary Progressive | Recruiting | |
| NCT05171049 | A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE (NCT05171049) | Venous Thromboembolism,Deep Venous Thrombosis,Pulmonary Embolism | Recruiting | |
| NCT05487235 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05487235) | Advanced Solid Tumors,Metastatic Solid Tumors | Recruiting | |
| NCT04449874 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874) | Non-Small Cell Lung Cancer,Colorectal Cancer,Advanced Solid Tumors | Recruiting | |
| NCT02735707 | Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (NCT02735707) | Community-acquired Pneumonia, Influenza, COVID-19 | Recruiting | |
| NCT03833024 | The MUFFIN-PTS Trial (NCT03833024) | Post-Thrombotic Syndrome | Recruiting | glegal@ohri.ca,joscyr@ohri.ca |
| NCT03559114 | PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST) (NCT03559114) | Traumatic Brain Injury | Recruiting | rporteous@ohri.ca,smiezitis@ohri.ca |
| NCT02675569 | ACCESS HD: Comparing Catheters to Fistulas in Elderly Patients Starting Hemodialysis (NCT02675569) | End-stage Kidney Failure | Recruiting | shiremath@toh.on.ca,jbiggs@ohri.ca |
| NCT04558593 | Surveillance of Complex Renal Cysts - The SOCRATIC Study (NCT04558593) | Complex Renal Cyst | Recruiting | |
| NCT04182776 | Fragility Fractures of the Pelvis (FFP) (NCT04182776) | Pelvic Fracture | Recruiting | |
| NCT03569826 | Canadian Network for Autoimmune Liver Disease (NCT03569826) | Primary Bilary Cirrhosis (PBC),Autoimmune Hepatitis,Overlap Syndrome | Recruiting | angcheung@toh.ca,mmuir@toh.ca |
| NCT05395819 | Clinical Evaluation of Reverse Versus Anatomic Shoulder Arthroplasty Techniques in the Treatment of Osteoarthritis (NCT05395819) | Shoulder Osteoarthritis | Recruiting | |
| NCT05032196 | Study of WVE-003 in Patients With Huntington's Disease (NCT05032196) | Huntington Disease | Recruiting | tanthompson@ohri.ca |
| NCT04874038 | Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) (NCT04874038) | Post-mastectomy Pain Syndrome,Breast Cancer,Pain, Postoperative,Pain, Chronic | Recruiting | |
| NCT05428735 | The DRAGON 2 Trial (NCT05428735) | Colorectal Cancer Liver Metastases (CRLM),Small Future Liver Remnant (FLR) | Recruiting | |
| NCT04624906 | Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia (NCT04624906) | Waldenstrom Macroglobulinemia | Recruiting | |
| NCT03573089 | Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE) (NCT03573089) | Kidney Failure, Chronic,Hyperphosphatemia | Recruiting | shiremath@toh.ca |
| NCT03589326 | A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia (NCT03589326) | Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) | Recruiting | jfulcher@toh.ca |
| NCT01574053 | Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort (NCT01574053) | Huntington's Disease | Recruiting | jading@toh.ca |
| NCT03944798 | Surveillance AFter Extremity Tumor surgerY (NCT03944798) | Soft Tissue Sarcoma,Lung Metastases | Recruiting | |
| NCT04683848 | Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury (NCT04683848) | Spinal Cord Injury | Recruiting | |
| NCT02355171 | Personalize My Treatment (PMT) Registry (NCT02355171) | Cancer | Recruiting | natremblay@ohri.ca |
| NCT03838718 | REtroperitoneal SArcoma Registry: an International Prospective Initiative (NCT03838718) | Retroperitoneal Sarcoma | Recruiting | cnessim@toh.ca |
| NCT04335292 | Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer With Osimertinib Third-line Rechallenge (NCT04335292) | Non-Small Cell Lung Cancer | Recruiting | |
| NCT03715478 | Multi-Center Study of GSK2857916 in Combination With Pomalidomide and Dex (NCT03715478) | Relapsed and/or Refractory Multiple Myeloma | Recruiting | |
| NCT04521413 | Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies (NCT04521413) | Advanced Solid Malignancies | Recruiting | |
| NCT02906943 | Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943) | Breast Cancer,Lung Cancer,Colorectal Cancer,Melanoma,Gynecological Cancer,Genitourinary Cancer,Pancreatobiliary Cancer,Gastrointestinal Cancer,Head and Neck Cancer,Rare Cancer,Unknown Primary Cancer | Recruiting | hanzhang@ohri.ca,kchristink@toh.ca |
