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Contact Information

Marjorie Brand, PhD
613-737-7700 ext 70336

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Marjorie Brand

Senior Scientist Affiliate, Regenerative Medicine
Ottawa Hospital Research Institute
Professor, Department of Medicine
University of Ottawa
Associate Member, Ottawa Institute for Systems Biology
University of Ottawa

Research Interests

Brief Biography

Marjorie started her lab at the Ottawa Hospital Research Institute (Sprott Center for Stem Cell Research)  in September 2004.

She received a PhD in Molecular Biology (2001) from Universite Louis Pasteur (Strasbourg, France) and did her postdoctoral studies (2001-2004) at the Fred Hutchinson Cancer Research Center (Seattle, WA, USA).

She was elected to the Royal Society of Canada's College of New Scholars, Artists and Scientists in 2014.

Selected Publications

M.A. Gillespie*, C.G. Palii*, D. Sanchez-Taltavull*, P. Shannon, W.J.R. Longabaugh, D.J. Downes, K. Sivaraman, H.M. Espinoza, J.R. Hughes, N.D. Price,T.J. Perkins**, J.A. Ranish** & M. Brand**. Absolute Quantification of Transcription Factors Reveal Principles  of Gene  Regulation in Erythropoiesis. Molecular Cell (2020),

C.G. Palii*, Q. Cheng*, M.A. Gillespie, P. Shannon, M. Mazurczyk, G. Napolitani, N.D. Price, J.A. Ranish, E. Morrissey**, D.R. Higgs** & M. Brand**. Single cell proteomics reveal that quantitative changes in co-expressed lineage-specific transcription factors determine cell fate. Cell Stem Cell (2019), 24:1-9

S. Fraineau, C.G. Palii, B. McNeill, M. Ritso, W.C Shelley, N. Prasain, A. Chu, E. Vion, K. Rieck, S. Nilufar, T.J. Perkins, M.A. Rudnicki, D.S. Allan, M.C. Yoder, E.J. Suuronen & M. Brand. Epigenetic activation of pro-angiogenic signaling pathways in human endothelial progenitors increases vasculogenesis. Stem Cell Reports, 9(5): 1573-1587, 2017

A. Benyoucef, C.G. Palii, C. Wang, C.J. Porter, A. Chu, F. Dai, V. Tremblay, P. Rakopoulos, K. Singh, S. Huang, F. Pflumio, J. Hebert, J-F. Couture, T.J. Perkins, K. Ge, F.J. Dilworth & M. Brand. UTX inhibition as a selective epigenetic therapy against TAL1-driven T cell acute lymphoblastic leukemia. Genes & Development, 30(5): 508-521, 2016

C.G. Palii, B. Vulesevic, S. Fraineau, E. Pranckeviciene, A.J. Griffith, A. Chu, H. Faralli, Y. Li, B. McNeill, J. Sun, T.J. Perkins, F.J. Dilworth, C. Perez-Iratxeta, E.J. Suuronen, D.S. Allan & M. Brand. Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes. Cell Stem Cell, 14(5): 644-657, 2014

C-P. Chaturvedi, B. Somasundaram, K. Singh, R.L. Carpenedo, W.L. Stanford, F.J. Dilworth & M. Brand. Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. Proceedings of the National Academy of Sciences USA, 109 (46): 18845-50, 2012

C.G. Palii*, C. Perez-Iratxeta*, Z. Yao, Y. Cao, F. Dai, J. Davison, H. Atkins, D. Allan, F.J. Dilworth, R. Gentleman, S. Tapscott & M. Brand. Differential genomic targeting of the transcription factor TAL1 in alternate hematopoietic lineages. The EMBO Journal, 30 (3): 494-509, 2011  * contributed equally

C-P. Chaturvedi*, A.M. Hosey*, C. Palii, C. Perez-Iratxeta, Y. Nakatani, J.A. Ranish, F.J. Dilworth & M. Brand. Dual role for the methyltransferase G9a in the maintenance of ß-globin gene transcription in adult erythroid cells. Proceedings of the National Academy of Sciences, 106 (43): 18303-18308, 2009 * contributed equally

C. Demers, C-P. Chaturvedi, J. A. Ranish, G. Juban, P. Lai, F. Morle, R. Aebersold, F. Dilworth, M. Groudine and M. Brand. Activator-mediated Recruitment of the MLL2 Methyltransferase Complex to the ß-globin Locus.  Molecular Cell, 27: 573-584, 2007

Diseases, conditions and populations of interest

Research and clinical approaches