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Fraser W. Scott, PhD

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Selected Publications

Dysregulated liver lipid metabolism and innate immunity associated with hepatic steatosis in neonatal BBdp rats and NOD mice. Serrano D, Crookshank JC, Morgan BS, Mueller RW, Paré M-F, Marandi L, Poussier P, Scott FW Scientific Reports 2019 Oct 10;9(1):14594.  PMID: 31601915

Changes in insulin, glucagon and ER stress precede immune activation in type 1 diabetes. Crookshank JA, Serrano D, Wang G-S, Patrick C, Morgan BS, Paré M-F, Scott FW Journal of Endocrinology August, 2018 PMID: 30139929

Where genes meet environment - Integrating the role of gut luminal contents, immunity and pancreas in type 1 diabetes. Scott FW, Pound LD, Patrick C, Eberhard C, Crookshank JA. Translational Research 179: 183-198, 2017 PMID: 27677687

Cathelicidin antimicrobial peptide: a novel regulator of islet function, islet regeneration and selected bacteria Pound LD, Patrick C, Eberhard C, Mottawea W, Wang GS, Abujamel T, Vandenbeek R, Stintzi A, Scott FW Diabetes 64:4135-47, 2015 PMID: 26370175

Jörns A, Arndt T, Vilsendorf AM, Klempnauer J, Wedekind D, Hedrich HJ, Marselli L, Marchetti P, Harada N, Nakaya Y, Wang GS, Scott FW, Gysemans C, Mathieu C, Lenzen S. Islet infiltration, immune cell activation and β-cell death in the NOD mouse, BB rat, Komeda rat, and LEW.1AR1-iddm rat in comparison with the pancreas of patients with type 1 diabetes. Diabetologia, 57:512-21 2014 PMID: 24310561

Patrick C, Wang GS, Lefebvre DE, Crookshank JA, Sonier B, Eberhard C, Mojibian M, Kennedy C, Brooks SPJ, Kalmokoff M, Maglio M, Troncone R, Poussier P, Scott FW. Promotion of autoimmune diabetes by cereal diet in the presence or absence of microbes associated with gut immune activation, regulatory imbalance and altered cathelicidin antimicrobial peptide. Diabetes 62:2036–2047, 2013  PMID: 23349499

Mojibian M, Chakir H, Lefebvre DE, Crookshank JA, Sonier B, Keely E, Scott FW. A diabetes-specific HLA-DR restricted pro-inflammatory T cell response to wheat polypeptides in tissue transglutaminase antibody negative patients with type 1 diabetes. Diabetes 58: 1789-1796, 2009 (Commentary, p. 1723) PMID: 19401421

MacFarlane AJ, Burghardt KM, Kelly J, Simell T, Simell O, Altosaar I, Scott FW A type 1 diabetes-related protein from wheat (Triticum aestivum): cDNA clone of a wheat storage globulin, Glb1, linked to islet damage J. Biol. Chem. 278:54-63, 2003 (Cover Article) PMID: 12409286

All Other Publications

Additional Publications

Chakir H, Wang H, Lefebvre D,  Webb J, Scott FW     T-bet/ Gata-3 ratio as a measure of Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3  J. Immunol. Methods 278: 157-169, 2003

Courtois P, Sener A, Scott FW, Malaisse WJ.  Disaccharidase activity in the intestinal tract of Wistar-Furth, BBc and BBdp rats Brit. J. Nutrition 91:201-9, 2004

Valverde I, Wang GS, Burghardt KM, Kauri LM, Redondo A, Acitores A, Villanueva-PeZacarrillo  ML,  Courtois P, Sener A, Cancelas J, Malaisse WJ, Scott FW.   Bioactive GLP-1 in gut, receptor expression in pancreas and insulin response to GLP-1 in diabetes-prone rats.  Endocrine 23:77-84, 2004

Courtois P, Sener A, Scott FW, Malaisse WJ. Peroxidase activity in the intestinal tract of Wistar-Furth, BBc and BBdp rats. Diabetes Metabolism Research & Reviews 20:305-14, 2004