| NCT05151172 | EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial) (NCT05151172) | Acute Ischemic Stroke | Recruiting | mdemetrof@ohri.ca |
| NCT03860883 | Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (NCT03860883) | Cutaneous Melanoma, Stage II | Recruiting | cnessim@toh.ca |
| NCT03297606 | Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (NCT03297606) | Lymphoma, Non-Hodgkin,Multiple Myeloma,Advanced Solid Tumors | Recruiting | |
| NCT05180097 | Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma (NCT05180097) | Hodgkin Lymphoma | Recruiting | |
| NCT02436707 | Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma (NCT02436707) | Lymphoma | Recruiting | |
| NCT00819208 | Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer (NCT00819208) | Anxiety Disorder,Cognitive/Functional Effects,Colorectal Cancer,Depression,Fatigue,Psychosocial Effects of Cancer and Its Treatment,Sleep Disorders,Excercise | Recruiting | |
| NCT03784755 | Local Ablative Therapy For Hormone Sensitive Oligometastatic Prostate Cancer (NCT03784755) | Prostate Cancer Metastatic | Recruiting | |
| NCT04675294 | Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03) (NCT04675294) | Head and Neck Cancer,Head and Neck Squamous Cell Carcinoma | Recruiting | |
| NCT03151629 | International Registry for Men With Advanced Prostate Cancer (IRONMAN) (NCT03151629) | Prostate Cancer | Recruiting | |
| NCT05132582 | A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer (NCT05132582) | HER2 Positive Breast Cancer | Recruiting | |
| NCT04151342 | CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS) (NCT04151342) | Cancer,Malignancies Multiple,Malignant Solid Tumor,Cancer, Therapy-Related,Molecular Sequence Variation,Genetic Alteration,Gene Fusion,Receptor Tyrosine Kinase Gene Mutation,RTK Family Gene Mutation,Ras (Kras or Nras) Gene Mutation | Recruiting | |
| NCT05229900 | A Study of SGN-ALPV in Advanced Solid Tumors (NCT05229900) | Ovarian Neoplasms,Endometrial Neoplasms,Carcinoma, Non-Small-Cell Lung,Stomach Neoplasms,Gastroesophageal Junction Carcinoma,Uterine Cervical Neoplasms,Testicular Neoplasms | Recruiting | |
| NCT02468024 | JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024) | Non-Small Cell Lung Cancer | Recruiting | sgilbert@toh.ca,afazekas@toh.ca |
| NCT05199272 | A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies (NCT05199272) | Solid Tumor,Clear Cell Renal Cell Carcinoma,Epithelial Ovarian Cancer,Fallopian Tube Cancer,Primary Peritoneal Carcinoma,Neuroendocrine Tumors,MSI-H Cancer,Cancer With A High Tumor Mutational Burden,Extensive-stage Small-cell Lung Cancer | Recruiting | |
| NCT04680442 | Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction (NCT04680442) | Breast Cancer,Heart Failure | Recruiting | kelross@ohri.ca |
| NCT03948074 | Cannabis For Cancer-Related Symptoms (NCT03948074) | Pain,Nausea,Anxiety,Sleep Disturbance | Recruiting | sdownar@ohri.ca |
| NCT03778502 | DOAC in Unusual Site Venous Thrombosis (NCT03778502) | Splanchnic Vein Thrombosis,Cerebral Vein Thrombosis,Ovarian Vein Thrombosis,Renal Vein Thrombosis,Retinal Vein Thrombosis | Recruiting | |
| NCT03020303 | Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease (NCT03020303) | Endstage Renal Disease | Recruiting | dzimmerman@toh.on.ca |
| NCT04650581 | Fulvestrant and Ipatasertib for Advanced HER-2 Negative and Estrogen Receptor Positive (ER+) Breast Cancer Following Progression on First Line CDK 4/6 Inhibitor and Aromatase Inhibitor (NCT04650581) | Breast Cancer | Recruiting | |
| NCT03496883 | Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial (NCT03496883) | Intracerebral Hemorrhage | Recruiting | ddowlat@toh.ca |
| NCT03127631 | A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (NCT03127631) | Prostate Cancer,Cardiovascular Disease | Recruiting | dyachnin@toh.ca |
| NCT04853576 | A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY) (NCT04853576) | Sickle Cell Disease,Hemoglobinopathies | Recruiting | |
