Marjorie started her lab at the Ottawa Hospital Research Institute (Sprott Center for Stem Cell Research) in September 2004.
She
received a PhD in
Molecular Biology (2001) from Universite Louis
Pasteur (Strasbourg, France) and did her postdoctoral studies
(2001-2004) at
the Fred Hutchinson Cancer Research Center
(Seattle, WA, USA).
She
was elected to the Royal Society of Canada's College of New Scholars, Artists and Scientists in 2014.
M.A. Gillespie*, C.G. Palii*, D. Sanchez-Taltavull*, P. Shannon, W.J.R. Longabaugh, D.J. Downes, K. Sivaraman, H.M. Espinoza, J.R. Hughes, N.D. Price,T.J. Perkins**, J.A. Ranish** & M. Brand**. Absolute Quantification of Transcription Factors Reveal Principles of Gene Regulation in Erythropoiesis.
Molecular Cell (2020), https://doi.org/10.1016/j.molcel.2020.03.03.031
C.G. Palii*, Q. Cheng*, M.A. Gillespie, P. Shannon, M. Mazurczyk, G. Napolitani, N.D. Price, J.A. Ranish, E. Morrissey**, D.R. Higgs** & M. Brand**. Single cell proteomics reveal that quantitative changes in co-expressed lineage-specific transcription factors determine cell fate.
Cell Stem Cell (2019), 24:1-9 https://doi.org/10.1016/j.stem.2019.02.006
S. Fraineau, C.G. Palii, B. McNeill, M. Ritso, W.C Shelley, N. Prasain, A. Chu, E. Vion, K. Rieck, S. Nilufar, T.J. Perkins, M.A. Rudnicki, D.S. Allan, M.C. Yoder, E.J. Suuronen & M. Brand. Epigenetic activation of pro-angiogenic signaling pathways in human endothelial progenitors increases vasculogenesis.
Stem Cell Reports, 9(5): 1573-1587, 2017
A. Benyoucef, C.G. Palii, C.
Wang, C.J. Porter, A. Chu, F. Dai, V. Tremblay, P. Rakopoulos, K.
Singh, S. Huang, F. Pflumio, J. Hebert, J-F. Couture, T.J. Perkins, K. Ge, F.J.
Dilworth & M. Brand. UTX
inhibition as a selective epigenetic therapy against TAL1-driven T cell acute
lymphoblastic leukemia.
Genes &
Development, 30(5): 508-521, 2016
C.G. Palii, B. Vulesevic, S.
Fraineau, E. Pranckeviciene, A.J. Griffith, A. Chu, H.
Faralli, Y. Li, B. McNeill, J. Sun, T.J. Perkins, F.J. Dilworth, C. Perez-Iratxeta, E.J. Suuronen, D.S. Allan & M.
Brand. Trichostatin A enhances vascular repair by injected human
endothelial progenitors through increasing the expression of TAL1-dependent genes.
Cell Stem Cell, 14(5): 644-657, 2014
C-P. Chaturvedi, B. Somasundaram, K. Singh, R.L. Carpenedo, W.L. Stanford, F.J.
Dilworth & M. Brand. Maintenance
of gene silencing by the coordinate action of the H3K9 methyltransferase
G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A.
Proceedings of the National Academy of Sciences USA, 109 (46): 18845-50, 2012
C.G.
Palii*, C. Perez-Iratxeta*, Z. Yao, Y. Cao, F. Dai, J. Davison, H.
Atkins, D. Allan, F.J. Dilworth, R. Gentleman, S. Tapscott & M. Brand. Differential genomic targeting of the transcription
factor TAL1 in alternate hematopoietic lineages.
The EMBO Journal, 30 (3):
494-509, 2011
* contributed
equally
C-P.
Chaturvedi*, A.M. Hosey*, C. Palii, C. Perez-Iratxeta, Y.
Nakatani, J.A. Ranish, F.J. Dilworth & M.
Brand. Dual role for the methyltransferase G9a in
the maintenance of ß-globin gene transcription in adult erythroid cells.
Proceedings
of the National Academy of Sciences, 106 (43): 18303-18308, 2009
* contributed
equally
C. Demers, C-P. Chaturvedi,
J. A. Ranish, G. Juban, P. Lai, F. Morle, R. Aebersold, F. Dilworth, M.
Groudine and M. Brand. Activator-mediated
Recruitment of the MLL2 Methyltransferase Complex to the ß-globin Locus.
Molecular Cell, 27: 573-584, 2007