Nikulina M, Habich C, Flohé SB, Scott FW, Kolb H.   Wheat gluten causes dendritic cell maturation and chemokine secretion.   Journal of Immunology 173:1925-33, 2004

Graham S, Courtois P, Malaisse WJ, Rozing J, Scott FW, Mowat AM.  Enteropathy precedes type 1 diabetes in the BB rat.  Gut 53: 1437-1444, 2004

Malaisse WJ, Courtois P, Scott FW.  Insulin-dependent diabetes and gut dysfunction: the BB rat model Hormone & Metabolic Research 36:585-94,  2004

Courtois P, Jurysta C, Sener A, Scott FW, Malaisse WJ.   Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats.  Int J Mol Med. 15:105-8, 2005

Courtois P, Nsimba G, Jijakli H, Sener A, Scott FW, Malaisse WJ.  Gut permeability and intestinal mucins, invertase and peroxidase in control and diabetes-prone BB rats fed either a protective or diabetogenic diet.  Digestive Diseases & Sciences 50: 266-275, 2005

Wang G-S, Rosenberg L, Scott FW  Tubular complexes as a source for islet neogenesis in the pancreas of diabetes-prone BB rats  Laboratory Investigation 85:675-688, 2005  (Editor Commentary – Inside Lab Invest)

Chakir H, Lefebvre D, Wang H, Caraher E, Scott FW  Wheat protein-induced pro-inflammatory Th1 bias in gut-associated lymphoid tissues of young diabetes-prone rats   Diabetologia  48:1576-84, 2005

Schmidt G,  Sirois F, Anini1 Y, Kauri LM,  Gyamera-Acheampong C, Fleck E, Scott FW, Chrétien M,  Mbikay M   Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus Sgne1    Diabetes 55:452-459, 2006

Mojibian M, Chakir H, MacFarlane AJ, Lefebvre DE,  Webb JR,  Touchie C, Karsh J,  Crookshank J, Scott FW    Immune Reactivity to a Glb1 Homologue in a Highly Wheat Sensitive Patient with Type 1 Diabetes and Celiac Disease  Diabetes Care 29:1108-1110, 2006

Lefebvre DE, Powell KL, Strom A, Scott FW.  Dietary Proteins as Environmental Modifiers of Type 1 Diabetes Mellitus  Annual Review of Nutrition 26:175-202, 2006

Wang GS, Kauri LM, Scott FW  The potential for dietary modification of islet ß-cell homeostasis in autoimmune diabetes.  Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry  (Formerly Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents) 7: 231-240, 2007

Strom A, Wang G-S, Reimer R, Finegood DT,  Scott FW.  Pronounced cytosolic aggregation of cellular prion protein in pancreatic ß-cells in response to hyperglycemia  Lab Investigation 87: 139-149, 2007 (Cover)

Kauri LM, Wang G-S, Patrick C, Bareggi M, Hill DJ, Scott FW.   Increased islet neogenesis without increased islet mass precedes autoimmune attack in diabetes-prone rats.  Laboratory Investigation 87:1240-51, 2007

Thakare K, Shi W, Barbeau WE, Bassaganya-Riera J, Hontecillas R, Scott FW  Investigation of chloroform-methanol soluble wheat proteins and sphingolipids as potential dietary triggers of  diabetes in BBdp rats  Food and Agr Immunol  19:25-48, 2008

Simpson M, Mojibian M, Barriga K, Scott FW, Fasano A, Rewers M, Norris JM.  An exploration of Glo-3A antibody levels in children at increased risk for type 1 diabetes mellitus. Pediatric Diabetes 10:563-72, 2009

Loit E, Melnyk CW, MacFarlane AJ, Scott FW, Altosaar I.   Identification of three wheat globulin genes by screening a T. aestivum BAC genomic library with cDNA from a diabetes-associated globulin BMC Plant Biology,  9:93, 2009