| NCT04401475 | A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients With COVID-19 (NCT04401475) | COVID-19,ARDS | Recruiting | |
| NCT03847649 | A Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies (NCT03847649) | Cancer | Recruiting | |
| NCT05364749 | Selective CT for Anticoagulated Head Injured Patients (NCT05364749) | Head Injury,Traumatic Brain Injury,Intracranial Hemorrhage, Traumatic,Blunt Head Injury | Recruiting | |
| NCT05376891 | Met Non Small Cell Cancer Registry (MOMENT) (NCT05376891) | Cancer | Recruiting | |
| NCT03419689 | Study Looking at Biomarkers in Ovarian Cancer (NCT03419689) | Gynecologic Cancer | Recruiting | jweberpals@toh.ca |
| NCT03674307 | Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates (NCT03674307) | Cardiovascular Diseases,End Stage Renal Disease,Kidney Transplantation,Dialysis Related Complication | Recruiting | erithomas@toh.ca,miricci@ohri.ca |
| NCT05382299 | Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Metastatic Triple-Negative Breast Cancer (NCT05382299) | Triple Negative Breast Cancer,PD-L1 Negative | Recruiting | |
| NCT05382286 | Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382286) | Triple Negative Breast Cancer,PD-L1 Positive | Recruiting | |
| NCT03642587 | Canadian Sudden Cardiac Arrest Network (NCT03642587) | Sudden Cardiac Death,Sudden Cardiac Arrest | Recruiting | |
| NCT05581004 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05581004) | Locally Advanced or Metastatic Solid Tumors,NSCLC,HNSCC,Melanoma,TNBC,Esophageal Cancer,Gastric Cancer,Cervical Cancer,Urothelial Carcinoma,Clear Cell RCC,HCC | Recruiting | |
| NCT04835805 | A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma. (NCT04835805) | Melanoma | Recruiting | |
| NCT05325866 | A Study Evaluating Bemarituzumab in Solid Tumors With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (NCT05325866) | Solid Tumors | Recruiting | |
| NCT04471844 | Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM (NCT04471844) | Glioblastoma Multiforme | Recruiting | gnicholas@toh.ca |
| NCT05388669 | A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer (NCT05388669) | Advanced or Metastatic Non-small Cell Lung Cancer | Recruiting | |
| NCT05052801 | Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (NCT05052801) | Gastric Cancer,Gastroesophageal Junction Adenocarcinoma | Recruiting | |
| NCT05379595 | A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (NCT05379595) | Advanced or Metastatic Colorectal Cancer | Recruiting | |
| NCT05269355 | A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS) (NCT05269355) | Leiomyosarcoma | Recruiting | |
| NCT05327530 | A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley) (NCT05327530) | Locally Advanced or Metastatic Urothelial Carcinoma | Recruiting | |
| NCT04894591 | To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC) (NCT04894591) | Extensive-stage Small-cell Lung Cancer | Recruiting | |
| NCT03968393 | Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery (NCT03968393) | Stroke,Atrial Fibrillation | Recruiting | |
| NCT03950076 | EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF) (NCT03950076) | Intracranial Hemorrhages,Atrial Fibrillation | Recruiting | |
| NCT05049798 | A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice (NCT05049798) | Arthritis, Psoriatic | Recruiting | |
| NCT04951622 | A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis (NCT04951622) | Myasthenia Gravis | Recruiting | |
| NCT05397470 | Efficacy and Safety of Losmapimod in Treating Participants With Facioscapulohumeral Muscular Dystrophy (FSHD) (REACH) (NCT05397470) | Facioscapulohumeral Muscular Dystrophy (FSHD) | Recruiting | ifisette@ohri.ca |
| NCT05054140 | Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis (NCT05054140) | Multiple Sclerosis | Recruiting | |
| NCT04467905 | ReVeRA-201: Etripamil in Atrial Fibrillation, Phase 2 (NCT04467905) | Atrial Fibrillation | Recruiting | |
| NCT05650632 | A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma (NCT05650632) | Multiple Myeloma | Recruiting | |
| NCT04468984 | Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis (NCT04468984) | Myelofibrosis (MF) | Recruiting | |
