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Contact Information

Marjorie Brand, PhD
613-737-7700 ext 70336

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Selected Publications

M.A. Gillespie*, C.G. Palii*, D. Sanchez-Taltavull*, P. Shannon, W.J.R. Longabaugh, D.J. Downes, K. Sivaraman, H.M. Espinoza, J.R. Hughes, N.D. Price,T.J. Perkins**, J.A. Ranish** & M. Brand**. Absolute Quantification of Transcription Factors Reveal Principles  of Gene  Regulation in Erythropoiesis. Molecular Cell (2020),

C.G. Palii*, Q. Cheng*, M.A. Gillespie, P. Shannon, M. Mazurczyk, G. Napolitani, N.D. Price, J.A. Ranish, E. Morrissey**, D.R. Higgs** & M. Brand**. Single cell proteomics reveal that quantitative changes in co-expressed lineage-specific transcription factors determine cell fate. Cell Stem Cell (2019), 24:1-9

S. Fraineau, C.G. Palii, B. McNeill, M. Ritso, W.C Shelley, N. Prasain, A. Chu, E. Vion, K. Rieck, S. Nilufar, T.J. Perkins, M.A. Rudnicki, D.S. Allan, M.C. Yoder, E.J. Suuronen & M. Brand. Epigenetic activation of pro-angiogenic signaling pathways in human endothelial progenitors increases vasculogenesis. Stem Cell Reports, 9(5): 1573-1587, 2017

A. Benyoucef, C.G. Palii, C. Wang, C.J. Porter, A. Chu, F. Dai, V. Tremblay, P. Rakopoulos, K. Singh, S. Huang, F. Pflumio, J. Hebert, J-F. Couture, T.J. Perkins, K. Ge, F.J. Dilworth & M. Brand. UTX inhibition as a selective epigenetic therapy against TAL1-driven T cell acute lymphoblastic leukemia. Genes & Development, 30(5): 508-521, 2016

C.G. Palii, B. Vulesevic, S. Fraineau, E. Pranckeviciene, A.J. Griffith, A. Chu, H. Faralli, Y. Li, B. McNeill, J. Sun, T.J. Perkins, F.J. Dilworth, C. Perez-Iratxeta, E.J. Suuronen, D.S. Allan & M. Brand. Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes. Cell Stem Cell, 14(5): 644-657, 2014

C-P. Chaturvedi, B. Somasundaram, K. Singh, R.L. Carpenedo, W.L. Stanford, F.J. Dilworth & M. Brand. Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. Proceedings of the National Academy of Sciences USA, 109 (46): 18845-50, 2012

C.G. Palii*, C. Perez-Iratxeta*, Z. Yao, Y. Cao, F. Dai, J. Davison, H. Atkins, D. Allan, F.J. Dilworth, R. Gentleman, S. Tapscott & M. Brand. Differential genomic targeting of the transcription factor TAL1 in alternate hematopoietic lineages. The EMBO Journal, 30 (3): 494-509, 2011  * contributed equally

C-P. Chaturvedi*, A.M. Hosey*, C. Palii, C. Perez-Iratxeta, Y. Nakatani, J.A. Ranish, F.J. Dilworth & M. Brand. Dual role for the methyltransferase G9a in the maintenance of ß-globin gene transcription in adult erythroid cells. Proceedings of the National Academy of Sciences, 106 (43): 18303-18308, 2009 * contributed equally

C. Demers, C-P. Chaturvedi, J. A. Ranish, G. Juban, P. Lai, F. Morle, R. Aebersold, F. Dilworth, M. Groudine and M. Brand. Activator-mediated Recruitment of the MLL2 Methyltransferase Complex to the ß-globin Locus.  Molecular Cell, 27: 573-584, 2007