Fu A,  Cheuk-Him Ng A, Depatie C, Wijesekara N, He Y, Wang GS, Bardeesy N, Scott FW, Touyz R, Wheeler MB, Screaton RA.  Loss of Lkb1 in adult β cells promotes insulin secretion and improves glucose tolerance in mice.  Cell Metabolism 10:285-295, 2009

Mbikay M, Sirois F, Mayne J, Wang GS, Chen A, Dewpura T, Prat A, Seidah NG, Chretien M, Scott FW.   PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities  FEBS Letters, 584:701-706, 2010

Strom A, Sonier B, Chapman H, Mojibian M, Wang GS, Slatculescu CR, Serreze DV, Scott FW.  Peripherin-reactive antibodies in mouse, rabbit and human  J Proteome Research  9:1203-8, 2010

Wang GS, Kauri LM, Patrick C, Bareggi M, Rosenberg L, Scott FW.  Enhanced islet expansion by β-cell proliferation in young diabetes-prone rats fed a protective diet.   Journal of Cellular Physiology 224:501-8 2010

Taplin CE, Mojibian M, Simpson M, Taki I, Liu E, Hoffenberg EJ, Norris JM, Scott FW, Rewers M.    Antibodies to the wheat storage globulin Glo-3A in children before and at diagnosis of celiac disease  Journal of Pediatric Gastroenterology and Nutrition  52:21-5, 2011

Strom A, Wang GS, Scott FW.   Impaired blood glucose regulation in mice lacking cellular prion protein.  Pancreas 40: 229-232, 2011

Strom A, Wang GS, Picketts DJ, Reimer R,  Stuke AW, Scott FW.  Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components.  Eur J Cell Biol, 90:  414–419, 2011   (Cover Article)

Sonier B, Strom A, Wang GS, Patrick C, Crookshank J, Mojibian M, Scott FW   Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163. Can J Gastroenterol  25:327-329, 2011

St. Denis M, Sonier B, Robinson R, Scott FW,  Cameron DW, Lee BC.  Identification and characterization of a heme periplasmic-binding protein in Haemophilus ducreyi.  Biometals 24:709-22, 2011

Bowerman M, Michalski JP, Wang G.-S, Reeks C, Beauvais A, Murphy K, Woulfe J, Swoboda KJ, Screaton RA, Scott FW, Kothary R.  Glucose metabolism and pancreatic developmental defects typify Spinal Muscular Atrophy Annals of Neurology 72:256-68, 2012

Koziol AG, Loit E, McNulty M, MacFarlane AJ, Scott FW, Altosaar, I.  Seed storage proteins of the globulin family are cleaved post-translationally in wheat embryos  BMC Research Notes 5:385, 2012

Strom A, Yutzy B, Kruip C, Völker I, Schloot NC, Roden M, Scott FW, Löwer J, Holznagel E  Spontaneous obesity-linked type 2 diabetes in the absence of islet amyloid in a BSE-infected cynomolgus monkey  Veterinary Pathology Vet Pathol 50:909-13, 2013

Lamb MM, Simpson M, Seifert J, Scott FW, Rewers M, Norris JM  The Association between IgG4 Antibodies to Dietary Factors, Islet Autoimmunity and Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young  PLoS One  8:e57936. 2013 doi: 10.1371/journal.pone.0057936. Epub 2013 Feb 28.

Mbikay M, Sirois F, Gyamera-Acheampong C, Wang G-S, Rippstein P, Chen A, Mayne J, Scott FW, Chrétien M.  Variable effects of gender and western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice J. Diabetes  Feb 18, 2014. doi: 10.1111/1753-0407.12139. [Epub ahead of print]

Strom A, Yutzy B, Kruip C, Ooms M, Schloot NC, Roden M, Scott FW, Loewer J, Holznagel E.  Foodborne transmission of bovine spongiform encephalopathy to Cynomolgus macaques results in rapid-onset obesity  PLoSone, 9:e104343, 2014