| NCT04340141 | Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer (NCT04340141) | Pancreatic Adenosquamous Carcinoma,Resectable Pancreatic Adenocarcinoma,Pancreatic Cancer | Recruiting | |
| NCT04477785 | PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort (NCT04477785) | Parkinson Disease | Recruiting | |
| NCT04045587 | International Severe Asthma Registry: Canadian Cohort (NCT04045587) | Severe Asthma | Recruiting | kvandemheen@ohri.ca |
| NCT04657081 | Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML) (NCT04657081) | Acute Myeloid Leukemia | Recruiting | |
| NCT04191499 | A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Patients With PIK3CA-Mutant, Hormone Receptor-Positive, Her2-Negative, Locally Advanced or Metastatic Breast Cancer (NCT04191499) | Breast Cancer | Recruiting | |
| NCT05085366 | A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age (NCT05085366) | Cytomegalovirus Infection | Recruiting | |
| NCT04295538 | Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI) (NCT04295538) | Spinal Cord Injury (SCI) | Recruiting | |
| NCT04529122 | A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test (NCT04529122) | Solid Tumours | Recruiting | |
| NCT05217446 | A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer (NCT05217446) | Metastatic Colorectal Cancer | Recruiting | |
| NCT05546476 | Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 (NCT05546476) | Non-small Cell Lung Cancer,Pancreatic Cancer,Colorectal Cancer,Loss of Appetite,Fatigue,Cachexia | Recruiting | |
| NCT04589845 | Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study (NCT04589845) | Solid Tumors | Recruiting | |
| NCT05646862 | A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy (NCT05646862) | Breast Cancer | Recruiting | |
| NCT05050942 | A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET (NCT05050942) | Gastro-enteropancreatic Neuroendocrine Tumor | Recruiting | |
| NCT04031677 | Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (NCT04031677) | Retroperitoneal Sarcoma,Liposarcoma,Leiomyosarcoma | Recruiting | |
| NCT05573555 | TACTIVE-U: A Study to Learn About the Study Medicine (Called ARV-471) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) (NCT05573555) | Breast Cancer | Recruiting | |
| NCT05355701 | A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors. (NCT05355701) | Melanoma,Colorectal Cancer,Non-Small-Cell Lung Cancer,Thyroid Cancer,Glioma | Recruiting | |
| NCT05090566 | MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma (NCT05090566) | Multiple Myeloma | Recruiting | |
| NCT05548127 | TACTIVE-U: A Study to Learn About the Study Medicine (Called ARV-471) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A) (NCT05548127) | Breast Cancer | Recruiting | |
| NCT05538130 | A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130) | Melanoma,Glioma,Thyroid Cancer,Non-Small Cell Lung Cancer,Malignant Neoplasms,Brain Neoplasms,Colorectal Cancer | Recruiting | |
| NCT05587296 | A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer (NCT05587296) | Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer,Hot Flashes | Recruiting | |
| NCT04728893 | Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (NCT04728893) | Hematologic Malignancies,Waldenstroms Macroglobulinaemia,Non-Hodgkins Lymphoma,Chronic Lymphocytic Leukaemia | Recruiting | |
| NCT03924869 | Efficacy and Safety Study of Stereotactic Body Radiotherapy (SBRT) With or Without Pembrolizumab (MK-3475) in Adults With Unresected Stage I or II Non-Small Cell Lung Cancer (NSCLC) (MK-3475-867/KEYNOTE-867) (NCT03924869) | Non-Small Cell Lung Cancer | Recruiting | |
| NCT03564691 | Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-4830-001) (NCT03564691) | Neoplasms | Recruiting | |
| NCT04633655 | International CIPN Assessment and Validation Study (NCT04633655) | Chemotherapy-induced Peripheral Neuropathy,Quality of Life | Recruiting | krdennis@toh.ca |
| NCT04548661 | Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (NCT04548661) | Surgical Site Infection | Recruiting | jaboukhalil@toh.ca |
| NCT05481151 | A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV (NCT05481151) | Polycythemia Vera | Recruiting | dmaassen@ohri.ca |
| NCT04513717 | Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial (NCT04513717) | Metastatic Malignant Neoplasm in the Bone,Prostate Adenocarcinoma,Stage III Prostate Cancer AJCC v8,Stage IIIA Prostate Cancer AJCC v8,Stage IIIB Prostate Cancer AJCC v8,Stage IIIC Prostate Cancer AJCC v8,Stage IVA Prostate Cancer AJCC v8 | Recruiting | |
| NCT04269902 | Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study (NCT04269902) | Chronic Lymphocytic Leukemia,Small Lymphocytic Lymphoma | Recruiting | |
| NCT03233191 | Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer (NCT03233191) | Breast Screening | Recruiting | |
| NCT03488693 | Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (NCT03488693) | Breast Cancer | Recruiting | |
| NCT04700124 | Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304) (NCT04700124) | Muscle Invasive Bladder Cancer | Recruiting | |
| NCT01864096 | The Metformin Active Surveillance Trial (MAST) Study (NCT01864096) | Prostate Cancer | Recruiting | |
| NCT03833167 | Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630) (NCT03833167) | Carcinoma, Squamous Cell | Recruiting | |
| NCT04210115 | Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975) (NCT04210115) | Esophageal Squamous Cell Carcinoma (ESCC),Gastroesophageal Junction Carcinoma (GEJC),Esophageal Adenocarcinoma (EAC) | Recruiting | |
| NCT04635891 | Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) (NCT04635891) | FSHD | Recruiting | ifisette@ohri.ca,jemacgregor@ohri.ca |
| NCT03969953 | Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease (NCT03969953) | Chronic Kidney Diseases,Dialysis-dependent Kidney Failure,Cardiovascular Disease | Recruiting | |
| NCT03969992 | A Dose-Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFact (NCT03969992) | Respiratory Distress Syndrome in Premature Infant | Recruiting | |
| NCT02598661 | Study to Evaluate Imetelstat (GRN163L) in Subjects With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) (NCT02598661) | Myelodysplastic Syndromes | Recruiting | |
| NCT04586023 | Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS) (NCT04586023) | Relapsing Multiple Sclerosis | Recruiting | |
| NCT05665595 | A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010) (NCT05665595) | Melanoma | Recruiting | |
| NCT05686070 | A Study to Test Asundexian to Prevent a Clot-related Stroke in Participants After an Acute Ischemic Stroke or High-risk TIA/Mini-stroke (Transient Ischemic Attack) (NCT05686070) | Prevention of Ischemic Stroke,Acute Non-cardioembolic Ischemic Stroke,High-risk Transient Ischemic Attack | Recruiting | |
| NCT04167527 | Endovascular Therapy for Low NIHSS Ischemic Strokes (NCT04167527) | Cerebral Ischemia | Recruiting | ddowlat@toh.ca,zdaham@ohri.ca |
| NCT04622319 | A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05) (NCT04622319) | HER2-Positive Primary Breast Cancer,Residual Invasive Breast Cancer | Recruiting | |
| NCT05269004 | A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis (NCT05269004) | Multiple Sclerosis | Recruiting | |
| NCT05358717 | A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) (NCT05358717) | Huntington Disease | Recruiting | |
| NCT04740918 | A Study of Trastuzumab Emtansine in Combination With Atezolizumab or Placebo as a Treatment for Participants With Human Epidermal Growth Factor 2 (HER2)-Positive and Programmed Death-ligand 1 (PD-L1)-Positive Locally Advanced (LABC) or Metastatic Breast Cancer (MBC) (NCT04740918) | Metastatic Breast Cancer | Recruiting | |
| NCT03599245 | This is an Extension Study of the Roche P-trials to Investigate Safety and Effectiveness of Ocrelizumab in Participants With Multiple Sclerosis (MS) (NCT03599245) | Multiple Sclerosis | Recruiting | |
| NCT04670016 | HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers (NCT04670016) | DIPG,Brain Tumor, Pediatric, Recurrent,Brain Tumor, DIPG,Radiation Toxicity,Radiation Exposure,Brain Tumor, Pediatric | Recruiting | |
